Wojtovich Lab
Mitochondrial Physiology and Hypoxic Stress Signaling
Mitochondria play a central role in stroke outcomes. We study ischemia reperfusion injury in neurons using optogenetic tools to control the mitochondrial membrane potential or reactive oxygen species production. Depending on where, when, and how mitochondrial function changes, damage or protective signaling can occur. We use CRISPR/Cas9, C. elegans genetics, primary neurons, and measures of mitochondrial bioenergetics to learn about the mechanisms of this damage or protection in our models.
Our laboratory is always looking for new mitochondriacs! Join our dynamic team.
Contact us for more information.

Andrew P. Wojtovich, Ph.D.
Principal Investigator
Publications
- Mitochondrial metabolism and redox signaling.; Redox biology. 2024 Nov 29.
- DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity.; Free radical biology & medicine. 2024 Sep 22.
- Fruit flavors in electronic cigarettes (ECIGs) are associated with nocturnal dry cough: A population longitudinal analysis.; PloS one; Vol 19(6), pp. e0306467. 2024 Jun 28.
- Mitochondrial energy state controls AMPK-mediated foraging behavior in C. elegans.; Science advances; Vol 10(16), pp. eadm8815. 2024 Apr 17.
- Oocyte mitochondria link maternal environment to offspring phenotype.; Research square. 2024 Mar 29.
Affiliations
- Anesthesiology and Perioperative Medicine
- Pharmacology & Physiology
- Mitochondrial Research and Innovation Group (MRIG)
- Neuroscience Graduate Program
- Cellular and Molecular Pharmacology and Physiology Graduate Program
News
February 3, 2025
Fish, Mercury, and the Developing Brain
October 8, 2024
Pete and Annika win poster prizes at TriMAD – Congrats!
October 7, 2024
TRiMAD Mitochondria Conference comes to Rochester
Contact Us
Wojtovich Lab
575 Elmwood Ave, Box 711/604
Rochester, NY 14642