URMC / Labs / Shrager Lab / Publications

Recent Publications

1. McKee C
2. Foley K
3. Andersh KM
4. Marola OJ
5. Wadzinski B
6. Libby RT
7. Shrager P
8. Xia H
Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerve.; bioRxiv : the preprint server for biology. 2024 May 10.
1. Schmitd LB
2. Hafner H
3. Ward A
4. Adib EA
5. Biscola NP
6. Kohen R
7. Patel M
8. Williamson RE
9. Desai E
10. Bennett J
11. Saxman G
12. Athaiya M
13. Wilborn D
14. Shumpert J
15. Zhao XF
16. Kawaguchi R
17. Geschwind DH
18. Hoke A
19. Shrager P
20. Collins CA
21. Havton LA
22. Kalinski AL
23. Giger RJ
Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.; bioRxiv : the preprint server for biology. 2024 Mar 08.
1. McKee C
2. Shrager P
3. Mazumder AG
4. Ganguly A
5. Mayer A
6. Foley K
7. Ward N
8. Youngman M
9. Hou H
10. Xia H
Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.; Molecular neurobiology. 2022 Jan 06.
1. Fernandes KA
2. Mitchell KL
3. Patel A
4. Marola OJ
5. Shrager P
6. Zack DJ
7. Libby RT
8. Welsbie DS
Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.; Experimental eye research. 2018 Mar 08.
1. Lin JP
2. Mironova YA
3. Shrager P
4. Giger RJ
LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair.; eLife; Vol 6. 2017 Dec 18.
1. Syc-Mazurek SB
2. Fernandes KA
3. Wilson MP
4. Shrager P
5. Libby RT
Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.; Molecular neurodegeneration; Vol 12(1). 2017 Oct 02.
1. Shrager P
2. Youngman M
Preferential conduction block of myelinated axons by nitric oxide.; Journal of neuroscience research; Vol 95(7). 2017 Jul.
1. Mironova YA
2. Lenk GM
3. Lin JP
4. Lee SJ
5. Twiss JL
6. Vaccari I
7. Bolino A
8. Havton LA
9. Min SH
10. Abrams CS
11. Shrager P
12. Meisler MH
13. Giger RJ
PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.; eLife; Vol 5. 2016 Mar 23.
1. Jones JM
2. Dionne L
3. Dell'Orco J
4. Parent R
5. Krueger JN
6. Cheng X
7. Dib-Hajj SD
8. Bunton-Stasyshyn RK
9. Sharkey LM
10. Dowling JJ
11. Murphy GG
12. Shakkottai VG
13. Shrager P
14. Meisler MH
Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.; Neurobiology of disease. 2016 Jan 22.
1. Carbajal KS
2. Mironova Y
3. Ulrich-Lewis JT
4. Kulkarni D
5. Grifka-Walk HM
6. Huber AK
7. Shrager P
8. Giger RJ
9. Segal BM
Th Cell Diversity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.; Journal of immunology (Baltimore, Md. : 1950). 2015 Aug 3.
1. Fernandes KA
2. Harder JM
3. John SW
4. Shrager P
5. Libby RT
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.; Neurobiology of disease; Vol 69. 2014 Sep.
1. Greminger AR
2. Lee DL
3. Shrager P
4. Mayer-Pröschel M
Gestational Iron Deficiency Differentially Alters the Structure and Function of White and Gray Matter Brain Regions of Developing Rats.; The Journal of nutrition. 2014 Apr 17.
1. Einheber S
2. Meng X
3. Rubin M
4. Lam I
5. Mohandas N
6. An X
7. Shrager P
8. Kissil J
9. Maurel P
10. Salzer JL
The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.; Glia; Vol 61(2). 2013 Feb.
1. Einheber S
2. Maurel P
3. Meng X
4. Rubin M
5. Lam I
6. Mohandas N
7. An X
8. Shrager P
9. Kissil JA
10. Salzer J
The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.; Glia. 2012 Jan 01.
1. Winters JJ
2. Ferguson CJ
3. Lenk GM
4. Giger-Mateeva VI
5. Shrager P
6. Meisler MH
7. Giger RJ
Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(48). 2011 Nov 30.
1. Winters J
2. Lenk G
3. Giger-Mateeva V
4. Shrager P
5. Meisler MA
6. Giger RJ
Congenital CNS hypomyelination and reduced number of mature oligodendrocytes in the Fig4 null mouse.; Journal of Neuroscience. 2011 Jan 01.
1. Raiker SJ
2. Lee H
3. Baldwin KT
4. Duan Y
5. Shrager P
6. Giger RJ
Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 30(37). 2010 Sep 15.
1. Feinberg K
2. Eshed-Eisenbach Y
3. Frechter S
4. Amor V
5. Salomon D
6. Sabanay H
7. Dupree JL
8. Grumet M
9. Brophy PJ
10. Shrager P
11. Peles E
A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.; Neuron; Vol 65(4). 2010 Feb 25.
1. Feinberg K
2. Eshed-Eisenbach Y
3. Frechter S
4. Amor V
5. Salomon D
6. Sabanay H
7. Dupree JL
8. Grumet M
9. Brophy PJ
10. Shrager P
11. Peles E
A glial signal consisting of Gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.; Neuron. 2010 Jan 01.
1. Raiker SJ
2. Lee H
3. Duan Y
4. Koelzer KT
5. Shrager PA
6. Giger RJ
Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.; Journal of Neuroscience; Vol 30, pp. 12432-12445. 2010 Jan 01.
1. Lee H
2. Raiker SJ
3. Venkatesh K
4. Geary R
5. Robak LA
6. Zhang Y
7. Yeh HH
8. Shrager P
9. Giger RJ
Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 28(11). 2008 Mar 12.
1. Lee H
2. Raiker S
3. Venkatesh K
4. Geary R
5. Robak LA
6. Zhang Y
7. Yeh HH
8. Shrager PA
9. Giger RJ
Synaptic function for the Nogo-66 receptor NgR1: Regulation of dendritic spine morphology and activity-dependent synaptic strength.; Journal of Neuroscience. 2008 Jan 01.
1. Hedstrom KL
2. Xu X
3. Ogawa Y
4. Frischknecht R
5. Seidenbecher CI
6. Shrager P
7. Rasband MN
Neurofascin assembles a specialized extracellular matrix at the axon initial segment.; The Journal of cell biology; Vol 178(5). 2007 Aug 27.
1. Hedstrom KL
2. Xu X
3. Ogawa Y
4. Frishnecht R
5. Seidenbecher CI
6. Shrager PA
7. Rasband MN
Neurofascin assembles a specialized extracellular matrix at the axon initial segment.; Journal of Cell Biology; Vol 178, pp. 875-886. 2007 Jan 01.
1. Schafer DP
2. Custer AW
3. Shrager P
4. Rasband MN
Early events in node of Ranvier formation during myelination and remyelination in the PNS.; Neuron glia biology; Vol 2(2). 2006 May.
1. Taveggia C
2. Zanazzi G
3. Petrylak A
4. Yano H
5. Rosenbluth J
6. Einheber S
7. Xu X
8. Esper RM
9. Loeb JA
10. Shrager P
11. Chao MV
12. Falls DL
13. Role L
14. Salzer JL
Neuregulin-1 type III determines the ensheathment fate of axons.; Neuron; Vol 47(5). 2005 Sep 1.
1. Xu X
2. Shrager P
Dependence of axon initial segment formation on Na+ channel expression.; Journal of neuroscience research; Vol 79(4). 2005 Feb 15.
1. Chen C
2. Westenbroek RE
3. Xu X
4. Edwards CA
5. Sorenson DR
6. Chen Y
7. McEwen DP
8. O'Malley HA
9. Bharucha V
10. Meadows LS
11. Knudsen GA
12. Vilaythong A
13. Noebels JL
14. Saunders TL
15. Scheuer T
16. Shrager P
17. Catterall WA
18. Isom LL
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 24(16). 2004 Apr 21.
1. Custer AW
2. Kazarinova-Noyes K
3. Sakurai T
4. Xu X
5. Simon W
6. Grumet M
7. Shrager P
The role of the ankyrin-binding protein NrCAM in node of Ranvier formation.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 23(31). 2003 Nov 5.
1. Poliak S
2. Salomon D
3. Elhanany H
4. Sabanay H
5. Kiernan B
6. Pevny L
7. Stewart CL
8. Xu X
9. Chiu SY
10. Shrager P
11. Furley AJ
12. Peles E
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.; The Journal of cell biology; Vol 162(6). 2003 Sep 15.
1. Chen C
2. Bharucha V
3. Chen Y
4. Westenbroek RE
5. Brown A
6. Malhotra JD
7. Jones D
8. Avery C
9. Gillespie PJ
10. Kazen-Gillespie KA
11. Kazarinova-Noyes K
12. Shrager P
13. Saunders TL
14. Macdonald RL
15. Ransom BR
16. Scheuer T
17. Catterall WA
18. Isom LL
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.; Proceedings of the National Academy of Sciences of the United States of America; Vol 99(26). 2002 Dec 24.
1. Kazarinova-Noyes K
2. Shrager P
Molecular constituents of the node of Ranvier.; Molecular neurobiology; Vol 26(2-3). 2002 Oct.
1. Chen C
2. Bharucha V
3. Chen Y
4. Westenbroek RE
5. Brown A
6. Malhotra JD
7. Jones D
8. Avery C
9. Gillespie PJ
10. Kazen-Gillespie KA
11. Kazarinova-Noyes K
12. Shrager P
13. Saunders TL
14. Macdonald RL
15. Ransom BR
16. Scheuer T
17. Catterall WA
18. Isom LL
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta2-subunits.; Proceedings of the National Academy of Sciences; Vol 99, pp. 17072-17077. 2002 Jan 01.
1. Kazarinova-Noyes K
2. Malhotra JD
3. McEwen DP
4. Mattei LN
5. Berglund EO
6. Ranscht B
7. Levinson SR
8. Schachner M
9. Shrager P
10. Isom LL
11. Xiao ZC
Contactin associates with Na+ channels and increases their functional expression.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 21(19). 2001 Oct 1.
1. Harroch S
2. Palmeri M
3. Rosenbluth J
4. Custer A
5. Okigaki M
6. Shrager P
7. Blum M
8. Buxbaum JD
9. Schlessinger J
No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta.; Molecular and cellular biology; Vol 20(20). 2000 Oct.
1. Rasband MN
2. Shrager P
Ion channel sequestration in central nervous system axons.; The Journal of physiology; Vol 525 Pt 1. 2000 May 15.
1. Rasband MN
2. Trimmer JS
3. Peles E
4. Levinson SR
5. Shrager P
K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve.; Journal of Neurocytology; Vol 28, pp. 319-331. 2000 Jan 01.
1. Poliak S
2. Gollan L
3. Martinez R
4. Custer A
5. Einheber S
6. Salzer JL
7. Trimmer JS
8. Shrager P
9. Peles E
Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.; Neuron; Vol 24(4). 1999 Dec.
1. Rasband MN
2. Peles E
3. Trimmer JS
4. Levinson SR
5. Lux SE
6. Shrager P
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 19(17). 1999 Sep 1.
1. Weber P
2. Bartsch U
3. Rasband MN
4. Czaniera R
5. Lang Y
6. Bluethmann H
7. Margolis RU
8. Levinson SR
9. Shrager P
10. Montag D
11. Schachner M
Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 19(11). 1999 Jun 1.
1. Rasband MN
2. Trimmer JS
3. Peles E
4. Levinson SR
5. Shrager P
K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve.; Journal of neurocytology; Vol 28(4-5). 1999 Apr.
1. Vabnick I
2. Trimmer JS
3. Schwarz TL
4. Levinson SR
5. Risal D
6. Shrager P
Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 19(2). 1999 Jan 15.
1. Vabnick I
2. Shrager P
Ion channel redistribution and function during development of the myelinated axon.; Journal of neurobiology; Vol 37(1). 1998 Oct.
1. Novakovic SD
2. Levinson SR
3. Schachner M
4. Shrager P
Disruption and reorganization of sodium channels in experimental allergic neuritis.; Muscle & nerve; Vol 21(8). 1998 Aug.
1. Shrager P
2. Custer AW
3. Kazarinova K
4. Rasband MN
5. Mattson D
Nerve conduction block by nitric oxide that is mediated by the axonal environment.; Journal of neurophysiology; Vol 79(2). 1998 Feb.
1. Rasband MN
2. Trimmer JS
3. Schwarz TL
4. Levinson SR
5. Ellisman MH
6. Schachner M
7. Shrager P
Potassium channel distribution, clustering, and function in remyelinating rat axons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 18(1). 1998 Jan 1.
1. Vabnick I
2. Messing A
3. Chiu SY
4. Levinson SR
5. Schachner M
6. Roder J
7. Li C
8. Novakovic S
9. Shrager P
Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice.; Journal of neuroscience research; Vol 50(2). 1997 Oct 15.
1. Vabnick I
2. Novaković SD
3. Levinson SR
4. Schachner M
5. Shrager P
The clustering of axonal sodium channels during development of the peripheral nervous system.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 16(16). 1996 Aug 15.
1. England JD
2. Levinson SR
3. Shrager P
Immunocytochemical investigations of sodium channels along nodal and internodal portions of demyelinated axons.; Microscopy research and technique; Vol 34(5). 1996 Aug 1.
1. Novakovic SD
2. Deerinck TJ
3. Levinson SR
4. Shrager P
5. Ellisman MH
Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells.; Journal of neurocytology; Vol 25(6). 1996 Jun.