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Kirsi M. Jarvinen-Seppo, M.D., Ph.D.

Kirsi M. Jarvinen-Seppo, M.D., Ph.D.

she/her/hers

Pediatrics , Pediatric Allergy/Immunology

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 276-7190

About Me

Dr. Järvinen-Seppo is the Chief of Pediatric Allergy and Immunology and holds the inaugural Founders' Distinguished Chair in Pediatric Allergy. She is the Director of the Center for Food Allergy, which is the FARE Clinical Network Center of Excellence, sponsored by the Food Allergy Research and Educ...
Dr. Järvinen-Seppo is the Chief of Pediatric Allergy and Immunology and holds the inaugural Founders' Distinguished Chair in Pediatric Allergy. She is the Director of the Center for Food Allergy, which is the FARE Clinical Network Center of Excellence, sponsored by the Food Allergy Research and Education. This is a multidisciplinary program that provides comprehensive care to families with food allergies including specialists in allergy, gastroenterology, dermatology, and counseling for dietary and psychologic aspects. Her clinical interests are focused on various types of food allergy, including immediate-type allergies, eosinophilic gastrointestinal disease, food protein-induced enterocolitis, and allergic proctocolitis, as well as atopic dermatitis, anaphylaxis, asthma, allergic rhinitis, and urticaria. Through her interest and research on human milk, she serves on the Executive Committee for the International Society for Research in Human Milk and Lactation (ISRHML) and on USDA-sponsored Dietary Guidance Development Project for Infants and Pregnant Mothers. She is also an active participant in the Allergy and Immunology Fellowship Training program and an Associate Editor for the Frontiers in Allergy, Section Allergens.

Certified Specialties

Allergy & Immunology - American Board of Allergy & Immunology

Pediatrics - American Board of Pediatrics

Faculty Appointments

Professor - Department of Pediatrics, Pediatric Allergy/Immunology (SMD)

Founders' Distinguished Professorship of Pediatric Allergy - Department of Pediatrics, Pediatric Allergy/Immunology (SMD)

Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD) - Joint

Professor - Department of Microbiology and Immunology (SMD) - Joint

Connect with Kirsi M. Jarvinen-Seppo, M.D., Ph.D.

Center for Food Allergy

Pediatric Allergy & Immunology

Credentials

Residency & Fellowship

Fellowship, Allergy & Immunology, Mount Sinai School of Medicine. 2005 - 2008

Residency, Pediatrics, Mount Sinai School of Medicine. 2004 - 2005

Internship, Pediatrics, Mount Sinai School of Medicine. 2003 - 2004

Fellowship, Pediatrics, Pediatric Allergy & Immunology, Mount Sinai School of Medicine. 1999 - 2001

Education

PHD | University of Helsinki (Finland). 2000

MD | University of Helsinki (Finland). 1996

Awards

"Health Care Hero" Medical Professional Award. 2022

Isil Berat Barlan Memorial Lectureship. 2022

Dr John J. Condemi Award. 2021

Ruth Lawrence Academic Faculty Service Award in Research. 2018

NIH NIAID Physician Scientist Award. 2011

Third-Year Fellow-in-Training Research Award. 2007

AAAAI Jaffe Food Allergy Research Award. 2007

Research

Dr. Järvinen-Seppo directs an NIH-funded translational research program focused on developmental aspects of the infant systemic and mucosal immune system relating to mechanisms behind development of food allergy, atopic dermatitis and the whole atopic march. She is particularly interested in the rol...
Dr. Järvinen-Seppo directs an NIH-funded translational research program focused on developmental aspects of the infant systemic and mucosal immune system relating to mechanisms behind development of food allergy, atopic dermatitis and the whole atopic march. She is particularly interested in the role of maternal and infant environmental factors and breast milk composition in shaping the early infant immune system and uses human cohorts and laboratory bench research approaches to answer the mechanistic questions. She is also interested in antibody-mediated protection against respiratory and diarrheal diseases provided by breast milk in infants, funded through the Bill and Melinda Gates Foundation. Her research has been published in leading medical journals and she is a regular speaker at local, national and international professional and community events.

Clinical Trials

The Development of Allergic Disease in Farming and Urban Infants

Lead Researcher: Kirsi Jarvinen-seppo

You are eligible if you are pregnant and 18 years old or older and give birth to a healthy infant. The purpose of this study is to compare a group of people at low risk for getting allergies, the Old Order Mennonite, with a group of people at higher...

A Phase 1b/2, randomized, double-blind, placebo-controlled, multi-center study of STMC-103H in neonates and infants at risk for developing allergic disease

Lead Researcher: Kirsi Jarvinen-seppo

Early administration of beneficial bacteria that promote immune tolerance represents a novel approach for the prevention and treatment of allergic diseases, such as atopic dermatitis and asthma. STMC-103H is a live biotherapeutic product (LBP) contai...

Publications

Journal Articles

Infant Microbiota Communities and Human Milk Oligosaccharide Supplementation Independently and Synergistically Shape Metabolite Production and Immune Responses in Healthy Mice.

Tripp P, Davis EC, Gurung M, Rosa F, Bode L, Fox R, LeRoith T, Simecka C, Seppo AE, Järvinen KM, Yeruva L

The Journal of nutrition.. 2024 September 154 (9):2871-2886. Epub 07/26/2024.

Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions.

Herman K, Brough HA, Pier J, Venter C, Järvinen KM

The journal of allergy and clinical immunology. In practice.. 2024 July 12 (7):1686-1694. Epub 04/25/2024.

Skin tape-strips in old order Mennonite toddlers reveal upregulated barrier markers and low T-helper inflammatory tone.

Rothenberg-Lausell C, David E, Del Duca E, Da Rosa JC, Dahabreh D, Gómez-Arias PJ, Catlin E, Nandymazumdar M, Järvinen KM, Guttman-Yassky E

Allergy.. 2024 July 79 (7):2012-2015. Epub 05/30/2024.

Human milk affects TLR4 activation and LPS-induced inflammatory cytokine expression in Caco-2 intestinal epithelial cells.

Pizzarello CR, Nelson A, Verekhman I, Seppo AE, Järvinen KM

Scientific reports.. 2024 June 1114 (1):13448. Epub 06/11/2024.

Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG.

Campo JJ, Seppo AE, Randall AZ, Pablo J, Hung C, Teng A, Shandling AD, Truong J, Oberai A, Miller J, Iqbal NT, Peñataro Yori P, Kukkonen AK, Kuitunen M, Guterman LB, Morris SK, Pell LG, Al Mahmud A, Ramakrishan G, Heinz E, Kirkpatrick BD, Faruque AS, Haque R, Looney RJ, Kosek MN, Savilahti E, Omer SB, Roth DE, Petri WA, Järvinen KM

The Journal of clinical investigation.. 2024 June 11134 (15)Epub 06/11/2024.

Gut microbiome in the first 1000 days and risk for childhood food allergy.

Davis EC, Monaco C, Insel R, Järvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2024 March 16 Epub 03/16/2024.

Exercising caution with infant diet elimination.

Martin VM, Järvinen KM

Journal of pediatric gastroenterology and nutrition.. 2024 March 78 (3):747-748. Epub 01/29/2024.

The role of IgA in food allergy remains elusive-timing is everything?

Seppo AE, Jackson CM, Järvinen KM

The Journal of allergy and clinical immunology.. 2023 June 151 (6):1481-1483. Epub 03/09/2023.

Evidence for human milk as a biological system and recommendations for study design-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 4.

Donovan SM, Aghaeepour N, Andres A, Azad MB, Becker M, Carlson SE, Järvinen KM, Lin W, Lönnerdal B, Slupsky CM, Steiber AL, Raiten DJ

The American journal of clinical nutrition.. 2023 April 117 Suppl 1 (Suppl 1):S61-S86. Epub 1900 01 01.

IgE Sensitization Drives the Atopic March.

Beck LA, Pesonen M, Thakar J, Georas SN, Järvinen KM

American journal of respiratory and critical care medicine.. 2023 March 1207 (5):632-633. Epub 1900 01 01.

Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes.

Jackson CM, Kaplan AN, Järvinen KM

Current allergy and asthma reports.. 2023 February 23 (2):77-91. Epub 01/07/2023.

Food protein-induced enterocolitis syndrome: Healthcare utilization and referral patterns among a pediatric cohort.

Pier J, Bingemann T, Badwal J, Rosloff D, Pasha M, Wang H, Lomas JM, Järvinen KM

Frontiers in allergy.. 2023 4 :1102410. Epub 02/10/2023.

Editorial: Allergic sensitization in infants.

Järvinen KM, Jain N, Munblit D, van Neerven RJJ

Frontiers in allergy.. 2023 4 :1339678. Epub 12/04/2023.

Protein and carbohydrate content of infant formula purchased in the United States.

Strzalkowski AJ, Järvinen KM, Schmidt B, Young BE

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2022 November 52 (11):1291-1301. Epub 10/19/2022.

Predictors and biomarkers of food allergy and sensitization in early childhood.

Davis EC, Jackson CM, Ting T, Harizaj A, Järvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2022 September 129 (3):292-300. Epub 04/29/2022.

Early-onset atopic dermatitis and food hypersensitivity increase the risk of atopic march.

Pesonen M, Kallio MJT, Ranki A, Siimes MA, Järvinen KM

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2022 September 52 (9):1110-1113. Epub 06/28/2022.

Gut microbiome and breast-feeding: Implications for early immune development.

Davis EC, Castagna VP, Sela DA, Hillard MA, Lindberg S, Mantis NJ, Seppo AE, Järvinen KM

The Journal of allergy and clinical immunology.. 2022 September 150 (3):523-534. Epub 1900 01 01.

The role of TGF-? and APRIL in human milk IgA production and development of allergic disease in early childhood.

Seppo AE, Rajani PS, Wong A, Varrone JJ, Fridy ST, Kuitunen M, Kukkonen K, Savilahti E, Järvinen KM

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 2022 June 33 (6):e13813. Epub 1900 01 01.

Thinking More About Inhibition of Breast Milk on the Infectivity of SARS-CoV-2-Reply.

Young BE, Järvinen KM, Seppo A

JAMA pediatrics.. 2022 May 1176 (5):527-528. Epub 1900 01 01.

Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review.

Gamirova A, Berbenyuk A, Levina D, Peshko D, Simpson MR, Azad MB, Järvinen KM, Brough HA, Genuneit J, Greenhawt M, Verhasselt V, Peroni D, Perkin MR, Warner JO, Palmer DJ, Boyle RJ, Munblit D

The journal of allergy and clinical immunology. In practice.. 2022 May 10 (5):1312-1324.e8. Epub 02/02/2022.

Broad Cross-reactive IgA and IgG Against Human Coronaviruses in Milk Induced by COVID-19 Vaccination and Infection.

Wang J, Young BE, Li D, Seppo AE, Zhou Q, Wiltse A, Nowak-Wegrzyn A, Murphy K, Widrick K, Diaz N, Cruz-Vasquez J, Järvinen KM, Zand MS

medRxiv : the preprint server for health sciences.. 2022 March 14 Epub 03/14/2022.

Assessing the safety of bioactive ingredients in infant formula that affect the immune system: recommendations from an expert panel.

Callahan EA, Chatila T, Deckelbaum RJ, Field CJ, Greer FR, Hernell O, Järvinen KM, Kleinman RE, Milner J, Neu J, Smolen KK, Wallingford JC

The American journal of clinical nutrition.. 2022 February 9115 (2):570-587. Epub 1900 01 01.

Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination.

Young BE, Seppo AE, Diaz N, Rosen-Carole C, Nowak-Wegrzyn A, Cruz Vasquez JM, Ferri-Huerta R, Nguyen-Contant P, Fitzgerald T, Sangster MY, Topham DJ, Järvinen KM

JAMA pediatrics.. 2022 February 1176 (2):159-168. Epub 1900 01 01.

Farming lifestyle and human milk: Modulation of the infant microbiome and protection against allergy.

Jackson CM, Mahmood MM, Järvinen KM

Acta paediatrica.. 2022 January 111 (1):54-58. Epub 10/28/2021.

Quantitative glycoproteomics of human milk and association with atopic disease.

Holm M, Saraswat M, Joenväärä S, Seppo A, Looney RJ, Tohmola T, Renkonen J, Renkonen R, Järvinen KM

PloS one.. 2022 17 (5):e0267967. Epub 05/13/2022.

Biomarkers of Development of Immunity and Allergic Diseases in Farming and Non-farming Lifestyle Infants: Design, Methods and 1 Year Outcomes in the "Zooming in to Old Order Mennonites" Birth Cohort Study.

Järvinen KM, Davis EC, Bevec E, Jackson CM, Pizzarello C, Catlin E, Klein M, Sunkara A, Diaz N, Miller J, Martina CA, Thakar J, Seppo AE, Looney RJ,

Frontiers in pediatrics.. 2022 10 :916184. Epub 07/06/2022.

Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle.

Seppo AE, Bu K, Jumabaeva M, Thakar J, Choudhury R, Yonemitsu C, Bode L, Martina CA, Allen M, Tamburini S, Piras E, Wallach DS, Looney RJ, Clemente JC, Järvinen KM

Allergy.. 2021 November 76 (11):3489-3503. Epub 05/14/2021.

Vitamin D and iron status in children with food allergy.

Nowak S, Wang H, Schmidt B, Jarvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2021 July 127 (1):57-63. Epub 03/08/2021.

Correction: Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk.

Demers-Mathieu V, Do DM, Mathijssen GB, Sela DA, Seppo A, Järvinen KM, Medo E

Journal of perinatology : official journal of the California Perinatal Association.. 2021 May 41 (5):1207. Epub 1900 01 01.

The role of immunoglobulin A in oral tolerance and food allergy.

Pier J, Liu EG, Eisenbarth S, Järvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2021 May 126 (5):467-468. Epub 02/03/2021.

Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk.

Demers-Mathieu V, Dung M, Mathijssen GB, Sela DA, Seppo A, Järvinen KM, Medo E

Journal of perinatology : official journal of the California Perinatal Association.. 2021 April 41 (4):850-859. Epub 09/01/2020.

Immunologic components in human milk and allergic diseases with focus on food allergy.

Burris AD, Pizzarello C, Järvinen KM

Seminars in perinatology.. 2021 March 45 (2):151386. Epub 12/31/2020.

Is It Time to Offer Peanut Oral Immunotherapy to Toddlers?

Burris AD, Lomas JM, Järvinen KM

The journal of allergy and clinical immunology. In practice.. 2021 March 9 (3):1357-1358. Epub 1900 01 01.

Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CDW, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan CL, Caffé B, Sangster MY, Topham D, McGuire MA, Seppo A, McGuire MK

mBio.. 2021 February 912 (1)Epub 02/09/2021.

Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.

Seppo AE, Choudhury R, Pizzarello C, Palli R, Fridy S, Rajani PS, Stern J, Martina C, Yonemitsu C, Bode L, Bu K, Tamburini S, Piras E, Wallach DS, Allen M, Looney RJ, Clemente JC, Thakar J, Järvinen KM

Frontiers in immunology.. 2021 12 :741513. Epub 10/11/2021.

Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies.

Pace RM, Williams JE, Järvinen KM, Meehan CL, Martin MA, Ley SH, Barbosa-Leiker C, Andres A, Yeruva L, Belfort MB, Caffé B, Navarrete AD, Lackey KA, Pace CDW, Gogel AC, Fehrenkamp BD, Klein M, Young BE, Rosen-Carole C, Diaz N, Gaw SL, Flaherman V, McGuire MA, McGuire MK, Seppo AE

Frontiers in immunology.. 2021 12 :801797. Epub 12/23/2021.

Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.

Burris AD, Burris J, Järvinen KM

NeoReviews.. 2020 December 21 (12):e795-e808. Epub 1900 01 01.

SARS-CoV-2 and human milk: What is the evidence?

Lackey KA, Pace RM, Williams JE, Bode L, Donovan SM, Järvinen KM, Seppo AE, Raiten DJ, Meehan CL, McGuire MA, McGuire MK

Maternal & child nutrition.. 2020 October 16 (4):e13032. Epub 05/30/2020.

Food allergy in at-risk adolescents with asthma: A key area for focus.

Stern J, Chen M, Jusko TA, Fagnano M, Järvinen KM, Halterman JS

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2020 October 125 (4):405-409.e1. Epub 06/10/2020.

COVID-19 and human milk: SARS-CoV-2, antibodies, and neutralizing capacity.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CD, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan C, Caffe B, Sangster MY, Topham DJ, McGuire MA, Seppo A, McGuire MK

medRxiv : the preprint server for health sciences.. 2020 September 18 Epub 09/18/2020.

Food allergy and breast-feeding.

Pier J, Järvinen KM

Journal of food allergy.. 2020 September 2 (1):99-103. Epub 09/01/2020.

Association of oral habits with food allergy and comorbid atopic disease.

Burris AD, Wang H, Wilson LM, Jarvinen KM, Lomas J

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2020 August 125 (2):230-231. Epub 05/11/2020.

SARS-CoV-2 and human milk: what is the evidence?

Lackey KA, Pace RM, Williams JE, Bode L, Donovan SM, Järvinen KM, Seppo AE, Raiten DJ, Meehan CL, McGuire MA, McGuire MK

medRxiv : the preprint server for health sciences.. 2020 April 11 Epub 04/11/2020.

Food allergy, breastfeeding, and introduction of complementary foods in the New York Old Order Mennonite Community.

Phillips JT, Stahlhut RW, Looney RJ, Järvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2020 March 124 (3):292-294.e2. Epub 01/08/2020.

Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies.

Bawany F, Beck LA, Järvinen KM

The journal of allergy and clinical immunology. In practice.. 2020 March 8 (3):860-875. Epub 1900 01 01.

Presentation and Management of Food Allergy in Breastfed Infants and Risks of Maternal Elimination Diets.

Rajani PS, Martin H, Groetch M, Järvinen KM

The journal of allergy and clinical immunology. In practice.. 2020 January 8 (1):52-67. Epub 11/18/2019.

Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study.

McGuire MK, Randall AZ, Seppo AE, Järvinen KM, Meehan CL, Gindola D, Williams JE, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Foster JA, Otoo GE, Rodríguez JM, Pareja RG, Bode L, McGuire MA, Campo JJ

Frontiers in immunology.. 2020 11 :614372. Epub 02/11/2021.

Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review.

Blyuss O, Cheung KY, Chen J, Parr C, Petrou L, Komarova A, Kokina M, Luzan P, Pasko E, Eremeeva A, Peshko D, Eliseev VI, Pedersen SA, Azad MB, Jarvinen KM, Peroni DG, Verhasselt V, Boyle RJ, Warner JO, Simpson MR, Munblit D

Nutrients.. 2019 October 1011 (10)Epub 10/10/2019.

Immunomodulatory effects of breast milk on food allergy.

Järvinen KM, Martin H, Oyoshi MK

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2019 August 123 (2):133-143. Epub 04/29/2019.

Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition.

Seppo AE, Kukkonen AK, Kuitunen M, Savilahti E, Yonemitsu C, Bode L, Järvinen KM

JAMA pediatrics.. 2019 March 1173 (3):286-288. Epub 1900 01 01.

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O'Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM

The American journal of clinical nutrition.. 2019 March 1109 (Suppl_7):772S-799S. Epub 1900 01 01.

Infant milk-feeding practices and childhood leukemia: a systematic review.

Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O'Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM

The American journal of clinical nutrition.. 2019 March 1109 (Suppl_7):757S-771S. Epub 1900 01 01.

Infant milk-feeding practices and cardiovascular disease outcomes in offspring: a systematic review.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O'Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM

The American journal of clinical nutrition.. 2019 March 1109 (Suppl_7):800S-816S. Epub 1900 01 01.

Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: a systematic review.

Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O'Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM

The American journal of clinical nutrition.. 2019 March 1109 (Suppl_7):838S-851S. Epub 1900 01 01.

Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O'Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM

The American journal of clinical nutrition.. 2019 March 1109 (Suppl_7):817S-837S. Epub 1900 01 01.

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department.

Sundquist BK, Jose J, Pauze D, Pauze D, Wang H, Järvinen KM

Allergy and asthma proceedings :. 2019 January 140 (1):41-47. Epub 1900 01 01.

Variations in Human Milk Composition: Impact on Immune Development and Allergic Disease Susceptibility.

Järvinen KM

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.. 2018 April 13 (S1):S11-S13. Epub 1900 01 01.

Food Protein-Induced Enterocolitis Syndrome.

Bingemann TA, Sood P, Järvinen KM

Immunology and allergy clinics of North America.. 2018 February 38 (1):141-152. Epub 10/26/2017.

Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population.

Rajani PS, Seppo AE, Järvinen KM

Frontiers in pediatrics.. 2018 6 :218. Epub 08/07/2018.

Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs.

Järvinen KM, Wang J, Seppo AE, Zand M

F1000Research.. 2018 7 :1822. Epub 11/20/2018.

Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy.

Frischmeyer-Guerrerio PA, Masilamani M, Gu W, Brittain E, Wood R, Kim J, Nadeau K, Jarvinen KM, Grishin A, Lindblad R, Sampson HA

The Journal of allergy and clinical immunology.. 2017 October 140 (4):1043-1053.e8. Epub 04/13/2017.

Breast milk IgA to foods has different epitope specificity than serum IgA-Evidence for entero-mammary link for food-specific IgA?

Seppo AE, Savilahti EM, Berin MC, Sampson HA, Järvinen KM

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2017 October 47 (10):1275-1284. Epub 05/26/2017.

Human milk oligosaccharides and development of cow's milk allergy in infants.

Seppo AE, Autran CA, Bode L, Järvinen KM

The Journal of allergy and clinical immunology.. 2017 February 139 (2):708-711.e5. Epub 10/01/2016.

Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum.

Jusko T, Oktapodas M, Palkovi?ová Murinová ?, Babinska K, Babjakova J, Verner MA, DeWitt J, Thevenet-Morrison K, Conka K, Drobná B, Chovancova J, Thurston S, Lawrence BP, Dozier A, Jarvinen K, Patayova H, Trnovec T, Legler J, Hertz-Picciotto I, Lamoree MH

Environmental science & technology.. 2016 July 550 (13):7152-62. Epub 06/14/2016.

Immune factors in breast milk related to infant milk allergy are independent of maternal atopy.

Järvinen KM, Suárez-Fariñas M, Savilahti E, Sampson HA, Berin MC

The Journal of allergy and clinical immunology.. 2015 May 135 (5):1390-3.e1-6. Epub 12/19/2014.

Impact of elimination diets on growth and nutritional status in children with multiple food allergies.

Berry MJ, Adams J, Voutilainen H, Feustel PJ, Celestin J, Järvinen KM

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 2015 March 26 (2):133-8. Epub 1900 01 01.

Managing nut-induced anaphylaxis: challenges and solutions.

Lomas JM, Järvinen KM

Journal of asthma and allergy.. 2015 8 :115-23. Epub 10/29/2015.

Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance.

Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, Sampson HA, Berin MC

PloS one.. 2015 10 (12):e0143855. Epub 12/10/2015.

The safety of maternal elimination diets in breastfeeding mothers with food-allergic infants.

Adams J, Voutilainen H, Ullner PM, Järvinen KM

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.. 2014 December 9 (10):555-6. Epub 1900 01 01.

Skin exposure promotes a Th2-dependent sensitization to peanut allergens.

Tordesillas L, Goswami R, Benedé S, Grishina G, Dunkin D, Järvinen KM, Maleki SJ, Sampson HA, Berin MC

The Journal of clinical investigation.. 2014 November 124 (11):4965-75. Epub 10/08/2014.

Clinical features and resolution of food protein-induced enterocolitis syndrome: 10-year experience.

Caubet JC, Ford LS, Sickles L, Järvinen KM, Sicherer SH, Sampson HA, Nowak-W?grzyn A

The Journal of allergy and clinical immunology.. 2014 August 134 (2):382-9. Epub 05/28/2014.

Role of maternal elimination diets and human milk IgA in the development of cow's milk allergy in the infants.

Järvinen KM, Westfall JE, Seppo MS, James AK, Tsuang AJ, Feustel PJ, Sampson HA, Berin C

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2014 January 44 (1):69-78. Epub 1900 01 01.

Anaphylaxis avoidance and management: educating patients and their caregivers.

Järvinen KM, Celestin J

Journal of asthma and allergy.. 2014 7 :95-104. Epub 07/10/2014.

Intestinal permeability in children with food allergy on specific elimination diets.

Järvinen KM, Konstantinou GN, Pilapil M, Arrieta MC, Noone S, Sampson HA, Meddings J, Nowak-W?grzyn A

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 2013 September 24 (6):589-95. Epub 08/02/2013.

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel ?2?1 integrin internalization pathway.

Siljamäki E, Rintanen N, Kirsi M, Upla P, Wang W, Karjalainen M, Ikonen E, Marjomäki V

PloS one.. 2013 8 (2):e55465. Epub 02/05/2013.

Allergy prevention via co-administration of intact food allergen and its epitope soup?

Järvinen KM

International archives of allergy and immunology.. 2013 161 (3):195-6. Epub 03/15/2013.

Food protein-induced enterocolitis syndrome (FPIES): current management strategies and review of the literature.

Järvinen KM, Nowak-W?grzyn A

The journal of allergy and clinical immunology. In practice.. 2013 1 (4):317-22. Epub 05/31/2013.

Heating does not decrease immunogenicity of goat's and ewe's milk.

Bencharitiwong R, Giavi S, Vereda A, Ibáñez MD, Järvinen KM, Papadopoulos NG, Nowak-W?grzyn A

The journal of allergy and clinical immunology. In practice.. 2013 1 (4):418-21. Epub 06/28/2013.

What's on the menu for prediction of natural history of cow's milk allergy beyond casein cocktails and epitope soup?

Järvinen KM, Celestin J

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2012 November 42 (11):1549-51. Epub 1900 01 01.

Diagnostic oral food challenges: procedures and biomarkers.

Järvinen KM, Sicherer SH

Journal of immunological methods.. 2012 September 28383 (1-2):30-8. Epub 03/04/2012.

Poor utility of atopy patch test in predicting tolerance development in food protein-induced enterocolitis syndrome.

Järvinen KM, Caubet JC, Sickles L, Ford LS, Sampson HA, Nowak-W?grzyn A

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2012 September 109 (3):221-2. Epub 07/25/2012.

Presence of functional, autoreactive human milk-specific IgE in infants with cow's milk allergy.

Järvinen KM, Geller L, Bencharitiwong R, Sampson HA

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2012 February 42 (2):238-47. Epub 09/21/2011.

Can we prevent food allergy by manipulating the timing of food exposure?

Järvinen KM, Fleischer DM

Immunology and allergy clinics of North America.. 2012 February 32 (1):51-65. Epub 12/16/2011.

Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes.

Huang F, Chawla K, Järvinen KM, Nowak-W?grzyn A

The Journal of allergy and clinical immunology.. 2012 January 129 (1):162-8.e1-3. Epub 10/22/2011.

Peanuts for preschoolers: less preposterous than previously perceived?

Kim JS, Järvinen KM

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2011 July 41 (7):914-6. Epub 1900 01 01.

Maternal peanut consumption provides protection in offspring against peanut sensitization that is further enhanced when co-administered with bacterial mucosal adjuvant.

López-Expósito I, Järvinen KM, Castillo A, Seppo AE, Song Y, Li XM

Food research international.. 2011 July 44 (6):1649-1656. Epub 1900 01 01.

Food-induced anaphylaxis.

Järvinen KM

Current opinion in allergy and clinical immunology.. 2011 June 11 (3):255-61. Epub 1900 01 01.

Milk and soy allergy.

Kattan JD, Cocco RR, Järvinen KM

Pediatric clinics of North America.. 2011 April 58 (2):407-26, x. Epub 1900 01 01.

Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children.

Järvinen KM, Amalanayagam S, Shreffler WG, Noone S, Sicherer SH, Sampson HA, Nowak-Wegrzyn A

The Journal of allergy and clinical immunology.. 2009 December 124 (6):1267-72. Epub 1900 01 01.

Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspring.

López-Expósito I, Song Y, Järvinen KM, Srivastava K, Li XM

The Journal of allergy and clinical immunology.. 2009 November 124 (5):1039-46. Epub 1900 01 01.

Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis.

Järvinen KM, Chatchatee P

Current opinion in allergy and clinical immunology.. 2009 June 9 (3):251-8. Epub 1900 01 01.

Allergic reactions to stinging and biting insects and arachnids.

Järvinen KM

Pediatric annals.. 2009 April 38 (4):199-209. Epub 1900 01 01.

Use of multiple doses of epinephrine in food-induced anaphylaxis in children.

Järvinen KM, Sicherer SH, Sampson HA, Nowak-Wegrzyn A

The Journal of allergy and clinical immunology.. 2008 July 122 (1):133-8. Epub 06/10/2008.

Identification of amino acids critical for IgE-binding to sequential epitopes of bovine kappa-casein and the similarity of these epitopes to the corresponding human kappa-casein sequence.

Han N, Järvinen KM, Cocco RR, Busse PJ, Sampson HA, Beyer K

Allergy.. 2008 February 63 (2):198-204. Epub 1900 01 01.

Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy.

Järvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA

Allergy.. 2007 July 62 (7):758-65. Epub 1900 01 01.

Mutational analysis of immunoglobulin E-binding epitopes of beta-casein and beta-lactoglobulin showed a heterogeneous pattern of critical amino acids between individual patients and pooled sera.

Cocco RR, Järvinen KM, Han N, Beyer K, Sampson HA

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2007 June 37 (6):831-8. Epub 1900 01 01.

IgE-binding peptides coupled to a commercial matrix as a diagnostic instrument for persistent cow's milk allergy.

Beyer K, Jarvinen KM, Bardina L, Mishoe M, Turjanmaa K, Niggemann B, Ahlstedt S, Venemalm L, Sampson HA

The Journal of allergy and clinical immunology.. 2005 September 116 (3):704-5. Epub 1900 01 01.

Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants.

Osterlund P, Smedberg T, Hakulinen A, Heikkilä H, Järvinen KM

Pediatric research.. 2004 February 55 (2):296-301. Epub 11/19/2003.

Expression of intercellular adhesion molecules on circulating lymphocytes in relation to different manifestations of cow's milk allergy.

Osterlund P, Smedberg T, Schröder J, Järvinen KM

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2003 October 33 (10):1368-73. Epub 1900 01 01.

Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen.

Cocco RR, Järvinen KM, Sampson HA, Beyer K

The Journal of allergy and clinical immunology.. 2003 August 112 (2):433-7. Epub 1900 01 01.

Concurrent cereal allergy in children with cow's milk allergy manifested with atopic dermatitis.

Järvinen KM, Turpeinen M, Suomalainen H

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2003 August 33 (8):1060-6. Epub 1900 01 01.

Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts.

Beyer K, Ellman-Grunther L, Järvinen KM, Wood RA, Hourihane J, Sampson HA

The Journal of allergy and clinical immunology.. 2003 July 112 (1):202-7. Epub 1900 01 01.

Cholesterol precursors and plant sterols in children with food allergy.

Joki P, Suomalainen H, Järvinen KM, Juntunen-Backman K, Gylling H, Miettinen TA, Antikainen M

The American journal of clinical nutrition.. 2003 January 77 (1):51-5. Epub 1900 01 01.

Identification of sequential IgE-binding epitopes on bovine alpha(s2)-casein in cow's milk allergic patients.

Busse PJ, Järvinen KM, Vila L, Beyer K, Sampson HA

International archives of allergy and immunology.. 2002 September 129 (1):93-6. Epub 1900 01 01.

B-cell epitopes as a screening instrument for persistent cow's milk allergy.

Järvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, Sampson HA

The Journal of allergy and clinical immunology.. 2002 August 110 (2):293-7. Epub 1900 01 01.

Leucocytes in human milk and lymphocyte subsets in cow's milk-allergic infants.

Järvinen KM, Suomalainen H

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 2002 August 13 (4):243-54. Epub 1900 01 01.

Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy.

Vila L, Beyer K, Järvinen KM, Chatchatee P, Bardina L, Sampson HA

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2001 October 31 (10):1599-606. Epub 1900 01 01.

IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy.

Järvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA

International archives of allergy and immunology.. 2001 October 126 (2):111-8. Epub 1900 01 01.

Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow's milk allergic patients.

Chatchatee P, Järvinen KM, Bardina L, Vila L, Beyer K, Sampson HA

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2001 August 31 (8):1256-62. Epub 1900 01 01.

Development of cow's milk allergy in breast-fed infants.

Järvinen KM, Suomalainen H

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2001 July 31 (7):978-87. Epub 1900 01 01.

Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy.

Chatchatee P, Järvinen KM, Bardina L, Beyer K, Sampson HA

The Journal of allergy and clinical immunology.. 2001 February 107 (2):379-83. Epub 1900 01 01.

Does low IgA in human milk predispose the infant to development of cow's milk allergy?

Järvinen KM, Laine ST, Järvenpää AL, Suomalainen HK

Pediatric research.. 2000 October 48 (4):457-62. Epub 1900 01 01.

Defective tumour necrosis factor-alpha production in mother's milk is related to cow's milk allergy in suckling infants.

Järvinen KM, Laine S, Suomalainen H

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2000 May 30 (5):637-43. Epub 1900 01 01.

Cow's milk challenge through human milk evokes immune responses in infants with cow's milk allergy.

Järvinen KM, Mäkinen-Kiljunen S, Suomalainen H

The Journal of pediatrics.. 1999 October 135 (4):506-12. Epub 1900 01 01.

Defective tumor necrosis factor-alpha production in infants with cow's milk allergy.

Osterlund P, Järvinen KM, Laine S, Suomalainen H

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 1999 August 10 (3):186-90. Epub 1900 01 01.

Relation between weak HLA-DR expression on human breast milk macrophages and cow milk allergy (CMA) in suckling infants.

Järvinen KM, Juntunen-Backman K, Suomalainen H

Pediatric research.. 1999 January 45 (1):76-81. Epub 1900 01 01.

[Breast milk and allergies].

Järvinen KM, Raitio H

Duodecim; lääketieteellinen aikakauskirja.. 1999 115 (18):1941-3. Epub 1900 01 01.

Large number of CD19+/CD23+ B cells and small number of CD8+ T cells as early markers for cow's milk allergy (CMA).

Järvinen KM, Aro A, Juntunen-Backman K, Suomalainen H

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 1998 August 9 (3):139-42. Epub 1900 01 01.

Books

Health Professional's Guide to Nutrition Management of Food Allergies. (2023)

Chapter: Choosing an Appropriate Cow's Milk Substitute While Breastfeeding, Formula Feeding, and Beyond.

Authors: Meyer R, Burris A, Järvinen KM, Szajewska H.

Publisher: Academy of Nutrition and Dietetics 2023

Allergy, immunity and tolerance in early childhood: The first two thousand days of the Atopic March (2014)

Chapter: Breast- always best?

Authors: Järvinen KM, Bergmann R.

Publisher: Elsevier 2014

Anaphylaxis and Hypersensitivity Reactions from Molecular Markers to Rapid Desensitizations. (2011)

Chapter: Food-Induced Anaphylaxis

Authors: Järvinen KM, Nowak-Wegrzyn A.

Publisher: Springer, New York 2011

Integrating population outcomes, biological mechanisms and research methods in the study of human milk and lactation (2002)

Chapter: IgA in human milk and development of cow's milk allergy in the breast-fed infant

Authors: Järvinen K-M, Laine S, Järvenpää A-L, Suomalainen H.

Publisher: Kluwer Academic/Plenum Publishers, New York 2002

). Integrating population outcomes, biological mechanisms and research methods in the study of human milk and lactation (2002)

Chapter: Abnormal cellular composition of human milk and development of cow's milk allergy in the breast-fed.

Authors: Järvinen KM, Österlund P, Suomalainen H

Publisher: Kluwer Academic/Plenum Publishers, New York 2002

Academic dissertation (2000)

Chapter: Human milk immunology in relation to the development of cow's milk allergy in the breast-fed

Authors: Järvinen KM

Publisher: University of Helsinki, September 2000