URMC / Labs / Munger Lab / Publications

Recent Publications

1. Scales TQ
2. Smith B
3. Blanchard LM
4. Wixom N
5. Tuttle ET
6. Altman BJ
7. Peppone LJ
8. Munger J
9. Campbell TM
10. Campbell EK
11. Harris IS
A whole food, plant-based diet reduces amino acid levels in patients with metastatic breast cancer.; Cancer & metabolism; Vol 12(1), pp. 38. 2024 Dec 19.
1. Hecht F
2. Zocchi M
3. Tuttle ET
4. Ward NP
5. Smith B
6. Kang YP
7. Cazarin J
8. Soares ZG
9. Ozgurses ME
10. Zhao H
11. Sheehan C
12. Alimohammadi F
13. Munger LD
14. Trivedi D
15. Asantewaa G
16. Blick-Nitko SK
17. Zoeller JJ
18. Chen Y
19. Vasiliou V
20. Turner BM
21. Muir A
22. Coloff JL
23. Munger J
24. DeNicola GM
25. Harris IS
Catabolism of extracellular glutathione supplies amino acids to support tumor growth.; bioRxiv : the preprint server for biology. 2024 Oct 11.
1. Scales TQ
2. Smith B
3. Blanchard LM
4. Wixom N
5. Tuttle ET
6. Altman BJ
7. Peppone LJ
8. Munger J
9. Campbell TM
10. Campbell EK
11. Harris IS
A whole food, plant-based diet reduces amino acid levels in patients with metastatic breast cancer.; medRxiv : the preprint server for health sciences. 2024 Oct 09.
1. Soto CA
2. Lesch ML
3. Becker JL
4. Sharipol A
5. Khan A
6. Schafer XL
7. Becker MW
8. Munger JC
9. Frisch BJ
The Lactate Receptor GPR81 is a Mechanism of Leukemia-Associated Macrophage Polarization in the Bone Marrow Microenvironment.; bioRxiv : the preprint server for biology. 2024 Aug 16.
1. Blick-Nitko SK
2. Ture SK
3. Schafer XL
4. Munger JC
5. Livada AC
6. Li C
7. Maurya P
8. Rondina MT
9. Morrell CN
Platelet Ido1 expression is induced during Plasmodium yoelii infection, altering plasma tryptophan metabolites.; Blood advances. 2024 Aug 12.
1. Asantewaa G
2. Tuttle ET
3. Ward NP
4. Kang YP
5. Kim Y
6. Kavanagh ME
7. Girnius N
8. Chen Y
9. Rodriguez K
10. Hecht F
11. Zocchi M
12. Smorodintsev-Schiller L
13. Scales TQ
14. Taylor K
15. Alimohammadi F
16. Duncan RP
17. Sechrist ZR
18. Agostini-Vulaj D
19. Schafer XL
20. Chang H
21. Smith ZR
22. O'Connor TN
23. Whelan S
24. Selfors LM
25. Crowdis J
26. Gray GK
27. Bronson RT
28. Brenner D
29. Rufini A
30. Dirksen RT
31. Hezel AF
32. Huber AR
33. Munger J
34. Cravatt BF
35. Vasiliou V
36. Cole CL
37. DeNicola GM
38. Harris IS
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.; Nature communications; Vol 15(1), pp. 6152. 2024 Jul 21.
1. Zhang K
2. Eldin P
3. Ciesla JH
4. Briant L
5. Lentini JM
6. Ramos J
7. Cobb J
8. Munger J
9. Fu D
Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.; eLife; Vol 12. 2024 May 30.
1. Ciesla J
2. Huang KL
3. Wagner EJ
4. Munger J
A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection.; PLoS pathogens; Vol 20(5), pp. e1012058. 2024 May 20.
1. Rasmussen AL
2. Gronvall GK
3. Lowen AC
4. Goodrum F
5. Alwine J
6. Andersen KG
7. Anthony SJ
8. Baines J
9. Banerjee A
10. Broadbent AJ
11. Brooke CB
12. Campos SK
13. Caposio P
14. Casadevall A
15. Chan GC
16. Cliffe AR
17. Collins-McMillen D
18. Connell N
19. Damania B
20. Daugherty MD
21. Debbink K
22. Dermody TS
23. DiMaio D
24. Duprex WP
25. Emerman M
26. Galloway DA
27. Garry RF
28. Goldstein SA
29. Greninger AL
30. Hartman AL
31. Hogue BG
32. Horner SM
33. Hotez PJ
34. Jung JU
35. Kamil JP
36. Karst SM
37. Laimins L
38. Lakdawala SS
39. Landais I
40. Letko M
41. Lindenbach B
42. Liu S-L
43. Luftig M
44. McFadden G
45. Mehle A
46. Morrison J
47. Moscona A
48. Mühlberger E
49. Munger J
50. Münger K
51. Murphy E
52. Neufeldt CJ
53. Nikolich JZ
54. O'Connor CM
55. Pekosz A
56. Permar SR
57. Pfeiffer JK
58. Popescu SV
59. Purdy JG
60. Racaniello VR
61. Rice CM
62. Runstadler JA
63. Sapp MJ
64. Scott RS
65. Smith GA
66. Sorrell EM
67. Speranza E
68. Streblow D
69. Tibbetts SA
70. Toth Z
71. Van Doorslaer K
72. Weiss SR
73. White EA
74. White TM
75. Wobus CE
76. Worobey M
77. Yamaoka S
78. Yurochko A
Virology-the path forward.; Journal of virology. 2024 Jan 03.
1. Wu J
2. Subbaiah KCV
3. Hedaya O
4. Chen S
5. Munger J
6. Tang WHW
7. Yan C
8. Yao P
FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.; Cardiovascular research. 2023 Jul 31.
1. Dunn DM
2. Pack LJ
3. Munger JC
Raf1 promotes successful Human Cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection.; bioRxiv : the preprint server for biology. 2023 Jul 26.
1. Goodrum F
2. Lowen A
3. Lakdawala S
4. Alwine J
5. Casadevall A
6. Imperiale M
7. Atwood W
8. Avgousti D
9. Baines J
10. Banfield B
11. Banks L
12. Bhaduri-McIntosh S
13. Bhattacharya D
14. Blanco-Melo D
15. Bloom D
16. Boon A
17. Boulant S
18. Brandt C
19. Broadbent A
20. Brooke C
21. Cameron C
22. Campos S
23. Caposio P
24. Chan G
25. Cliffe A
26. Coffin J
27. Collins K
28. Damania B
29. Daugherty M
30. Debbink K
31. DeCaprio J
32. Dermody T
33. Dikeakos J
34. DiMaio D
35. Dinglasan R
36. Duprex WP
37. Dutch R
38. Elde N
39. Emerman M
40. Enquist L
41. Fane B
42. Fernandez-Sesma A
43. Flenniken M
44. Frappier L
45. Frieman M
46. Frueh K
47. Gack M
48. Gaglia M
49. Gallagher T
50. Galloway D
51. García-Sastre A
52. Geballe A
53. Glaunsinger B
54. Goff S
55. Greninger A
56. Hancock M
57. Harris E
58. Heaton N
59. Heise M
60. Heldwein E
61. Hogue B
62. Horner S
63. Hutchinson E
64. Hyser J
65. Jackson W
66. Kalejta R
67. Kamil J
68. Karst S
69. Kirchhoff F
70. Knipe D
71. Kowalik T
72. Lagunoff M
73. Laimins L
74. Langlois R
75. Lauring A
76. Lee B
77. Leib D
78. Liu SL
79. Longnecker R
80. Lopez C
81. Luftig M
82. Lund J
83. Manicassamy B
84. McFadden G
85. McIntosh M
86. Mehle A
87. Miller WA
88. Mohr I
89. Moody C
90. Moorman N
91. Moscona A
92. Mounce B
93. Munger J
94. Münger K
95. Murphy E
96. Naghavi M
97. Nelson J
98. Neufeldt C
99. Nikolich J
100. O'Connor C
101. Ono A
102. Orenstein W
103. Ornelles D
104. Ou JH
105. Parker J
106. Parrish C
107. Pekosz A
108. Pellett P
109. Pfeiffer J
110. Plemper R
111. Polyak S
112. Purdy J
113. Pyeon D
114. Quinones-Mateu M
115. Renne R
116. Rice C
117. Schoggins J
118. Roller R
119. Russell C
120. Sandri-Goldin R
121. Sapp M
122. Schang L
123. Schmid S
124. Schultz-Cherry S
125. Semler B
126. Shenk T
127. Silvestri G
128. Simon V
129. Smith G
130. Smith J
131. Spindler K
132. Stanifer M
133. Subbarao K
134. Sundquist W
135. Suthar M
136. Sutton T
137. Tai A
138. Tarakanova V
139. tenOever B
140. Tibbetts S
141. Tompkins S
142. Toth Z
143. van Doorslaer K
144. Vignuzzi M
145. Wallace N
146. Walsh D
147. Weekes M
148. Weinberg J
149. Weitzman M
150. Weller S
151. Whelan S
152. White E
153. Williams B
154. Wobus C
155. Wong S
156. Yurochko A
Virology under the Microscope-a Call for Rational Discourse.; mBio. 2023 Jan 26.
1. Raymonda MH
2. Rodríguez-Sánchez I
3. Schafer XL
4. Smorodintsev-Schiller L
5. Harris IS
6. Munger J
Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation.; mBio. 2023 Jan 20.
1. Ciesla J
2. Moreno I
3. Munger J
TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state.; PLoS pathogens; Vol 18(7), pp. e1010722. 2022 Jul 14.
1. Moreno I
2. Rodríguez-Sánchez I
3. Schafer X
4. Munger J
Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 119(49), pp. e2205789119. 2022 Jan 02.
1. Raymonda MH
2. Ciesla JH
3. Monaghan M
4. Leach J
5. Asantewaa G
6. Smorodintsev-Schiller LA
7. Lutz MM
8. Schafer XL
9. Takimoto T
10. Dewhurst S
11. Munger J
12. Harris IS
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
1. Monaghan M
2. Munger J
Contributions of the HCMV UL30-associated open reading frames to infection.; Journal of virology. 2021 Feb 10.
1. Dunn DM
2. Rodriguez-Sanchez I
3. Schafer X
4. Munger J
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection.; Journal of virology. 2020 Dec 02.
1. Dunn DM
2. Munger J
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection.; Frontiers in cellular and infection microbiology; Vol 10. 2020.
1. Goodwin CM
2. Schafer X
3. Munger J
UL26 attenuates IKKβ-mediated induction of ISG expression and enhanced protein ISGylation during HCMV infection.; Journal of virology. 2019 Sep 18.
1. Meade N
2. King M
3. Munger J
4. Walsh D
mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.; Journal of virology; Vol 93(15). 2019 Aug 01.
1. Rodríguez-Sánchez I
2. Munger J
Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism.; Viruses; Vol 11(3). 2019 Mar 19.
1. Goodwin CM
2. Munger J
The IκB kinases restrict human cytomegalovirus infection.; Journal of virology. 2019 Feb 13.
1. King MW
2. Munger J
Editing the human cytomegalovirus genome with the CRISPR/Cas9 system.; Virology; Vol 529. 2019 Jan 26.
1. Rodríguez-Sánchez I
2. Schafer XL
3. Monaghan M
4. Munger J
The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2.; PLoS pathogens; Vol 15(1). 2019 Jan 24.
1. Goodwin CM
2. Ciesla JH
3. Munger J
Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.; Viruses; Vol 10(9). 2018 Aug 21.
1. Nadtochiy SM
2. Wang YT
3. Nehrke K
4. Munger J
5. Brookes PS
Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.; Journal of molecular and cellular cardiology. 2018 Jun 26.
1. Zhang J
2. Wang YT
3. Miller JH
4. Day MM
5. Munger JC
6. Brookes PS
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.; Cell reports; Vol 23(9). 2018 May 29.
1. Nadtochiy SM
2. Wang YT
3. Zhang J
4. Nehrke K
5. Schafer X
6. Welle K
7. Ghaemmaghami S
8. Munger J
9. Brookes PS
Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.; The Biochemical journal. 2017 Jul 03.
1. Murphy PS
2. Wang J
3. Bhagwat SP
4. Munger JC
5. Janssen WJ
6. Wright TW
7. Elliott MR
CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.; Cell death and differentiation; Vol 24(3). 2017 Mar.
1. Smith B
2. Schafer XL
3. Ambeskovic A
4. Spencer CM
5. Land H
6. Munger J
Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.; Cell reports; Vol 17(3). 2016 Oct 11.
1. Nadtochiy SM
2. Schafer X
3. Fu D
4. Nehrke K
5. Munger J
6. Brookes PS
Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.; The Journal of biological chemistry; Vol 291(38). 2016 Sep 16.
1. Xu S
2. Schafer X
3. Munger J
Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection.; Journal of virology; Vol 90(9). 2016 May 1.
1. Hollenbaugh JA
2. Montero C
3. Schinazi RF
4. Munger J
5. Kim B
Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.; Virology; Vol 491. 2016 Apr.
1. Goodwin CM
2. Xu S
3. Munger J
Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network.; Trends in microbiology; Vol 23(12). 2015 Dec.
1. Nadtochiy SM
2. Urciuoli W
3. Zhang J
4. Schafer X
5. Munger J
6. Brookes PS
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation.; Journal of molecular and cellular cardiology; Vol 88. 2015 Nov.
1. Campbell A
2. Bushman J
3. Munger J
4. Noble M
5. Pröschel C
6. Mayer-Pröschel M
Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.; Glia. 2015 Oct 15.
1. Buescher JM
2. Antoniewicz MR
3. Boros LG
4. Burgess SC
5. Brunengraber H
6. Clish CB
7. DeBerardinis RJ
8. Feron O
9. Frezza C
10. Ghesquiere B
11. Gottlieb E
12. Hiller K
13. Jones RG
14. Kamphorst JJ
15. Kibbey RG
16. Kimmelman AC
17. Locasale JW
18. Lunt SY
19. Maddocks OD
20. Malloy C
21. Metallo CM
22. Meuillet EJ
23. Munger J
24. Nöh K
25. Rabinowitz JD
26. Ralser M
27. Sauer U
28. Stephanopoulos G
29. St-Pierre J
30. Tennant DA
31. Wittmann C
32. Vander Heiden MG
33. Vazquez A
34. Vousden K
35. Young JD
36. Zamboni N
37. Fendt SM
A roadmap for interpreting (13)C metabolite labeling patterns from cells.; Current opinion in biotechnology; Vol 34. 2015 Aug.
1. Xu S
2. Spencer CM
3. Munger J
Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition.; Journal of virology; Vol 89(12). 2015 Jun.
1. DeVito SR
2. Ortiz-Riaño E
3. Martínez-Sobrido L
4. Munger J
Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 111(50). 2014 Dec 16.
1. Mathers C
2. Schafer X
3. Martínez-Sobrido L
4. Munger J
The human cytomegalovirus UL26 protein antagonizes NF-κB activation.; Journal of virology; Vol 88(24). 2014 Dec.
1. Proschel C
2. Stripay JL
3. Shih CH
4. Munger JC
5. Noble MD
Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons.; EMBO molecular medicine; Vol 6(4). 2014 Apr.
1. Ortiz-Riaño E
2. Ngo N
3. Devito S
4. Eggink D
5. Munger J
6. Shaw ML
7. de la Torre JC
8. Martínez-Sobrido L
Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor.; Journal of virology; Vol 88(2). 2014 Jan.
1. Mathers C
2. Spencer CM
3. Munger J
Distinct domains within the human cytomegalovirus U(L)26 protein are important for wildtype viral replication and virion stability.; PloS one; Vol 9(2). 2014.
1. Pei S
2. Minhajuddin M
3. Callahan KP
4. Balys M
5. Ashton JM
6. Neering SJ
7. Lagadinou ED
8. Corbett C
9. Ye H
10. Liesveld JL
11. O'Dwyer KM
12. Li Z
13. Shi L
14. Greninger P
15. Settleman J
16. Benes C
17. Hagen FK
18. Munger J
19. Crooks PA
20. Becker MW
21. Jordan CT
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.; The Journal of biological chemistry; Vol 288(47). 2013 Nov 22.
1. Sasaki M
2. Knobbe CB
3. Munger JC
4. Lind EF
5. Brenner D
6. Brüstle A
7. Harris IS
8. Holmes R
9. Wakeham A
10. Haight J
11. You-Ten A
12. Li WY
13. Schalm S
14. Su SM
15. Virtanen C
16. Reifenberger G
17. Ohashi PS
18. Barber DL
19. Figueroa ME
20. Melnick A
21. Zúñiga-Pflücker JC
22. Mak TW
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.; Nature; Vol 488(7413). 2012 Aug 30.
1. McArdle J
2. Moorman NJ
3. Munger J
HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.; PLoS pathogens; Vol 8(1). 2012 Jan.
1. Wang R
2. Dillon CP
3. Shi LZ
4. Milasta S
5. Carter R
6. Finkelstein D
7. McCormick LL
8. Fitzgerald P
9. Chi H
10. Munger J
11. Green DR
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.; Immunity; Vol 35(6). 2011 Dec 23.
1. Hollenbaugh JA
2. Munger J
3. Kim B
Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC-MS/MS analysis.; Virology; Vol 415(2). 2011 Jul 5.
1. Spencer CM
2. Schafer XL
3. Moorman NJ
4. Munger J
Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication.; Journal of virology; Vol 85(12). 2011 Jun.