Thakar Lab
Welcome to the Thakar Lab
Immune response to infections, vaccination and environmental exposures depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology, and dynamic modeling tools. We typically integrate different datasets including gene expression, metabolomics, single-cell RNA seq, proteomics, serum cytokine levels and known information about signaling and metabolic pathways. Recently, we are also working with adaptive immune receptor repertoire sequencing.
Juilee Thakar, Ph.D.
Principal Investigator
Publications
View All Publications- Immune digital twins for complex human pathologies: applications, limitations, and challenges.; NPJ systems biology and applications; Vol 10(1), pp. 141. 2024 Nov 30.
- Comparative analysis of single-cell pathway scoring methods and a novel approach.; NAR genomics and bioinformatics; Vol 6(3), pp. lqae124. 2024 Sep 24.
- The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction.; GeroScience. 2024 Jun 15.
- Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.; Nature communications; Vol 15(1), pp. 4991. 2024 Jun 11.
- SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses.; Frontiers in immunology; Vol 15, pp. 1347926. 2024 Jun 06.
- Discrete-state models identify pathway specific B cell states across diseases and infections at single-cell resolution.; Journal of theoretical biology. 2024 Feb 27.
News
Affiliations
- Microbiology & Immunology
- Center for Biomedical Informatics
- NIH T32 Training Grant in Immunology
- Biomedical Genetics and Genomics Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Immunology, Microbiology, and Virology Ph.D. Program
- PhD Program in Pathology - Cell Biology of Disease
- Translational Biomedical Science Ph.D. Program
- Program for Advanced Immune Bioimaging
August 10, 2020
Thakar Lab publishes article on the Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature
August 3, 2019
Celebrating Juilee’s promotion to Associate level and acceptance of Rohith’s paper in PLoS Computational Biology
July 16, 2019
Juilee presented on use of metabolomics to infer signatures of HIV vaccine response at HVTN2019
March 16, 2019
Rohith Palli presenting at Cold Spring Harbor Systems Immunology meeting
Contact Us
Thakar Lab
KMRB 3-9834
601 Elmwood Ave
Rochester, NY 14642