Yeh Lab
Welcome to the Yeh Lab
The primary research interest of the Yeh lab is to develop intravital imaging-based approaches for direct visualization, quantification, and molecular profiling of the local regulatory machineries that harbor the skeletal, hematopoietic, and malignant stem cells.
The long-term goal is to identify distinct pathways in the bone marrow microenvironment that can be targeted to confront hematopoietic malignancy and aging.
Shu-Chi Yeh, Ph.D.
Principal Investigator
Projects
- The stem cell niche of myelodysplastic syndrome
- The interplay of bone remodeling and the bone marrow microenvironment for normal hematopoiesis and malignancies
- Intravital pH sensing of the cancer microenvironment
- Visualizing and manipulating the communicative network of bone marrow stromal cells
Publications
View All Publications- Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis.; Scientific reports; Vol 14(1), pp. 20486. 2024 Sep 03.
- A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model.; PloS one; Vol 19(6), pp. e0296140. 2024 Jun 20.
- Expansion of the sagittal suture induces proliferation of skeletal stem cells and sustains endogenous calvarial bone regeneration.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(16), pp. e2120826120. 2023 Apr 11.