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Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in...
Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in rheumatoid arthritis. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.
Certified Specialties
Rheumatology
- American Board of Internal Medicine
Faculty Appointments
Professor
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Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Associate Chair, Research
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Department of Medicine (SMD)
Interim Division Chief
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Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Professor
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Department of Microbiology and Immunology (SMD) - Joint
Professor
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Department of Pathology and Laboratory Medicine (SMD) - Joint
Fellowship, Rheumatology, University of Rochester Medical Center. 1999 - 2001
Residency, Internal Medicine, University of Rochester Medical Center. 1997 - 1999
Internship, Internal Medicine, University of Rochester Medical Center. 1996 - 1997
Education
MD | University of Rochester School of Medicine/Dentistry (USA).1996
PhD | University of Rochester School of Medicine/Dentistry (USA).Medical Biochemical Genetics.1994
Awards
American Society for Clinical Investigation.2015
Eisenberg Memorial Lupus Lectureship.2008
Lawrence Kohn Senior Teaching Fellow.2006 - 2008
Edmund Dubois Memorial Lectureship Award.2005
Buswell Fellowship.2003
Rheumatology Fellow Award.2001
NIH Training Grant T32-AI07169-16.2000 - 2002
Stuber Fellowship.1999 - 2000
Raphael Dolin Resident Research Award.1999
Medical Scientist Training Program Scholarship.1994 - 1996
Stotz Fellowship.1991 - 1992
Medical Scientist Training Program Scholarship.1988 - 1990
Phi Beta Kappa.1988
Sigma Xi Scientific Research Society.1988
Outstanding Senior Chemistry Student Award.1988
Dean's Letter of Recognition.1988 - 1989
Summer Research Fellowship.1987
Research
Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compa...
Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.
Research Lab
The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity.
You may be eligible to take part in the study because you have an autoimmune disease known as “lupus.” In autoimmune diseases, the immune system sees the body’s own tissues as “foreign” and attacks itself, resulting in inflammation. Systemic lupus er...
Bell RD, Brendel M, Konnaris MA, Xiang J, Otero M, Fontana MA, Bai Z, , Krenitsky DM, Meednu N, Rangel-Moreno J, Scheel-Toellner D, Carr H, Nayar S, McMurray J, DiCarlo E, Anolik JH, Donlin LT, Orange DE, Kenney HM, Schwarz EM, Filer A, Ivashkiv LB, Wang F
Nature communications.. 2024 August 2915 (1):7503. Epub 08/29/2024.
Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH, , Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE
Science translational medicine.. 2024 April 1016 (742):eadk3506. Epub 04/10/2024.
Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, Gutierrez-Arcelus M, Eisenhaure TM, Guthridge J, Hoover PJ, Dall'Era M, Wofsy D, Kamen DL, Kalunian KC, Furie R, Belmont M, Izmirly P, Clancy R, Hildeman D, Woodle ES, Apruzzese W, McMahon MA, Grossman J, Barnas JL, Payan-Schober F, Ishimori M, Weisman M, Kretzler M, Berthier CC, Hodgin JB, Demeke DS, Putterman C, , Brenner MB, Anolik JH, Raychaudhuri S, Hacohen N, James JA, Davidson A, Petri MA, Buyon JP, Diamond B, Zhang F, Lederer JA, Rao DA
bioRxiv : the preprint server for biology.. 2024 March 9 Epub 03/09/2024.
Fava A, Buyon J, Magder L, Hodgin J, Rosenberg A, Demeke DS, Rao DA, Arazi A, Celia AI, Putterman C, Anolik JH, Barnas J, Dall'Era M, Wofsy D, Furie R, Kamen D, Kalunian K, James JA, Guthridge J, Atta MG, Monroy Trujillo J, Fine D, Clancy R, Belmont HM, Izmirly P, Apruzzese W, Goldman D, Berthier CC, Hoover P, Hacohen N, Raychaudhuri S, Davidson A, Diamond B, , Petri M
JCI insight.. 2024 January 239 (2)Epub 01/23/2024.
Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K, , Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Luo Y, Sakaue S, Raychaudhuri S
Nature genetics.. 2023 December 55 (12):2255-2268. Epub 11/30/2023.
Kang JB, Shen AZ, Sakaue S, Luo Y, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta K, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K, , Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Raychaudhuri S
medRxiv : the preprint server for health sciences.. 2023 March 20 Epub 03/20/2023.
Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL
Frontiers in immunology.. 2023 14 :1237498. Epub 08/25/2023.
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S, Donlin LT, Raychauduri S, Bombardieri M, Pitzalis C, Orange DE, , McDavid A, Anolik JH
Cell reports.. 2022 May 339 (5):110766. Epub 1900 01 01.
Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine D, Arazi A, Berthier CC, Davidson A, James JA, Diamond B, Hacohen N, Wofsy D, Raychaudhuri S, Apruzzese W, , Buyon J, Petri M
Arthritis & rheumatology.. 2022 May 74 (5):829-839. Epub 04/16/2022.
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Eun-Hyung Lee F, Boss JM, Lund FE, Sanz I
Immunity.. 2020 January 1452 (1):203. Epub 1900 01 01.
Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA,
JCI insight.. 2019 October 174 (20)Epub 10/17/2019.
Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B,
Nature immunology.. 2019 October 20 (10):1404. Epub 1900 01 01.
Dieudonné Y, Gies V, Guffroy A, Keime C, Bird AK, Liesveld J, Barnas JL, Poindron V, Douiri N, Soulas-Sprauel P, Martin T, Meffre E, Anolik JH, Korganow AS
Journal of autoimmunity.. 2019 August 102 :150-158. Epub 05/10/2019.
Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B,
Nature immunology.. 2019 July 20 (7):902-914. Epub 06/17/2019.
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Lee FE, Boss JM, Lund FE, Sanz I
Immunity.. 2018 October 1649 (4):725-739.e6. Epub 10/09/2018.
Gies V, Schickel JN, Jung S, Joublin A, Glauzy S, Knapp AM, Soley A, Poindron V, Guffroy A, Choi JY, Gottenberg JE, Anolik JH, Martin T, Soulas-Sprauel P, Meffre E, Korganow AS
TLR9 stimulation adversely impacts B cell depletion and reconstitution in the mouse
Wang, R.; Owen, T.; Bekar, K.; Anolik, J.
In preparation. .
Ratings & Comments
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Ratings
Concern the care provider showed for your questions or worries
4.7 stars
Care provider's efforts to include you in decisions about your care
4.7 stars
Explanations the care provider gave you about your problem or condition
4.7 stars
Likelihood of recommending this care provider to others
4.7 stars
Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)
4.7 stars
Patient Comments
5.0 stars
Dr. Anolik has been my doctor for more that 15 years. You can't better than Dr. Anolik
Oct 21, 2024
5.0 stars
She is a very knowledgeable doctor about my health.
Jun 07, 2024
5.0 stars
I have recommended Dr. Anolik several times with excellent results.
Mar 01, 2023
5.0 stars
Dr. Anolik is the best!
Oct 12, 2022
3.8 stars
Provide timeliness response regarding blood work.
Sep 27, 2022
5.0 stars
Dr. Anolik always spends enough time with patients and is an excellent listener.
Aug 31, 2022
5.0 stars
Dr. Anolik is the bomb!! She helped me she's great!!