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Dr. Zand is Professor of Medicine and Medical Humanities in the Division of Nephrology. He is also Co-Director of the Clinical and Translational Science Institute, Co-Director of The Center for Leading Innovation and Collaboration and Director of the Rochester Center for Health Informatics. His cl...
Dr. Zand is Professor of Medicine and Medical Humanities in the Division of Nephrology. He is also Co-Director of the Clinical and Translational Science Institute, Co-Director of The Center for Leading Innovation and Collaboration and Director of the Rochester Center for Health Informatics. His clinical practice is focused on the care of kidney transplant patients. His approach emphasizes holistic care of the whole person, mind and body. He brings to his practice of medicine an extensive experience in cutting edge clinical immunology, and a practical approach to wellness emphasizing exercise, diet, stress-reduction, and mindfulness. He has an active research program in the biology of antibody producing cells and their role in vaccine responses, transplant rejection, and health informatics.
Faculty Appointments
Professor
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Department of Medicine, Nephrology (SMD)
Co-Director
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Clinical & Translational Science Institute
Senior Associate Dean, Clinical Research
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Dean's Office, SMD (SMD)
Dean's Professorship
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Department of Medicine, Nephrology (SMD)
Credentials
Residency & Fellowship
Fellowship, Nephrology, Beth Israel Deaconess Medical Center. 1995 - 1998
Internship, Internal Medicine, Beth Israel Deaconess Medical Center. 1992 - 1993
Residency, Internal Medicine, Beth Israel Deaconess Medical Center. 1992 - 1995
Education
MD | Northwestern University Feinberg School of Medicine.1992
Awards
Technology Innovation Award - Cleveland Clinic.2006
American Society of Transplant Physicians Young Investigator Award.1998
Northwestern University Medical Scientist Training Program Scholarship.1985
Honors Program in Medical Education Scholarship.1981 - 1992
Research
My research is focused in two areas: Understanding how B cells respond to vaccines and organ transplants to produce antibodies, and using graph theory to understand how we can understand and improve population health and healthcare delivery. My groups use a similar core set of analytic methods in...
My research is focused in two areas: Understanding how B cells respond to vaccines and organ transplants to produce antibodies, and using graph theory to understand how we can understand and improve population health and healthcare delivery. My groups use a similar core set of analytic methods in both areas, including high dimensional clustering methods, graph theory, differential equation and stochastic branching process modeling.
My laboratory studies how B cells and plasma cells participate in the adaptive immune response, through antibody production, antigen presentation, and modulation of immune responses by other immune cells. Our goal is to understand how B cell differentiation and antibody production is regulated if we are to enhance B cell anti-viral and vaccine responses, or to prevent transplant rejection. We use innovative mathematical modeling and statistical analyses to gain insights from complex and large experimental data sets. Our experiments often involve daily analysis of gene expression and cellular phenotypes from single subjects over 5-10 days after vaccination. The scientific questions we are focused on include:
1. What is the timing of B cell differentiation and antibody secretion, and how can we alter the molecular and cellular events to improve vaccine responses? 2. What are the molecular gene expression signatures of a successful B cell vaccine response? 3. How can we use mathematical models to create individualized treatment protocols for kidney transplant patients with antibody mediated rejection or allosensitization?
My Health Informatics Group uses advanced data science analytics to understand how people make their way through the healthcare system, and how larger factors such as employment, mental health, community engagement, and socio-economic status contribute to population health. We use network theory to investigate connections between these factors, and turn those insights into population health based research initiatives that we refer to as the "living healthcare laboratory". We collaborate with groups in the Institute for Data Science, the University of Rochester Medical Center, and numerous community and population health groups within the greater Rochester community.
Dziorny AC, Drury S, Clark A, Farris RW, Nishisaki A, Cornell TT, Tawfik DS, Bennett TD, Shah SS, Weiss SL, Mohamed T, Shah N, McMahon J, Muthu N, Wetzel RC, Zand M, Nelson Sanchez-Pinto L
medRxiv : the preprint server for health sciences.. 2025 February 6 Epub 02/06/2025.
Park HS, Yin A, Barranta C, Lee JS, Caputo CA, Sachithanandham J, Li M, Yoon S, Sitaras I, Jedlicka A, Eby Y, Ram M, Fernandez RE, Baker OR, Shenoy AG, Mosnaim GS, Fukuta Y, Patel B, Heath SL, Levine AC, Meisenberg BR, Spivak ES, Anjan S, Huaman MA, Blair JE, Currier JS, Paxton JH, Gerber JM, Petrini JR, Broderick PB, Rausch W, Cordisco ME, Hammel J, Greenblatt B, Cluzet VC, Cruser D, Oei K, Abinante M, Hammitt LL, Sutcliffe CG, Forthal DN, Zand MS, Cachay ER, Raval JS, Kassaye SG, Marshall CE, Yarava A, Lane K, McBee NA, Gawad AL, Karlen N, Singh A, Ford DE, Jabs DA, Appel LJ, Shade DM, Lau B, Ehrhardt S, Baksh SN, Shapiro JR, Ou J, Na YB, Knoll MD, Ornelas-Gatdula E, Arroyo-Currás N, Gniadek TJ, Caturegli P, Wu J, Ndahiro N, Betenbaugh MJ, Ziman A, Hanley DF, Casadevall A, Shoham S, Bloch EM, Gebo KA, Tobian AA, Laeyendecker O, Pekosz A, Klein SL, Sullivan DJ
Park HS, Barranta C, Yin A, Lee JS, Caputo CA, Li M, Yoon S, Sitaras I, Jedlicka A, Eby Y, Ram M, Fernandez RE, Baker OR, Shenoy AG, Mosnaim GS, Fukuta Y, Patel B, Heath SL, Levine AC, Meisenberg BR, Spivak ES, Anjan S, Huaman MA, Blair JE, Currier JS, Paxton JH, Gerber JM, Petrini JR, Broderick PB, Rausch W, Cordisco ME, Hammel J, Greenblatt B, Cluzet VC, Cruser D, Oei K, Abinante M, Hammitt LL, Sutcliffe CG, Forthal DN, Zand MS, Cachay ER, Raval JS, Kassaye SG, Marshall CE, Yarava A, Lane K, McBee NA, Gawad AL, Karlen N, Singh A, Ford DE, Jabs DA, Appel LJ, Shade DM, Lau B, Ehrhardt S, Baksh SN, Shapiro JR, Ou J, Gniadek TJ, Caturegli P, Wu J, Ndahiro N, Betenbaugh MJ, Ziman A, Hanley DF, Casadevall A, Shoham S, Bloch EM, Gebo KA, Tobian AAR, Laeyendecker O, Pekosz A, Klein SL, Sullivan DJ
medRxiv : the preprint server for health sciences.. 2023 December 15 Epub 12/15/2023.
Dziorny AC, Jones C, Salant JA, Kubis S, Zand MS, Wolfe HA, Srinivasan V
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2023 November 124 (11):e520-e530. Epub 05/23/2023.
Huaman MA, Raval JS, Paxton JH, Mosnaim GS, Patel B, Anjan S, Meisenberg BR, Levine AC, Marshall CE, Yarava A, Shenoy AG, Heath SL, Currier JS, Fukuta Y, Blair JE, Spivak ES, Petrini JR, Broderick PB, Rausch W, Cordisco M, Hammel J, Greenblatt B, Cluzet VC, Cruser D, Oei K, Abinante M, Hammitt LL, Sutcliffe CG, Forthal DN, Zand MS, Cachay ER, Kassaye SG, Ram M, Wang Y, Das P, Lane K, McBee NA, Gawad AL, Karlen N, Ford DE, Laeyendecker O, Pekosz A, Klein SL, Ehrhardt S, Lau B, Baksh SN, Shade DM, Casadevall A, Hanley DF, Ou J, Gniadek TJ, Ziman A, Shoham S, Gebo KA, Bloch EM, Tobian AAR, Sullivan DJ, Gerber JM
Transfusion.. 2023 September 63 (9):1639-1648. Epub 08/03/2023.
Goldman JL, Kalu IC, Schuster JE, Erickson T, Mast DK, Zimmerman K, Benjamin DK, Kalb LG, Gurnett C, Newland JG, Sherby M, Godambe M, Shinde N, Watterson T, Walsh T, Foxe J, Zand M, Dewhurst S, Coller R, DeMuri GP, Archuleta S, Ko LK, Inkelas M, Manuel V, Lee R, Oh H, Murugan V, Kramer J, Okihiro M, Gwynn L, Pulgaron E, McCulloh R, Broadhurst J, McDaniels-Davidson C, Kiene S, Oren E, Wu Y, Wetter DW, Stump T, Brookhart MA, Fist A, Haroz E
Pediatrics.. 2023 July 1152 (Suppl 1)Epub 1900 01 01.
Shoham S, Bloch EM, Casadevall A, Hanley D, Lau B, Gebo K, Cachay E, Kassaye SG, Paxton JH, Gerber J, Levine AC, Naeim A, Currier J, Patel B, Allen ES, Anjan S, Appel L, Baksh S, Blair PW, Bowen A, Broderick P, Caputo CA, Cluzet V, Elena MC, Cruser D, Ehrhardt S, Forthal D, Fukuta Y, Gawad AL, Gniadek T, Hammel J, Huaman MA, Jabs DA, Jedlicka A, Karlen N, Klein S, Laeyendecker O, Karen L, McBee N, Meisenberg B, Merlo C, Mosnaim G, Park HS, Pekosz A, Petrini J, Rausch W, Shade DM, Shapiro JR, Singleton RJ, Sutcliffe C, Thomas DL, Yarava A, Zand M, Zenilman JM, Tobian AAR, Sullivan DJ
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2023 February 876 (3):e477-e486. Epub 1900 01 01.
Stebegg M, Bignon A, Hill DL, Silva-Cayetano A, Krueger C, Vanderleyden I, Innocentin S, Boon L, Wang J, Zand MS, Dooley J, Clark J, Liston A, Carr E, Linterman MA
Wang J, Hilchey SP, DeDiego M, Perry S, Hyrien O, Nogales A, Garigen J, Amanat F, Huertas N, Krammer F, Martinez-Sobrido L, Topham DJ, Treanor JJ, Sangster MY, Zand MS
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2008 December 8 (12):2489-90. Epub 1900 01 01.
Greenbaum JA, Andersen PH, Blythe M, Bui HH, Cachau RE, Crowe J, Davies M, Kolaskar AS, Lund O, Morrison S, Mumey B, Ofran Y, Pellequer JL, Pinilla C, Ponomarenko JV, Raghava GP, van Regenmortel MH, Roggen EL, Sette A, Schlessinger A, Sollner J, Zand M, Peters B
Maloo M, Abt P, Kashyap R, Younan D, Zand M, Orloff M, Jain A, Pentland A, Scott G, Bozorgzadeh A
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2006 September 6 (9):2212-7. Epub 06/19/2006.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2006 January 6 (1):225-31. Epub 1900 01 01.
Zand MS, Bose A, Vo T, Coppage M, Pellegrin T, Arend L, Lee FE, Bozorgzadeh A, Leong N
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2005 January 5 (1):76-86. Epub 1900 01 01.
Journal of biomechanics.. 1983 16 (5):305-11. Epub 1900 01 01.
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