URMC / Labs / Noble Lab / Publications

Publications

1. Scott-Hewitt NJ
2. Folts CJ
3. Noble MD
Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage.; Neural regeneration research; Vol 13(3). 2018 Mar.
1. Scott-Hewitt NJ
2. Folts CJ
3. Hogestyn JM
4. Piester G
5. Mayer-Pröschel M
6. Noble MD
Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.; Human molecular genetics. 2017 May 31.
1. Folts CJ
2. Scott-Hewitt N
3. Pröschel C
4. Mayer-Pröschel M
5. Noble M
Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity.; PLoS biology; Vol 14(12). 2016 Dec.
1. Geary MB
2. Li H
3. Zingman A
4. Ketz J
5. Zuscik M
6. De Mesy Bentley KL
7. Noble M
8. Elfar JC
Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury.; Muscle & nerve. 2016 Nov 07.
1. Sundem L
2. Chris Tseng KC
3. Li H
4. Ketz J
5. Noble M
6. Elfar J
Erythropoietin Enhanced Recovery After Traumatic Nerve Injury: Myelination and Localized Effects.; The Journal of hand surgery. 2016 Sep 1.
1. Tseng KC
2. Li H
3. Clark A
4. Sundem L
5. Zuscik M
6. Noble M
7. Elfar J
4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.; EMBO molecular medicine; Vol 8(12). 2016 Jan.
1. Campbell A
2. Bushman J
3. Munger J
4. Noble M
5. Pröschel C
6. Mayer-Pröschel M
Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.; Glia. 2015 Oct 15.
1. Campbell A
2. Krupp B
3. Bushman J
4. Noble M
5. Pröschel C
6. Mayer-Pröschel M
A novel mouse model for Ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.; Human molecular genetics. 2015 Aug 26.
1. Tanner DC
2. Campbell A
3. O'Banion KM
4. Noble M
5. Mayer-Pröschel M
cFLIP is critical for oligodendrocyte protection from inflammation.; Cell death and differentiation. 2015 Jan 30.
1. Noble M
2. Mayer-Pröschel M
3. Li Z
4. Dong T
5. Cui W
6. Pröschel C
7. Ambeskovic I
8. Dietrich J
9. Han R
10. Miranda Yang Y
11. Folts C
12. Stripay J
13. Chen HY
14. Stevens BM
Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.; Free radical biology & medicine. 2014 Dec 3.
1. Stevens BM
2. Folts CJ
3. Cui W
4. Bardin AL
5. Walter K
6. Carson-Walter E
7. Vescovi A
8. Noble M
Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo.; Stem cells (Dayton, Ohio); Vol 32(5). 2014 May.
1. Proschel C
2. Stripay JL
3. Shih CH
4. Munger JC
5. Noble MD
Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons.; EMBO molecular medicine; Vol 6(4). 2014 Apr.
1. Wang J
2. Bushman J
3. Wang X
4. Mayer-Proschel M
5. Johnson M
6. Noble M
Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(42). 2013 Oct 16.
1. Chen HY
2. Yang YM
3. Han R
4. Noble M
MEK1/2 inhibition suppresses tamoxifen toxicity on CNS glial progenitor cells.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(38). 2013 Sep 18.
1. Noble M
2. Mayer-Pröschel M
3. Pröschel C
iOPs: a new tool for studying myelin pathologies?; Cell stem cell; Vol 12(5). 2013 May 2.
1. Chen HY
2. Yang YM
3. Stevens BM
4. Noble M
Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.; EMBO molecular medicine; Vol 5(5). 2013 May.
1. Noble M
2. Mayer-Pröschel M
3. Davies JE
4. Davies SJ
5. Pröschel C
Cell therapies for the central nervous system: how do we identify the best candidates?; Current opinion in neurology; Vol 24(6). 2011 Dec.
1. Noble M
2. Davies JE
3. Mayer-Pröschel M
4. Pröschel C
5. Davies SJ
Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury.; Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics; Vol 8(4). 2011 Oct.
1. Noble M
2. Pröschel C
3. Mayer-Pröschel M
Oxidative-reductionist approaches to stem and progenitor cell function.; Cell stem cell; Vol 8(1). 2011 Jan 7.
1. Chen R
2. Hyrien O
3. Noble M
4. Mayer-Pröschel M
A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process.; Biostatistics (Oxford, England); Vol 12(1). 2011 Jan.
1. Davies SJ
2. Shih CH
3. Noble M
4. Mayer-Proschel M
5. Davies JE
6. Proschel C
Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury.; PloS one; Vol 6(3). 2011.
1. Hyrien O
2. Dietrich J
3. Noble M
Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors.; Cancer research; Vol 70(24). 2010 Dec 15.
1. Hyrien O
2. Chen R
3. Mayer-Pröschel M
4. Noble M
Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications.; Biometrics; Vol 66(2). 2010 Jun.
1. Han R
2. Yang YM
3. Dietrich J
4. Luebke A
5. Mayer-Pröschel M
6. Noble M
Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system.; Journal of biology; Vol 7(4). 2008.
1. Davies JE
2. Pröschel C
3. Zhang N
4. Noble M
5. Mayer-Pröschel M
6. Davies SJ
Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury.; Journal of biology; Vol 7(7). 2008.
1. Li Z
2. Dong T
3. Pröschel C
4. Noble M
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.; PLoS biology; Vol 5(2). 2007 Feb.
1. Jordan CT
2. Guzman ML
3. Noble M
Cancer stem cells.; The New England journal of medicine; Vol 355(12). 2006 Sep 21.
1. Noble M
Implications for CNS repair of redox modulation of cell survival, division and differentiation.; Current Alzheimer research; Vol 3(1). 2006 Feb.
1. Dietrich J
2. Han R
3. Yang Y
4. Mayer-Pröschel M
5. Noble M
CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo.; Journal of biology; Vol 5(7). 2006.
1. Davies JE
2. Huang C
3. Proschel C
4. Noble M
5. Mayer-Proschel M
6. Davies SJ
Astrocytes derived from glial-restricted precursors promote spinal cord repair.; Journal of biology; Vol 5(3). 2006.
1. Hyrien O
2. Ambeskovic I
3. Mayer-Proschel M
4. Noble M
5. Yakovlev A
Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data.; Theoretical biology & medical modelling; Vol 3. 2006.
1. Noble M
Ethics in the trenches: a multifaceted analysis of the stem cell debate.; Stem cell reviews; Vol 1(4). 2005 Dec.
1. Noble M
2. Mayer-Pröschel M
3. Pröschel C
Redox regulation of precursor cell function: insights and paradoxes.; Antioxidants & redox signaling; Vol 7(11-12). 2005 Nov.
1. Hyrien O
2. Mayer-Pröschel M
3. Noble M
4. Yakovlev A
A stochastic model to analyze clonal data on multi-type cell populations.; Biometrics; Vol 61(1). 2005 Mar.
1. Dietrich J
2. Lacagnina M
3. Gass D
4. Richfield E
5. Mayer-Pröschel M
6. Noble M
7. Torres C
8. Pröschel C
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.; Nature medicine; Vol 11(3). 2005 Mar.
1. Hyrien O
2. Mayer-Pröschel M
3. Noble M
4. Yakovlev A
Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture.; Mathematical biosciences; Vol 193(2). 2005 Feb.
1. Noble M
Neural precursor cells and toxicant action: Addressing the analysis of low-level toxicant exposure; Role of Glia in Neurotoxicity; Vol 2nd Edition, pp. 1-28. 2005 Jan 01.
1. Hill CE
2. Proschel C
3. Noble M
4. Mayer-Proschel M
5. Gensel JC
6. Beattie MS
7. Bresnahan JC
Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration.; Experimental neurology; Vol 190(2). 2004 Dec.
1. Noble M
2. Dietrich J
The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity.; Trends in neurosciences; Vol 27(3). 2004 Mar.
1. Noble M
The possible role of myelin destruction as a precipitating event in Alzheimer's disease.; Neurobiology of aging; Vol 25(1). 2004 Jan.
1. Noble M
2. Pröschel C
3. Mayer-Pröschel M
Getting a GR(i)P on oligodendrocyte development.; Developmental biology; Vol 265(1). 2004 Jan 1.
1. Biran R
2. Noble MD
3. Tresco PA
Directed nerve outgrowth is enhanced by engineered glial substrates.; Experimental neurology; Vol 184(1). 2003 Nov.
1. Noble M
2. Smith J
3. Power J
4. Mayer-Pröschel M
Redox state as a central modulator of precursor cell function.; Annals of the New York Academy of Sciences; Vol 991. 2003 Jun.
1. Noble M
2. Arhin A
3. Gass D
4. Mayer-Pröschel M
The cortical ancestry of oligodendrocytes: common principles and novel features.; Developmental neuroscience; Vol 25(2-4). 2003 Mar.
1. Dietrich J
2. Noble M
3. Mayer-Proschel M
Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells.; Glia; Vol 40(1). 2002 Oct.
1. Power J
2. Mayer-Pröschel M
3. Smith J
4. Noble M
Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions.; Developmental biology; Vol 245(2). 2002 May 15.
1. Noble M
2. Dietrich J
Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage.; Trends in neurosciences; Vol 25(2). 2002 Feb.
1. Gregori N
2. Pröschel C
3. Noble M
4. Mayer-Pröschel M
The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 22(1). 2002 Jan 1.
1. Mayer-Pröschel M
2. Morath D
3. Noble M
Are hypothyroidism and iron deficiency precursor cell diseases?; Developmental neuroscience; Vol 23(4-5). 2001.
1. Noble M
Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?; Proceedings of the National Academy of Sciences of the United States of America; Vol 97(23). 2000 Nov 7.