Skip to content
Find a Provider
Stephen R. Hammes, M.D., Ph.D.

Stephen R. Hammes, M.D., Ph.D.

Endocrinology, Diabetes & Metabolism , Internal Medicine

4.9 out of 5 stars
40 Ratings
3 Comments
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 275-2901
Fax (585) 320-1091
Administrative (585) 275-2901

Locations

Endocrinology - Brighton

Clinton Crossings, Building H
2400 South Clinton Avenue, Suite 135
Rochester, NY 14620

(585) 341-7066 Get Directions

About Me

Dr. Hammes received his B.A. in chemistry from Cornell University in 1985, where he worked with Dr. Barbara Baird studying the IgE receptor. Dr. Hammes then entered the MD/PhD program at Duke. For his PhD, Dr. Hammes studied retroviral gene regulation with Dr. Warner Greene. He then traveled to S...
Dr. Hammes received his B.A. in chemistry from Cornell University in 1985, where he worked with Dr. Barbara Baird studying the IgE receptor. Dr. Hammes then entered the MD/PhD program at Duke. For his PhD, Dr. Hammes studied retroviral gene regulation with Dr. Warner Greene. He then traveled to San Francisco, where he completed an internship and residency in General Medicine, followed by a fellowship in Endocrinology. For his postdoctoral research, Dr. Hammes again chose an alternative direction, working with a cardiologist rather than an endocrinologist. He trained with Dr. Shaun Coughlin, where he studied G protein-coupled receptors.

In 1999, Dr. Hammes left UCSF to become faculty at the UT Southwestern Medical Center in Dallas, where he started an entirely new research program, choosing to study transcription-independent, or nongenomic, steroid signaling. Specifically, Dr. Hammes studied steroid-triggered maturation (meiotic progression) of oocytes, one of the few physiologically relevant steroid-triggered processes that is generally accepted to be nongenomic. Dr. Hammes has recently expanded his work to study ovarian development and function, with a focus on diseases of androgen excess such as polycystic ovarian syndrome. He also studies hormone-sensitive cancers such as prostate cancer and the rare disease lymphangioleiomyomatosis.

Finally, in 2009 Dr. Hammes moved back to Upstate New York, where he is the Louis S. Wolk Professor of Biomedical Research and the Chief of the Division of Endocrinology at the University of Rochester Medical Center.

Certified Specialties

Endocrinology, Diabetes and Metabolism - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Endocrine/Metabolism (SMD)

Louis S. Wolk Distinguished Professorship in Medicine - Department of Medicine, Endocrine/Metabolism (SMD)

Chief - Department of Medicine, Endocrine/Metabolism (SMD)

Executive Vice Chair - Department of Medicine (SMD)

Professor - Department of Microbiology and Immunology (SMD) - Joint

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Internal Medicine, Endocrinology, Diabetes & Metabolism, University of CA at San Francisco School of Medicine. 1995 - 1999

Residency, Internal Medicine, University of CA at San Francisco School of Medicine. 1994 - 1995

Fellowship, Research, Duke University Medical Center. 1993 - 1993

Internship, Internal Medicine, University of CA at San Francisco School of Medicine. 1993 - 1994

Education

MD | Duke University School of Medicine. 1992

PhD | Duke University School of Medicine. Pathology - Medical Microbiology. 1992

Research

The Hammes laboratory studies steroid signaling and steroid production, with a focus on how steroids regulate fertility as well as how steroid promote hormone-sensitive cancer such as breast and prostate cancer.

With regard to steroid signaling, the Hammes laboratory pioneered research relate...
The Hammes laboratory studies steroid signaling and steroid production, with a focus on how steroids regulate fertility as well as how steroid promote hormone-sensitive cancer such as breast and prostate cancer.

With regard to steroid signaling, the Hammes laboratory pioneered research related to rapid, extranuclear, or "nongenomic," steroid effects, demonstrating that these rapid responses that initiate at or near the membrane of cells are critical for the subsequent steroid-mediated nuclear effects on transcription. The Hammes laboratory demonstrated that extranuclear androgen signaling via classical androgen receptors located outside of the nucleus initiate rapid activation of G protein and kinase signals that modulate normal fertility in males and females, as well as prostate cancer progression in response to androgens.

The Hammes laboratory was also one of the first to use genetic mouse models to demonstrate that androgen signaling in granulosa cells of the ovary (both nuclear and extranuclear effects) is critical for normal follicle development and subsequent ovulation. Too much androgen signaling, as seen in the disease polycystic ovary syndrome, leads to excessive and unregulated follicle growth.

The Hammes laboratory has also been studying androgen effects on prostate cancer, demonstrating that these same signaling extranuclear and nuclear pathways work together to regulate prostate cancer growth. The laboratory has also recently taken an interest in inflammation and its effects on prostate cancer progression.

Finally, the Hammes laboratory studies a rare lung disease found almost exclusively in women called lymphangioleiomyomatosis, or LAM. The laboratory has developed a mouse model for this disease, and is currently examining the roles of estrogen as well as inflammation in progression of this devastating disorder.

Publications

Journal Articles

Glycoprotein non-metastatic melanoma protein B promotes tumor growth and is a biomarker for lymphangioleiomyomatosis.

Gibbons E, Taya M, Wu H, Lopa SH, Moss J, Henske EP, Mccormack FX, Hammes SR

Endocrine-related cancer.. 2024 June 131 (6)Epub 05/09/2024.

From Fundamentals to the Clinic: Advancing Obesity Research in Endocrinology.

Madak-Erdogan Z, Hammes SR, Burak MF

Journal of the Endocrine Society.. 2024 April 68 (6):bvae066. Epub 04/12/2024.

Lymphangioleiomyomatosis: where endocrinology, immunology and tumor biology meet.

Gibbons E, Minor BMN, Hammes SR

Endocrine-related cancer.. 2023 September 130 (9)Epub 08/02/2023.

Estradiol Augments Tumor-Induced Neutrophil Production to Promote Tumor Cell Actions in Lymphangioleiomyomatosis Models.

Minor BMN, LeMoine D, Seger C, Gibbons E, Koudouovoh J, Taya M, Kurtz D, Xu Y, Hammes SR

Endocrinology.. 2023 April 17164 (6)Epub 1900 01 01.

Expanding Our Scope and Our Identity.

Erdogan ZM, Hammes SR

Journal of the Endocrine Society.. 2022 October 116 (11):bvac149. Epub 10/19/2022.

Prolactin is Expressed in Uterine Leiomyomas and Promotes Signaling and Fibrosis in Myometrial Cells.

DiMauro A, Seger C, Minor B, Amitrano AM, Okeke I, Taya M, Rackow AR, Kumar D, Kottman RM, Bhagavath B, Hammes SR

Reproductive sciences.. 2022 September 29 (9):2525-2535. Epub 11/01/2021.

AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells.

Xiao Z, Hammes SR

iScience.. 2021 November 1924 (11):103270. Epub 10/14/2021.

Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation.

Astapova O, Seger C, Hammes SR

Journal of the Endocrine Society.. 2021 May 15 (5):bvab035. Epub 03/05/2021.

Publish or Perish: Five Steps to Navigating a Less Painful Peer Review.

Lange CA, Hammes SR

Endocrinology.. 2021 March 1162 (3)Epub 1900 01 01.

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.

Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y

American journal of respiratory and critical care medicine.. 2020 November 15202 (10):1373-1387. Epub 1900 01 01.

Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.

Hammes SR, Gibbons E, Minor B, Rangel-Moreno J, Garcia-Hernandez M, Taya M

Endocrine-related cancer.. 2020 April 27 (4):261-274. Epub 1900 01 01.

Paxillin regulated genomic networks in prostate cancer.

Ma X, Biswas A, Hammes SR

Steroids.. 2019 November 151 :108463. Epub 07/22/2019.

Compensation, Productivity, and Other Demographics of Academic Divisions of Endocrinology, Diabetes, and Metabolism.

Ringel MD, Murphy EJ, Hammes SR

Journal of the Endocrine Society.. 2019 August 13 (8):1485-1502. Epub 06/07/2019.

Physiological and Pathological Androgen Actions in the Ovary.

Astapova O, Minor BMN, Hammes SR

Endocrinology.. 2019 May 1160 (5):1166-1174. Epub 1900 01 01.

Impact of estrogens in males and androgens in females.

Hammes SR, Levin ER

The Journal of clinical investigation.. 2019 May 1129 (5):1818-1826. Epub 05/01/2019.

Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.

Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR

Molecular cancer research : MCR.. 2019 April 17 (4):845-859. Epub 01/04/2019.

A fatal case of parathyroid hormone-related peptide (PTHrP)-producing squamous cell carcinoma arising in the context of long-standing hidradenitis suppurativa.

Pitch MA, Bryan DJ, McMillan J, Chavez L, Hammes SR, Scott G, Mercurio MG, Somers KE

JAAD case reports.. 2018 June 4 (5):426-428. Epub 04/30/2018.

Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target.

Taya M, Hammes SR

Steroids.. 2018 May 133 :102-107. Epub 10/31/2017.

Paxillin actions in the nucleus.

Ma X, Hammes SR

Steroids.. 2018 May 133 :87-92. Epub 10/31/2017.

Neutrophil elastase in the tumor microenvironment.

Lerman I, Hammes SR

Steroids.. 2018 May 133 :96-101. Epub 11/16/2017.

Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease.

Hammes SR

Steroids.. 2018 May 133 :1. Epub 1900 01 01.

Bilateral Pheochromocytomas in a Patient with Y175C Von Hippel-Lindau Mutation.

Astapova O, Biswas A, DiMauro A, Moalem J, Hammes SR

Case reports in endocrinology.. 2018 2018 :8967159. Epub 07/10/2018.

Reflections on Endocrinology, 2013-2017.

Gore AC, Hammes SR

Endocrinology.. 2017 December 1158 (12):4123-4125. Epub 1900 01 01.

Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity.

Ma X, Hayes E, Biswas A, Seger C, Prizant H, Hammes SR, Sen A

Endocrinology.. 2017 September 1158 (9):2944-2954. Epub 1900 01 01.

Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase.

Lerman I, Garcia-Hernandez ML, Rangel-Moreno J, Chiriboga L, Pan C, Nastiuk KL, Krolewski JJ, Sen A, Hammes SR

Molecular cancer research : MCR.. 2017 September 15 (9):1138-1152. Epub 05/16/2017.

Paxillin and embryonic PolyAdenylation Binding Protein (ePABP) engage to regulate androgen-dependent Xenopus laevis oocyte maturation - A model of kinase-dependent regulation of protein expression.

Miedlich SU, Taya M, Young MR, Hammes SR

Molecular and cellular endocrinology.. 2017 June 15448 :87-97. Epub 03/28/2017.

A Phase II Clinical Trial of an Aromatase Inhibitor for Postmenopausal Women with Lymphangioleiomyomatosis.

Lu C, Lee HS, Pappas GP, Dilling DF, Burger CD, Shifren A, Veeraraghavan S, Chapman JT, Parambil J, Ruoss SJ, Young LR, Hammes SR, Kopras EJ, Roads T, Krischer JP, McCormack FX,

Annals of the American Thoracic Society.. 2017 June 14 (6):919-928. Epub 1900 01 01.

Aromatase deficiency in a male patient - Case report and review of the literature.

Miedlich SU, Karamooz N, Hammes SR

Bone.. 2016 December 93 :181-186. Epub 09/29/2016.

Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors.

Levin ER, Hammes SR

Nature reviews. Molecular cell biology.. 2016 December 17 (12):783-797. Epub 10/12/2016.

Editorial: Final Musings on the Impact of Molecular Endocrinology.

Hammes SR

Molecular endocrinology.. 2016 October 30 (10):1027-1028. Epub 1900 01 01.

Minireview: Lymphangioleiomyomatosis (LAM): The "Other" Steroid-Sensitive Cancer.

Prizant H, Hammes SR

Endocrinology.. 2016 September 157 (9):3374-83. Epub 07/13/2016.

Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.

Prizant H, Taya M, Lerman I, Light A, Sen A, Mitra S, Foster T, Hammes SR

Endocrine-related cancer.. 2016 April 23 (4):265-80. Epub 02/15/2016.

Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females.

Ma X, Hayes E, Prizant H, Srivastava RK, Hammes SR, Sen A

Endocrinology.. 2016 March 157 (3):1248-57. Epub 01/05/2016.

LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands.

Light A, Hammes SR

Biology of reproduction.. 2015 September 93 (3):65. Epub 07/22/2015.

Editorial: Selling Science in the 21st Century (Or, Trying to Teach an Old Dog New Tricks).

Hammes SR

Molecular endocrinology.. 2015 August 29 (8):1093-4. Epub 1900 01 01.

Overlapping nongenomic and genomic actions of thyroid hormone and steroids.

Hammes SR, Davis PJ

Best practice & research. Clinical endocrinology & metabolism.. 2015 August 29 (4):581-93. Epub 04/22/2015.

Editorial: selling your science: where preparation meets genius.

Hammes SR

Molecular endocrinology.. 2015 May 29 (5):643-4. Epub 1900 01 01.

Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ

Hormones & cancer.. 2015 February 6 (1):1. Epub 1900 01 01.

Statement of Principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman M, Hammes SR, Lange CA, Santen RJ

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.. 2015 January 21 (1):87. Epub 1900 01 01.

Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.

Singhai A, Wakefield DL, Bryant KL, Hammes SR, Holowka D, Baird B

Biophysical journal.. 2014 December 2107 (11):2639-51. Epub 12/02/2014.

Recent insights on circulating catecholamines in hypertension.

Ton QV, Hammes SR

Current hypertension reports.. 2014 December 16 (12):498. Epub 1900 01 01.

Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman M, Hammes SR, Lange CA, Santen RJ

Endocrine reviews.. 2014 December 35 (6):850. Epub 11/03/2014.

Editorial: Debates in graduate medical education: who will care for us when we get older?

Hammes SR

Molecular endocrinology.. 2014 November 28 (11):1753-5. Epub 1900 01 01.

Lost in translation: can we afford to miss the trees for the forest?

Hammes SR, Lange CA

Hormones & cancer.. 2014 August 5 (4):203-6. Epub 1900 01 01.

Editorial: Sex matters in preclinical research.

Hammes SR

Molecular endocrinology.. 2014 August 28 (8):1209-10. Epub 07/28/2014.

Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC

Journal of the American College of Cardiology.. 2014 June 1763 (23):2549-2557. Epub 04/02/2014.

Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression.

Sen A, Prizant H, Light A, Biswas A, Hayes E, Lee HJ, Barad D, Gleicher N, Hammes SR

Proceedings of the National Academy of Sciences of the United States of America.. 2014 February 25111 (8):3008-13. Epub 02/10/2014.

Editorial: welcome to molecular endocrinology: pitfalls and promises for the future.

Hammes SR

Molecular endocrinology.. 2014 January 28 (1):1-2. Epub 1900 01 01.

Paxillin and steroid signaling: from frog to human.

Hammes SR, Miedlich SU, Sen A

Methods in molecular biology.. 2014 1204 :95-108. Epub 1900 01 01.

Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.

Prizant H, Sen A, Light A, Cho SN, Demayo FJ, Lydon JP, Hammes SR

Molecular endocrinology.. 2013 September 27 (9):1403-14. Epub 07/02/2013.

Membrane receptor cross talk in steroidogenesis: recent insights and clinical implications.

Light A, Hammes SR

Steroids.. 2013 June 78 (6):633-8. Epub 02/01/2013.

Targeted approaches toward understanding and treating pulmonary lymphangioleiomyomatosis (LAM).

Hammes SR, Krymskaya VP

Hormones & cancer.. 2013 April 4 (2):70-7. Epub 11/27/2012.

Two cases of malignant struma ovarii with metastasis to pelvic bone.

Steinman RA, De Castro IO, Shrayyef M, Chengazi V, Giampoli E, Van Der Sloot P, Calvi LM, Wittlin SD, Hammes SR, Hou R

Gynecologic and obstetric investigation.. 2013 75 (2):139-44. Epub 02/06/2013.

Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation.

Sen A, De Castro I, Defranco DB, Deng FM, Melamed J, Kapur P, Raj GV, Rossi R, Hammes SR

The Journal of clinical investigation.. 2012 July 122 (7):2469-81. Epub 06/11/2012.

A local paracrine and endocrine network involving TGF?, Cox-2, ROS, and estrogen receptor ? influences reactive stromal cell regulation of prostate cancer cell motility.

Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB

Molecular endocrinology.. 2012 June 26 (6):940-54. Epub 05/16/2012.

Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer.

Yang L, Ravindranathan P, Ramanan M, Kapur P, Hammes SR, Hsieh JT, Raj GV

Molecular endocrinology.. 2012 April 26 (4):550-61. Epub 03/08/2012.

Minireview: Recent advances in extranuclear steroid receptor actions.

Hammes SR, Levin ER

Endocrinology.. 2011 December 152 (12):4489-95. Epub 10/25/2011.

Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology.

Sen A, Prizant H, Hammes SR

Steroids.. 2011 August 76 (9):822-8. Epub 02/25/2011.

The physiology of integrated nuclear and extranuclear steroid signaling: introductory comments.

Hammes SR, Kelly MJ, Slingerland JM

Steroids.. 2011 August 76 (9):821. Epub 05/30/2011.

GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.

Carbajal L, Biswas A, Niswander LM, Prizant H, Hammes SR

Molecular endocrinology.. 2011 June 25 (6):1055-65. Epub 03/31/2011.

GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis.

Strauss TJ, Castrillon DH, Hammes SR

Reproduction : the official journal of the Society for the Study of Fertility.. 2011 February 141 (2):173-81. Epub 12/01/2010.

Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells.

Sen A, O'Malley K, Wang Z, Raj GV, Defranco DB, Hammes SR

The Journal of biological chemistry.. 2010 September 10285 (37):28787-95. Epub 07/13/2010.

Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function.

Sen A, Hammes SR

Molecular endocrinology.. 2010 July 24 (7):1393-403. Epub 05/25/2010.

Just when you thought it was safe to go into the membrane: the growing complexities of extra-nuclear progesterone signaling.

Sen A, Hammes SR

Breast cancer research : BCR.. 2010 12 (3):109. Epub 06/16/2010.

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP

Molecular endocrinology.. 2009 August 23 (8):1171-82. Epub 04/23/2009.

Nongenomic steroid-triggered oocyte maturation: of mice and frogs.

Deng J, Carbajal L, Evaul K, Rasar M, Jamnongjit M, Hammes SR

Steroids.. 2009 July 74 (7):595-601. Epub 11/24/2008.

Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways.

Carbajal L, Deng J, Dressing GE, Hagan CR, Lange CA, Hammes SR

Steroids.. 2009 July 74 (7):551-4. Epub 11/27/2008.

Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior.

Ghayee HK, Havekes B, Corssmit EP, Eisenhofer G, Hammes SR, Ahmad Z, Tessnow A, Lazúrová I, Adams KT, Fojo AT, Pacak K, Auchus RJ

Endocrine-related cancer.. 2009 March 16 (1):291-9. Epub 12/15/2008.

Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells.

Evaul K, Hammes SR

The Journal of biological chemistry.. 2008 October 10283 (41):27525-27533. Epub 08/13/2008.

The Xenopus laevis isoform of G protein-coupled receptor 3 (GPR3) is a constitutively active cell surface receptor that participates in maintaining meiotic arrest in X. laevis oocytes.

Deng J, Lang S, Wylie C, Hammes SR

Molecular endocrinology.. 2008 August 22 (8):1853-65. Epub 05/29/2008.

Extranuclear steroid receptors: nature and actions.

Hammes SR, Levin ER

Endocrine reviews.. 2007 December 28 (7):726-41. Epub 10/04/2007.

G beta gamma signaling reduces intracellular cAMP to promote meiotic progression in mouse oocytes.

Gill A, Hammes SR

Steroids.. 2007 February 72 (2):117-23. Epub 12/18/2006.

GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development.

Li S, Lu MM, Zhou D, Hammes SR, Morrisey EE

Developmental biology.. 2007 January 1301 (1):106-16. Epub 08/11/2006.

Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors.

Evaul K, Jamnongjit M, Bhagavath B, Hammes SR

Molecular endocrinology.. 2007 January 21 (1):186-96. Epub 10/04/2006.

Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.

Lange CA, Gioeli D, Hammes SR, Marker PC

Annual review of physiology.. 2007 69 :171-99. Epub 1900 01 01.

Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop.

Rasar M, DeFranco DB, Hammes SR

The Journal of biological chemistry.. 2006 December 22281 (51):39455-64. Epub 10/25/2006.

The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury.

VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, Hammes SR, Jamnongjit M, Stein DG

Neuropharmacology.. 2006 November 51 (6):1078-85. Epub 08/22/2006.

Ovarian steroids: the good, the bad, and the signals that raise them.

Jamnongjit M, Hammes SR

Cell cycle.. 2006 June 5 (11):1178-83. Epub 06/01/2006.

The physiology of the Xenopus laevis ovary.

Rasar MA, Hammes SR

Methods in molecular biology.. 2006 322 :17-30. Epub 1900 01 01.

Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation.

Jamnongjit M, Gill A, Hammes SR

Proceedings of the National Academy of Sciences of the United States of America.. 2005 November 8102 (45):16257-62. Epub 10/31/2005.

The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes.

Haas D, White SN, Lutz LB, Rasar M, Hammes SR

Molecular endocrinology.. 2005 August 19 (8):2035-46. Epub 04/14/2005.

Oocyte maturation: the coming of age of a germ cell.

Jamnongjit M, Hammes SR

Seminars in reproductive medicine.. 2005 August 23 (3):234-41. Epub 1900 01 01.

Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5.

Yang WH, Hammes SR

The Journal of biological chemistry.. 2005 March 18280 (11):10196-201. Epub 01/07/2005.

Specific modulation of nongenomic androgen signaling in the ovary.

White SN, Jamnongjit M, Gill A, Lutz LB, Hammes SR

Steroids.. 2005 70 (5-7):352-60. Epub 03/16/2005.

Steroids and oocyte maturation--a new look at an old story.

Hammes SR

Molecular endocrinology.. 2004 April 18 (4):769-75. Epub 11/20/2003.

Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosis.

Gill A, Jamnongjit M, Hammes SR

Molecular endocrinology.. 2004 January 18 (1):97-104. Epub 10/23/2003.

Expression of the germ cell-specific transcription factor ALF in Xenopus oocytes compensates for translational inactivation of the somatic factor TFIIA.

Han S, Xie W, Hammes SR, DeJong J

The Journal of biological chemistry.. 2003 November 14278 (46):45586-93. Epub 08/14/2003.

Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands.

Lutz LB, Jamnongjit M, Yang WH, Jahani D, Gill A, Hammes SR

Molecular endocrinology.. 2003 June 17 (6):1106-16. Epub 03/13/2003.

Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production.

Yang WH, Lutz LB, Hammes SR

The Journal of biological chemistry.. 2003 March 14278 (11):9552-9. Epub 01/09/2003.

The further redefining of steroid-mediated signaling.

Hammes SR

Proceedings of the National Academy of Sciences of the United States of America.. 2003 March 4100 (5):2168-70. Epub 02/26/2003.

New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor.

Thøgersen IB, Hammes SR, Rubenstein DS, Pizzo SV, Valnickova Z, Enghild JJ

Biochimica et biophysica acta.. 2002 July 291598 (1-2):131-9. Epub 1900 01 01.

Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.

Lutz LB, Cole LM, Gupta MK, Kwist KW, Auchus RJ, Hammes SR

Proceedings of the National Academy of Sciences of the United States of America.. 2001 November 2098 (24):13728-33. Epub 11/13/2001.

G protein beta gamma subunits inhibit nongenomic progesterone-induced signaling and maturation in Xenopus laevis oocytes. Evidence for a release of inhibition mechanism for cell cycle progression.

Lutz LB, Kim B, Jahani D, Hammes SR

The Journal of biological chemistry.. 2000 December 29275 (52):41512-20. Epub 1900 01 01.

Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail.

Hammes SR, Shapiro MJ, Coughlin SR

Biochemistry.. 1999 July 2038 (29):9308-16. Epub 1900 01 01.

Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand.

Hammes SR, Coughlin SR

Biochemistry.. 1999 February 2338 (8):2486-93. Epub 1900 01 01.

Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.

Trejo J, Hammes SR, Coughlin SR

Proceedings of the National Academy of Sciences of the United States of America.. 1998 November 1095 (23):13698-702. Epub 1900 01 01.

Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.

Kahn ML, Hammes SR, Botka C, Coughlin SR

The Journal of biological chemistry.. 1998 September 4273 (36):23290-6. Epub 1900 01 01.

Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3.

Hsu DK, Hammes SR, Kuwabara I, Greene WC, Liu FT

The American journal of pathology.. 1996 May 148 (5):1661-70. Epub 1900 01 01.

Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function.

Hammes SR, Greene WC

Virology.. 1993 March 193 (1):41-9. Epub 1900 01 01.

A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor.

Fung MR, Scearce RM, Hoffman JA, Peffer NJ, Hammes SR, Hosking JB, Schmandt R, Kuziel WA, Haynes BF, Mills GB

The Journal of immunology : official journal of the American Association of Immunologists.. 1991 August 15147 (4):1253-60. Epub 1900 01 01.

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.

Hammes SR, Dixon EP, Malim MH, Cullen BR, Greene WC

Proceedings of the National Academy of Sciences of the United States of America.. 1989 December 86 (23):9549-53. Epub 1900 01 01.

Membrane-bound IgE receptor complexes fused with rat basophilic leukemia cells mediate degranulation.

Estes K, Monfalcone LL, Hammes SR, Holowka D, Baird B

The Journal of cell biology.. 1987 August 105 (2):747-53. Epub 1900 01 01.

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.

Ratings

Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)

4.7 stars

Likelihood of recommending this care provider to others

4.8 stars

Explanations the care provider gave you about your problem or condition

4.8 stars

Care provider's efforts to include you in decisions about your care

4.8 stars

Concern the care provider showed for your questions or worries

4.8 stars

Patient Comments

5.0 stars

After my last experience (at a completely unrelated practice), this team was a relief. They listened to me, noted all of my concerned, were kind and courteous. I had come here for a second opinion, and got a similar answer to the first opinion BUT was offered more tests to see if there was anything else to track down or have findings on. I felt like a whole person, acknowledged and cared for and I deeply appreciate all the consideration shown to me

Oct 09, 2024

5.0 stars

Good.

Jun 22, 2023

5.0 stars

Excellent care provider.

Apr 22, 2022