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Brea C. Lipe, M.D.

Brea C. Lipe, M.D.

Hematology & Oncology , Cancer

4.9 out of 5 stars
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
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About Me

I am the clinical director of Wilmot's multiple myeloma program, and in the laboratory and in the clinic, I am focused on improving the care of patients with multiple myeloma and other plasma cell dyscrasias. Treatment options and our understanding of multiple myeloma have changed dramatically in th...
I am the clinical director of Wilmot's multiple myeloma program, and in the laboratory and in the clinic, I am focused on improving the care of patients with multiple myeloma and other plasma cell dyscrasias. Treatment options and our understanding of multiple myeloma have changed dramatically in the last 10 years. The rapid pace of change, intrinsic disease complexity, and the ability to impact patient lives still leaves me amazed and humbled every day.

I believe that it's important to know my patients as individuals to understand the situational circumstance and personality that drives their treatment goals. Multiple myeloma is a lifelong journey and a strong partnership with my patients is essential to achieving the best quality of care. I have a strong interest in clinical research and like to offer my patients a variety of clinical trial options and treatments based on the most recent data. I have a dedicated support team, so that we can offer patients a team with real myeloma-specific expertise.

In my research laboratory, I am particularly interested in understanding the mechanisms that allow multiple myeloma to develop. I have created a system that lets us mimic in a laboratory, the growth of cancer cells that become multiple myeloma. By studying disease progression, my ultimate goal is to develop therapies to prevent multiple myeloma.

Outside of work, I love to grow things -- flowers, vegetables, orchids, animals, children. I have gotten some of my best gardening tips from my patients.

Conditions I treat:

- Multiple myeloma
- Other plasma cell disorders

Certified Specialties

Hematology - American Board of Internal Medicine

Medical Oncology - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Hematology/Oncology (SMD)

Credentials

Residency & Fellowship

Fellowship, Hematology & Oncology, Dartmouth-Hitchcock Medical Center. 2008 - 2011

Residency, Internal Medicine, Dartmouth-Hitchcock Medical Center. 2006 - 2008

Internship, Internal Medicine, Dartmouth-Hitchcock Medical Center. 2005 - 2006

Education

MD | Albany Medical College. 2005

Awards

Leadership Academy. 2017

Department of Internal Medicine OSARM Faculty Incubator Scholar. 2011

Clinical Research Training Institute Clinical Scholar for ASH. 2011

Award for Excellence in Teaching. 2009

Award for Excellence in Teaching. 2007

Frank C. Knievel Scholarship Award. 2001 - 2005

First Generation Diversity Scholarship. 1996 - 2001

Research

In my research laboratory, I am particularly interested in understanding the mechanisms that allow multiple myeloma to develop. I have created a system that lets us mimic in a laboratory, the growth of cancer cells that become multiple myeloma. By studying disease progression, my ultimate goal is ...
In my research laboratory, I am particularly interested in understanding the mechanisms that allow multiple myeloma to develop. I have created a system that lets us mimic in a laboratory, the growth of cancer cells that become multiple myeloma. By studying disease progression, my ultimate goal is to develop therapies to prevent multiple myeloma.

Clinical Trials

Phase III Study of Daratumumab/rHuPH20 (NSC- 810307) + Lenalidomide or Lenalidomide as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients with Multiple Myeloma (MM) Using Minimal Residual Disease to Direct Therapy Duration (DRAMMATIC Study)

Lead Researcher: Brea C Lipe

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidom...

A Phase III Randomized Trial for Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail or in a Subset of "Intermediate Fit" Comparing Upfront Three-Drug Induction Regimens Followed by Double or Single-Agent Maintenance

Lead Researcher: Brea C Lipe

This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail ...

Efficacy of Curcumin and Piperine in Patients on Active Surveillance for Either Monoclonal Gammopathy of Unknown Significance (MGUS), Low-risk Smoldering Multiple Myeloma (SMM) or Early Stage Prostate Cancer: A Pilot Study

Lead Researcher: Brea C Lipe

To explore the use of curcumin and piperine supplementation at a dose of 4 gram/5mg twice a day in early stage prostate cancer patient undergoing active surveillance or patients on observation for MGUS/ low-risk smoldering myeloma.

A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Talquetamab, a Humanized GPRC5D x CD3 Bispecific Antibody, in Subjects With Relapsed or Refractory Multiple Myeloma

Lead Researcher: Brea C Lipe

The purpose of this study is to evaluate the efficacy and safety of talquetamab in participants with relapsed or refractory multiple myeloma at the recommended Phase 2 dose(s) (RP2Ds) (Part 3).

Publications

Journal Articles

Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies.

Keren DF, Bocsi G, Billman BL, Etzell J, Faix JD, Kumar S, Lipe B, McCudden C, Montgomery R, Murray DL, Rai AJ, Redondo TC, Souter L, Ventura CB, Ansari MQ

Archives of pathology & laboratory medicine.. 2022 May 1146 (5):575-590. Epub 1900 01 01.

Bisphosphonates for delivering drugs to bone.

Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell G, McKenna CE, Ebetino FH

British journal of pharmacology.. 2021 May 178 (9):2008-2025. Epub 04/10/2021.

Management of Frail Older Adults with Newly Diagnosed Multiple Myeloma - Moving Toward a Personalized Approach.

Grant SJ, Lipe B

Clinical lymphoma, myeloma & leukemia.. 2020 September 20 Suppl 1 (Suppl 1):S76-S80. Epub 1900 01 01.

Integrating Touchscreen-Based Geriatric Assessment and Frailty Screening for Adults With Multiple Myeloma to Drive Personalized Treatment Decisions.

Nathwani N, Kurtin SE, Lipe B, Mohile SG, Catamero DD, Wujcik D, Birchard K, Davis A, Dudley W, Stricker CT, Wildes TM

JCO oncology practice.. 2020 January 16 (1):e92-e99. Epub 11/25/2019.

Selinexor, daratumumab, and dexamethasone in patients with relapsed or refractory multiple myeloma

Gasparetto, C; Lentzsch, S; Schiller, G; Callander, N; Tuchman, S; Chen, C; White, D; Kotb, R; Sutherland, H; Sebag, M; Baljevic, M; Bensinger, W; LeBlanc, R; Venner, C; Bahlis, N; Rossi, A; Biran, N; Sheehan, H; Saint-Martin, J; Van Domelen, D; Kai, K; Shah, J; Shacham, S; Kauffman, M; Lipe, B.

eJHaem. 2020; .

A review of thrombotic microangiopathies in multiple myeloma.

Lipe B, Passero FC, Gleber C, Portuguese AJ

Leukemia research.. 2019 October 85 :106195. Epub 07/29/2019.

Results of the First Clinical Study in Humans That Combines Hyperbaric Oxygen Pretreatment with Autologous Peripheral Blood Stem Cell Transplantation.

Lipe B, Divine C, Abhyankar S, Singh AK, Ganguly S, Lin TL, Baran A, Cantilena AR, Bhatti S, Shune L, Abdelhakim H, McGuirk J, Allin D, Aljitawi OS

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2019 September 25 (9):1713-1719. Epub 06/03/2019.

International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders.

Hillengass J, Usmani S, Rajkumar SV, Durie BGM, Mateos MV, Lonial S, Joao C, Anderson KC, GarcĂ­a-Sanz R, Riva E, Du J, van de Donk N, Berdeja JG, Terpos E, Zamagni E, Kyle RA, San Miguel J, Goldschmidt H, Giralt S, Kumar S, Raje N, Ludwig H, Ocio E, Schots R, Einsele H, Schjesvold F, Chen WM, Abildgaard N, Lipe BC, Dytfeld D, Wirk BM, Drake M, Cavo M, Lahuerta JJ, Lentzsch S

The Lancet. Oncology.. 2019 June 20 (6):e302-e312. Epub 1900 01 01.

Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline.

Mikhael J, Ismaila N, Cheung MC, Costello C, Dhodapkar MV, Kumar S, Lacy M, Lipe B, Little RF, Nikonova A, Omel J, Peswani N, Prica A, Raje N, Seth R, Vesole DH, Walker I, Whitley A, Wildes TM, Wong SW, Martin T

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2019 May 1037 (14):1228-1263. Epub 04/01/2019.

Decellularized Wharton jelly matrix: a biomimetic scaffold for ex vivo hematopoietic stem cell culture.

Li D, Chiu G, Lipe B, Hopkins RA, Lillis J, Ashton JM, Paul S, Aljitawi OS

Blood advances.. 2019 April 93 (7):1011-1026. Epub 1900 01 01.

Hemophagocytic Lymphohistiocytosis in a Patient With Multiple Myeloma.

Hsu CM, Bennett JM, Lipe B

Clinical lymphoma, myeloma & leukemia.. 2019 January 19 (1):e29-e32. Epub 09/05/2018.

Application of risk factors for venous thromboembolism in patients with multiple myeloma starting chemotherapy, a real-world evaluation.

Baker HA, Brown AR, Mahnken JD, Shireman TI, Webb CE, Lipe BC

Cancer medicine. 2019 January 8 (1):455-462. Epub 12/25/2018.

Induction Therapy for Newly Diagnosed Multiple Myeloma.

Paul B, Lipe B, Ocio EM, Usmani SZ

American Society of Clinical Oncology educational book. 2019 January 39 :e176-e186. Epub 05/17/2019.

Induction Therapy for Newly Diagnosed Multiple Myeloma.

Paul, B; Lipe, B; Ocio, EM; Usmani, SZ.

Am Soc Clin Oncol Educ Book. 2019; 39: e176-e186.

Carfilzomib-induced aHUS responds to early eculizumab and may be associated with heterozygous deletion.

Portuguese AJ, Lipe B

Blood advances.. 2018 December 112 (23):3443-3446. Epub 1900 01 01.

A novel extracellular matrix-based leukemia model supports leukemia cells with stem cell-like characteristics.

Li D, Lin TL, Lipe B, Hopkins RA, Shinogle H, Aljitawi OS

Leukemia research.. 2018 September 72 :105-112. Epub 08/16/2018.

Correlation between markers of bone metabolism and vitamin D levels in patients with monoclonal gammopathy of undetermined significance (MGUS).

Lipe B, Kambhampati S, Veldhuizen PV, Yacoub A, Aljitawi O, Mikhael J

Blood cancer journal.. 2017 December 147 (12):646. Epub 12/14/2017.

Combined deficiency of factor V and factor VIII: management during cardiothoracic surgery.

Howard C, Lipe B

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.. 2017 April 28 (3):267-268. Epub 1900 01 01.

Erythropoietin modulation is associated with improved homing and engraftment after umbilical cord blood transplantation.

Aljitawi OS, Paul S, Ganguly A, Lin TL, Ganguly S, Vielhauer G, Capitano ML, Cantilena A, Lipe B, Mahnken JD, Wise A, Berry A, Singh AK, Shune L, Lominska C, Abhyankar S, Allin D, Laughlin M, McGuirk JP, Broxmeyer HE

Blood.. 2016 December 22128 (25):3000-3010. Epub 10/19/2016.

The role of maintenance therapy in multiple myeloma.

Lipe B, Vukas R, Mikhael J

Blood cancer journal.. 2016 October 216 (10):e485. Epub 10/21/2016.

A pharmacokinetics and safety phase 1/1b study of oral ixazomib in patients with multiple myeloma and severe renal impairment or end-stage renal disease requiring haemodialysis.

Gupta N, Hanley MJ, Harvey RD, Badros A, Lipe B, Kukreti V, Berdeja J, Yang H, Hui AM, Qian M, Zhang X, Venkatakrishnan K, Chari A

British journal of haematology.. 2016 September 174 (5):748-59. Epub 05/16/2016.

Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma.

Palumbo A, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I, Hungria V, Munder M, Mateos MV, Mark TM, Qi M, Schecter J, Amin H, Qin X, Deraedt W, Ahmadi T, Spencer A, Sonneveld P,

The New England journal of medicine.. 2016 August 25375 (8):754-66. Epub 1900 01 01.

Monoclonal Gammopathy of Undetermined Significance (MGUS).

Lipe, B; Drurie, B.

Pocket Guide for American Society of Hematology. 2016; .

Phase I safety data of lenalidomide, bortezomib, dexamethasone, and elotuzumab as induction therapy for newly diagnosed symptomatic multiple myeloma: SWOG S1211.

Usmani SZ, Sexton R, Ailawadhi S, Shah JJ, Valent J, Rosenzweig M, Lipe B, Zonder JA, Fredette S, Durie B, Hoering A, Bartlett B, Orlowski RZ

Blood cancer journal.. 2015 August 75 (8):e334. Epub 08/07/2015.

IgG kappa monoclonal gammopathy of undetermined significance presenting as acquired type III Von Willebrand syndrome.

Howard CR, Lin TL, Cunningham MT, Lipe BC

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.. 2014 September 25 (6):631-3. Epub 1900 01 01.

Toward personalized medicine in acute myelogenous leukemia.

Lin, TL; Lipe, BC.

Personalized Medicine. 2013; 10(6): 427-430.

Bone marrow transplant for multiple myeloma: impact of distance from the transplant center.

Lipe BC, Lansigan F, Gui J, Meehan K

Clinical advances in hematology & oncology : H&O.. 2012 January 10 (1):28-32. Epub 1900 01 01.

Granulocytic sarcoma 12 years following allogeneic marrow transplant for AML.

Lipe BC, Cogbill E, Hill J, Meehan K

Clinical advances in hematology & oncology : H&O.. 2011 December 9 (12):948-51. Epub 1900 01 01.

Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin.

Lipe B, Ornstein DL

Circulation.. 2011 October 4124 (14):e365-8. Epub 1900 01 01.

Von Willebrand disease in pregnancy.

Lipe BC, Dumas MA, Ornstein DL

Hematology/oncology clinics of North America.. 2011 April 25 (2):335-58, viii. Epub 1900 01 01.

Lipoprotein lipase links dietary fat to solid tumor cell proliferation.

Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, Swinnen JV, Timmerman LA, Chaychi L, Fricano CJ, Eisenberg BL, Coleman WB, Kinlaw WB

Molecular cancer therapeutics.. 2011 March 10 (3):427-36. Epub 01/31/2011.

An overview of angiotensin-converting enzyme inhibitors in the treatment of hypertension.

Weber MA

The Journal of the American Osteopathic Association.. 1987 February 87 (2 Suppl):175-80. Epub 1900 01 01.

Ratings & Comments

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Ratings

During this visit, did this provider spend enough time with you?

4.9 stars

During this visit, did this provider show respect for what you had to say?

5.0 stars

During this visit did this provider give you easy to understand information about these health questions or concerns?

4.9 stars

During this visit, did this provider listen carefully to you?

5.0 stars

During this visit, did this provider explain things in a way that was easy to understand?

4.9 stars

Patient Comments

Seemed hurried; very fast and cursory meeting

Aug 02, 2024

Dr. Lipe is very patient answering any questions that are asked explaining in detail that is easily understood. Her sincerity and professional demeanor instill confidence that I'm being treated in the best place with the finest handpicked staff.

Jul 13, 2024

5.0 stars

I've been treated by Dr. Lipe for the past three years as she monitored [...]. My blood work recently indicated significant changes that prompted Dr. Lipe to schedule me for further diagnostic testing. Within a week of receiving test test results confirming that my disease had now progressed to actionable [...] I was scheduled for a consult with Dr. Lipe. My wife accompanied me to the appointment and Dr. Lipe answered all the questions we had, discussed treatment options, offered her recommendations based in large part on her understanding of what is importance to me and my lifestyle. I accepted her treatment recommendations without hesitation and that day immediately started chemotherapy. I feel very grateful to have had such attention to my care that allowed me to begin treatment before the onset of symptoms or irreversible damage. I could not have received better medical care for my condition than I've had from Dr. Lipe and the hematology-oncology team.

Jun 09, 2024

Always very good and we highly recommend Dr. Lipe.

Jun 02, 2024

5.0 stars

It was easy to see why Dr. Lipe has such an amazing reputation. She was able to get me transferred to her department after getting diagnosed [...]. She got me in quickly, and had a treatment plan ready to go so we could hit the ground running and fight the cancer right away. She was extremely informative in a way that was easy to understand, and she answered all of my questions. You can tell that she really cares about her patients and wants the best for them. Her passion for this is like nothing I've ever seen, I'm extremely lucky I get to call myself her patient and I look forward to working with her more.

May 08, 2024

5.0 stars

My recent visit included some proposed changes to my treatment plan. Dr Lipe provided excellent background, discussion, and options to consider. And a plan to move one step closer to deciding which plan is best. I have the opportunity to engage with others who have the same disease as I do (not associated with UR - through friend networks) and always make the recommendation to see Dr Lipe and team. For those who have made the switch, they have been extremely happy they did.

May 05, 2024

5.0 stars

Good

Mar 28, 2024

5.0 stars

[...] I would definitely recommended this physician [...] Positives points were very caring, clear presentation of symptoms and diagnosis.

Mar 24, 2024

5.0 stars

Very caring, pleasant and professional.

Jan 19, 2024

Always Very Good and Yes, We Do and We Would Recommend Dr. Bria Lipe.

Dec 21, 2023

5.0

All nice to me

Nov 30, 2023

5.0

Dr. Lipe answers all of our questions and explains things to us very effectively, She has been a major factor in my successful treatment.

Nov 13, 2023

5.0

Dr. Lipe was professional, caring and very thorough. Explained everything so I could understand.

Aug 30, 2023

5.0

I believe Dr Lipe to be the best possible provider for my disease.

Aug 01, 2023

5.0

Dr. Lipe is a wonderful doctor. Besides being very knowledgeable she is always interested in how I'm doing overall.

Jul 17, 2023

5.0

Dr. Lipe is excellent I would recommend her to anyone.

Jul 07, 2023

We have recommended Dr. Lipe to many others.

Jun 28, 2023

5.0

I have found the doctors, nurses, techs, and receptionists to all be helpful and professional during my visits.

Apr 23, 2023

5.0

Dr. Lipe has s a wonderful doctor and is an advocate for my health.

Mar 18, 2023

Yes we will recommend this care provider to others.

Mar 09, 2023

5.0

I have already recommended WCC.

Mar 04, 2023

I had been very concerned about the future of my Multiple Myeloma going forward however she explained what I could expect which put me at ease.

Feb 28, 2023

5.0

They explain everything I had questions about my health

Feb 09, 2023

5.0

Dr Lipe was great

Jan 30, 2023

5.0

I owe my life to Dr. Lipe and her staff I understand that she fought to get me into the Car T Therapy Trial which eventually got me back into remission from Multiple Myeloma

Jan 05, 2023

5.0

Very happy with my care, best doctor I could have.

Dec 29, 2022

5.0

Dr. Lipe is the best doctor who has cured me. She is a good person.

Nov 21, 2022

5.0

I have recommended Dr. Lipe to other people who have multiple myeloma

Nov 10, 2022

5.0

Always good.

Oct 18, 2022

5.0

Dr. Lipe is great

Oct 11, 2022

5.0

I am part of a Clinical Trial for Multiple Myeloma Dr. Lipe, and her PA Gina are very good at listening and getting answers to questions. I have recommended Dr. Lipe to several Multiple Myeloma patients that I have encountered.

Sep 15, 2022

1.0

No compassion - makes me sad [...]

Sep 15, 2022

5.0

Bria is fabulous. She didn't have an easy message for me that day and was great with my family and myself. She has the best plan available for me moving forward.

Sep 04, 2022

5.0

Best Dr. I have ever been to in my 79yrd

Aug 31, 2022

2.5

At times very negative, i.e., not hopeful. Not supportive.

Aug 18, 2022

5.0

Very capable provider; very knowledgeable & helpful & personable.

Aug 15, 2022

5.0

Dr. Lipe is the absolute best and her team! Phenomenal.

Aug 05, 2022

5.0

I am very lucky to have Dr. Lipe as my Oncologist she is very knowledgeable [...] and she has help put me into remission twice

Jun 25, 2022

Dr. Lipe is a specialist [...] and we value her expertise.

Jun 05, 2022

5.0

Never had a bad experience with this provider or her staff.

May 02, 2022

5.0

Dr Lipe is very caring person and listens to what patient has to say about my medical condition. If she does not have answer she gets back to me with answer to question.

Apr 28, 2022

5.0

Good

Apr 12, 2022

5.0

I have complete confidence and trust in my care

Apr 03, 2022

5.0

Dr. Lipe is excellent provider. Straight shooter - Aggressive.

Mar 18, 2022

5.0

Dr. Lipe is always prepared for my visits and interested in how feel and any problems. I am in remission from Multiple Myeloma and had been accepted into a Clinical trials for myeloma. I would recommend Dr. Lipe to anyone looking to be treated by Dr Lipe and her staff.

Mar 06, 2022

5.0

All comments made to me were very considerate & kind to me.

Feb 18, 2022

5.0

Dr. Lipe provides me with excellent care.

Feb 06, 2022