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Mark W. Frampton, M.D.

Mark W. Frampton, M.D.

Pulmonary & Critical Care Medicine

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Appointment (585) 275-4161
Fax (585) 273-1171
Administrative (585) 275-4861

About Me

Dr. Mark Frampton is Professor Emeritus of Medicine in Pulmonary and Critical Care at the University of Rochester Medical Center. He received his MD from New York University School of Medicine and then trained in Internal Medicine at Buffalo General Hospital. After nine years of private practice in ...
Dr. Mark Frampton is Professor Emeritus of Medicine in Pulmonary and Critical Care at the University of Rochester Medical Center. He received his MD from New York University School of Medicine and then trained in Internal Medicine at Buffalo General Hospital. After nine years of private practice in Williamson, New York, he completed Pulmonary and Critical Care training at the University of Rochester, and then joined the faculty. His research focuses on the human health effects of air pollution.

Dr. Frampton directed the NIH-funded training program in pulmonary research at the Medical Center for several years. He is former director the Pulmonary Function Laboratory at Strong Memorial Hospital, and previously served as the Associate Director of the Clinical Research Center at the University of Rochester.

Dr. Frampton continues to see outpatients with pulmonary disease, and to teach Pulmonary and Critical Care trainees. He has a special interest in tuberculosis, having directed the Wayne County Tuberculosis Clinic for more than 30 years, and has been caring for patients with tuberculosis infection and disease at the Monroe County Health Department for more than 25 years.

Certified Specialties

Internal Medicine - American Board of Internal Medicine

Pulmonary Disease - American Board of Internal Medicine

Faculty Appointments

Professor Emeritus - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 1985 - 1988

Residency, Internal Medicine, University at Buffalo. 1974 - 1976

Internship, Internal Medicine, University at Buffalo. 1973 - 1974

Education

MD | New York University School of Medicine. 1973

Awards

Thomas T. Mercer Joint Prize Award. 2020

Fellow. 1974

Research

Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. With each breath, gaseous and particulate contaminants in that air gain access to the body, with both short- and long-term effects on human health. Dr. Frampton and his colleagues at URMC have studied air p...
Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. With each breath, gaseous and particulate contaminants in that air gain access to the body, with both short- and long-term effects on human health. Dr. Frampton and his colleagues at URMC have studied air pollution effects on respiratory function, host defense against infection, airway and systemic inflammation, and cardiovascular function. Volunteers are invited to participate in studies of environmentally relevant concentrations of pollutants, using both environmental chamber and mouthpiece exposure systems, at rest and during exercise.

Ultrafine particles (UFP, less than 100 nm diameter) may be particularly important with regard to cardiovascular effects because of their potential for evading clearance mechanisms and entering the lung interstitium and vascular space. We have demonstrated in healthy nonsmokers that inhalation of low concentrations of UFP causes changes in leukocyte expression of adhesion molecules, and reductions in the pulmonary diffusing capacity, that are consistent with altered pulmonary vascular function. In people with type 2 diabetes, inhalation of carbon UFP altered heart rate and heart rate variability in comparison with clean air.

Inhalation of the gaseous pollutant, ozone, has been linked with cardiovascular effects. Dr. Frampton directed the University of Rochester Medical Center's participation in the first multi-center human controlled exposure study of ozone, the “Multicenter Ozone Exposure study in oldEr Subjects (MOSES)”, funded by the Health Effects Institute. This study, using novel, noninvasive markers of cardiac and vascular function to study low concentrations of ozone in healthy older volunteers, found effects of ozone on pulmonary function, but not on cardiovascular function in these participants. Findings from these human controlled exposure studies help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards.

Dr. Frampton is currently a chartered member of the Clean Air Scientific Advisory Committee (CASAC), which advises the U.S. Environmental Protection Agency on issues relevant to national air quality standards. In 2020 he was the recipient of the Mercer Joint Prize Award from the American Association for Aerosol Research and the International Society for Aerosols in Medicine.

Publications

Journal Articles

Do Ultrafine Particles Carry Any Weight When It Comes to Progression of Pulmonary Fibrosis?

Frampton MW

American journal of respiratory and critical care medicine.. 2024 May 1209 (9):1050-1051. Epub 1900 01 01.

Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: A panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2).

Frampton MW, Balmes JR, Bromberg PA, Arjomandi M, Hazucha MJ, Thurston SW, Alexis NE, Ganz P, Zareba W, Koutrakis P, Thevenet-Morrison K, Rich DQ

Environmental research.. 2022 April 1205 :112522. Epub 12/15/2021.

Do Ambient Ozone or Other Pollutants Modify Effects of Controlled Ozone Exposure on Pulmonary Function?

Rich DQ, Thurston SW, Balmes JR, Bromberg PA, Arjomandi M, Hazucha MJ, Alexis NE, Ganz P, Zareba W, Thevenet-Morrison K, Koutrakis P, Frampton MW

Annals of the American Thoracic Society.. 2020 May 17 (5):563-572. Epub 1900 01 01.

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. Effects of Personal and Ambient Concentrations of Ozone and Other Pollutants on Cardiovascular and Pulmonary Function.

Rich DQ, Frampton MW, Balmes JR, Bromberg PA, Arjomandi M, Hazucha MJ, Thurston SW, Alexis NE, Ganz P, Zareba W, Koutrakis P, Thevenet-Morrison K

Research report. 2020 March 2020 (192, Pt 2):1-90. Epub 1900 01 01.

Does Breathing Wood Smoke Make the Flu Worse? Sex Might Matter.

Frampton MW

American journal of respiratory and critical care medicine.. 2019 April 15199 (8):940-941. Epub 1900 01 01.

Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.

Breitner S, Peters A, Zareba W, Hampel R, Oakes D, Wiltshire J, Frampton MW, Hopke PK, Cyrys J, Utell MJ, Kane C, Schneider A, Rich DQ

Scientific reports.. 2019 February 139 (1):1946. Epub 02/13/2019.

Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES).

Balmes JR, Arjomandi M, Bromberg PA, Costantini MG, Dagincourt N, Hazucha MJ, Hollenbeck-Pringle D, Rich DQ, Stark P, Frampton MW

PloS one.. 2019 14 (9):e0222601. Epub 09/25/2019.

Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES).

Rich DQ, Balmes JR, Frampton MW, Zareba W, Stark P, Arjomandi M, Hazucha MJ, Costantini MG, Ganz P, Hollenbeck-Pringle D, Dagincourt N, Bromberg PA

Environment international.. 2018 October 119 :193-202. Epub 07/04/2018.

Influenza Virus Infection of Human Lymphocytes Occurs in the Immune Cell Cluster of the Developing Antiviral Response.

Mock DJ, Frampton MW, Nichols JE, Domurat FM, Signs DJ, Roberts NJ

Viruses.. 2018 August 1010 (8)Epub 08/10/2018.

Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects).

Arjomandi M, Balmes JR, Frampton MW, Bromberg P, Stark P, Alexis NE, Rich DQ, Costantini M, Hollenbeck-Pringle D, Dagincourt N, Hazucha MJ

American journal of respiratory and critical care medicine.. 2018 May 15197 (10):1319-1327. Epub 1900 01 01.

A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework.

Thurston GD, Kipen H, Annesi-Maesano I, Balmes J, Brook RD, Cromar K, De Matteis S, Forastiere F, Forsberg B, Frampton MW, Grigg J, Heederik D, Kelly FJ, Kuenzli N, Laumbach R, Peters A, Rajagopalan ST, Rich D, Ritz B, Samet JM, Sandstrom T, Sigsgaard T, Sunyer J, Brunekreef B

The European respiratory journal.. 2017 January 49 (1)Epub 01/11/2017.

Multicenter Ozone Study in oldEr Subjects (MOSES). Part 1. Effects of exposure to low concentrations of ozone on respiratory and cardiovascular outcomes.

Frampton MW; Balmes JR; Bromberg PA; Stark P; Arjomandi M; Hazucha MJ; Rich DQ; Hollenbeck-Pringle D; Alexis N; Ganz P; Zareba W; Costantini MG.

Health Effects Institute Research Report. 2017; 192.

Human Alveolar Macrophages May Not Be Susceptible to Direct Infection by a Human Influenza Virus.

Ettensohn DB, Frampton MW, Nichols JE, Roberts NJ

The Journal of infectious diseases.. 2016 December 1214 (11):1658-1665. Epub 09/06/2016.

Does total antioxidant capacity modify adverse cardiac responses associated with ambient ultrafine, accumulation mode, and fine particles in patients undergoing cardiac rehabilitation?

Wang M, Utell MJ, Schneider A, Zareba W, Frampton MW, Oakes D, Hopke PK, Wiltshire J, Kane C, Peters A, Breitner S, Chalupa D, Rich DQ

Environmental research.. 2016 August 149 :15-22. Epub 05/10/2016.

Ambient and Controlled Particle Exposures as Triggers for Acute ECG Changes.

Rich DQ, Peters A, Schneider A, Zareba W, Breitner S, Oakes D, Wiltshire J, Kane C, Frampton MW, Hampel R, Hopke PK, Cyrys J, Utell MJ

Research report. 2016 May (186):5-75. Epub 1900 01 01.

Does particle size matter? Ultrafine particles and hospital visits in Eastern Europe

Frampton MW; Rich DQ.

Am J Respir Crit Care Med. 2016; 194: 1180-1182.

Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.

Becerra AZ, Georas S, Brenna JT, Hopke PK, Kane C, Chalupa D, Frampton MW, Block R, Rich DQ

Journal of toxicology and environmental health. Part A.. 2016 79 (6):287-98. Epub 03/30/2016.

Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.

Frampton MW, Pietropaoli A, Dentler M, Chalupa D, Little EL, Stewart J, Frasier L, Oakes D, Wiltshire J, Vora R, Utell MJ

Inhalation toxicology.. 2015 February 27 (2):113-9. Epub 1900 01 01.

Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.

Vora R, Zareba W, Utell MJ, Pietropaoli AP, Chalupa D, Little EL, Oakes D, Bausch J, Wiltshire J, Frampton MW

Particle and fibre toxicology.. 2014 July 1611 :31. Epub 07/16/2014.

Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study.

Gardner B, Ling F, Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa D, Kane C, Kulandhaisamy S, Topf MC, Rich DQ

Particle and fibre toxicology.. 2014 January 211 :1. Epub 01/02/2014.

Acute changes in ambient temperature are associated with adverse changes in cardiac rhythm

Wasserman, E; Zareba, W; Utell, MJ; Oakes, D; Hopke, PK; Frampton, M; Chalupa, D; Beckett, W; Rich, DQ;.

2014; 7: 357-367.

US EPA particulate matter research centers: summary of research results for 2005–2011

Patrick N. Breysse; Ralph J. Delfino; Francesca Dominici; Alison C. P. Elder; Mark W. Frampton; John R. Froines; Alison S. Geyh; John J. Godleski; Diane R. Gold; Philip K. Hopke; Petros Koutrakis; Ning Li; Günter Oberdörster; Kent E. Pinkerton; Jonathan M. Samet; Mark J. Utell; Anthony S. Wexler.

Air Qual Atmos Health. 2013; 6: 333-355.

Understanding the Health Effects of Ambient Ultrafine Particles.

HEI Review Panel on Ultrafine Particles.

HEI Perspectives 3. Health Effects Institute. 2013; .

Brachial artery reactivity in patients with severe sepsis: an observational study.

Wexler O, Morgan MA, Gough MS, Steinmetz SD, Mack CM, Darling DC, Doolin KP, Apostolakos MJ, Graves BT, Frampton MW, Chen X, Pietropaoli AP

Critical care : the official journal of the Critical Care Forum.. 2012 December 1216 (2):R38. Epub 12/12/2012.

Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes.

Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ

Inhalation toxicology.. 2012 October 24 (12):831-8. Epub 1900 01 01.

Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation?

Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O'Shea K, Wang Y, Utell MJ

Environmental health perspectives.. 2012 August 120 (8):1162-9. Epub 04/27/2012.

The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis.

Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP

Critical care medicine.. 2011 June 39 (6):1351-8. Epub 1900 01 01.

Long-Term health Consequences of Exposure to Burn Pits in Iraq and Afghanistan.

IOM (Institute of Medicine).

Washington, DC. The National Academies Press. 2011; .

Vascular effects of ultrafine particles in persons with type 2 diabetes.

Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW

Environmental health perspectives.. 2010 December 118 (12):1692-8. Epub 09/07/2010.

Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.

Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB

Inhalation toxicology.. 2010 August 22 (10):835-46. Epub 1900 01 01.

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season.

Hampel R, Breitner S, Rückerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A

Occupational and environmental medicine.. 2010 June 67 (6):408-16. Epub 11/02/2009.

Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.

Morgan MA, Frasier LM, Stewart JC, Mack CM, Gough MS, Graves BT, Apostolakos MJ, Doolin KP, Darling DC, Frampton MW, Pietropaoli AP

Critical care medicine.. 2010 April 38 (4):1069-77. Epub 1900 01 01.

Traffic-Related Air Pollution: a Critical Review of the Literature on Emissions, Exposure, and Health Effects

HEI Panel on the Health Effects of Traffic-Related Air Pollution;.

2010; .

Critical considerations in evaluating scientific evidence of health effects of ambient ozone: a conference report.

McClellan RO, Frampton MW, Koutrakis P, McDonnell WF, Moolgavkar S, North DW, Smith AE, Smith RL, Utell MJ

Inhalation toxicology.. 2009 September 21 Suppl 2 :1-36. Epub 1900 01 01.

ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.

Zareba W, Couderc JP, Oberdörster G, Chalupa D, Cox C, Huang LS, Peters A, Utell MJ, Frampton MW

Inhalation toxicology.. 2009 February 21 (3):223-33. Epub 1900 01 01.

Particulate matter (PM) research centers (1999-2005) and the role of interdisciplinary center-based research.

Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdörster G, Frampton M, Godleski J, Larson TV

Environmental health perspectives.. 2009 February 117 (2):167-74. Epub 09/15/2008.

Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease

Hildebrandt K, Rückerl R, Koenig W, Schneider A, Pitz M, Heinrich J, Marder V, Frampton M, Oberdörster G, Wichmann HE, Peters A.

Part Fibre Toxicol. 2009; 6: 25.

Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects.

Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang LS, Utell MJ, Frampton MW

Environmental health perspectives.. 2008 March 116 (3):375-80. Epub 1900 01 01.

Changes in fluorescence intensity of selected leukocyte surface markers following fixation.

Stewart JC, Villasmil ML, Frampton MW

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2007 June 71 (6):379-85. Epub 1900 01 01.

Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli.

Pietropaoli AP, Perillo IB, Perkins PT, Frasier LM, Speers DM, Frampton MW, Utell MJ, Hyde RW

Inhalation toxicology.. 2007 May 19 (6-7):533-41. Epub 1900 01 01.

Ultrafine particles and platelet activation in patients with coronary heart disease - Results from a prospective panel study.

Rückerl R; Phipps R; Schneider A; Frampton M; Cyrys J; Oberdörster G; Wichmann HE; Peters A.

Part Fibre Toxicol. 2007; 4: 1-14.

Does inhalation of ultrafine particles cause pulmonary vascular effects in humans?

Frampton MW

Inhalation toxicology.. 2007 19 Suppl 1 :75-9. Epub 1900 01 01.

Changes in markers of epithelial permeability and inflammation in chronic smokers switching to a nonburning tobacco device (Eclipse).

Stewart JC, Hyde RW, Boscia J, Chow MY, O'Mara RE, Perillo I, Pietropaoli A, Smith CJ, Torres A, Utell MJ, Frampton MW

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2006 December 8 (6):773-83. Epub 1900 01 01.

Air pollution and markers of inflammation and coagulation in patients with coronary heart disease.

Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A

American journal of respiratory and critical care medicine.. 2006 February 15173 (4):432-41. Epub 11/17/2005.

Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans.

Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ

Environmental health perspectives.. 2006 January 114 (1):51-8. Epub 1900 01 01.

Inflammation and airborne particles.

Frampton MW

Clinics in occupational and environmental medicine. 2006 5 (4):797-815. Epub 1900 01 01.

Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study.

Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang LS, Cox C, Zareba W, Oberdörster G

American journal of respiratory and critical care medicine.. 2005 May 15171 (10):1129-35. Epub 02/25/2005.

Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma.

Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J

Research report. 2004 December (126):1-47; discussion 49-63. Epub 1900 01 01.

Ultrafine particle deposition in subjects with asthma.

Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW

Environmental health perspectives.. 2004 June 112 (8):879-82. Epub 1900 01 01.

Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains.

Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G

Inhalation toxicology.. 2004 June 16 (6-7):461-71. Epub 1900 01 01.

Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma

Frampton MW; Utell MJ; Zareba W; Oberdörster G; Cox C; Huang L-S; Morrow PE; Lee FE-H; Chalupa D; Frasier LM; Speers DM; Stewart J.

Health Effects Institute Research Report No. 126. 2004; : 1-47.

Blood markers of coagulation and inflammation in healthy human subjects exposed to carbon ultrafine particles

Pietropaoli AP; Frampton MW; Oberdörster G; Cox C; Huang L-S; Marder V; Utell MJ.

Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecular to Meta Analysis. INIS Monographs, Fraunhofer IRB Verlag, Stuttgart, Germany. 2004; : 181-194.

On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats.

Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G

Inhalation toxicology.. 2004 16 Suppl 1 :41-53. Epub 1900 01 01.

Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles.

Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ

Inhalation toxicology.. 2004 16 Suppl 1 :59-72. Epub 1900 01 01.

The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans.

Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu LJ, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J

Environmental health perspectives.. 2003 June 111 (8):1074-92. Epub 1900 01 01.

Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.

Hjort MR, Brenyo AJ, Finkelstein JN, Frampton MW, LoMonaco MB, Stewart JC, Johnston CJ, D'Angio CT

Inflammation.. 2003 June 27 (3):137-45. Epub 1900 01 01.

Ultrafine particle deposition in humans during rest and exercise.

Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW

Inhalation toxicology.. 2003 May 15 (6):539-52. Epub 1900 01 01.

Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing.

Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE

Inhalation toxicology.. 2002 December 14 (12):1231-47. Epub 1900 01 01.

Nitrogen dioxide exposure: effects on airway and blood cells.

Frampton MW, Boscia J, Roberts NJ, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ

American journal of physiology. Lung cellular and molecular physiology.. 2002 January 282 (1):L155-65. Epub 1900 01 01.

A facility for controlled human exposures to ultrafine particles

Chalupa DF; Gibb FR; Morrow PE; Oberdörster G; Riesenfeld E; Gelein R; Utell MJ; Frampton MW.

Crucial issues in inhalation research--mechanistic, clinical and epidemiologic. INIS Monographs, Fraunhofer IRB Verlag, Stuttgart, Germany. 2002; .

Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans.

Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE, Utell MJ, Frampton MW

Journal of applied physiology.. 2001 November 91 (5):1931-40. Epub 1900 01 01.

Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans.

Frampton MW

Environmental health perspectives.. 2001 August 109 Suppl 4 (Suppl 4):529-32. Epub 1900 01 01.

Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans.

Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW

Inhalation toxicology.. 2001 June 13 (6):465-83. Epub 1900 01 01.

Neutrophils in lung inflammation: Which reactive oxygen species are being measured?

Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW

Inhalation toxicology.. 2001 June 13 (6):485-95. Epub 1900 01 01.

Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung.

Avissar NE, Reed CK, Cox C, Frampton MW, Finkelstein JN

American journal of respiratory and critical care medicine.. 2000 October 162 (4 Pt 1):1342-7. Epub 1900 01 01.

Toxicologic methods: controlled human exposures.

Utell MJ, Frampton MW

Environmental health perspectives.. 2000 August 108 Suppl 4 (Suppl 4):605-13. Epub 1900 01 01.

Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma.

Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR, Olson DA, Willey JC

Cancer research.. 2000 March 1560 (6):1609-18. Epub 1900 01 01.

Ultrafine Particle Concentrations in a Hospital.

Riesenfeld E, Chalupa D, Gibb FR, Oberdörster G, Gelein R, Morrow PE, Utell MJ, Frampton MW

Inhalation toxicology.. 2000 January 12 Suppl 2 :83-94. Epub 1900 01 01.

Ultrafine particle concentrations in a hospital

Riesenfeld, E.; Chalupa, D.; Gibb, F.R.; Oberdörster, G.; Gelein, R.; Morrow, P.E.; Utell, M.J.; Frampton, M.W.;.

Inhalation Toxicology. 2000; 12 (Suppl 2): 83-94.

Who is susceptible to particulate matter and why?

Utell, M.J.; Frampton, M.W.;.

Inhalation Toxicology. 2000; 12 (Suppl. 1): 37-40.

Acute health effects of ambient air pollution: the ultrafine particle hypothesis.

Utell MJ, Frampton MW

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.. 2000 13 (4):355-59. Epub 1900 01 01.

Effects of aqueous extracts of PMfilters from the Utah Valley on human airway epithelial cells.

Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, Devlin RB

American journal of physiology. Lung cellular and molecular physiology.. 1999 November 1277 (5):L960-L967. Epub 1900 01 01.

Effects of aqueous extracts of PM(10) filters from the Utah valley on human airway epithelial cells.

Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, Devlin RB

The American journal of physiology.. 1999 November 277 (5):L960-7. Epub 1900 01 01.

Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure.

Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ

Research report. 1999 November (90):1-15; discussion 17-8. Epub 1900 01 01.

Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans.

Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, Hyde RW

Journal of applied physiology.. 1999 October 87 (4):1532-42. Epub 1900 01 01.

Ozone exposure increases aldehydes in epithelial lining fluid in human lung.

Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ

American journal of respiratory and critical care medicine.. 1999 April 159 (4 Pt 1):1134-7. Epub 1900 01 01.

Role of cytomegalovirus in the T cell changes seen in elderly individuals.

Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN

Clinical immunology : the official journal of the Clinical Immunology Society.. 1999 February 90 (2):213-9. Epub 1900 01 01.

Rate of nitric oxide production by lower alveolar airways of human lungs.

Geigel EJ, Hyde RW, Perillo IB, Torres A, Perkins PT, Pietropaoli AP, Frasier LM, Frampton MW, Utell MJ

Journal of applied physiology.. 1999 January 86 (1):211-21. Epub 1900 01 01.

Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure

Frampton, M.W.; Pryor, W.A.; Cueto, R.; Cox, C.; Morrow, P.E.; Utell, M.J.;.

Health Effects Institute Research Report. 1999; 90.

Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells.

Crawford EL, Weaver DA, DeMuth JP, Jackson CM, Khuder SA, Frampton MW, Utell MJ, Thilly WG, Willey JC

Carcinogenesis.. 1998 October 19 (10):1867-71. Epub 1900 01 01.

Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.

Looney RJ, Frampton MW, Byam J, Kenaga C, Speers DM, Cox C, Mast R, Klykken PC, Morrow PE, Utell MJ

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 August 44 (2):214-20. Epub 1900 01 01.

Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins.

Coller HA, Khrapko K, Torres A, Frampton MW, Utell MJ, Thilly WG

Cancer research.. 1998 March 1558 (6):1268-77. Epub 1900 01 01.

Effects of nitrogen dioxide exposure on human host defense

Azadniv, M.; Utell, M.J.; Morrow, P.E.; Gibb, F.R.; Nichols, J.; Roberts, N.J., Jr.; Speers, D.M.; Torres, A.; Tsai, Y.; Abraham, M.K.; Voter, K.Z.; Frampton, M.W.;.

Inhalation Toxicology. 1998; 10: 585-602.

Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone.

Torres A, Utell MJ, Morow PE, Voter KZ, Whitin JC, Cox C, Looney RJ, Speers DM, Tsai Y, Frampton MW

American journal of respiratory and critical care medicine.. 1997 September 156 (3 Pt 1):728-36. Epub 1900 01 01.

Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers.

Willey JC, Coy EL, Frampton MW, Torres A, Apostolakos MJ, Hoehn G, Schuermann WH, Thilly WG, Olson DE, Hammersley JR, Crespi CL, Utell MJ

American journal of respiratory cell and molecular biology.. 1997 July 17 (1):114-24. Epub 1900 01 01.

Patterns of gene expression in human airway epithelial cells.

Willey JC, Frampton MW, Utell MJ, Apostolakos MJ, Coy EL, Olson DE, Hammersley JR, Matteson D, Thilly WG

Chest.. 1997 June 111 (6 Suppl):83S. Epub 1900 01 01.

Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers.

Frampton MW, Morrow PE, Torres A, Voter KZ, Whitin JC, Cox C, Speers DM, Tsai Y, Utell MJ

Research report. 1997 June (78):39-72; discussion 81-99. Epub 1900 01 01.

Effects of ozone on normal and potentially sensitive human subjects. Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study.

Frampton MW, Balmes JR, Cox C, Krein PM, Speers DM, Tsai Y, Utell MJ

Research report. 1997 June (78):73-9; discussion 81-99. Epub 1900 01 01.

Determination of production of nitric oxide by lower airways of humans--theory.

Hyde RW, Geigel EJ, Olszowka AJ, Krasney JA, Forster RE, Utell MJ, Frampton MW

Journal of applied physiology.. 1997 April 82 (4):1290-6. Epub 1900 01 01.

Neurogenic inflammation: with additional discussion of central and perceptual integration of nonneurogenic inflammation.

Bascom R, Meggs WJ, Frampton M, Hudnell K, Killburn K, Kobal G, Medinsky M, Rea W

Environmental health perspectives.. 1997 March 105 Suppl 2 (Suppl 2):531-7. Epub 1900 01 01.

Ozone responsiveness in smokers and nonsmokers.

Frampton MW, Morrow PE, Torres A, Cox C, Voter KZ, Utell MJ

American journal of respiratory and critical care medicine.. 1997 January 155 (1):116-21. Epub 1900 01 01.

Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study

Frampton, M.W.; Balmes, J.R.; Cox, C.; Krein, P.M.; Speers, D.M.; Tsai, Y.; Utell, M.J.;.

Health Effects Institute Research Report. 1997; 78: 73-79.

Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers

Frampton, M.W.; Morrow, P.E.; Torres, A.; Voter, K.Z.; Whitin, J.C.; Cox, C.; Speers, D.M.; Tsai, Y.; Utell, M.J.;.

Health Effects Institute Research Report. 1997; 78: 39-64.

Optimized flow cytometric assay of Fc-receptor mediated phagocytosis

Schürmann, W.H.T.; Frampton, M.W.; Schürmann, G.; Roberts Jr., N.J.; Nichols, J.E.; Finkelstein, J.N.; Oberdörster, G.; Utell, M.J.;.

Journal of Aerosol Medicine. 1997; 10: 1-12.

Effects of inhaled sulfuric acid aerosols on pulmonary immunocompetence: a comparative study in humans and animals

Zelikoff, J.T.; Frampton, M.W.; Cohen, M.D.; Morrow, P.E.; Sisco, M.; Tsai, Y.; Utell, M.J.; Schlesinger, R.B.;.

Inhalation Toxicology. 1997; 9: 731-752.

Human performance during exposure to toluene.

Rahill AA, Weiss B, Morrow PE, Frampton MW, Cox C, Gibb R, Gelein R, Speers D, Utell MJ

Aviation, space, and environmental medicine.. 1996 July 67 (7):640-7. Epub 1900 01 01.

Production of reactive oxygen intermediates following exposure to ozone. Relative contribution of alveolar macrophages.

Torres A, Voter KZ, Utell MJ, Whitin JC, Morrow PE, Frampton MW

Chest.. 1996 March 109 (3 Suppl):8S. Epub 1900 01 01.

Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells.

Willey JC, Coy E, Brolly C, Utell MJ, Frampton MW, Hammersley J, Thilly WG, Olson D, Cairns K

American journal of respiratory cell and molecular biology.. 1996 March 14 (3):262-71. Epub 1900 01 01.

Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells.

Avissar N, Finkelstein JN, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu YL, Cohen HJ

The American journal of physiology.. 1996 February 270 (2 Pt 1):L173-82. Epub 1900 01 01.

Human performance during exposure to toluene

Rahill, A.A.; Weiss, B.; Morrow, P.E.; Frampton, M.W.; Cox, C.; Gibb, R.; Gelein, R.; Speers, D.; Utell, M.J.;.

Aviation, Space and Environmental Medicine. 1996; 67: 640-647.

Composition of human airway mucins and effects after inhalation of acid aerosol.

Culp DJ, Latchney LR, Frampton MW, Jahnke MR, Morrow PE, Utell MJ

The American journal of physiology.. 1995 September 269 (3 Pt 1):L358-70. Epub 1900 01 01.

Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects.

Frampton MW, Morrow PE, Cox C, Levy PC, Condemi JJ, Speers D, Gibb FR, Utell MJ

Environmental research.. 1995 April 69 (1):1-14. Epub 1900 01 01.

Particles and mortality: a clinical perspective

Utell, M.J.; Frampton, M.W.;.

Inhalation Toxicology. 1995; 7: 645-655.

Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma.

Utell MJ, Frampton MW, Morrow PE, Cox C, Levy PC, Speers DM, Gibb FR

Research report. 1994 November (70):37-93, discussion 95-112. Epub 1900 01 01.

Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma

Utell, M.J.; Frampton, M.W.; Morrow, P.E.; Cox, C.; Levy, P.C.; Speers, D.; Gibb, F.R.;.

Health Effects Institute Research Report. 1994; 70: 37-93.

Expression of membrane antigens on human alveolar macrophages after exposure to nitrogen dioxide

Gavras, J.B.; Frampton, M.W.; Ryan, D.H.; Levy, P.C.; Looney, R.J.; Cox, C.; Morrow, P.E.; Utell, M.J.;.

Inhalation Toxicology. 1994; 6: 633-646.

Measurement of gene expression by multiplex competitive polymerase chain reaction.

Apostolakos MJ, Schuermann WH, Frampton MW, Utell MJ, Willey JC

Analytical biochemistry.. 1993 September 213 (2):277-84. Epub 1900 01 01.

Asthma, lymphocytes, and dendritic cells.

Frampton MW

Chest.. 1993 April 103 (4):986-7. Epub 1900 01 01.

Sulfuric acid aerosol exposure in humans assessed by bronchoalveolar lavage.

Frampton MW, Voter KZ, Morrow PE, Roberts NJ, Culp DJ, Cox C, Utell MJ

The American review of respiratory disease.. 1992 September 146 (3):626-32. Epub 1900 01 01.

An outbreak of tuberculosis among hospital personnel caring for a patient with a skin ulcer.

Frampton MW

Annals of internal medicine.. 1992 August 15117 (4):312-3. Epub 1900 01 01.

Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide.

Morrow PE, Utell MJ, Bauer MA, Smeglin AM, Frampton MW, Cox C, Speers DM, Gibb FR

The American review of respiratory disease.. 1992 February 145 (2 Pt 1):291-300. Epub 1900 01 01.

Environmental factors and atmospheric pollutants.

Frampton MW, Samet JM, Utell MJ

Seminars in respiratory infections.. 1991 December 6 (4):185-93. Epub 1900 01 01.

Mechanisms of nitrogen dioxide toxicity in humans.

Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE

Research report. 1991 August (43):1-33. Epub 1900 01 01.

Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans.

Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ

The American review of respiratory disease.. 1991 March 143 (3):522-7. Epub 1900 01 01.

Mechanisms of nitrogen dioxide toxicity in humans

Utell, M.J.; Frampton, M.W.; Roberts, N.J., Jr.; Finkelstein, J.N.; Cox, C.; Morrow, P.E.;.

Health Effects Institute Research Report. 1991; : 1-44.

Environmental Factors and Atmospheric Pollutants.

Frampton MW, Samet JM, Utell MJ.

Semin Respir Infect. 1991; 6: 185-193.

Air pollution and asthma: clinical studies with sulfuric acid aerosols.

Utell MJ, Frampton MW, Morrow PE

Allergy proceedings : the official journal of regional and state

Inhalation of nitrogen dioxide fails to reduce the activity of human lung alpha-1-proteinase inhibitor.

Johnson DA, Frampton MW, Winters RS, Morrow PE, Utell MJ

The American review of respiratory disease.. 1990 October 142 (4):758-62. Epub 1900 01 01.

Alveolar and peritoneal macrophages bear three distinct classes of Fc receptors for IgG.

Anderson CL, Looney RJ, Culp DJ, Ryan DH, Fleit HB, Utell MJ, Frampton MW, Manganiello PD, Guyre PM

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 July 1145 (1):196-201. Epub 1900 01 01.

Effects of exposure to ambient levels of NO2: is host defense altered in humans? 90-147.4:1-15, .

Frampton MW, Roberts NJ Jr, Finkelstein JN, Morrow PE, Utell MJ.

Journal of the Air and Waste Management Association. 1990; .

Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.

Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ

American journal of respiratory cell and molecular biology.. 1989 December 1 (6):499-505. Epub 1900 01 01.

Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro.

Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ

Environmental research.. 1989 April 48 (2):179-92. Epub 1900 01 01.

A 45 m3 environmental chamber for controlled clinical studies of air pollutants

Morrow, P.E.; Utell, M.J.; Gibb, F.R.; Speers, D.; Frampton, M.W.; Bauer, M.; Beiter, H.; Miles, E.;.

Journal of Aerosol Medicine. 1988; 1: 281.

Physicians' and nurses' attitudes toward withholding treatment in a community hospital.

Frampton MW, Mayewski RJ

Journal of general internal medicine.. 1987 2 (6):394-9. Epub 1900 01 01.

Lower extremity ischemia associated with use of military antishock trousers.

Frampton MW

Annals of emergency medicine.. 1984 December 13 (12):1155-7. Epub 1900 01 01.

Temporal arteritis. Seven variations.

Frampton MW

New York state journal of medicine.. 1981 July 81 (8):1179-82. Epub 1900 01 01.

Books

Cardiovascular effects of inhaled ultrafine and nano-sized particles (2011)

Chapter: "Human exposure studies"

Authors: Langrish, JP; Frampton, MW; Blomberg, A.

Publisher: John Wiley & Sons, Hoboken, NJ 2011

Environmental and occupational medicine (1992)

Chapter: Sulfur dioxide and sulfuric acid aerosols

Authors: Utell MJ; Frampton MW

Publisher: Little, Brown & Co, Boston 1992

Susceptibility to inhaled pollutants (1989)

Chapter: Respiratory infection and oxidants

Authors: Frampton MW, Roberts NJ Jr.

Publisher: American Society for Testing and Materials, Philadelphia 1989

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