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Dr. Mark Frampton is Professor Emeritus of Medicine in Pulmonary and Critical Care at the University of Rochester Medical Center. He received his MD from New York University School of Medicine and then trained in Internal Medicine at Buffalo General Hospital. After nine years of private practice in ...
Dr. Mark Frampton is Professor Emeritus of Medicine in Pulmonary and Critical Care at the University of Rochester Medical Center. He received his MD from New York University School of Medicine and then trained in Internal Medicine at Buffalo General Hospital. After nine years of private practice in Williamson, New York, he completed Pulmonary and Critical Care training at the University of Rochester, and then joined the faculty. His research focuses on the human health effects of air pollution.
Dr. Frampton directed the NIH-funded training program in pulmonary research at the Medical Center for several years. He is former director the Pulmonary Function Laboratory at Strong Memorial Hospital, and previously served as the Associate Director of the Clinical Research Center at the University of Rochester.
Dr. Frampton continues to see outpatients with pulmonary disease, and to teach Pulmonary and Critical Care trainees. He has a special interest in tuberculosis, having directed the Wayne County Tuberculosis Clinic for more than 30 years, and has been caring for patients with tuberculosis infection and disease at the Monroe County Health Department for more than 25 years.
Certified Specialties
Internal Medicine
- American Board of Internal Medicine
Pulmonary Disease
- American Board of Internal Medicine
Faculty Appointments
Professor Emeritus
-
Department of Medicine, Pulmonary Diseases and Critical Care (SMD)
Credentials
Residency & Fellowship
Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 1985 - 1988
Residency, Internal Medicine, University at Buffalo. 1974 - 1976
Internship, Internal Medicine, University at Buffalo. 1973 - 1974
Education
MD | New York University School of Medicine.1973
Awards
Thomas T. Mercer Joint Prize Award.2020
Fellow.1974
Research
Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. With each breath, gaseous and particulate contaminants in that air gain access to the body, with both short- and long-term effects on human health. Dr. Frampton and his colleagues at URMC have studied air p...
Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. With each breath, gaseous and particulate contaminants in that air gain access to the body, with both short- and long-term effects on human health. Dr. Frampton and his colleagues at URMC have studied air pollution effects on respiratory function, host defense against infection, airway and systemic inflammation, and cardiovascular function. Volunteers are invited to participate in studies of environmentally relevant concentrations of pollutants, using both environmental chamber and mouthpiece exposure systems, at rest and during exercise.
Ultrafine particles (UFP, less than 100 nm diameter) may be particularly important with regard to cardiovascular effects because of their potential for evading clearance mechanisms and entering the lung interstitium and vascular space. We have demonstrated in healthy nonsmokers that inhalation of low concentrations of UFP causes changes in leukocyte expression of adhesion molecules, and reductions in the pulmonary diffusing capacity, that are consistent with altered pulmonary vascular function. In people with type 2 diabetes, inhalation of carbon UFP altered heart rate and heart rate variability in comparison with clean air.
Inhalation of the gaseous pollutant, ozone, has been linked with cardiovascular effects. Dr. Frampton directed the University of Rochester Medical Center's participation in the first multi-center human controlled exposure study of ozone, the “Multicenter Ozone Exposure study in oldEr Subjects (MOSES)”, funded by the Health Effects Institute. This study, using novel, noninvasive markers of cardiac and vascular function to study low concentrations of ozone in healthy older volunteers, found effects of ozone on pulmonary function, but not on cardiovascular function in these participants. Findings from these human controlled exposure studies help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards.
Dr. Frampton is currently a chartered member of the Clean Air Scientific Advisory Committee (CASAC), which advises the U.S. Environmental Protection Agency on issues relevant to national air quality standards. In 2020 he was the recipient of the Mercer Joint Prize Award from the American Association for Aerosol Research and the International Society for Aerosols in Medicine.
Thurston GD, Kipen H, Annesi-Maesano I, Balmes J, Brook RD, Cromar K, De Matteis S, Forastiere F, Forsberg B, Frampton MW, Grigg J, Heederik D, Kelly FJ, Kuenzli N, Laumbach R, Peters A, Rajagopalan ST, Rich D, Ritz B, Samet JM, Sandstrom T, Sigsgaard T, Sunyer J, Brunekreef B
The European respiratory journal.. 2017 January 49 (1)Epub 01/11/2017.
Multicenter Ozone Study in oldEr Subjects (MOSES). Part 1. Effects of exposure to low concentrations of ozone on respiratory and cardiovascular outcomes.
Frampton MW; Balmes JR; Bromberg PA; Stark P; Arjomandi M; Hazucha MJ; Rich DQ; Hollenbeck-Pringle D; Alexis N; Ganz P; Zareba W; Costantini MG.
Health Effects Institute Research Report. 2017; 192.
US EPA particulate matter research centers: summary of research results for 2005–2011
Patrick N. Breysse; Ralph J. Delfino; Francesca Dominici; Alison C. P. Elder; Mark W. Frampton; John R. Froines; Alison S. Geyh; John J. Godleski; Diane R. Gold; Philip K. Hopke; Petros Koutrakis; Ning Li; Günter Oberdörster; Kent E. Pinkerton; Jonathan M. Samet; Mark J. Utell; Anthony S. Wexler.
Air Qual Atmos Health. 2013; 6: 333-355.
Understanding the Health Effects of Ambient Ultrafine Particles.
HEI Review Panel on Ultrafine Particles.
HEI Perspectives 3. Health Effects Institute. 2013; .
Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecular to Meta Analysis. INIS Monographs, Fraunhofer IRB Verlag, Stuttgart, Germany. 2004; : 181-194.
Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G
American journal of respiratory and critical care medicine.. 1997 January 155 (1):116-21. Epub 1900 01 01.
Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study
Research report. 1994 November (70):37-93, discussion 95-112. Epub 1900 01 01.
Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma
New York state journal of medicine.. 1981 July 81 (8):1179-82. Epub 1900 01 01.
Books
Cardiovascular effects of inhaled ultrafine and nano-sized particles
(2011)
Chapter: "Human exposure studies"
Authors: Langrish, JP; Frampton, MW; Blomberg, A.
Publisher:
John Wiley & Sons, Hoboken, NJ 2011
Environmental and occupational medicine
(1992)
Chapter: Sulfur dioxide and sulfuric acid aerosols
Authors: Utell MJ; Frampton MW
Publisher:
Little, Brown & Co, Boston 1992
Susceptibility to inhaled pollutants
(1989)
Chapter: Respiratory infection and oxidants
Authors: Frampton MW, Roberts NJ Jr.
Publisher:
American Society for Testing and Materials, Philadelphia 1989
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