McGrath Lab
Nanomembrane Research Group
The Nanomembrane Research Group (NRG) includes students, engineers, scientists, faculty and entrepreneurs at UR, a local nanomembrane manufacturer SiMPore Inc., and the Rochester Institute of Technology (RIT) and a growing network of academic and industry collaborators from around the world. Together, we have grown a serendipitous material discovery into a growing Rochester-based enterprise.
We introduced the first practical ultrathin freestanding nanoporopus membranes at the University of Rochester in 2007. Today, we manufacture and apply a variety of nanoporous and microporous membranes with the common characteristics that they are ultrathin (15 nm - 400 nm) and made with silicon-based manufacturing. Because these 'nanomembranes' are orders-of-magnitude thinner than conventional membranes, they are orders-of-magnitude more permeable to both diffusing molecules and pressurized flows. Molecular scale thickness also enhances the resolution of separations when the membranes are used as sieves. The silicon platform enables the ready assembly of membranes into devices using easily customized, but also highly scalable, layer-by-layer assembly. The unique properties of silicon nanomembranes have sparked paradigm-shifting research programs in:
- Biological tissue models
- Small format hemodialysis
- Biosensors
- Electrokinetic devices
In addition to these applications, our team focuses on the basic science of ultrathin membranes including studies of transport and mechanics.
James L. McGrath
Principal Investigator
- Human Tendon-on-a-Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis.; Advanced healthcare materials. 2024 Nov 15.
- Pericytes Enrich the Basement Membrane and Reduce Neutrophil Transmigration in an In Vitro Model of Peripheral Inflammation at the Blood-Brain Barrier.; Biomaterials research; Vol 28, pp. 0081. 2024 Oct 03.
- Rapid Assessment of Biomarkers on Single Extracellular Vesicles Using "Catch and Display" on Ultrathin Nanoporous Silicon Nitride Membranes.; Small (Weinheim an der Bergstrasse, Germany). 2024 Oct 02.
- Ingestion of polyethylene terephthalate microplastic water contaminants by Xenopus laevis tadpoles negatively affects their resistance to ranavirus infection and antiviral immunity.; Environmental pollution (Barking, Essex : 1987); Vol 356, pp. 124340. 2024 Jun 06.
News
Affiliations
- Biomedical Engineering
- Del Monte Institute for Neuroscience
- Environmental Health Sciences Center
- James P. Wilmot Cancer Center
- NIH T32 Training Grant in Immunology
- Pulmonary T32 Training Grant
- Biomedical Engineering Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Neuroscience Ph.D. Program
February 23, 2021
Rochester to advance research in biological imaging through new grant
September 29, 2020
Awad, McGrath and Miller receive a $4M NCATS/NIAMS Clinical Trials on a Chip grant to study tendon inflammation and fibrosis
April 21, 2020
Rochester researchers pursue quick ways to detect COVID-19—and better understand it
January 9, 2020
Detecting microplastics first step in assessing environmental harm
Contact Us
McGrath Lab
306 Goergen Hall
Rochester, NY 14620
(585) 273-4746