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URMC / Labs / Ovitt Lab / Research Projects / Homeostasis and Regeneration

Homeostasis and Regeneration

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We are working to identify cells involved in maintenance and regeneration of head and neck exocrine glands. We recently demonstrated that salivary gland homeostasis is based predominantly on self-duplication of differentiated secretory acinar cells. However, the mechanisms – and cell types- involved in gland regeneration remain unresolved.

Current projects include: investigations into the normal mechanisms of exocrine gland development and maintenance; and investigating regeneration in salivary, lacrimal and olfactory glands.

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