Rahman Lab
Welcome to the Rahman Lab
My laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation and DNA methylation), involvement of anti-inflammatory and anti-aging proteins sirtuins, HDACs, DNA damage/repair, and cellular senescence in chronic lung inflammatory diseases including COPD. Recent research includes in understanding the role of sirtuins/HDACs in aging and accelerated decline in lung function, cellular senescence, and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in the pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants (tobacco smoke, e-cigarettes, oxidants/aldehydes), identifying molecular targets, and the potential benefit of therapeutic interventions in airways disease.
New Book
Inflammation, Advancing Age and Nutrition, 1st Edition
The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine.
Irfan Rahman, Ph.D.
Principal Investigator
Projects
View All Projects
Publications
View All Publications- HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance.; Cells; Vol 13(23). 2024 Dec 05.
- A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence.; Cell communication and signaling : CCS; Vol 22(1), pp. 544. 2024 Nov 14.
- scDOT: optimal transport for mapping senescent cells in spatial transcriptomics.; Genome biology; Vol 25(1), pp. 288. 2024 Nov 08.
- Cold ischemia time alters cell-type specific senescence leading to loss of cellular integrity in mouse lungs.; Experimental lung research; Vol 50(1), pp. 184-198. 2024 Oct 20.
- Cav1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis.; American journal of respiratory cell and molecular biology. 2024 Sep 18.
- Kick Vaping: Feasibility, acceptability, and preliminary impact of a vaping cessation text messaging intervention for Latino young adults.; Journal of ethnicity in substance abuse. 2024 Aug 28.
- MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation.; Journal of inflammation (London, England); Vol 21(1), pp. 31. 2024 Aug 27.
- Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations.; International journal of molecular sciences; Vol 25(16). 2024 Aug 13.
News
Affiliations
- Environmental Medicine
- Dentistry
- Medicine
- Public Health Sciences
- Center for Inhalation and Flavoring Toxicological Research (CIFT)
- Environmental Health Sciences Center
- James P. Wilmot Cancer Center
- Lung Biology and Disease Program
- Pulmonary T32 Training Grant
- Master’s Degree in Pharmacology
- Master’s Degree in Physiology
- PhD Program in Pathology - Cell Biology of Disease
- Toxicology Ph.D. Program
February 14, 2024
Irfan Rahman, PhD interviewed by Scientific American on Smoking compromises immune health even in former smokers
January 25, 2024
Irfan Rahman, PhD interviewed by NY Times on oral effects of Nicotine Pouches
November 27, 2023
Flavored Oral Nicotine Pouches as Chewing Gums – Interview by Irfan Rahman, PhD
Contact Us
Rahman Lab
601 Elmwood Ave
MRBX 3-11001
Rochester, NY 14642