URMC / Labs / Whasil Lee Lab / Publications

Publications

1. Jing X
2. Kotelsky A
3. Zhang Y
4. Dirksen R
5. Mannava S
6. Buckley M
7. Lee W
Mechano-adaptation: Exercise-driven Piezo1 & Piezo2 augmentation and chondroprotection in articular cartilage.; bioRxiv : the preprint server for biology. 2024 Aug 06.
1. Anderson DE
2. Broun KG
3. Kundu P
4. Jing X
5. Tang X
6. Lu C
7. Kotelsky A
8. Mannava S
9. Lee W
PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.; Frontiers in bioengineering and biotechnology; Vol 11, pp. 1244975. 2023 Sep 05.
1. Wise BC
2. Mora KE
3. Lee W
4. Buckley MR
Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.; Journal of visualized experiments : JoVE. 2023 Jan 08.
1. Fraser D
2. Nguyen T
3. Kotelsky A
4. Lee W
5. Buckley M
6. Benoit DSW
Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces.; ACS biomaterials science & engineering. 2022 Jul 06.
1. Gao W
2. Hasan H
3. Anderson DE
4. Lee W
The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis.; Frontiers in cell and developmental biology; Vol 10. 2022.
1. Lee W
2. Nims RJ
3. Savadipour A
4. Zhang Q
5. Leddy HA
6. Liu F
7. McNulty AL
8. Chen Y
9. Guilak F
10. Liedtke WB
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.; Proceedings of the National Academy of Sciences of the United States of America; Vol 118(13). 2021 Mar 30.
1. Kotelsky A
2. Elahi A
3. Nejat Yigit C
4. Proctor A
5. Mannava S
6. Pröschel C
7. Lee W
Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice.; Osteoarthritis and cartilage open; Vol 4(1), pp. 100227. 2021 Jan 15.
1. Kanju P
2. Chen Y
3. Lee W
4. Yeo M
5. Lee SH
6. Romac J
7. Shahid R
8. Fan P
9. Gooden DM
10. Simon SA
11. Spasojevic I
12. Mook RA
13. Liddle RA
14. Guilak F
15. Liedtke WB
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.; Scientific reports; Vol 6. 2016 Jun 01.
1. Chen Y
2. Kanju P
3. Fang Q
4. Lee SH
5. Parekh PK
6. Lee W
7. Moore C
8. Brenner D
9. Gereau RW
10. Wang F
11. Liedtke W
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.; Pain; Vol 155(12). 2014 Dec.
1. Lee W
2. Leddy HA
3. Chen Y
4. Lee SH
5. Zelenski NA
6. McNulty AL
7. Wu J
8. Beicker KN
9. Coles J
10. Zauscher S
11. Grandl J
12. Sachs F
13. Guilak F
14. Liedtke WB
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.; Proceedings of the National Academy of Sciences of the United States of America; Vol 111(47). 2014 Nov 25.
1. Lee W
2. Strümpfer J
3. Bennett V
4. Schulten K
5. Marszalek PE
Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats.; The Journal of biological chemistry; Vol 287(23). 2012 Jun 01.
1. Lee W
2. Zeng X
3. Rotolo K
4. Yang M
5. Schofield CJ
6. Bennett V
7. Yang W
8. Marszalek PE
Mechanical anisotropy of ankyrin repeats.; Biophysical journal; Vol 102(5). 2012 Mar 07.
1. Lee W
2. Zeng X
3. Zhou HX
4. Bennett V
5. Yang W
6. Marszalek PE
Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations.; The Journal of biological chemistry; Vol 285(49). 2010 Dec 03.
1. Kim M
2. Abdi K
3. Lee G
4. Rabbi M
5. Lee W
6. Yang M
7. Schofield CJ
8. Bennett V
9. Marszalek PE
Fast and forceful refolding of stretched alpha-helical solenoid proteins.; Biophysical journal; Vol 98(12). 2010 Jun 16.
1. Serquera D
2. Lee W
3. Settanni G
4. Marszalek PE
5. Paci E
6. Itzhaki LS
Mechanical unfolding of an ankyrin repeat protein.; Biophysical journal; Vol 98(7). 2010 Apr 07.
1. Jiang Y
2. Rabbi M
3. Kim M
4. Ke C
5. Lee W
6. Clark RL
7. Mieczkowski PA
8. Marszalek PE
UVA generates pyrimidine dimers in DNA directly.; Biophysical journal; Vol 96(3). 2009 Feb.
1. Rivera M
2. Lee W
3. Ke C
4. Marszalek PE
5. Cole DG
6. Clark RL
Minimizing pulling geometry errors in atomic force microscope single molecule force spectroscopy.; Biophysical journal; Vol 95(8). 2008 Oct.