Elizabeth Doty Lecture Series
Upcoming Event
Doty Lecture: “Prefrontal-amygdala interactions in social cognition and decision making”
Elisabeth A. Murray, PHD - Chief, Section on the Neurobiology of Learning & Memory, Laboratory of Neuropsychology
National Institute of Mental Health, NIH
Apr 16, 2025 @ 4:00 p.m.
ABSTRACT
The adaptive capabilities of animals and humans are remarkable. Some of our most astonishing abilities appear to stem from contributions of the prefrontal cortex (PFC), yet there are few well defined and experimentally verified specializations within PFC. To address this shortcoming, our laboratory investigates the causal contributions of the ventral and medial prefrontal cortex to learning and decision making in macaques. For example, studies using permanent, selective lesions have contrasted the causal contributions of orbitofrontal cortex (OFC) and the neighboring ventrolateral prefrontal cortex (VLPFC) to decision making. We found that OFC and VLPFC play complementary roles in tracking changes in value and—by extension—decision making. The former depends on dynamic internal states; the latter depends on dynamic external contingencies (Murray and Rudebeck, 2018). Other studies have examined the PFC contributions to social cognition. We found that medial frontal cortex (MFC) but not OFC is essential for aspects of social valuation, in part through interactions with the amygdala (Pujara et al., 2022).
Conclusions: In macaques, MFC and OFC contribute to social cognition and value-based decision-making, respectively, in part through interactions with the amygdala. Thus, specialized prefrontal areas contribute to choices relating to conspecifics or choices independent of others.
Zoom Link: TBAElizabeth Doty Lectureship
Consciousness from Neurons
The Department of Neuroscience is proud to host the Elizabeth Doty Lectureship. Robert W. Doty, PhD, created this neuroscience lectureship to honor his wife and the 58 years they shared in marriage. The Dotys came to the University of Rochester in 1961, where Dr. Doty established his successful research program in which her remained an active scientist until his death in 2011. He was among the group of scientists who created the Society for Neuroscience in 1969 and served as the 7th President of SfN.
Dr. Doty is best known for his work on how the left and right hemispheres of our brain work together through the corpus callosum. A particular passion of Dr. Doty’s was a quest to understand the meaning of consciousness and its underlying neural basis. Hence, the topic of this lectureship is, “Consciousness from Neurons.” In his publication of the same title, Dr. Doty enthusiastically states: “What more challenging quest than to learn how the multi-millioned shuttling of damp sparks can weave a comprehending self, within the fatty fabric of the brain!”
The Department of Neuroscience is proud to call Dr. Doty one of our own. We are thankful for the remarkable gift he has given us in the Elizabeth Doty Lectureship, and we look forward to hosting world-class speakers for years to come.
Précis, by Dr. Robert W. Doty
Mankind faces two all-encompassing enigmas: the nature of reality, and the nature of mental existence. Physics has studiously probed the former, and returned a baffling series of conundrums, albeit experimentally and mathematically precise: space, warped by matter, aboil with virtual particles, particles themselves, bosons or fermions, concurrently diffusely wavelike yet punctuate, and by entanglement instantaneously linked across distances outside of time.
While the suspicion is readily entertained that these mysteries of physics may yet clarify the mysteries of the mind used to reveal them, science is not yet there. The evidence is overwhelming, however, that the brain is the origin of thought and experience; and, given the seeming necessity for rapid intercommunication among the functioning elements, the role falls unequivocally upon neurons. Yet it is equally clear that not all neurons or neuronal activity yield conscious perception. The profound question must thus be faced as to just what form of neuronal activity underlies consciousness, and how its nature is to be distinguished from the vast neuronal interplay that lacks the magic of this capacity. Even were that distinction in hand, the experience so engendered by the neuronal tumult is utterly devoid of palpable reference, a gap between neurons and mind that may forever be unbridgeable, though undeniable.
The annual lectures here proposed are to be dedicated to contending with these riddles of mind, how (and why?) consciousness emanates from the activity of certain populations of neurons, and not from others. This is, indeed, the quintessential question of science, in that the nature of reality is apprehended only by these processes of the brain.
Past Events
The Internal Focus of Attention
Anna Christina Nobre, PhD - Wu Tsa Professor of Psychology
Director, Center for Neurocognition and Behavior, Wu Tsa Institute, Yale University, New Haven, CT
May 2, 2024 @ 4:00 pm
Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience
Gamma Oscillations, Long-range Inhibition And Prefrontal-Dependent Cognition
Vikaas Sohal, MD, PhD - Associate Professor, Psychiatry, Weill Institute for Neurosciences<br/>University of California at San Francisco
Jan 12, 2023 @ 4:00 p.m.
Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience
How Nature and Nurture Conspire to Control Brain Development, Function, and Plasticity
Michael Eldon Greenberg, PhD - Nathan Marsh Pusey Professor of Neurobiology, Harvard Medical School
Nov 3, 2022 @ 4:00 p.m.
Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience
Rethinking brain areas: Embedded functional subnetworks in the macaque face patch system
David Leopold, Ph.D. - Chief, Section on Cognitive Neurophysiology and Imaging (SCNI), NIMH, National Institutes of Health
Mar 18, 2020 @ 4:00 p.m.
Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience
Stability and Change in Human Functional Brain Networks
Steven Petersen, Ph.D. - The James S. McDonnell Professor of Cognitive Neuroscience in Neurology
Professor of Neuroscience, Biomedical Engineering, Psychological & Brain Sciences, and Radiology
Washington University
Mar 14, 2019 @ 4:00 p.m.
Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience
Multiscale Studies of Human Cortical Oscillations during Sleep and Cognition
Syd Cash, MD, PhD - Harvard Univ.
May 24, 2018 @ 2:30 p.m.
Host: Dept. Neuroscience
Human Brain Networks for Task-Directed Attention & Perceptual Working Memory
David Somers, PhD - Boston University
May 03, 2018 @ 4:00 p.m.
Host: Dept. Neuroscience
Neural mechanisms that support and constrain working memory
Clayton Curtis, Ph.D. - Asst. Prof. Psychology & Neural Science
New York University
May 11, 2017 @ 12:00 p.m.
Functional Modules: How do we get them and what good are they?
Margaret Livingstone, PhD - Harvard Medical School
Apr 13, 2017 @ 4:00 p.m.
Host: Tatiana Pasternak, PhD
Individual Differences in Executive Function: Genes, Brain, and Behavior
Chandan Vaidya, PhD - Georgetown Univ.
Apr 13, 2016 @ 4:00 p.m.
Host: John Foxe
Organization and Function of Thalamus
S. Murray Sherman - Maurice Goldblatt Professor and Chairman, Department of Neurobiology, The University of Chicago
Sep 17, 2015 @ 2:00 p.m.
Host: NBA
Attention, Perception, and the Representations of Visual Stimuli by Neuronal Populations
John H. R. Maunsell, Ph.D. - Alice and Rodman W. Moorhead III Professor of Neurobiology Harvard Medical School
May 12, 2014 @ 4:00 p.m.
Host: NBA