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Archibald S. Perkins, M.D., Ph.D.

Archibald S. Perkins, M.D., Ph.D.

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UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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Contact

Office (585) 276-3399
Fax (585) 756-4468

About Me

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective th...
Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective therapies at present. His clinical responsibilities include interpretation of bone marrow biopsies and smears, lymph node biopsies, and spleen; and laboratory analyses of coagulation disorders and hemoglobinopathies.

Certified Specialties

Pathology - Anatomic - American Board of Pathology

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Fellowship, National Cancer Institute/National Institute of Health. 1988 - 1992

Residency, Pathology, Anatomic Pathology & Clinical Pathology, Brigham & Womens Hospital. 1987 - 1988

Internship, Pathology, Brigham & Womens Hospital. 1986 - 1987

Education

MD | Columbia University College of Physicians & Surgeons. 1986

Awards

Phi Beta Kappa. 1979

Sigma Xi. 1979

Research

Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal Hematopoiesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging surv...
Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal Hematopoiesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survival, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecule Bc12a1. His current work encompasses embryogenesis in genetically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.

Research Lab

Cancer research, using mouse models to investigate molecular mechanisms in acute myeloid leukemia and myelodysplastic syndrome, with focus on the function of the zinc finger oncoprotein EVI1.

Visit Research Lab Website

Publications

Journal Articles

Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells.

Ping Koh C, Govind Bahirvani A, Qiuxia Wang C, Yokomizo T, Ee Lin Ng C, Du L, Tergaonkar V, Chih-Cheng Voon D, Kitamura H, Hosoi H, Sonoki T, Meng Huang Michelle M, Jye Tan L, Niibori-Nambu A, Zhang Y, Perkins AS, Hossain Z, Tenen DG, Ito Y, Venkatesh B, Osato M

Gene.. 2023 January 30851 :147049. Epub 11/13/2022.

Mds1, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells.

Zhang Y, McGrath KE, Ayoub E, Kingsley PD, Yu H, Fegan K, McGlynn KA, Rudzinskas S, Palis J, Perkins AS

Cell reports.. 2021 August 1736 (7):109562. Epub 1900 01 01.

Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.

McGlynn KA, Sun R, Vonica A, Rudzinskas S, Zhang Y, Perkins AS

Experimental hematology.. 2020 May 85 :20-32.e3. Epub 05/11/2020.

Live-animal imaging of native haematopoietic stem and progenitor cells.

Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, Calogero RA, Schroeder T, Lin CP, Camargo FD

Nature.. 2020 February 578 (7794):278-283. Epub 02/05/2020.

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

Frisch BJ, Hoffman CM, Latchney SE, LaMere MW, Myers J, Ashton J, Li AJ, Saunders J, Palis J, Perkins AS, McCabe A, Smith JN, McGrath KE, Rivera-Escalera F, McDavid A, Liesveld JL, Korshunov VA, Elliott MR, MacNamara KC, Becker MW, Calvi LM

JCI insight.. 2019 April 185 (10)Epub 04/18/2019.

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.

Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS

Nature communications.. 2018 October 129 (1):4239. Epub 10/12/2018.

Leukemic presentation of diffuse large B-cell lymphoma: an unusual pattern associated with splenic involvement.

Crane GM, Perkins AS

Blood.. 2017 November 16130 (20):2233. Epub 1900 01 01.

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EE, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JW, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA

Oncogene.. 2017 May 1136 (19):2737-2749. Epub 12/19/2016.

EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements.

Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS

The Journal of biological chemistry.. 2016 June 24291 (26):13591-607. Epub 04/21/2016.

Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS

Bone.. 2014 March 60 :148-61. Epub 12/04/2013.

The role of EVI1 in myeloid malignancies.

Glass C, Wilson M, Gonzalez R, Zhang Y, Perkins AS

Blood cells, molecules & diseases.. 2014 53 (1-2):67-76. Epub 02/01/2014.

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG

PloS one.. 2014 9 (2):e89397. Epub 02/27/2014.

Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.

Zhang Y, Owens K, Hatem L, Glass CH, Karuppaiah K, Camargo F, Perkins AS

Blood.. 2013 October 17122 (16):2888-92. Epub 09/10/2013.

Overexpression of Evi-1 oncoprotein represses TGF-? signaling in colorectal cancer.

Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM, Thompson EA, Ko TC

Molecular carcinogenesis.. 2013 April 52 (4):255-264. Epub 12/07/2011.

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.

Bresnick EH, Katsumura KR, Lee HY, Johnson KD, Perkins AS

Nucleic acids research.. 2012 July 40 (13):5819-31. Epub 04/05/2012.

Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.

Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda KA, Wheeler JC, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS

Biochemistry.. 2011 December 650 (48):10431-41. Epub 11/10/2011.

PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function.

Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS

Blood.. 2011 October 6118 (14):3853-61. Epub 06/10/2011.

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors.

Qiu Y, Lynch J, Guo L, Yatsula B, Perkins AS, Michalak M

Biochemistry.. 2008 March 2547 (12):3697-704. Epub 02/28/2008.

Burkitt lymphoma in adults.

Perkins AS, Friedberg JW

Hematology. 2008 :341-8. Epub 1900 01 01.

Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4.

Jackson-Fisher AJ, Bellinger G, Shum E, Duong JK, Perkins AS, Gassmann M, Muller W, Kent Lloyd KC, Stern DF

Oncogene.. 2006 September 1425 (41):5664-72. Epub 05/01/2006.

Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.

Boyd KE, Xiao YY, Fan K, Poholek A, Copeland NG, Jenkins NA, Perkins AS

Blood.. 2006 January 15107 (2):733-41. Epub 10/04/2005.

Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2.

Yatsula B, Galvao C, McCrann M, Perkins AS

Leukemia.. 2006 January 20 (1):162-5. Epub 1900 01 01.

Identification of binding sites of EVI1 in mammalian cells.

Yatsula B, Lin S, Read AJ, Poholek A, Yates K, Yue D, Hui P, Perkins AS

The Journal of biological chemistry.. 2005 September 2280 (35):30712-22. Epub 07/08/2005.

cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model.

Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, Sapi E

Laboratory investigation; a journal of technical methods and pathology.. 2004 March 84 (3):320-31. Epub 1900 01 01.

Gene expression profiling of ErbB receptor and ligand-dependent transcription.

Amin DN, Perkins AS, Stern DF

Oncogene.. 2004 February 1923 (7):1428-38. Epub 1900 01 01.

Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion.

Chatterjee G, Rosner A, Han Y, Zelazny ET, Li B, Cardiff RD, Perkins AS

The American journal of pathology.. 2002 December 161 (6):2241-53. Epub 1900 01 01.

F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4.

Kone J, Arroyo J, Savinelli T, Lin S, Boyd K, Wu Y, Nimmakayalu M, Copeland NG, Jenkins NA, Qumsiyeh M, Hu P, Prescott A, Wu H, Yang L, Roe B, Perkins AS

Leukemia.. 2002 September 16 (9):1827-34. Epub 1900 01 01.

Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library.

Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, Perkins AS

Blood.. 2002 August 1100 (3):833-44. Epub 1900 01 01.

Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma).

Hui P, Glusac EJ, Sinard JH, Perkins AS

Journal of cutaneous pathology.. 2002 August 29 (7):385-9. Epub 1900 01 01.

Functional genomics in the mouse.

Perkins AS

Functional & integrative genomics.. 2002 August 2 (3):81-91. Epub 03/09/2002.

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC,

Blood.. 2002 July 1100 (1):238-45. Epub 1900 01 01.

Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis.

Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 July 17 (7):1164-70. Epub 1900 01 01.

Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and mouse mammary tumor virus.

Zelazny E, Li B, Anagnostopoulos AM, Coleman A, Perkins AS

Experimental and molecular pathology.. 2001 June 70 (3):183-93. Epub 1900 01 01.

Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome.

Hui P, Parkash V, Perkins AS, Carcangiu ML

Laboratory investigation; a journal of technical methods and pathology.. 2000 June 80 (6):965-72. Epub 1900 01 01.

Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy.

Kim JH, Hui P, Yue D, Aycock J, Leclerc C, Bjoring AR, Perkins AS

Oncogene.. 1998 September 2417 (12):1527-38. Epub 1900 01 01.

Vaccination with a recombinant vesicular stomatitis virus expressing an influenza virus hemagglutinin provides complete protection from influenza virus challenge.

Roberts A, Kretzschmar E, Perkins AS, Forman J, Price R, Buonocore L, Kawaoka Y, Rose JK

Journal of virology.. 1998 June 72 (6):4704-11. Epub 1900 01 01.

Gotta find GATA a friend.

Krause DS, Perkins AS

Nature medicine.. 1997 September 3 (9):960-1. Epub 1900 01 01.

neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice.

Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS

Molecular and cellular biology.. 1997 June 17 (6):3155-63. Epub 1900 01 01.

Retroviral insertional activation of the EVI1 oncogene does not prevent G-CSF-induced maturation of the murine pluripotent myeloid cell line 32Dcl3.

Khanna-Gupta A, Lopingco MC, Savinelli T, Zibello T, Berliner N, Perkins AS

Oncogene.. 1996 February 112 (3):563-9. Epub 1900 01 01.

Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding.

Perkins AS, Kim JH

The Journal of biological chemistry.. 1996 January 12271 (2):1104-10. Epub 1900 01 01.

Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia.

Lopingco MC, Perkins AS

Current topics in microbiology and immunology.. 1996 211 :211-22. Epub 1900 01 01.

Molecular regulation of myelopoiesis.

Wolff L, Perkins AS

Trends in cell biology.. 1995 September 5 (9):369-71. Epub 1900 01 01.

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG

Genes & development.. 1994 May 18 (9):1019-29. Epub 1900 01 01.

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A

Cell.. 1993 October 875 (1):59-72. Epub 1900 01 01.

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF

Genes & development.. 1992 December 6 (12A):2235-47. Epub 1900 01 01.

Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies.

Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH

Proceedings of the National Academy of Sciences of the United States of America.. 1991 October 188 (19):8505-9. Epub 1900 01 01.

Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.

Perkins AS, Fishel R, Jenkins NA, Copeland NG

Molecular and cellular biology.. 1991 May 11 (5):2665-74. Epub 1900 01 01.

Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development.

Perkins AS, Mercer JA, Jenkins NA, Copeland NG

Development.. 1991 February 111 (2):479-87. Epub 1900 01 01.

Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies.

Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH

Transactions of the Association of American Physicians. 1990 103 :129-36. Epub 1900 01 01.

Transduction of the human insulin gene via retroviral vectors fails to yield spliced transcripts.

Perkins AS, Kirschmeier PT, Weinstein IB

DNA.. 1989 8 (1):59-68. Epub 1900 01 01.

The pathology of murine myelogenous leukemias.

Perkins AS

Current topics in microbiology and immunology.. 1989 149 :3-21. Epub 1900 01 01.

Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.

Kirschmeier PT, Housey GM, Johnson MD, Perkins AS, Weinstein IB

DNA.. 1988 April 7 (3):219-25. Epub 1900 01 01.

Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells.

Perkins AS, Kirschmeier PT, Gattoni-Celli S, Weinstein IB

Molecular and cellular biology.. 1983 June 3 (6):1123-32. Epub 1900 01 01.

Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes.

Segre GV, Perkins AS, Witters LA, Potts J

The Journal of clinical investigation.. 1981 February 67 (2):449-57. Epub 1900 01 01.

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