Projects

Inflammatory-Erosive Arthritis, Arthritic Flare, and Bone Marrow Edema

Based on the success of biologic therapy, it is clear that rheumatoid arthritis (RA) is mediated by increased TNF levels, and an emerging role for B cells has been identified. However, the functional relationship between TNF and B cells in RA pathogenesis is unknown. Additionally, how arthritic flare, as defined by the initiation of synovitis and focal erosion, occurs in select joints during a chronic-systemic autoimmune disease remains an enigma.

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Bone Infection and MRSA Vaccine

Although improvements in surgical technique and aggressive antibiotic prophylaxis have decreased the infection rate following orthopaedic implant surgery to 1-5%, osteomyelitis (OM) remains a serious problem and appears to be on the rise from minimally invasive surgery. The significance of this resurgence, 80% of which is due to Staphylococcus aureus, is amplified by the fact that ˜50% of clinical isolates are methicillin resistant S. aureus (MRSA).

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Bone Repair and Regeneration

Although most bone fractures have remarkable reparative potential to heal common injuries on their own, or with well establish clinical interventions, the same is not true for large segmental defects caused by trauma or bone cancers. To address these major unmet clinical need, we proposed a Revitalizing Allograft solution.

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Wear Debris-Induced Osteolysis and Aseptic Loosening of Total Joint Replacements

Although total joint replacement (TJR) is amongst the most successful and beneficial medical procedures to date, long-term outcomes continue to suffer from aseptic loosening secondary to periprosthetic osteolysis. Extensive research over the last two decades has elucidated a central mechanism for osteolysis, in which wear debris generated from the implant stimulates inflammatory cells to promote osteoclastogenesis and bone resorption.

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