Thakar Lab
Welcome to the Thakar Lab
Immune response to infections, vaccination and environmental exposures depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology, and dynamic modeling tools. We typically integrate different datasets including gene expression, metabolomics, single-cell RNA seq, proteomics, serum cytokine levels and known information about signaling and metabolic pathways. Recently, we are also working with adaptive immune receptor repertoire sequencing.
Juilee Thakar, Ph.D.
Principal Investigator
Publications
View All Publications- Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus.; Frontiers in immunology; Vol 15, pp. 1499551. 2025 Jan 10.
- Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells.; Clinical and experimental immunology. 2025 Jan 09.
- Immune digital twins for complex human pathologies: applications, limitations, and challenges.; NPJ systems biology and applications; Vol 10(1), pp. 141. 2024 Nov 30.
- Comparative analysis of single-cell pathway scoring methods and a novel approach.; NAR genomics and bioinformatics; Vol 6(3), pp. lqae124. 2024 Sep 24.
- The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction.; GeroScience. 2024 Jun 15.
- Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.; Nature communications; Vol 15(1), pp. 4991. 2024 Jun 11.
News
Affiliations
- Microbiology & Immunology
- Center for Biomedical Informatics
- NIH T32 Training Grant in Immunology
- Biomedical Genetics and Genomics Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Immunology, Microbiology, and Virology Ph.D. Program
- PhD Program in Pathology - Cell Biology of Disease
- Translational Biomedical Science Ph.D. Program
- Program for Advanced Immune Bioimaging
August 10, 2020
Thakar Lab publishes article on the Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature
August 3, 2019
Celebrating Juilee’s promotion to Associate level and acceptance of Rohith’s paper in PLoS Computational Biology
July 16, 2019
Juilee presented on use of metabolomics to infer signatures of HIV vaccine response at HVTN2019
March 16, 2019
Rohith Palli presenting at Cold Spring Harbor Systems Immunology meeting
Contact Us
Thakar Lab
KMRB 3-9834
601 Elmwood Ave
Rochester, NY 14642