UR Medicine Faculty
The University of Rochester Medical Faculty Group
(URMFG) consists of over 900 specialist and primary care providers spanning 19
departments.
URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner
Accountable Health Partners (AHP) is a network of
over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the
region. AHP offers a full range of care.
As a clinician, educator, and researcher in pulmonary and critical care medicine, I strive to improve the health of individuals with respiratory diseases significantly. With nearly 12 years of experience as an associate professor of medicine at the University of Buffalo and now as a faculty member a...
As a clinician, educator, and researcher in pulmonary and critical care medicine, I strive to improve the health of individuals with respiratory diseases significantly. With nearly 12 years of experience as an associate professor of medicine at the University of Buffalo and now as a faculty member at the University of Rochester, I am dedicated to fostering excellence in education. My role involves teaching medical students, residents, and fellows, ensuring they acquire the necessary skills and knowledge to provide high-quality care to patients with pulmonary diseases and critical illnesses.
In my clinical practice, primarily at Strong Memorial Hospital, I provide comprehensive care to patients with various pulmonary conditions, including ARDS, asthma, COPD, interstitial lung disease, pleural disease, pulmonary hypertension, and lung cancer. Additionally, I am actively involved in the Mary Parkes Asthma Center, evaluating patients in the outpatient setting who present with pulmonary disorders. Collaborating with a dedicated team of healthcare professionals, I strive to deliver exceptional care across multiple practice locations.
Beyond my clinical, research, and educational activities, I am dedicated to leadership and service in the field. As an executive board member of the New York State Thoracic Society (NYSTS), I have held positions such as program chair of the annual conference, secretary, treasurer, vice president and currently serve as the president-elect. Additionally, I am a chapter council representative to the ATS and have served as the president of the ATS's Council of Chapters Committee and ATS board of directors. These roles allow me to contribute to the advancement of the field, impact global health, and transform patient care.
In summary, my passion lies in advancing the field of pulmonary and critical care medicine through clinical practice, research, education, leadership, and service. My focus on computational approaches, multi-omic data analysis, and guideline development allows me to make significant contributions to understanding COPD pathogenesis, identifying therapeutic targets, and improving patient outcomes. I strive to empower the next generation of healthcare professionals to provide exceptional care through my dedication to education and professional development.
Certified Specialties
Critical Care Medicine
- American Board of Internal Medicine
Internal Medicine
- American Board of Internal Medicine
Pulmonary Disease
- American Board of Internal Medicine
Faculty Appointments
Associate Professor
-
Department of Medicine, Pulmonary Diseases and Critical Care (SMD)
Credentials
Residency & Fellowship
Fellowship, National Cancer Institute/National Institute of Health. 2016 - 2018
Fellowship, Buffalo General Hospital-Kaleida Health. 2014 - 2016
Fellowship, Pulmonary and Critical Care Medicine, Baylor College of Medicine-Pulmonary/Critical Care Fellowship. 2007 - 2010
Residency, Internal Medicine, Baylor College of Medicine. 2005 - 2007
Internship, Internal Medicine, Baylor College of Medicine. 2004 - 2005
Education
MS | SUNY at Buffalo-School of Medicine & Biomedical Sciences (USA).Medical Genetics, Clinical Genetics (M.D.).2016
MD | Rutgers New Jersey Medical School.2004
Research
Throughout my research career, I have been engaged in a diverse range of studies and clinical trials aimed at advancing our understanding of various diseases and enhancing patient outcomes. These endeavors have been supported by prestigious organizations, including the National Institutes of Health ...
Throughout my research career, I have been engaged in a diverse range of studies and clinical trials aimed at advancing our understanding of various diseases and enhancing patient outcomes. These endeavors have been supported by prestigious organizations, including the National Institutes of Health (NIH), the National Center for Advancing Translational Sciences (NCATS), and the Department of Defense (DoD) . The recognition and funding provided by these esteemed agencies have empowered me to conduct innovative investigations and make significant contributions to the field.
One of the main focuses of my research has been chronic obstructive pulmonary disease (COPD), a complex respiratory condition associated with significant morbidity and mortality. Collaborating with renowned experts, I have explored the intricate mechanisms driving COPD pathogenesis, particularly the network biology of pathogen-host interactions during disease exacerbations. As a co-investigator, I have played a crucial role in analyzing transcriptome and microbiome data obtained from clinical samples. This research, funded by esteemed organizations, aims to uncover novel insights into COPD exacerbations and identify potential therapeutic targets.
Additionally, I have actively contributed to the study of COVID-19, a global pandemic that has posed significant challenges to healthcare systems worldwide. As a site principal investigator, I have made substantial contributions to two prominent clinical trials investigating potential treatments for COVID-19. These trials, funded by the NIH and NCATS/NIH, are evaluating the efficacy and safety of immune-based interventions for COVID-19. My responsibilities have included overseeing trial selection, site activation, and study execution, with a focus on maximizing enrollment and data quality. The outcomes of these trials have the potential to shape treatment strategies and improve patient outcomes.
Furthermore, I have explored the connection between the airway microbiome and lung cancer in a COPD cohort, offering valuable insights into the complex relationships between these conditions.
In my research, I have also focused on investigating the role of galectin-3 in asthma. Galectin-3 is a protein involved in inflammation and tissue remodeling. By studying its implications in asthma, I aim to gain insights into the underlying mechanisms of the disease and potentially identify novel therapeutic targets. This research contributes to our understanding of asthma pathogenesis and may lead to the development of more effective treatment strategies for individuals with this chronic respiratory condition.
In addition to translational and clinical research, I actively engage in developing and implementing clinical practice guidelines, utilizing the GRADE methodology, and advancing evidence-based medicine. As a member of the American Thoracic Society (ATS), I have played a critical role in creating guidelines for the treatment of COPD and interstitial lung disease. I additionally co-authored surviving sepsis guidelines for COVID-19 management during the COVID-19 pandemic. These guidelines, based on rigorous evaluation of the available evidence, optimize patient care and ensure standardized approaches to management.
In summary, my research journey is dedicated to unraveling the complexities of respiratory diseases, identifying therapeutic targets, and making meaningful contributions to patient care. Through collaborations, funding support, and guideline development, I aim to transform patient care, improve outcomes, and shape the future of pulmonary medicine.
Thomas P, Alexander PE, Ahmed U, Elderhorst E, El-Khechen H, Mammen MJ, Debono VB, Aponte Torres Z, Aryal K, Brocard E, Sagastuy B, Alhazzani W
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.. 2022 June 35 (12):2387-2394. Epub 07/01/2020.
Raghu G, Remy-Jardin M, Richeldi L, Thomson CC, Inoue Y, Johkoh T, Kreuter M, Lynch DA, Maher TM, Martinez FJ, Molina-Molina M, Myers JL, Nicholson AG, Ryerson CJ, Strek ME, Troy LK, Wijsenbeek M, Mammen MJ, Hossain T, Bissell BD, Herman DD, Hon SM, Kheir F, Khor YH, Macrea M, Antoniou KM, Bouros D, Buendia-Roldan I, Caro F, Crestani B, Ho L, Morisset J, Olson AL, Podolanczuk A, Poletti V, Selman M, Ewing T, Jones S, Knight SL, Ghazipura M, Wilson KC
American journal of respiratory and critical care medicine.. 2022 May 1205 (9):e18-e47. Epub 1900 01 01.
Khor YH, Bissell B, Ghazipura M, Herman D, Hon SM, Hossain T, Kheir F, Knight SL, Kreuter M, Macrea M, J Mammen M, Molina-Molina M, Selman M, Wijsenbeek M, Raghu G, Wilson KC
Annals of the American Thoracic Society.. 2022 May 19 (5):833-844. Epub 1900 01 01.
Alhazzani W, Evans L, Alshamsi F, Møller MH, Ostermann M, Prescott HC, Arabi YM, Loeb M, Ng Gong M, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Machado F, Wunsch H, Crowther M, Cecconi M, Koh Y, Burry L, Chertow DS, Szczeklik W, Belley-Cote E, Greco M, Bala M, Zarychanski R, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Nainan Myatra S, Arrington A, Kleinpell R, Citerio G, Lewis K, Bridges E, Memish ZA, Hammond N, Hayden FG, Alshahrani M, Al Duhailib Z, Martin GS, Kaplan LJ, Coopersmith CM, Antonelli M, Rhodes A
Critical care medicine.. 2021 March 149 (3):e219-e234. Epub 1900 01 01.
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A
Critical care medicine.. 2020 June 48 (6):e440-e469. Epub 1900 01 01.
Nici L, Mammen MJ, Charbek E, Alexander PE, Au DH, Boyd CM, Criner GJ, Donaldson GC, Dreher M, Fan VS, Gershon AS, Han MK, Krishnan JA, Martinez FJ, Meek PM, Morgan M, Polkey MI, Puhan MA, Sadatsafavi M, Sin DD, Washko GR, Wedzicha JA, Aaron SD
American journal of respiratory and critical care medicine.. 2020 May 1201 (9):e56-e69. Epub 1900 01 01.
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A
Intensive care medicine.. 2020 May 46 (5):854-887. Epub 03/28/2020.
Hesselbacher SE, Ross R, Schabath MB, Smith EO, Perusich S, Barrow N, Smithwick P, Mammen MJ, Coxson H, Krowchuk N, Corry DB, Kheradmand F
International journal of environmental research and public health.. 2011 May 8 (5):1324-40. Epub 04/29/2011.
Ratings & Comments
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aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying
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Ratings
Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)
4.8 stars
Likelihood of recommending this care provider to others
4.9 stars
Explanations the care provider gave you about your problem or condition
4.9 stars
Care provider's efforts to include you in decisions about your care
4.9 stars
Concern the care provider showed for your questions or worries
4.9 stars
Patient Comments
5.0 stars
Dr Mammen is amazing!
Jan 05, 2024
5.0 stars
Mr. Mammen is an outstanding doctor. In one visit he addresses a number of issues and is extremely efficient. I am so lucky to have help from this provider!!!
Nov 17, 2023
Dr. Mammen has been fantastic with everything. He explains things very well and always checks to see if I have any questions.
Jun 16, 2023
5.0 stars
This provider is a specialist and if someone ask me who did I see for my pulmonary problem I will recommend.
Jun 02, 2023
5.0 stars
Dr. Mammen is the best provider I have had at URMC. He is a very kind person.
Apr 06, 2023
5.0 stars
He is very polite & shows true concern, also, very knowledgeable.
Feb 23, 2023
5.0 stars
Excellent listening skills thorough explanations of conditions.
Feb 16, 2023
Dr. Mammen is very good at explaining this condition and the treatment plan very well to me.
Feb 13, 2023
5.0 stars
He was awesome. He spent time and actually listened to me.
