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Matthew D. McGraw, M.D.

Matthew D. McGraw, M.D.

Pediatrics , Pediatric Pulmonology

5 out of 5 stars
26 Ratings
1 Comment
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 275-2464
Fax (585) 275-8706
Administrative (585) 275-2464

About Me

Dr. McGraw's primary goal as a pediatric pulmonologist is to provide excellent care for all children and adolescents with underlying lung disease. He sees all patients with pediatric lung diseases including but not limited to cystic fibrosis, chronic lung disease of prematurity, and asthma. The pri...
Dr. McGraw's primary goal as a pediatric pulmonologist is to provide excellent care for all children and adolescents with underlying lung disease. He sees all patients with pediatric lung diseases including but not limited to cystic fibrosis, chronic lung disease of prematurity, and asthma. The primary focus of his basic science is better understanding the mechanisms of rare lung diseases, such as childhood interstitial lung disease (chILD) and bronchiolitis obliterans (BO), in order to identify new medical therapies.

Certified Specialties

Pediatric Pulmonology - American Board of Pediatrics

Faculty Appointments

Associate Professor - Department of Pediatrics, Pulmonology (SMD)

George Washington Goler Chair in Pediatrics - Department of Pediatrics (SMD)

Credentials

Residency & Fellowship

Fellowship, Pediatric Pulmonology, University of Colorado Hospital- GME. 2015 - 2018

Residency, Pediatrics, University of Virginia-Radiology GME. 2013 - 2015

Internship, Pediatrics, University of Virginia-Radiology GME. 2012 - 2013

Education

MD | SUNY Upstate College of Health Professions. 2012

Awards

George Washington Goler Endowed Chair, Department of Pediatrics. 2022 - 2023

Furth Award. 2020 - 2021

KL2 Award. 2020 - 2022

NIH Loan Repayment Program. 2019 - 2023

Keynote Speaker, 24th Annual Master's Program Preceptor Day. 2019 - 2019

Most Valuable Player, Pediatrics Residency Morning Report. 2019 - 2019

Best Research Poster, Junior Faculty. 2018

Society of Toxicology's Donald E. Gardner Inhalation Toxicology Education Award 2017. 2017

NIH T32 Training Grant, University of Colorado SOM, 2016 –2018. 2016 - 2018

Mulholland Resident and Fellow Teaching Award, Honorable Mention, 2015. 2015

American Academy of Pediatrics, Resident CATCH Implementation Grant, 2014 – 2015. 2014 - 2015

University of Virginia Pediatrics Resident Teaching Award, 2014 & 2015. 2014 - 2015

Gold Humanism Honor Society. 2011 - 2012

Bucknell University Department of Biomedical Engineering, Magna Cum Laude. 2008

Tau Beta Pi Engineering Honor Society. 2007 - 2008

Bucknell University Dean's List. 2005 - 2008

Research

Dr. McGraw's research involves understanding the mechanisms of aberrant airway epithelial repair after inhalation injuries. The primary pediatric lung disease studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal nar...
Dr. McGraw's research involves understanding the mechanisms of aberrant airway epithelial repair after inhalation injuries. The primary pediatric lung disease studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal narrowing and obliteration of the small airways, or bronchioles. Despite BO's high morbidity and mortality, very little is known about its pathogenesis, and even less is available in terms of prevention, intervention and treatment.

Inhalation agents used to study the mechanisms of aberrant airway epithelial repair include sulfur mustard (SM), a chemical warfare inhalation agent, and diacetyl, a volatile chemical in many flavorings. Both of these inhalation agents can cause bronchiolitis obliterans in children.

Basic science techniques include: small animal model development; primary airway epithelial cell isolation; flow sorting; 3D cell culture; single cell RNA sequencing.

Publications

Journal Articles

Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus.

McGraw MD, Yee M, Kim SY, Dylag AM, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 November 1323 (5):L578-L592. Epub 09/06/2022.

Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells.

Katzen J, Rodriguez L, Tomer Y, Babu A, Zhao M, Murthy A, Carson P, Barrett M, Basil MC, Carl J, Leach JP, Morley M, McGraw MD, Mulugeta S, Pelura T, Rosen G, Morrisey EE, Beers MF

Proceedings of the National Academy of Sciences of the United States of America.. 2022 October 25119 (43):e2123187119. Epub 10/17/2022.

Post-translational modifications to hemidesmosomes in human airway epithelial cells following diacetyl exposure.

Kim SY, McGraw MD

Scientific reports.. 2022 June 1312 (1):9738. Epub 06/13/2022.

Reduced plasma phosphatidylethanolamines in e-cigarette, or vaping, product use-associated lung injury (EVALI).

McGraw MD, Croft DP, Nacca NE, Rahman I

Pediatric pulmonology.. 2022 May 57 (5):1350-1354. Epub 03/09/2022.

Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study.

Podguski S, Kaur G, Muthumalage T, McGraw MD, Rahman I

ERJ open research.. 2022 April 8 (2)Epub 04/04/2022.

Fibrin airway cast obstruction: Experience, classification, and treatment guideline from Denver.

Liptzin DR, McGraw MD, Houin PR, Veress LA

Pediatric pulmonology.. 2022 February 57 (2):529-537. Epub 11/08/2021.

Proteomic Analysis of Human Lung Development.

Clair G, Bramer LM, Misra R, McGraw MD, Bhattacharya S, Kitzmiller JA, Feng S, Danna VG, Bandyopadhyay G, Bhotika H, Huyck HL, Deutsch GH, Mariani TJ, Carson J, Whitsett JA, Pryhuber GS, Adkins JN, Ansong C

American journal of respiratory and critical care medicine.. 2022 January 15205 (2):208-218. Epub 1900 01 01.

An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue.

Lukowski JK, Olson H, Velickovic M, Wang J, Kyle JE, Kim YM, Williams SM, Zhu Y, Huyck HL, McGraw MD, Poole C, Rogers L, Misra R, Alexandrov T, Ansong C, Pryhuber GS, Clair G, Adkins JN, Carson JP, Anderton CR

Frontiers in molecular biosciences.. 2022 9 :1022775. Epub 11/16/2022.

Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4CD25 T Cells in the Rat.

House EL, Kim SY, Johnston CJ, Groves AM, Hernady E, Misra RS, McGraw MD

Toxics.. 2021 December 209 (12)Epub 12/20/2021.

Weight loss in adolescents presenting with EVALI.

Nacca N, McGraw MD, Croft DP, Kalininskiy A

Pediatric pulmonology.. 2021 August 56 (8):2785-2786. Epub 06/08/2021.

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD

Archives of toxicology.. 2021 July 95 (7):2469-2483. Epub 05/24/2021.

E-cigarette exposures, respiratory tract infections, and impaired innate immunity: a narrative review.

Kalininskiy A, Kittel J, Nacca NE, Misra RS, Croft DP, McGraw MD

Pediatric medicine.. 2021 February 4 Epub 02/28/2021.

Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure.

McGraw MD, Kim SY, White CW, Veress LA

Annals of the New York Academy of Sciences.. 2020 November 1479 (1):223-233. Epub 05/14/2020.

Reply to McCarthy : Lipid-Laden Macrophages Are Not Diagnostic of Pulmonary Alveolar Proteinosis Syndrome and Can Indicate Lung Injury.

Israel AK, McGraw MD, Agrawal T

American journal of respiratory and critical care medicine.. 2020 October 15202 (8):1198-1199. Epub 1900 01 01.

Protein thiol oxidation in the rat lung following e-cigarette exposure.

Wang J, Zhang T, Johnston CJ, Kim SY, Gaffrey MJ, Chalupa D, Feng G, Qian WJ, McGraw MD, Ansong C

Redox biology.. 2020 October 37 :101758. Epub 10/10/2020.

A Unique Case of Secondary Pulmonary Alveolar Proteinosis after E-Cigarette, or Vaping, Product Use-associated Lung Injury.

Israel AK, Velez MJ, Staicu SA, Ambrosini R, McGraw M, Agrawal T

American journal of respiratory and critical care medicine.. 2020 September 15202 (6):890-893. Epub 1900 01 01.

Face Coverings in a Pandemic.

McGraw MD, Achanta S, Castner J, Gold DR, Hines SE, Redlich CA, Sockrider MM

American journal of respiratory and critical care medicine.. 2020 September 1202 (5):P17-P18. Epub 1900 01 01.

Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE.

Heymann PW, Platts-Mills TA, Woodfolk JA, Borish L, Murphy DD, Carper HT, Conaway MR, Steinke JW, Muehling L, Gerald TW, Kennedy JL, Irani AM, McGraw MD, Early SV, Wheatley LM, Adams AP, Turner RB

The Journal of allergy and clinical immunology.. 2020 September 146 (3):545-554. Epub 02/01/2020.

Pulmonary Toxicity and Inflammatory Response of E-Cigarette Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI.

Muthumalage T, Lucas JH, Wang Q, Lamb T, McGraw MD, Rahman I

Toxics.. 2020 June 288 (3)Epub 06/28/2020.

Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN

Toxicology letters.. 2020 June 1325 :25-33. Epub 02/26/2020.

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).

Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I

Toxics.. 2020 April 38 (2)Epub 04/03/2020.

E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach.

Croft DP, McGraw MD, Navarette KA, Marraffa J, Ginsberg G, Nacca NE, Bach CT, Kalininskiy A

The Lancet. Respiratory medicine.. 2019 December 7 (12):1017-1026. Epub 11/08/2019.

Marijuana medusa: The many pulmonary faces of marijuana inhalation in adolescent males.

McGraw MD, Houser GH, Galambos C, Wartchow EP, Stillwell PC, Weinman JP

Pediatric pulmonology.. 2018 December 53 (12):1619-1626. Epub 10/23/2018.

Developmental Origins of Chronic Lung Diseases. Mechanical Stretch, Micro-RNAs, and Hydrogels.

McGraw MD, Sherlock LG, Bailey KL, Abman SH

American journal of respiratory cell and molecular biology.. 2018 August 59 (2):267-270. Epub 1900 01 01.

The use of light's criteria in hospitalized children with a pleural effusion of unknown etiology.

McGraw MD, Robison K, Kupfer O, Brinton JT, Stillwell PC

Pediatric pulmonology.. 2018 August 53 (8):1101-1106. Epub 05/27/2018.

Reply to: Comment on "Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats".

McGraw MD, Veress LA

American journal of respiratory cell and molecular biology.. 2018 August 59 (2):274-275. Epub 1900 01 01.

Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats.

McGraw MD, Dysart MM, Hendry-Hofer TB, Houin PR, Rioux JS, Garlick RB, Loader JE, Smith R, Paradiso DC, Holmes WW, Anderson DR, White CW, Veress LA

American journal of respiratory cell and molecular biology.. 2018 June 58 (6):696-705. Epub 1900 01 01.

Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine-exposed Rats.

Okponyia OC, McGraw MD, Dysart MM, Garlick RB, Rioux JS, Murphy AL, Roe GB, White CW, Veress LA

American journal of respiratory cell and molecular biology.. 2018 January 58 (1):107-116. Epub 1900 01 01.

Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard.

McGraw MD, Osborne CM, Mastej EJ, Di Paola JA, Anderson DR, Holmes WW, Paradiso DC, Garlick RB, Hendry-Hofer TB, Rancourt RC, Smith RW, Burns C, Roe GB, Rioux JS, White CW, Veress LA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 October 1159 (2):461-469. Epub 1900 01 01.

Uremic pleuritis: A case report and review of recurrent exudative pleural effusions in children.

McGraw MD, Galambos C, Stillwell PC

Pediatric pulmonology.. 2017 September 52 (9):E52-E54. Epub 04/25/2017.

From the Cover: ImpairedProliferation and Differentiation of the Conducting Airway Epithelium Associated With Bronchiolitis Obliterans After Sulfur Mustard Inhalation Injury in Rats.

McGraw MD, Rioux JS, Garlick RB, Rancourt RC, White CW, Veress LA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 June 1157 (2):399-409. Epub 1900 01 01.

Inner-city asthma: special considerations for management.

Dutmer CM, McGraw MD, Liu AH

Current opinion in allergy and clinical immunology.. 2016 April 16 (2):148-56. Epub 1900 01 01.

Activation of human neutrophil Mac-1 by anion substitution.

Lomakina E, Knauf PA, Schultz JB, Law FY, McGraw MD, Waugh RE

Blood cells, molecules & diseases.. 2009 42 (3):177-84. Epub 02/25/2009.

E-cigarette exposures, respiratory tract infections, and impaired innate immunity: a narrative review

Kalininskiy, A.; Kittel J; Nacca NE; Misra RS; Croft DP; McGraw MD.

Pediatric Medicine. .

Ratings & Comments

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Ratings

During this visit, did this provider spend enough time with you?

4.9 stars

During this visit, did this provider show respect for what you had to say?

5.0 stars

During this visit did this provider give you easy to understand information about these health questions or concerns?

5.0 stars

During this visit, did this provider listen carefully to you?

5.0 stars

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5.0 stars

Patient Comments

5.0 stars

Dr. Mcgraw is excellent - We feel so grateful for his care for our daughter!

Aug 05, 2022