Recent Publications - Schwarz Lab - University of Rochester Medical Center

URMC / Labs / Schwarz Lab / Publications

1. Saito M
2. McDonald KA
3. Grier AK
4. Meghwani H
5. Rangel-Moreno J
6. Becerril-Villanueva E
7. Gamboa-Dominguez A
8. Bruno J
9. Beck CA
10. Proctor RA
11. Kates SL
12. Schwarz EM
13. Muthukrishnan G
Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical Outcome.; bioRxiv : the preprint server for biology. 2024 Dec 31.
1. Zhou H
2. Ren Y
3. Zou K
4. Jin Y
5. Liu H
6. Jiang H
7. Shi L
8. Sheng X
9. Weeks J
10. Wang H
11. Xue T
12. Schwarz EM
13. Xie C
14. Deng Z
15. Wang L
16. Chu L
Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.; Advanced healthcare materials. 2024 Nov 27.
1. Kuhn EMA
2. Sominsky LA
3. Chittò M
4. Schwarz EM
5. Moriarty TF
Antibacterial Mechanisms and Clinical Impact of Sitafloxacin.; Pharmaceuticals (Basel, Switzerland); Vol 17(11). 2024 Nov 16.
1. Kates SL
2. Owen JR
3. Xie C
4. Ren Y
5. Muthukrishnan G
6. Schwarz EM
Vaccines: Do they have a role in orthopedic trauma?; Injury; Vol 55 Suppl 6, pp. 111631. 2024 Nov.
1. Bell RD
2. Brendel M
3. Konnaris MA
4. Xiang J
5. Otero M
6. Fontana MA
7. Bai Z
8. Krenitsky DM
9. Meednu N
10. Rangel-Moreno J
11. Scheel-Toellner D
12. Carr H
13. Nayar S
14. McMurray J
15. DiCarlo E
16. Anolik JH
17. Donlin LT
18. Orange DE
19. Kenney HM
20. Schwarz EM
21. Filer A
22. Ivashkiv LB
23. Wang F
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.; Nature communications; Vol 15(1), pp. 7503. 2024 Aug 29.
1. Kenney HM
2. Chen KL
3. Schnur L
4. Fox JI
5. Wood RW
6. Xing L
7. Ritchlin CT
8. Rahimi H
9. Schwarz EM
10. Awad HA
High-throughput micro-CT analysis identifies sex-dependent biomarkers of erosive arthritis in TNF-Tg mice and differential response to anti-TNF therapy.; PloS one; Vol 19(7), pp. e0305623. 2024 Jul 05.
1. Lekkala S
2. Ren Y
3. Weeks J
4. Lee K
5. Tay AJH
6. Liu B
7. Xue T
8. Rainbolt J
9. Xie C
10. Schwarz EM
11. Yeh SA
A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model.; PloS one; Vol 19(6), pp. e0296140. 2024 Jun 20.
1. Sechrist ZR
2. Lee G
3. Schwarz EM
4. Cole CL
Validation of dual energy X-ray absorptiometry for longitudinal quantification of tumor burden in a murine model of pancreatic ductal adenocarcinoma.; PloS one; Vol 19(1), pp. e0292196. 2024 Jan 02.
1. Kenney HM
2. Rangel-Moreno J
3. Peng Y
4. Chen KL
5. Bruno J
6. Embong A
7. Pritchett E
8. Fox JI
9. Becerril-Villanueva E
10. Gamboa-Domínguez A
11. Quataert S
12. Muthukrishnan G
13. Wood RW
14. Korman BD
15. Anolik JH
16. Xing L
17. Ritchlin CT
18. Schwarz EM
19. Wu CL
Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.; Frontiers in immunology; Vol 14, pp. 1237498. 2023 Aug 25.
1. Maloney MD
2. Haddas R
3. Schwarz EM
4. Nelms S
5. Rizzone K
Efforts to Improve Diversity, Equality, and Inclusion in Sports Medicine via Community Engagement Initiatives Within American Cities Divided by Racial, Social, and Economic Factors.; Clinics in sports medicine; Vol 43(2), pp. 271-277. 2023 Jul 26.
1. Ren Y
2. Liu L
3. Sun D
4. Zhang Z
5. Li M
6. Lan X
7. Ni J
8. Yan M
9. Huang W
10. Liu Z
11. Peng A
12. Zhang Y
13. Jiang N
14. Song K
15. Huang Z
16. Bi Q
17. Zhang J
18. Yang Q
19. Yang J
20. Liu Y
21. Fu W
22. Tian X
23. Wang Y
24. Zhong W
25. Song X
26. Abudurexiti A
27. Xia Z
28. Jiang Q
29. Shi H
30. Liu X
31. Wang G
32. Hu Y
33. Zhang Y
34. Yin G
35. Fan J
36. Feng S
37. Zhou X
38. Li Z
39. He W
40. Weeks J
41. Schwarz EM
42. Kates SL
43. Huang L
44. Chai Y
45. Yu B
46. Xie Z
47. Deng Z
48. Xie C
Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicenter cohort study.; International journal of surgery (London, England). 2023 May 29.
1. Ren Y
2. Zhang S
3. Weeks J
4. Rangel-Moreno J
5. He B
6. Xue T
7. Rainbolt J
8. Morita Y
9. Shu Y
10. Liu Y
11. Kates SL
12. Schwarz EM
13. Xie C
Reduced Angiogenesis and Delayed Endochondral Ossification in CD163-/- Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Mar 27.
1. Zhang H
2. Liesveld JL
3. Calvi LM
4. Lipe BC
5. Xing L
6. Becker MW
7. Schwarz EM
8. Yeh SA
The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies.; Bone research; Vol 11(1), pp. 15. 2023 Mar 14.
1. Kenney HM
2. Dieudonne G
3. Yee S
4. Maki JH
5. Wood RW
6. Schwarz EM
7. Ritchlin CT
8. Rahimi H
Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands.; Lymphatic research and biology. 2023 Feb 20.
1. Kenney HM
2. Wood RW
3. Ramirez G
4. Bell RD
5. Chen KL
6. Schnur L
7. Rahimi H
8. Korman BD
9. Xing L
10. Ritchlin CT
11. Schwarz EM
12. Cole CL
Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice.; Arthritis research & therapy; Vol 25(1), pp. 17. 2023 Feb 02.
1. Kenney HM
2. Peng Y
3. de Mesy Bentley KL
4. Xing L
5. Ritchlin CT
6. Schwarz EM
The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?; Current rheumatology reviews. 2023 Jan 27.
1. Hickok NJ
2. Li B
3. Oral E
4. Zaat SAJ
5. Armbruster DA
6. Atkins GJ
7. Chen AF
8. Coraça-Huber DC
9. Dai T
10. Greenfield EM
11. Kasinath R
12. Libera M
13. Marques CNH
14. Moriarty TF
15. Scott Phillips K
16. Raghuraman K
17. Ren D
18. Rimondini L
19. Saeed K
20. Schaer TP
21. Schwarz EM
22. Spiegel C
23. Stoodley P
24. Truong VK
25. Tsang SJ
26. Wildemann B
27. Zelmer AR
28. Zinkernagel AS
The 2023 Orthopaedic Research Society's International Consensus Meeting on Musculoskeletal Infection: Summary from the In Vitro Section.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jan 25.
1. Ren Y
2. Weeks J
3. Xue T
4. Rainbolt J
5. de Mesy Bentley KL
6. Shu Y
7. Liu Y
8. Masters E
9. Cherian P
10. McKenna CE
11. Neighbors J
12. Ebetino FH
13. Schwarz EM
14. Sun S
15. Xie C
Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis.; Bone research; Vol 11(1), pp. 51. 2023 Jan 18.
1. Schwarz EM
2. Archer NK
3. Atkins GJ
4. Bentley KLM
5. Botros M
6. Cassat JE
7. Chisari E
8. Coraça-Huber DC
9. Daiss JL
10. Gill SR
11. Goodman SB
12. Harro J
13. Hernandez CJ
14. Ivashkiv LB
15. Kates SL
16. Marques CNH
17. Masters EA
18. Muthukrishnan G
19. Owen JR
20. Raafat D
21. Saito M
22. Veis DJ
23. Xie C
The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jan 16.
1. Peng Y
2. Kenney HM
3. de Mesy Bentley KL
4. Xing L
5. Ritchlin CT
6. Schwarz EM
Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice.; Frontiers in immunology; Vol 14, pp. 1275871. 2023 Jan 14.
1. Moriarty TF
2. Hickok NJ
3. Saeed K
4. Schaer TP
5. Chen AF
6. Schwarz EM
The 2023 Orthopaedic Research Society International Consensus Meeting on musculoskeletal infection.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jan 12.
1. Lin X
2. Bell RD
3. Catheline SE
4. Takano T
5. McDavid A
6. Jonason JH
7. Schwarz EM
8. Xing L
Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice.; Arthritis & rheumatology (Hoboken, N.J.). 2023 Jan 10.
1. Amber Jennings J
2. Arts C
3. Falconer R
4. Ashton N
5. Williams D
6. Duffy H
7. Hamilton J
8. Markovics A
9. Gianotti S
10. Tate J
11. Montgomery EC
12. Abuhussein E
13. Dintakurthi Y
14. Ren Y
15. Weeks J
16. Xie C
17. Ricciardi B
18. van Hoogstraten S
19. Mdingi V
20. Vanvelk N
21. Hylen A
22. Baertl S
23. Alt V
24. Morgenstern M
25. Priddy LB
26. Tucker LJ
27. Gautreaux MA
28. Ducheyne P
29. Bhattacharyya S
30. Obremskey WT
31. Libos A
32. Cain JD
33. Hickok NJ
34. Schwarz EM
35. Fintan Moriarty T
2023 International Consensus Meeting on Musculoskeletal Infection: Summary from the Treatment Workgroup and Consensus on Treatment in Preclinical Models.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jan 09.
1. Xie C
2. Ren Y
3. Weeks J
4. Rainbolt J
5. Mark Kenney H
6. Xue T
7. Allen F
8. Shu Y
9. Tay AJH
10. Lekkala S
11. Yeh SA
12. Muthukrishnan G
13. Gill AL
14. Gill SR
15. Kim M
16. Kates SL
17. Schwarz EM
Longitudinal Intravital Imaging of the Bone Marrow (LIMB) for Analysis of the Race for the Surface in a Murine Osteomyelitis Model.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Jan 09.
1. Lekkala S
2. Ren Y
3. Weeks J
4. Lee K
5. Jia Hui Tay A
6. Liu B
7. Xue T
8. Rainbolt J
9. Xie C
10. Schwarz EM
11. Yeh SA
A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model.; bioRxiv : the preprint server for biology. 2023 Jan 08.
1. Siegel RJ
2. Singh AK
3. Panipinto PM
4. Shaikh FS
5. Vinh J
6. Han SU
7. Kenney HM
8. Schwarz EM
9. Crowson CS
10. Khuder SA
11. Khuder BS
12. Fox DA
13. Ahmed S
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts.; Cellular & molecular immunology. 2022 Sep 07.
1. Morita Y
2. Saito M
3. Rangel-Moreno J
4. Franchini AM
5. Owen JR
6. Martinez JC
7. Daiss JL
8. de Mesy Bentley KL
9. Kates SL
10. Schwarz EM
11. Muthukrishnan G
Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.; Bone research; Vol 10(1), pp. 56. 2022 Aug 26.
1. Kenney HM
2. Peng Y
3. Bell RD
4. Wood RW
5. Xing L
6. Ritchlin CT
7. Schwarz EM
Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy.; Scientific reports; Vol 12(1), pp. 12751. 2022 Jul 26.
1. Sherchand SP
2. Adhikari RP
3. Muthukrishnan G
4. Kanipakala T
5. Owen JR
6. Xie C
7. Aman MJ
8. Proctor RA
9. Schwarz EM
10. Kates SL
Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot.; Frontiers in cellular and infection microbiology; Vol 12, pp. 876898. 2022 Jul 18.
1. Ren Y
2. Xue T
3. Rainbolt J
4. Bentley KLM
5. Galloway CA
6. Liu Y
7. Cherian P
8. Neighbors J
9. Hofstee MI
10. Ebetino FH
11. Moriarty TF
12. Sun S
13. Schwarz EM
14. Xie C
Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi.; Frontiers in cellular and infection microbiology; Vol 12, pp. 910970. 2022 Jun 24.
1. Kenney HM
2. Peng Y
3. Chen KL
4. Ajalik R
5. Schnur L
6. Wood RW
7. Schwarz EM
8. Awad HA
A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets.; Bone reports; Vol 16. 2022 Jun.
1. Kong P
2. Ren Y
3. Yang J
4. Fu W
5. Liu Z
6. Li Z
7. He W
8. Wang Y
9. Zheng Z
10. Ding M
11. Schwarz EM
12. Deng Z
13. Xie C
Relapsed boyhood tibia polymicrobial osteomyelitis linked to dermatophytosis: a case report.; BMC surgery; Vol 22(1). 2022 May 04.
1. Schwarz EM
What are the immune responses that allow us to live with incurable bone infection, and how can they be augmented to improve outcomes following prosthetic joint infection?; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022 Apr 18.
1. Kenney HM
2. Wu CL
3. Loiselle AE
4. Xing L
5. Ritchlin CT
6. Schwarz EM
Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model.; Arthritis research & therapy; Vol 24(1). 2022 Mar 07.
1. Cohn-Schwartz D
2. Schary Y
3. Yalon E
4. Krut Z
5. Da X
6. Schwarz EM
7. Gazit D
8. Pelled G
9. Gazit Z
PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling.; Cells; Vol 11(5). 2022 Mar 05.
1. Masters EA
2. Ricciardi BF
3. Bentley KLM
4. Moriarty TF
5. Schwarz EM
6. Muthukrishnan G
Skeletal infections: microbial pathogenesis, immunity and clinical management.; Nature reviews. Microbiology. 2022 Feb 15.
1. Moriarty TF
2. Metsemakers WJ
3. Morgenstern M
4. Hofstee MI
5. Vallejo Diaz A
6. Cassat JE
7. Wildemann B
8. Depypere M
9. Schwarz EM
10. Richards RG
Fracture-related infection.; Nature reviews. Disease primers; Vol 8(1), pp. 67. 2022 Jan 20.
1. Garcia-Hernandez ML
2. Rangel-Moreno J
3. Garcia-Castaneda M
4. Kenney HM
5. Paine A
6. Thullen M
7. Anandarajah AP
8. Schwarz EM
9. Dirksen RT
10. Ritchlin CT
Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.; Frontiers in immunology; Vol 13, pp. 1026574. 2022 Jan 07.
1. Young M
2. Walsh DJ
3. Masters E
4. Gondil VS
5. Laskey E
6. Klaczko M
7. Awad H
8. McGrath J
9. Schwarz EM
10. Melander C
11. Dunman PM
Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors.; Antibiotics (Basel, Switzerland); Vol 11(10). 2022 Jan 04.
1. Sutipornpalangkul W
2. Nishitani K
3. Schwarz EM
Quantitative flow chamber system for evaluating in vitro biofilms and the kinetics of S. aureus biofilm formation in human plasma media.; BMC microbiology; Vol 21(1). 2021 Nov 11.
1. Adjei-Sowah E
2. Peng Y
3. Weeks J
4. Jonason JH
5. de Mesy Bentley KL
6. Masters E
7. Morita Y
8. Muthukrishnan G
9. Cherian P
10. Hu XE
11. McKenna CE
12. Ebetino FH
13. Sun S
14. Schwarz EM
15. Xie C
Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid.; Antibiotics (Basel, Switzerland); Vol 10(6). 2021 Jun 17.
1. Cole CL
2. Bachman JF
3. Ye J
4. Murphy J
5. Gerber SA
6. Beck CA
7. Boyce BF
8. Muthukrishnan G
9. Chakkalakal JV
10. Schwarz EM
11. Linehan D
Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.; Journal of cachexia, sarcopenia and muscle. 2021 May 07.
1. Liang Q
2. Zhang L
3. Xu H
4. Li J
5. Chen Y
6. Schwarz EM
7. Shi Q
8. Wang Y
9. Xing L
Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice.; Arthritis research & therapy; Vol 23(1). 2021 Feb 19.
1. de Mesy Bentley KL
2. Galloway CA
3. Muthukrishnan G
4. Echternacht SR
5. Masters EA
6. Zeiter S
7. Schwarz EM
8. Leckenby JI
Emerging electron microscopy and 3D methodologies to interrogate Staphylococcus aureus osteomyelitis in murine models.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 39(2). 2021 Feb.
1. Schwarz EM
2. Arts JJC
3. Chen AF
Introduction for the Journal of Orthopaedic Research Special Issue on musculoskeletal infection.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Jan 17.
1. Morita Y
2. Masters EA
3. Schwarz EM
4. Muthukrishnan G
Interleukin-27 and Its Diverse Effects on Bacterial Infections.; Frontiers in immunology; Vol 12. 2021.
1. Muthukrishnan G
2. Wallimann A
3. Rangel-Moreno J
4. Bentley KLM
5. Hildebrand M
6. Mys K
7. Kenney HM
8. Sumrall ET
9. Daiss JL
10. Zeiter S
11. Richards RG
12. Schwarz EM
13. Moriarty TF
Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis.; Frontiers in immunology; Vol 12. 2021.
1. Masters EA
2. Muthukrishnan G
3. Ho L
4. Gill AL
5. de Mesy Bentley KL
6. Galloway CA
7. McGrath JL
8. Awad HA
9. Gill SR
10. Schwarz EM
Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis.; Frontiers in microbiology; Vol 12. 2021.
1. Scallan JP
2. Bouta EM
3. Rahimi H
4. Kenney HM
5. Ritchlin CT
6. Davis MJ
7. Schwarz EM
Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis.; Frontiers in physiology; Vol 12. 2021.
1. Masters EA
2. Hao SP
3. Mark Kenney H
4. Morita Y
5. Galloway CA
6. de Mesy Bentley KL
7. Ricciardi BF
8. Boyce BF
9. Schwarz EM
10. Oh I
Distinct Vasculotropic vs. Osteotropic Features of S. agalactiae vs. S. aureus Implant-Associated Bone Infection in Mice.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Dec 18.