URMC / Labs / Yule Lab / Publications

1. Rosa N
2. Ivanova H
3. Wagner LE
4. Kale J
5. La Rovere R
6. Welkenhuyzen K
7. Louros N
8. Karamanou S
9. Shabardina V
10. Lemmens I
11. Vandermarliere E
12. Hamada K
13. Ando H
14. Rousseau F
15. Schymkowitz J
16. Tavernier J
17. Mikoshiba K
18. Economou A
19. Andrews DW
20. Parys JB
21. Yule DI
22. Bultynck G
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis.; Cell death and differentiation. 2021 Nov 08.
1. Arige V
2. Yule DI
Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis.; Cell calcium; Vol 90. 2020 Sep.
1. Wahl AM
2. Yule DI
An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca2+ sensitivity.; Cell calcium; Vol 90. 2020 Jul 08.
1. Hou H
2. Wang L
3. Fu T
4. Papasergi M
5. Yule DI
6. Xia H
Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.; Molecular neurobiology; Vol 57(6). 2020 Jun.
1. Yoast RE
2. Emrich SM
3. Zhang X
4. Xin P
5. Johnson MT
6. Fike AJ
7. Walter V
8. Hempel N
9. Yule DI
10. Sneyd J
11. Gill DL
12. Trebak M
The native ORAI channel trio underlies the diversity of Ca2+ signaling events.; Nature communications; Vol 11(1). 2020 May 15.
1. Vera-Sigüenza E
2. Pages N
3. Rugis J
4. Yule DI
5. Sneyd J
A Multicellular Model of Primary Saliva Secretion in the Parotid Gland.; Bulletin of mathematical biology; Vol 82(3). 2020 Mar 11.
1. Aulestia FJ
2. Groeling J
3. Bomfim GHS
4. Costiniti V
5. Manikandan V
6. Chaloemtoem A
7. Concepcion AR
8. Li Y
9. Wagner LE
10. Idaghdour Y
11. Yule DI
12. Lacruz RS
Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells.; Science signaling; Vol 13(619). 2020 Feb 18.
1. Ivanova H
2. Wagner LE
3. Tanimura A
4. Vandermarliere E
5. Luyten T
6. Welkenhuyzen K
7. Alzayady KJ
8. Wang L
9. Hamada K
10. Mikoshiba K
11. De Smedt H
12. Martens L
13. Yule DI
14. Parys JB
15. Bultynck G
Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.; Cellular and molecular life sciences : CMLS; Vol 76(19). 2019 Oct.
1. Ivanova H
2. Vervliet T
3. Monaco G
4. Terry LE
5. Rosa N
6. Baker MR
7. Parys JB
8. Serysheva II
9. Yule DI
10. Bultynck G
Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.; Cold Spring Harbor perspectives in biology. 2019 Sep 09.
1. Leonard A
2. Su PY
3. Yule DI
4. Rahman A
5. Fazal F
Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury.; Shock (Augusta, Ga.). 2019 Sep 04.
1. Bartok A
2. Weaver D
3. Golenár T
4. Nichtova Z
5. Katona M
6. Bánsághi S
7. Alzayady KJ
8. Thomas VK
9. Ando H
10. Mikoshiba K
11. Joseph SK
12. Yule DI
13. Csordás G
14. Hajnóczky G
IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.; Nature communications; Vol 10(1). 2019 Aug 19.
1. Pages N
2. Vera-Sigüenza E
3. Rugis J
4. Kirk V
5. Yule DI
6. Sneyd J
A Model of [Formula: see text] Dynamics in an Accurate Reconstruction of Parotid Acinar Cells.; Bulletin of mathematical biology; Vol 81(5). 2019 May.
1. Almássy J
2. Diszházi G
3. Skaliczki M
4. Márton I
5. Magyar ZÉ
6. Nánási PP
7. Yule DI
Expression of BK channels and Na+-K+ pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion.; The ocular surface; Vol 17(2). 2019 Apr.
1. Vera-Sigüenza E
2. Pages N
3. Rugis J
4. Yule DI
5. Sneyd J
A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.; Bulletin of mathematical biology; Vol 81(3). 2019 Mar.
1. Bennett JA
2. Ture SK
3. Schmidt RA
4. Mastrangelo MA
5. Cameron SJ
6. Terry LE
7. Yule DI
8. Morrell CN
9. Lowenstein CJ
Acetylcholine inhibits platelet activation.; The Journal of pharmacology and experimental therapeutics. 2019 Feb 14.
1. Leonard A
2. Grose V
3. Paton AW
4. Paton JC
5. Yule DI
6. Rahman A
7. Fazal F
Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.; Scientific reports; Vol 9(1). 2019 Feb 14.
1. Schulman JJ
2. Szczesniak LM
3. Bunker EN
4. Nelson HA
5. Roe MW
6. Wagner LE
7. Yule DI
8. Wojcikiewicz RJH
Bok regulates mitochondrial fusion and morphology.; Cell death and differentiation; Vol 26(12). 2019 Jan.
1. de Rubio RG
2. Ransom RF
3. Malik S
4. Yule DI
5. Anantharam A
6. Smrcka AV
Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.; Science signaling; Vol 11(547). 2018 Sep 11.
1. Wang L
2. Wagner LE
3. Alzayady KJ
4. Yule DI
Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.; The Journal of biological chemistry; Vol 293(34). 2018 Aug 24.
1. Terry LE
2. Alzayady KJ
3. Furati E
4. Yule DI
Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease.; Messenger (Los Angeles, Calif. : Print); Vol 6(1-2). 2018 Jun.
1. Williams JA
2. Yule DI
Can pancreatitis be treated by inhibiting Ca2+ signaling?; Annals of translational medicine; Vol 6(7). 2018 Apr.
1. Almássy J
2. Siguenza E
3. Skaliczki M
4. Matesz K
5. Sneyd J
6. Yule DI
7. Nánási PP
New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells.; Pflugers Archiv : European journal of physiology; Vol 470(4). 2018 Apr.
1. Lock JT
2. Alzayady KJ
3. Yule DI
4. Parker I
All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics.; Science signaling; Vol 11(561). 2018 Jan 18.
1. Joseph SK
2. Young MP
3. Alzayady K
4. Yule DI
5. Ali M
6. Booth DM
7. Hajnóczky G
Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.; The Journal of biological chemistry; Vol 293(45). 2018 Jan 09.
1. Wang L
2. Yule DI
Differential regulation of ion channels function by proteolysis.; Biochimica et biophysica acta. Molecular cell research; Vol 1865(11 Pt B). 2018 Jan.
1. Nurbaeva MK
2. Eckstein M
3. Devotta A
4. Saint-Jeannet JP
5. Yule DI
6. Hubbard MJ
7. Lacruz RS
Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.; Frontiers in physiology; Vol 9. 2018.
1. Vervliet T
2. Yule DI
3. Bultynck G
Carbohydrate Loading to Combat Acute Pancreatitis.; Trends in biochemical sciences; Vol 43(10). 2018 Jan.
1. Wang L
2. Wagner LE
3. Alzayady KJ
4. Yule DI
Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.; The Journal of biological chemistry; Vol 292(28). 2017 Jul 14.
1. Luyten T
2. Welkenhuyzen K
3. Roest G
4. Kania E
5. Wang L
6. Bittremieux M
7. Yule DI
8. Parys JB
9. Bultynck G
Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.; Biochimica et biophysica acta. Molecular cell research; Vol 1864(6). 2017 Jun.
1. Bittremieux M
2. Gerasimenko JV
3. Schuermans M
4. Luyten T
5. Stapleton E
6. Alzayady KJ
7. De Smedt H
8. Yule DI
9. Mikoshiba K
10. Vangheluwe P
11. Gerasimenko OV
12. Parys JB
13. Bultynck G
DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.; Cell calcium; Vol 62. 2017 Mar.
1. Sneyd J
2. Han JM
3. Wang L
4. Chen J
5. Yang X
6. Tanimura A
7. Sanderson MJ
8. Kirk V
9. Yule DI
On the dynamical structure of calcium oscillations.; Proceedings of the National Academy of Sciences of the United States of America; Vol 114(7). 2017 Feb 14.
1. Ivanova H
2. Ritane A
3. Wagner L
4. Luyten T
5. Shapovalov G
6. Welkenhuyzen K
7. Seitaj B
8. Monaco G
9. De Smedt H
10. Prevarskaya N
11. Yule DI
12. Parys JB
13. Bultynck G
The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.; Oncotarget. 2016 Aug 2.
1. Wang L
2. Alzayady KJ
3. Yule DI
Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity?; The Journal of physiology; Vol 594(11). 2016 Jun 1.
1. Gerber S
2. Alzayady KJ
3. Burglen L
4. Brémond-Gignac D
5. Marchesin V
6. Roche O
7. Rio M
8. Funalot B
9. Calmon R
10. Durr A
11. Gil-da-Silva-Lopes VL
12. Ribeiro Bittar MF
13. Orssaud C
14. Héron B
15. Ayoub E
16. Berquin P
17. Bahi-Buisson N
18. Bole C
19. Masson C
20. Munnich A
21. Simons M
22. Delous M
23. Dollfus H
24. Boddaert N
25. Lyonnet S
26. Kaplan J
27. Calvas P
28. Yule DI
29. Rozet JM
30. Fares Taie L
Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.; American journal of human genetics; Vol 98(5). 2016 May 5.
1. Sneyd J
2. Means S
3. Zhu D
4. Rugis J
5. Won JH
6. Yule DI
Modeling Calcium Waves in an Anatomically Accurate Three-Dimensional Parotid Acinar Cell.; Journal of theoretical biology. 2016 May 4.
1. Chandrasekhar R
2. Alzayady KJ
3. Wagner LE
4. Yule DI
Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.; The Journal of biological chemistry; Vol 291(10). 2016 Mar 4.
1. Alzayady KJ
2. Wang L
3. Chandrasekhar R
4. Wagner LE
5. Van Petegem F
6. Yule DI
Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.; Science signaling; Vol 9(422). 2016.
1. Concepcion AR
2. Vaeth M
3. Wagner LE
4. Eckstein M
5. Hecht L
6. Yang J
7. Crottes D
8. Seidl M
9. Shin HP
10. Weidinger C
11. Cameron S
12. Turvey SE
13. Issekutz T
14. Meyts I
15. Lacruz RS
16. Cuk M
17. Yule DI
18. Feske S
Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.; The Journal of clinical investigation; Vol 126(11). 2016 Jan 01.
1. Teos LY
2. Zhang Y
3. Cotrim AP
4. Swaim W
5. Won JH
6. Ambrus J
7. Shen L
8. Bebris L
9. Grisius M
10. Jang SI
11. Yule DI
12. Ambudkar IS
13. Alevizos I
IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome.; Scientific reports; Vol 5. 2015 Sep 14.
1. Vervloessem T
2. Yule DI
3. Bultynck G
4. Parys JB
The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.; Biochimica et biophysica acta; Vol 1853(9). 2015 Sep.
1. Alzayady KJ
2. Sebé-Pedrós A
3. Chandrasekhar R
4. Wang L
5. Ruiz-Trillo I
6. Yule DI
Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.; Molecular biology and evolution; Vol 32(9). 2015 Sep.
1. Chandrasekhar R
2. Alzayady KJ
3. Yule DI
Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.; Biochemical Society transactions; Vol 43(3). 2015 Jun.
1. Hedgepeth SC
2. Garcia MI
3. Wagner LE
4. Rodriguez AM
5. Chintapalli SV
6. Snyder RR
7. Hankins GD
8. Henderson BR
9. Brodie KM
10. Yule DI
11. van Rossum DB
12. Boehning D
The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.; The Journal of biological chemistry; Vol 290(11). 2015 Mar 13.
1. Wagner LE
2. Groom LA
3. Dirksen RT
4. Yule DI
Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.; Cell calcium; Vol 56(2). 2014 Aug.
1. Yule DI
Cell Calcium. Special issue: Ca²⁺ signaling and secretory function. Preface.; Cell calcium; Vol 55(6). 2014 Jun.
1. Bánsághi S
2. Golenár T
3. Madesh M
4. Csordás G
5. RamachandraRao S
6. Sharma K
7. Yule DI
8. Joseph SK
9. Hajnóczky G
Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.; The Journal of biological chemistry; Vol 289(12). 2014 Mar 21.
1. Kemény LV
2. Schnúr A
3. Czepán M
4. Rakonczay Z
5. Gál E
6. Lonovics J
7. Lázár G
8. Simonka Z
9. Venglovecz V
10. Maléth J
11. Judák L
12. Németh IB
13. Szabó K
14. Almássy J
15. Virág L
16. Geisz A
17. Tiszlavicz L
18. Yule DI
19. Wittmann T
20. Varró A
21. Hegyi P
Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.; American journal of physiology. Gastrointestinal and liver physiology; Vol 305(8). 2013 Oct 15.
1. Alzayady KJ
2. Wagner LE
3. Chandrasekhar R
4. Monteagudo A
5. Godiska R
6. Tall GG
7. Joseph SK
8. Yule DI
Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.; The Journal of biological chemistry; Vol 288(41). 2013 Oct 11.
1. Alzayady KJ
2. Chandrasekhar R
3. Yule DI
Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.; The Journal of biological chemistry; Vol 288(16). 2013 Apr 19.
1. Wei-LaPierre L
2. Gong G
3. Gerstner BJ
4. Ducreux S
5. Yule DI
6. Pouvreau S
7. Wang X
8. Sheu SS
9. Cheng H
10. Dirksen RT
11. Wang W
Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.; The Journal of biological chemistry; Vol 288(15). 2013 Apr 12.