URMC / Labs / Maquat Lab / Publications

Recent Publications

1. McMahon M
2. Maquat LE
Exploring the therapeutic potential of modulating nonsense-mediated mRNA decay.; RNA (New York, N.Y.). 2024 Dec 12.
1. Rambout X
2. Maquat LE
Nuclear mRNA decay: regulatory networks that control gene expression.; Nature reviews. Genetics. 2024 Apr 18.
1. Alessandrini F
2. Wright M
3. Kurosaki T
4. Maquat LE
5. Kiskinis E
ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length.; bioRxiv : the preprint server for biology. 2024 Feb 02.
1. Kurosaki T
2. Rambout X
3. Maquat LE
FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells.; Genome biology; Vol 25(1), pp. 31. 2024 Jan 23.
1. Rambout X
2. Cho H
3. Blanc R
4. Lyu Q
5. Miano JM
6. Chakkalakal JV
7. Nelson GM
8. Yalamanchili HK
9. Adelman K
10. Maquat LE
PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.; Molecular cell; Vol 83(2), pp. 186-202.e11. 2023 Jan 19.
1. Cho H
2. Abshire ET
3. Popp MW
4. Pröschel C
5. Schwartz JL
6. Yeo GW
7. Maquat LE
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.; Molecular cell. 2022 Jun 03.
1. Maquat L
2. Johnson R
3. Valadkhan S
4. Carninci P
Lessons from the functional characterization of lncRNAs: introduction to mammalian genome special issue.; Mammalian genome : official journal of the International Mammalian Genome Society. 2022 May 09.
1. Kurosaki T
2. Mitsutomi S
3. Hewko A
4. Akimitsu N
5. Maquat LE
Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.; Molecular cell. 2022 Jan 01.
1. Cable J
2. Heard E
3. Hirose T
4. Prasanth KV
5. Chen LL
6. Henninger JE
7. Quinodoz SA
8. Spector DL
9. Diermeier SD
10. Porman AM
11. Kumar D
12. Feinberg MW
13. Shen X
14. Unfried JP
15. Johnson R
16. Chen CK
17. Wilusz JE
18. Lempradl A
19. McGeary SE
20. Wahba L
21. Pyle AM
22. Hargrove AE
23. Simon MD
24. Marcia M
25. Przanowska RK
26. Chang HY
27. Jaffrey SR
28. Contreras LM
29. Chen Q
30. Shi J
31. Mendell JT
32. He L
33. Song E
34. Rinn JL
35. Lalwani MK
36. Kalem MC
37. Chuong EB
38. Maquat LE
39. Liu X
Noncoding RNAs: biology and applications-a Keystone Symposia report.; Annals of the New York Academy of Sciences. 2021 Nov 17.
1. Kurosaki T
2. Sakano H
3. Pröschel C
4. Wheeler J
5. Hewko A
6. Maquat LE
NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.; Genome biology; Vol 22(1). 2021 Nov 16.
1. Kurosaki T
2. Imamachi N
3. Pröschel C
4. Mitsutomi S
5. Nagao R
6. Akimitsu N
7. Maquat LE
Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay.; Nature cell biology; Vol 23(1). 2021 Jan.
1. Rambout X
2. Maquat LE
NCBP3: A Multifaceted Adaptive Regulator of Gene Expression.; Trends in biochemical sciences. 2020 Oct 05.
1. Rambout X
2. Maquat LE
The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing.; Genes & development; Vol 34(17-18). 2020 Sep 01.
1. Zheng D
2. Cho H
3. Wang W
4. Rambout X
5. Tian B
6. Maquat LE
3'READS+RIP defines differential Staufen1 binding to alternative 3'UTR isoforms and reveals structures and sequence motifs influencing binding and polysome association.; RNA (New York, N.Y.). 2020 Aug 12.
1. Popp MW
2. Cho H
3. Maquat LE
Viral subversion of nonsense-mediated mRNA decay.; RNA (New York, N.Y.). 2020 Jul 22.
1. Rambout X
2. Cho H
3. Maquat LE
Transcriptional Coactivator PGC-1α Binding to Newly Synthesized RNA via CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation.; Cold Spring Harbor symposia on quantitative biology. 2020 Apr 15.
1. Maquat LE
Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 375(1795). 2020 Mar 30.
1. Kurosaki T
2. Popp MW
3. Maquat LE
Publisher Correction: Quality and quantity control of gene expression by nonsense-mediated mRNA decay.; Nature reviews. Molecular cell biology; Vol 20(6). 2019 Jun.
1. Kurosaki T
2. Popp MW
3. Maquat LE
Quality and quantity control of gene expression by nonsense-mediated mRNA decay.; Nature reviews. Molecular cell biology. 2019 Apr 16.
1. Kim YK
2. Maquat LE
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.; RNA (New York, N.Y.); Vol 25(4). 2019 Apr.
1. Kurosaki T
2. Myers JR
3. Maquat LE
Defining nonsense-mediated mRNA decay intermediates in human cells.; Methods (San Diego, Calif.); Vol 155. 2019 Feb 15.
1. Wolin SL
2. Maquat LE
Cellular RNA surveillance in health and disease.; Science (New York, N.Y.); Vol 366(6467). 2019 Jan 15.
1. Kurosaki T
2. Myers JA
3. Maquat LE
Defining nonsense-mediated mRNA decay intermediates in human cells.; Methods: Biochemical and next generation sequencing approaches to study RNA regulation.. 2019 Jan 01.
1. Elbarbary RA
2. Maquat LE
Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro.; Methods: MicroRNA biogenesis, identification, function and decay.; Vol 152, pp. 18-22. 2019 Jan 01.
1. Kurosaki T
2. Miyoshi K
3. Myers JR
4. Maquat LE
Publisher Correction: NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.; Nature structural & molecular biology; Vol 25(11). 2018 Nov.
1. Kurosaki T
2. Miyoshi K
3. Myers JR
4. Maquat LE
NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.; Nature structural & molecular biology; Vol 25(10). 2018 Oct.
1. Elbarbary R
2. Maquat LE
Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro.; Methods (San Diego, Calif.). 2018 May 16.
1. Walter NG
2. Maquat LE
Introduction-RNA: From Single Molecules to Medicine.; Chemical reviews; Vol 118(8). 2018 Apr 25.
1. Kurosaki T
2. Maquat LE
Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation.; Nature structural & molecular biology; Vol 25(4). 2018 Apr.
1. Cho H
2. Rambout X
3. Gleghorn ML
4. Nguyen PQT
5. Phipps CR
6. Miyoshi K
7. Myers JR
8. Kataoka N
9. Fasan R
10. Maquat LE
Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.; Genes & development; Vol 32(7-8). 2018 Apr 01.
1. Lucas BA
2. Lavi E
3. Shiue L
4. Cho H
5. Katzman S
6. Miyoshi K
7. Siomi MC
8. Carmel L
9. Ares M
10. Maquat LE
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.; Proceedings of the National Academy of Sciences of the United States of America. 2018 Jan 16.
1. Kurosaki T
2. Hoque M
3. Maquat LE
Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP-Seq).; Methods in molecular biology (Clifton, N.J.); Vol 1720. 2018.
1. Rambout X
2. Dequiedt F
3. Maquat LE
Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.; Chemical reviews. 2017 Dec 18.
1. Popp MW
2. Maquat LE
Nonsense-mediated mRNA Decay and Cancer.; Current opinion in genetics & development; Vol 48. 2017 Nov 07.
1. Elbarbary RA
2. Miyoshi K
3. Hedaya O
4. Myers JR
5. Maquat LE
UPF1 helicase promotes TSN-mediated miRNA decay.; Genes & development; Vol 31(14). 2017 Jul 15.
1. Elbarbary RA
2. Maquat LE
Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism.; Nature structural & molecular biology; Vol 24(6). 2017 Jun 06.
1. Elbarbary RA
2. Miyoshi K
3. Myers JR
4. Du P
5. Ashton JM
6. Tian B
7. Maquat LE
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.; Science (New York, N.Y.); Vol 356(6340). 2017 May 26.
1. Gleghorn ML
2. Zhao J
3. Turner DH
4. Maquat LE
Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation.; Nucleic acids research. 2016 Jun 10.
1. Popp MW
2. Maquat LE
Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.; Cell; Vol 165(6). 2016 Jun 2.
1. Maquat LE
Eukaryotic antisense ahead of its time.; Nature reviews. Molecular cell biology; Vol 17(4). 2016 Apr.
1. Elbarbary RA
2. Maquat LE
Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock.; Genes & development; Vol 30(5). 2016 Mar 1.
1. Elbarbary RA
2. Lucas BA
3. Maquat LE
Retrotransposons as regulators of gene expression.; Science (New York, N.Y.); Vol 351(6274). 2016 Feb 12.
1. Kurosaki T
2. Maquat LE
Nonsense-mediated mRNA decay in humans at a glance.; Journal of cell science; Vol 129(3). 2016 Feb 1.
1. Maquat LE
The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences.; RNA (New York, N.Y.); Vol 21(4). 2015 Apr.
1. Elbarbary RA
2. Maquat LE
CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.; Genes & development; Vol 29(7). 2015 Apr 1.
1. Popp MW
2. Maquat LE
RNA. A TRICK'n way to see the pioneer round of translation.; Science (New York, N.Y.); Vol 347(6228). 2015 Mar 20.
1. Popp MW
2. Maquat LE
Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.; Nature communications; Vol 6. 2015.
1. Gong C
2. Maquat LE
Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells.; Methods in molecular biology (Clifton, N.J.); Vol 1206. 2015.
1. Jackson KL
2. Dayton RD
3. Orchard EA
4. Ju S
5. Ringe D
6. Petsko GA
7. Maquat LE
8. Klein RL
Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.; Gene therapy; Vol 22(1). 2015 Jan.
1. Kurosaki T
2. Li W
3. Hoque M
4. Popp MW
5. Ermolenko DN
6. Tian B
7. Maquat LE
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.; Genes & development; Vol 28(17). 2014 Sep 1.