URMC /
Labs /
Sant Lab /
Publications
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- White CL
- Richards KA
- Huertas N
- Nayak JL
- Sant AJ
Human HKU1-reactive CD4 T cells are enriched for cytolytic potential that persists in older adults.; The Journal of infectious diseases. 2025 Jan 15.
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- Richards KA
- Changrob S
- Thomas PG
- Wilson PC
- Sant AJ
Lack of memory recall in human CD4 T cells elicited by the first encounter with SARS-CoV-2.; iScience; Vol 27(6), pp. 109992. 2024 May 17.
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- White CL
- Glover MA
- Gandhapudi SK
- Richards KA
- Sant AJ
Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems.; Vaccines; Vol 12(3). 2024 Mar 07.
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- Henson TR
- Richards KA
- Gandhapudi SK
- Woodward JG
- Sant AJ
R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination.; Viruses; Vol 15(2). 2023 Feb 15.
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- Sant AJ
- Stern LJ
Editorial overview: The life and times of peptide-MHC.; Current opinion in immunology; Vol 78, pp. 102244. 2022 Sep 28.
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- Sant AJ
- Wilson PC
Learning from our differences.; Nature immunology. 2022 Sep 27.
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- Moritzky SA
- Richards KA
- Glover MA
- Krammer F
- Chaves FA
- Topham DJ
- Branche A
- Nayak JL
- Sant AJ
The negative effect of pre-existing immunity on influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history.; The Journal of infectious diseases. 2022 Feb 24.
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- Rattan A
- White CL
- Nelson S
- Eismann M
- Padilla-Quirarte H
- Glover MA
- Dileepan T
- Marathe BM
- Govorkova EA
- Webby RJ
- Richards KA
- Sant AJ
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection.; Pathogens (Basel, Switzerland); Vol 11(2). 2022 Feb 15.
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- Nelson SA
- Richards KA
- Glover MA
- Chaves FA
- Crank MC
- Graham BS
- Kanekiyo M
- Sant AJ
CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines.; NPJ vaccines; Vol 7(1), pp. 124. 2022 Jan 26.
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- Richards KA
- Lavery C
- Keller GLJ
- Miller J
- Baker BM
- Sant AJ
A previously unappreciated polymorphism in the beta chain of I-As expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability.; Molecular immunology; Vol 143. 2022 Jan 04.
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- Nelson SA
- Dileepan T
- Rasley A
- Jenkins MK
- Fischer NO
- Sant AJ
Intranasal nanoparticle vaccination elicits a persistent, polyfunctional CD4 T cell response in the murine lung specific for a highly conserved influenza antigen that are sufficient to mediate protection from influenza virus challenge.; Journal of virology. 2021 Jun 02.
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- Richards KA
- Glover M
- Crawford JC
- Thomas P
- White C
- Sant AJ
Circulating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and age.; The Journal of infectious diseases. 2021 Feb 08.
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- Nelson SA
- Sant AJ
Potentiating Lung Mucosal Immunity Through Intranasal Vaccination.; Frontiers in immunology; Vol 12. 2021.
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- Richards KA
- Moritzky S
- Shannon I
- Fitzgerald T
- Yang H
- Branche A
- Topham DJ
- Treanor JJ
- Nayak J
- Sant AJ
Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans.; NPJ vaccines; Vol 5(1). 2020 Aug 26.
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- Koroleva M
- Batarse F
- Moritzky S
- Henry C
- Chaves F
- Wilson P
- Krammer F
- Richards K
- Sant AJ
Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.; NPJ vaccines; Vol 5(1). 2020 Jan 10.
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- Richards KA
- Moritzky S
- Shannon I
- Fitzgerald T
- Yang H
- Branche A
- Topham DJ
- Treanor JJ
- Nayak J
- Sant AJ
Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans.; NPJ vaccines; Vol 5. 2020.
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- Koroleva M
- Batarse F
- Moritzky S
- Henry C
- Chaves F
- Wilson P
- Krammer F
- Richards K
- Sant AJ
Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.; NPJ vaccines; Vol 5. 2020.
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- Knowlden ZAG
- Richards KA
- Moritzky SA
- Sant AJ
Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection.; Pathogens (Basel, Switzerland); Vol 8(4). 2019 Nov 05.
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- DiPiazza AT
- Fan S
- Rattan A
- DeDiego ML
- Chaves F
- Neumann G
- Kawaoka Y
- Sant AJ
A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza.; Journal of immunology (Baltimore, Md. : 1950); Vol 203(6). 2019 Sep 15.
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- Richards KA
- Shannon I
- Treanor JJ
- Yang H
- Nayak JL
- Sant AJ
Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects.; The Journal of infectious diseases. 2019 Aug 26.
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- Rattan A
- Richards KA
- Knowlden ZAG
- Sant AJ
Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection.; Journal of virology. 2019 Jul 24.
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- Sant AJ
The way forward: Potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells.; The Journal of infectious diseases. 2019 Jan 31.
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- Varga SM
- Sant AJ
Editorial: Orchestration of an Immune Response to Respiratory Pathogens.; Frontiers in immunology; Vol 10. 2019.
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- Nelson SA
- Sant AJ
Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus.; Frontiers in immunology; Vol 10. 2019.
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- Sant AJ
- DiPiazza AT
- Nayak JL
- Rattan A
- Richards KA
CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.; Immunological reviews; Vol 284(1). 2018 Jul.
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- Richards KA
- Treanor JJ
- Nayak JL
- Sant AJ
Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B CD4 T Cell Repertoire.; The Journal of infectious diseases. 2018 May 12.
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- DiPiazza A
- Laniewski N
- Rattan A
- Topham DJ
- Miller J
- Sant AJ
CD4 T cell epitope specificity and cytokine potential are preserved as cells transition from the lung vasculature to lung tissue following influenza infection.; Journal of virology. 2018 Apr 18.
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- Sant AJ
- Richards KA
- Nayak J
Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.; Current opinion in immunology; Vol 53. 2018 Apr 02.
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- Richards KA
- DiPiazza AT
- Rattan A
- Knowlden ZAG
- Yang H
- Sant AJ
Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection.; Frontiers in immunology; Vol 9. 2018.
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- DiPiazza AT
- Richards KA
- Liu WC
- Albrecht RA
- Sant AJ
Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection.; Methods in molecular biology (Clifton, N.J.); Vol 1836. 2018.
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- DiPiazza A
- Nogales A
- Poulton N
- Wilson PC
- Martínez-Sobrido L
- Sant AJ
Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo.; Scientific reports; Vol 7(1). 2017 Sep 07.
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- DiPiazza A
- Richards K
- Poulton N
- Sant AJ
Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity.; Clinical and vaccine immunology : CVI; Vol 24(3). 2017 Mar.
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- DiPiazza A
- Richards K
- Batarse F
- Lockard L
- Zeng H
- García-Sastre A
- Albrecht RA
- Sant AJ
Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection.; Journal of virology; Vol 90(17). 2016 Sep 01.
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- Knowlden ZA
- Sant AJ
CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination.; Scientific reports; Vol 6. 2016.
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- DiPiazza A
- Richards KA
- Knowlden ZA
- Nayak JL
- Sant AJ
The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza.; Frontiers in immunology; Vol 7. 2016.
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- Leddon SA
- Richards KA
- Treanor JJ
- Sant AJ
Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults.; Immunology; Vol 146(1). 2015 Sep.
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- Richards KA
- Nayak J
- Chaves FA
- DiPiazza A
- Knowlden ZA
- Alam S
- Treanor JJ
- Sant AJ
Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza.; The Journal of infectious diseases; Vol 212(1). 2015 Jul 1.
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- Nayak JL
- Richards KA
- Yang H
- Treanor JJ
- Sant AJ
Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses.; The Journal of infectious diseases; Vol 211(9). 2015 May 1.
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- Alam S
- Knowlden ZA
- Sangster MY
- Sant AJ
CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.; Journal of virology; Vol 88(1). 2014 Jan.
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- Weilhammer DR
- Blanchette CD
- Fischer NO
- Alam S
- Loots GG
- Corzett M
- Thomas C
- Lychak C
- Dunkle AD
- Ruitenberg JJ
- Ghanekar SA
- Sant AJ
- Rasley A
The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge.; Biomaterials; Vol 34(38). 2013 Dec.
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- Nayak JL
- Alam S
- Sant AJ
Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin.; Journal of immunology (Baltimore, Md. : 1950); Vol 191(3). 2013 Aug 1.
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- Tung J
- Sant AJ
Orchestration of CD4 T cell epitope preferences after multipeptide immunization.; Journal of immunology (Baltimore, Md. : 1950); Vol 191(2). 2013 Jul 15.
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- Nayak JL
- Fitzgerald TF
- Richards KA
- Yang H
- Treanor JJ
- Sant AJ
CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine.; The Journal of infectious diseases; Vol 207(2). 2013 Jan 15.
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- Sant AJ
- Chaves FA
- Leddon SA
- Tung J
The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.; Frontiers in immunology; Vol 4. 2013.
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- Richards KA
- Chaves FA
- Alam S
- Sant AJ
Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins.; Vaccine; Vol 31(1). 2012 Dec 17.
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- Nayak JL
- Sant AJ
Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host.; Immunology; Vol 136(4). 2012 Aug.
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- Sant AJ
- McMichael A
Revealing the role of CD4(+) T cells in viral immunity.; The Journal of experimental medicine; Vol 209(8). 2012 Jul 30.
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- Chaves FA
- Lee AH
- Nayak JL
- Richards KA
- Sant AJ
The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection.; Journal of immunology (Baltimore, Md. : 1950); Vol 188(9). 2012 May 1.
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- Engels B
- Chervin AS
- Sant AJ
- Kranz DM
- Schreiber H
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 20(3). 2012 Mar.
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- Leddon SA
- Sant AJ
The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization.; PloS one; Vol 7(10). 2012.