Meeks Lab
Welcome to the Chemosensation and Social Learning Lab
The goal of the Meeks Lab is to better understand the mechanisms by which nonvolatile olfactory cues, including pheromones, guide animal social and reproductive behaviors. The neural pathway that detects and processes this information is called the accessory olfactory system, or AOS. This system begins in the nose in a small blind-ended tube called the vomeronasal organ (VNO), which sends information from the periphery into the first AOS neural circuit – the accessory olfactory bulb (AOB).
The AOB is a very compact (less than 1 cubic millimeter) neural circuit that contains at least four distinct types of neurons. However, we know relatively little about the specific connections between these neurons, and even less about how they “sculpt” the information coming into the circuit. Despite its small size, disruptions in this circuit cause profound changes in animal social and reproductive behavior. Recent innovations have allowed us to pursue more systematic exploration of the AOB and its various neurons.
It is our goal to use new tools and ideas to establish a comprehensive description of the computations performed by the AOB and, ultimately, determine how those computations impact on animal behavior.
Julian P. Meeks, Ph.D.
Principal Investigator
Projects
Information processing the accessory olfactory bulb
Experience-dependent neuroplasticity in chemosensory circuits
Chemosensation and social learning
Mechanisms of excreted steroid detection
Discovery of bile acid receptors
Publications
View All Publications- Combinatorial responsiveness of single chemosensory neurons to external stimulation of mouse explants revealed by DynamicNeuronTracker.; bioRxiv : the preprint server for biology. 2024 Sep 24.
- Endogenous pathology in tauopathy mice progresses via brain networks.; bioRxiv : the preprint server for biology. 2023 May 24.
- Arc-Expressing Accessory Olfactory Bulb Interneurons Support Chemosensory Social Behavioral Plasticity.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 Jan 05.
- A layered, hybrid machine learning analytic workflow for mouse risk assessment behavior.; eNeuro. 2022 Jan 22.