Pathology Grand Rounds

'Classification and reporting guidelines for the pathology diagnosis of placenta accreta spectrum (PAS) disorders: recommendations from and expert panel' presented by Wila Lima, MD, DDS.

'SHERLOCK: A CRISPR-Based COVID-19 Diagnostic Tool' presented by Leah Militello, MD, MBA

 Dec 13, 2021 @ 12:00 p.m.

W. Richard Burack, MD, PhD - Professor, Vice Chair, Clinical Operations, URMC, Dept of Pathology & Laboratory Medicine

'Using Immunogenetics to Understand the Clinical Evolution of Lymphoma' presented by Dr. Richard Burack, Professor of Pathology & Laboratory Medicine, Vice Chair, Clinical Operations

 Nov 29, 2021 @ 12:00 p.m.

'Fibrinogen Replacement in Perioperative Bleeding: Cryoprecipitate vs Fibrinogen Concentrate' presented by Melissa Cushing, MD. Professor of Pathology & Laboratory Medicine at Weill Cornell Medicine. The importance of the targeted treatment of acquired hypofibrinogenemia during hemorrhage with a concentrated fibrinogen product (either cryoprecipitate or fibrinogen concentrate) cannot be underestimated. Fibrinogen concentrate is a pathogen inactivated, pooled product that offers a highly purified single factor concentrate. Cryoprecipitate is a pooled product that comes with a spectrum of other coagulation factors which may further enhance (additional procoagulant effect) or even disturb (prothrombotic risk) hemostasis. The pros and cons of each product will be discussed.

 Nov 15, 2021 @ 12:00 p.m.

Christa Whitney-Miller - Associate Professor, Vice Chair, Anatomic Pathology, URMC Dept of Pathology & Laboratory Medicine

Title TBD

 Nov 01, 2021 @ 12:00 p.m.

Moises Velez, MD - Assistant Professor, URMC

'The Evolving Role of Molecular Testing for Treatment Planning in Non-Small Cell Lung Cancer(NSCLS)'

 Oct 25, 2021 @ 12:00 p.m.

Michael Laposata, MD, PhD - Professor and Chair, University of Texas Medical Branch Galveston

'Variants of SARS-CoV-2: Impact on Testing and Efficacy of Vaccines'

 Oct 18, 2021 @ 12:00 p.m.

'Immune Alterations in Patients with COVID-19' presented by Dr. Chen and The Hidden Prognostics within 'Normal' Results' presented by Dr. Cardillo

 Oct 11, 2021 @ 12:00 p.m.

Steve Oghumu, PhD - Assistant Professor, Ohio State University Wexner Medical Center

 Oct 04, 2021 @ 12:00 p.m.

Host: Dr. Whitney-Miller

Mahlon Johnson, MD - Professor, University of Rochester Medical Center

Meningeal growth regulatory pathways and cerebrospinal fluid as targets for new chemotherapy

 Sep 27, 2021 @ 12:00 p.m.

'The homeostatic role of autophagy in the liver' presented by Dr. Yin, Professor and Chair of the Department of Pathology & Laboratory Medicine at Tulane University School of Medicine. Autophagy is an evolutionarily conserved mechanism that regulates nutrients metabolism, organelle turnover and clearance of cellular "garbages". In the absence of autophagy function, the liver can undergo a variety of pathological changes including inflammation, injury, fibrosis and tumorigenesis. The mechanisms of some of these changes will be discussed in this seminar.

 Sep 20, 2021 @ 12:00 p.m.

Harsimran Kaur, MBBS, MD; Treyc Terry, MD - Resident

Register in advance for this meeting:

https://urmc.zoom.us/meeting/register/tJcsde-spzIrG9YTYtpgtSt3-Dr3iN_MpaX3

 Sep 13, 2021 @ 12:00 p.m.

Carlos Ortiz-Bonilla, MS, PhD Candidate - URMC Pathology and Lab Medicine

'Extracellular vesicles as immune response modulators in bladder cancer'

 Jun 21, 2021 @ 12:00 p.m.

George J. Netto, M.D. Professor and Chair,  - University of Alabama at Birmingham | UAB Department of Pathology

'Liquid Biopsy: Plasma, Urine and Beyond'.  The presentation contains a review of the principles and potential clinical applications of Liquid Biopsy in solid tumor diagnostics, prognostics and therapeutic response monitoring.

 Jun 14, 2021 @ 12:00 p.m.

James L. Kirkland, M.D., Ph.D. - Mayo Clinic, Rochester, MN.

Keynote Speaker

 Jun 07, 2021 @ 12:30 p.m.

Achim A Jungbluth MD, PhD; Director of Immunohistochemistry .  - Memorial Sloan Kettering Cancer Center

Making IHC Great Again - Developing and Validating Protocols for Clinical Immunohistochemical Assays (In the Time of the Cholera and Precision Medicine). Immunohistochemistry has an important part in diagnostic surgical pathology. The correct in-situ detection of detectable molecules in histological section rests on the generation reliable IHC protocols. The establishment of IHC protocols incl choice of primary antibodies, limitations and perspectives for the future will be presented.

 May 17, 2021 @ 12:00 p.m.

Leah Militello, MD, MBA. / Harsimran Kaur, MBBS, MD - University of Rochester Medical Center

Got Covid? Ask Your Smartphone; Looking at a New Point of Care Assay / Fecal microbiota transplant as new hope for immunotherapy-refractory melanoma patients

 May 10, 2021 @ 12:00 p.m.

Rhonda K Yantiss, MD - Weill Cornell Medicine

'The Pathogenesis of Coronavirus Disease-2019: Insights from Surgical Pathologists' This presentation will discuss the pathologic changes related to COVID-19 in the context of clinical manifestations of disease. The pathophysiology of COVID-19 will also be discussed with focus on some potential risk factors for more severe disease among infected patients.

 May 03, 2021 @ 12:00 p.m.

Brynn Levy, M.Sc.(Med)., Ph.D., FACMG. - Columbia University

'Optical Genome Mapping for Assessment of Genomic Aberrations in Acute Myeloid Leukemia: A National Multicenter Evaluation' In this study, we report the performance of OGM in a cohort of 100 AML cases, which were previously characterized by karyotype alone or karyotype and FISH. CMA was performed as an additional test in some cases. Our findings showed that OGM identified all the clinically relevant SVs and CNVs reported by these standard cytogenetic methods (100% concordance). The additional diagnostic yield by OGM will be discussed.

 Apr 26, 2021 @ 12:00 p.m.

Craig Morrell, DVM, PhD - University of Rochester Medical Center

Megakaryocytes and Platelets - Big and Small They Do It All In Homeostasis and Inflammation - Under appreciated roles for platelets, and their parent cell the megakaryocyte, in hemostasis and inflammation will be discussed.

 Apr 19, 2021 @ 12:00 p.m.

Wilrama Lima, MD and Xiaoqin Liu, MD,PhD - University of Rochester Medical Center

'Teeth as a fundamental tool in forensic science - Aging estimation techniques' Teeth are a fundamental tool in forensic odontology for identification in a legal context of those individuals who cannot be identified visually or by other means. This presentation will address important techniques such as tracing elements in dentin. / 'A Direct Link between Intestinal Microbial Environment and Colorectal Cancer:  Mutational Signature in Colorectal Cancer Caused by Genotoxic pks+ E. coli' Colibactin- producing bacteria are abundant in the gut microbiota. A new study exposed human intestinal organoid to  colibactin -producing E.Coli, subsequent whole genome sequencing revealed a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.  

 Apr 12, 2021 @ 12:00 p.m.

Hatice Betul Zengin, MD / Dingani Nkosi, MBBS, PhD - University of Rochester Medical Center Department of Pathology & Laboratory Medicine

Fact or Fiction?: Stress Causes Gray Hair / Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

 Apr 05, 2021 @ 12:00 p.m.

Ellen J. Giampoli MD - Department of Pathology and Laboratory Medicine University of Rochester Medical Center

'SMARCB1 (INI-1) Deficient Sinonasal Carcinoma' As a new provisional diagnosis within the WHO classification of sinonasal carcinomas, this presentation will explain how it developed and its relationship to other SMARCB1 deficient tumors. A brief overview of sinonasal carcinomas will be discussed. As an emerging entity, what is currently known about its clinical features, histologic appearance and treatment will be shared.

 Mar 22, 2021 @ 12:00 p.m.

Dingani Nkosi, MMBS, PhD - University of Rochester Medical Center, Pathology & Laboratory Medicine

'Mechanisms of Epstein-Barr Virus Latent membrane protein 1 (LMP1) trafficking to extracellular vesicles & tumor microenvironment remodeling' Latent membrane protein 1 (LMP1), the major EBV oncoprotein is released from infected cells in extracellular vesicles (EVs) and transferred to neighboring uninfected cells. LMP1 containing EVs enhance cell proliferation, migration, invasion, and radio resistance. Despite the significance of LMP1-modified EVs in EBV malignancies, very little is known about how this viral protein hijacks the host EV pathways for secretion to remodel the cellular microenvironment. My talk starts to shed more light on the different mechanisms responsible for orchestrating the incorporation of this viral protein into EVs and how LMP1 modified EVs remodel the tumor microenvironment

 Mar 05, 2021 @ 12:00 p.m.

John E. Tomaszewski MD, MASCP. SUNY Distinguished Professor, Peter A Nickerson PhD Professor and Chair of Pathology and Anatomical Sciences - Jacobs School of Medicine and Biomedical Sciences, University at Buffalo

'The Digital Assistant in 21st Century Diagnostics'  The recent widespread availability of high performance computing along with advances in machine learning algorithms are together changing the landscape of  the opportunities for quantitative cell and tissue image analytics. Computational structural analysis offers a quantitative view of human disease. The "digital histo-caddie" is conceptualized as a computational assistant which can reduce repetitive tasks in diagnostics and free pathologists to focus on complex medical decision making. Some of the approaches and tools to developing such an assistant will be discussed.

 Mar 01, 2021 @ 12:00 p.m.

Bahadir Yildiz, MD Resident, Pathology and Lab Medicine / Anna Israel, MD, Resident, Pathology and Lab Medicine. - University of Rochester Medical Center

‘mRNA Based Covid-19 Vaccines’ Pathogenesis of SARS-CoV-2, basic pharmacology of mRNA vaccines and mRNA based COVID-19 vaccines. / ‘MDM2 inhibition in cancer therapy’ Discussion of MDM2-p53 axis and potential of drugs targeting this pathway in various cancers and non-cancerous conditions

 Feb 08, 2021 @ 12:00 p.m.

Philip Katzman, M.D. - University of Rochester Medical Center

'The Evolution of Eosinophilic Esophagitis in the Pediatric Population' Eosinophilic esophagitis (EoE) has evolved since its initial recognition in the 1970's. Extensive investigations of the etiology of EoE over the past 20 years has led to several consensus group revisions of recommendations for Its diagnosis and treatment. Pathologic diagnosis of esophageal biopsies remains a modality that influences treatment regimens and therefore GI and pediatric pathologists need to be able to recognize and understand the significance of abnormalities seen in these biopsies.  Furthermore, GI clinicians need to know how to interpret the biopsy results to effectively treat their patients.

 Feb 01, 2021 @ 12:00 p.m.

Milton Finegold, MD. Emeritus Professor of Pathology-Immunology - Baylor College of Medicine

A Career in Pediatric Pathology and a look ahead

 Jan 25, 2021 @ 12:00 p.m.

Michael Karasick, MD - Resident, URMC

'Effects of the COVID-19 Pandemic on Supply and Use of Blood for Transfusion' One of the areas that the COVID-19 Pandemic has affected is transfusion medicine. Societal changes have resulted in a reduction in the overall blood supply. Hospital changes to reduce unnecessary procedures have created a decrease in overall blood usage. Blood banks must be able to adapt to these simultaneous changes in supply and demand in order to meet the needs of hospitals and the greater community. These lessons also help inform decision making in future long-term crisis scenarios.

 Jan 11, 2021 @ 12:00 p.m.

Chia-Hao Wu, MS - Department of Pathology & Laboratory Medicine, Cell Biology of Disease Graduate Program, University of Rochester

Roles of protein disulfide isomerase-enriched extracellular vesicles bladder cancer survival and recurrence

 Jan 04, 2021 @ 12:00 p.m.