IgE-Mediated Inhibition of Innate Cell Antivral Responses

Innate immune cells, such as dendritic cells and monocytes, from allergic individuals have been shown to have diminished antiviral responses. Specifically, IgE-mediated stimulation of innate cells in vitro inhibits multiple antiviral cellular functions such as type I interferon production, cellular maturation, and virus-driven Th1 differentiation. The mechanisms underlying how IgE-mediated stimulation inhibits these critical cellular processes is poorly understood. The goal of this project is to identify how IgE-driven signaling interrupts cellular antiviral responses to drive allergic inflammation.