meningioma

Mahlon Johnson Lab

Welcome to the Mahlon Johnson Lab

My lab studies leptomeningeal diseases especially meningeal neoplasia. Our emphasis in the past has been on identifying the role of growth factor/growth factor receptor expression and downstream signaling in the pathogenesis of meningiomas. This has included, for the first time, identifying expression and possible roles for the transforming growth factor beta superfamily, MEK-1- MAPK and PI3K-Akt pathways. We have also evaluated cerebrospinal effects on the leptomeningeal and meningioma cell proliferation. Additional studies have evaluated the expression and roles of mesothelin in the leptomeninges, metastases to the leptomeninges and in meningiomas.

We are currently working on the following projects:

Mechanisms of meningiomas invasion
Characterization of metaplastic meningiomas
Non-meningioma dural tumors

Mahlon D. Johnson, M.D., Ph.D.
Principal Investigator

Publications

View All Publications

1. Galbraith K
2. Vasudevaraja V
3. Serrano J
4. Shen G
5. Tran I
6. Abdallat N
7. Wen M
8. Patel S
9. Movahed-Ezazi M
10. Faustin A
11. Spino-Keeton M
12. Roberts LG
13. Maloku E
14. Drexler SA
15. Liechty BL
16. Pisapia D
17. Krasnozhen-Ratush O
18. Rosenblum M
19. Shroff S
20. Boué DR
21. Davidson C
22. Mao Q
23. Suchi M
24. North P
25. Hopp A
26. Segura A
27. Jarzembowski JA
28. Parsons L
29. Johnson MD
30. Mobley B
31. Samore W
32. McGuone D
33. Gopal PP
34. Canoll PD
35. Horbinski C
36. Fullmer JM
37. Farooqui MS
38. Gokden M
39. Wadhwani NR
40. Richardson TE
41. Umphlett M
42. Tsankova NM
43. DeWitt JC
44. Sen C
45. Placantonakis DG
46. Pacione D
47. Wisoff JH
48. Teresa Hidalgo E
49. Harter D
50. William CM
51. Cordova C
52. Kurz SC
53. Barbaro M
54. Orringer DA
55. Karajannis MA
56. Sulman EP
57. Gardner SL
58. Zagzag D
59. Tsirigos A
60. Allen JC
61. Golfinos JG
62. Snuderl M
Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.; Neuro-oncology advances; Vol 5(1), pp. vdad076. 2023 Jun 26.
1. Johnson MD
2. Rogers EJ
3. Khan MW
4. McMullen PD
5. Akkipeddi SMK
6. Mattingly T
7. Benesch CG
8. Bender MT
Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology: Case Report.; Neurology. Clinical practice; Vol 13(1), pp. e200129. 2023 Jan 19.
1. Santangelo G
2. Stone J
3. Johnson M
4. Walter K
Lumbar cistern Candida intradural abscess following epidural anesthesia.; Surgical neurology international; Vol 13, pp. 435. 2022 Sep 23.
1. Johnson MD
Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins.; Cancers; Vol 14(23). 2022 Jan 29.
1. Johnson MD
2. Almast J
3. Pieters T
4. Walter K
Atypical papillary glioneuronal tumor of the lateral ventricle. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 28: 2022; Interdisciplinary Neurosurgery: Advanced Techniques and Case Management; Vol 28. 2022 Jan 01.

Affiliations

Contact Us

Mahlon Johnson Lab
601 Elmwood Ave, Box 626
Rochester, NY 14642

Mahlon_Johnson@urmc.rochester.edu

(585) 276-3087

(585) 273-1027