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Jill M. Cholette, M.D.

Pediatrics , Pediatric Cardiology , Pediatric Critical Care

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Jill M. Cholette, M.D.

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About Me
Credentials
Research
Publications
Ratings & Comments

About Me

Thrombosis
Hemostasis
Inflammation

Faculty Appointments

Professor - Department of Pediatrics, Critical Care (SMD)

Gordon Family Professor in Pediatrics - Department of Pediatrics, Critical Care (SMD)

Credentials

Residency & Fellowship

Fellowship, Pediatric Cardiology, University of Rochester Medical Center. 2011 - 2014

Fellowship, Pediatric Critical Care Medicine, University of Rochester Medical Center. 2003 - 2006

Residency, Pediatrics, Internal Medicine, University of Rochester Medical Center. 2000 - 2003

Internship, Pediatrics, Internal Medicine, University of Rochester Medical Center. 1999 - 2000

Education

MD | University of Rochester School of Medicine/Dentistry (USA). 1999

Awards

Therapeutics Specialty Award. 2012

Research Citation Finalist. 2012

Strong Children's Research Center New Investigator. 2007 - 2010

Clausen-Bradford Fellowship Training Award. 2005

David A. Haller Award - outstanding devotion and contribution to patient care. 2000 - 2000

Alpha Omega Alpha Honors Medical Society. 1999

The Bryce Collier Prize (student whose performance demonstrates exceptional qualities of responsibility. 1999

The Benjamin Rush Prize (4th yr med student who gave unusual promise of creative scholars. 1999

The Glasgow Citation (awarded by the American Medical Women's Assoc to those whose academic work is high quality. 1999

American Medical Women's Association Award. 1999

Sigma Xi, The Scientific Research Society. 1995

Psi Chi, The National Honor Society in Psychology. 1994

Sarah Williston Scholar for academic excellence. 1993

Who's Who Among Students in American Universities & Colleges. 1993 - 1994

Abbey Howe Turner Award excellence in biological sciences. 1992

Research

Dr. Jill Cholette has research interests in thrombosis and use of blood products in critically ill pediatric patients, particularly those undergoing cardiac surgery. Dr. Cholette is working to clarify the role of inflammation in the development of thrombosis, and to determine the optimal anticoagulation regimen for the pediatric post-op cardiac surgery patient.

Her other work involves blood utilization in the pediatric ICU patient, and she is developing a transfusion strategy for the pediatric post-op cardiac surgery patients.

Dr. Cholette's clinical interests are: thrombosis, hemostasis, and inflammation.

Scientific Reviewer for Pediatric Clinical Research Organization (PCRO) at URMC 2009-present

Scientific Reviewer for Strong Children's Research Center Small Grant Program URMC June 2013

Journal Reviewer:
The Annals of Thoracic Surgery 2007-present
Thrombosis Research 2008-present
Postgraduate Medicine 2009-present

Pediatric Acute Lung Injury and Sepsis (PALISI) Member
March 2010-present

Pediatric Blood Research Network (BLOOD NET) Member
September 2011-present

Prevalence of Acute critical Neurologic disease in children: a Global Epidemiological Assessment (PANGEA). November 2011-present; PI: Erika Fink; University of Pittsburgh
Site PI: Jill M. Cholette

Prophylaxis against thrombosis practice (PROTRACT) Study February 2012-present
PI: Vince Faustino MD; Yale University Site PI: Jill M. Cholette

Ongoing studies:
Prospective randomized controlled clinical trial comparing a restrictive v. liberal transfusion strategy in neonates and infants undergoing surgery for congenital heart disease. Principle Investigator: Cholette JM

Impact of washed blood on outcomes in adults with acute leukemia.
Co-principle investigator: Cholette JM

Comparing Ultrasound Dilution with Fick Principle in Assessing Cardiac Output and Shunt Fraction in Patients with Congenital Heart Disease.
Co-investigator Cholette JM.

Identification and significance of biologic mediators in red cell concentrates.
Co-investigator: Cholette JM

An investigation of the adverse effects of the storage age of RBC transfusions to critically ill medical patients.
Co-investigator: Cholette JM

Clinical Trials

ECMO Hemostatic Transfusions in Children

Lead Researcher: Jill Marie Cholette

Hospitalized children who need help breathing often get platelet transfusions to prevent bleeding. However, these transfusions can also cause problems. This study is looking at two different ways of giving platelet transfusions to sick children to se...

Publications

Journal Articles

Changes in Neonatal Intraoperative Electroencephalogram Alpha: Delta Ratios Precede Neurologic Injury.

Swartz MF, Lansinger J, Scheffler EJ, Duncan A, Cholette JM, Yoshitake S, Alfieris GM

World journal for pediatric & congenital heart surgery.. 2025 January 16 (1):21-29. Epub 09/12/2024.

Quantitative Electroencephalography Alpha:Delta Ratio and Suppression Ratio Monitoring During Infant Aortic Arch Reconstruction.

Lansinger J, Swartz MF, Scheffler EJ, Duncan A, Cholette JM, Yoshitake S, Clifford HS, Wang H, Alfieris GM

Pediatric neurology.. 2024 December 9163 :96-103. Epub 12/09/2024.

Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.

Faustino EVS, Kandil SB, Leroue MK, Sochet AA, Kong M, Cholette JM, Nellis ME, Pinto MG, Chegondi M, Ramirez M, Schreiber H, Kerris EWJ, Glau CL, Kolmar A, Muisyo TM, Sharathkumar A, Polikoff L, Silva CT, Ehrlich L, Navarro OM, Spinella PC, Raffini L, Taylor SN, McPartland T, Shabanova V,

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2024 November 19 Epub 11/19/2024.

Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors.

Tonna JE, Boonstra PS, MacLaren G, Paden M, Brodie D, Anders M, Hoskote A, Ramanathan K, Hyslop R, Fanning JJ, Rycus P, Stead C, Barrett NA, Mueller T, Gómez RD, Malhotra Kapoor P, Fraser JF, Bartlett RH, Alexander PMA, Barbaro RP,

ASAIO journal : a peer-reviewed journal of the American Society for Artificial Internal Organs.. 2024 February 170 (2):131-143. Epub 01/05/2024.

Antithrombin activity and central venous catheter-associated thrombosis in critically ill children at high risk of bleeding.

Quinn T, Cholette JM, Pinto MG, Schreiber H, Madden MA, Bennett E, Kolmar A, Poole A, Silva CT, Ehrlich L, Navarro OM, Faustino EVS,

Journal of thrombosis and haemostasis : JTH.. 2024 January 22 (1):213-224. Epub 10/04/2023.

Using Serum Cystatin C to Predict Acute Kidney Injury Following Infant Cardiac Surgery.

Abadeer M, Swartz MF, Martin SD, Groves AM, Kent AL, Schwartz GJ, Brophy P, Alfieris GM, Cholette JM

Pediatric cardiology.. 2023 April 44 (4):855-866. Epub 01/13/2023.

Pulmonary Venous Gradients in Healthy Controls and Following the Repair of Total Anomalous Pulmonary Venous Return.

Swartz MF, Meagher C, Yoshitake S, Atallah-Yunes N, Angona R, Cholette JM, Alfieris GM

Pediatric cardiology.. 2023 February 44 (2):325-332. Epub 08/20/2022.

The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.

Benamar M, Chen Q, Chou J, Julé AM, Boudra R, Contini P, Crestani E, Lai PS, Wang M, Fong J, Rockwitz S, Lee P, Chan TMF, Altun EZ, Kepenekli E, Karakoc-Aydiner E, Ozen A, Boran P, Aygun F, Onal P, Sakalli AAK, Cokugras H, Gelmez MY, Oktelik FB, Cetin EA, Zhong Y, Taylor ML, Irby K, Halasa NB, Mack EH, , Signa S, Prigione I, Gattorno M, Cotugno N, Amodio D, Geha RS, Son MB, Newburger J, Agrawal PB, Volpi S, Palma P, Kiykim A, Randolph AG, Deniz G, Baris S, De Palma R, Schmitz-Abe K, Charbonnier LM, Henderson LA, Chatila TA

The Journal of clinical investigation.. 2023 January 3133 (1)Epub 01/03/2023.

A modified approach in the repair of type I and II truncus arteriosus to promote branch pulmonary arterial growth and limit early reoperation.

Swartz MF, Yoshitake S, Cholette JM, Atallah-Yunes N, Wang H, Alfieris GM

JTCVS techniques.. 2022 December 16 :196-211. Epub 09/29/2022.

Transfusion Strategies for Hemostatic Blood Products in Critically Ill Children: A Narrative Review and Update on Expert Consensus Guidelines.

Valentine SL, Cholette JM, Goobie SM

Anesthesia and analgesia.. 2022 September 1135 (3):545-557. Epub 08/17/2022.

Enoxaparin Reduces Catheter-associated Venous Thrombosis After Infant Cardiac Surgery.

Swartz MF, Hutchinson DJ, Stauber SD, Taillie ER, Alfieris GM, Cholette JM

The Annals of thoracic surgery.. 2022 September 114 (3):881-888. Epub 05/29/2021.

Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs.

Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC,

Critical care medicine.. 2022 February 150 (2):173-182. Epub 1900 01 01.

Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.

Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI

Pediatrics.. 2022 January 1149 (1 Suppl 1):S74-S78. Epub 1900 01 01.

What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE,

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2022 January 123 (13 Suppl 1 1S):e1-e13. Epub 1900 01 01.

Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Russell R, Bauer DF, Goobie SM, Haas T, Nellis ME, Nishijima DK, Vogel AM, Lacroix J,

Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM,

Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME,

Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Noncardiac Surgery and Critically Ill Children Undergoing Invasive Procedures Outside the Operating Room: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Tucci M, Crighton G, Goobie SM, Russell RT, Parker RI, Haas T, Nellis ME, Vogel AM, Lacroix J, Stricker PA,

Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Nellis ME, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Vogel AM, Crighton G, Valentine SL, Delaney M, Parker RI,

Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB).

Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI,

Factors Associated With an Abnormal Blood Pressure Response During Exercise After Coarctation Repair.

Pivirotto M, Swartz MF, McGreevy MB, Atallah-Yunes N, Cholette JM, Lipshultz SE, Alfieris GM

World journal for pediatric & congenital heart surgery.. 2022 January 13 (1):53-59. Epub 1900 01 01.

Case report and review of the literature: Successful transition from acute continuous veno-venous hemodiafiltration therapy to chronic peritoneal dialysis in a chronically ventilated child with hypoplastic left heart syndrome following fontan.

Martin SD, Lande MB, Kuebler JD, Cholette JM

Frontiers in pediatrics.. 2022 10 :1040869. Epub 11/01/2022.

Cell Saver Blood Reinfusion Up to 24 Hours Post Collection in Pediatric Cardiac Surgical Patients Does Not Increase Incidence of Hospital-Acquired Infections or Mortality.

Boulos L, Kuebler JD, Angona R, Sweeney D, Wang H, Nocera E, Cholette JM

The journal of extra-corporeal technology.. 2021 September 53 (3):161-169. Epub 1900 01 01.

In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A.

Cholette JM, McRae HL, Angona R, Cahill C, Swartz MF, Alfieris GM, Refaai MA

The journal of extra-corporeal technology.. 2021 September 53 (3):214-219. Epub 1900 01 01.

Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes.

Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG,

The New England journal of medicine.. 2021 July 1385 (1):23-34. Epub 06/16/2021.

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.

Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, Randolph AG, Newhams M, Thomas D, Magleby R, Hsu K, Burns M, Dufort E, Maxted A, Pietrowski M, Longenberger A, Bidol S, Henderson J, Sosa L, Edmundson A, Tobin-D'Angelo M, Edison L, Heidemann S, Singh AR, Giuliano JS, Kleinman LC, Tarquinio KM, Walsh RF, Fitzgerald JC, Clouser KN, Gertz SJ, Carroll RW, Carroll CL, Hoots BE, Reed C, Dahlgren FS, Oster ME, Pierce TJ, Curns AT, Langley GE, Campbell AP, , Balachandran N, Murray TS, Burkholder C, Brancard T, Lifshitz J, Leach D, Charpie I, Tice C, Coffin SE, Perella D, Jones K, Marohn KL, Yager PH, Fernandes ND, Flori HR, Koncicki ML, Walker KS, Di Pentima MC, Li S, Horwitz SM, Gaur S, Coffey DC, Harwayne-Gidansky I, Hymes SR, Thomas NJ, Ackerman KG, Cholette JM

JAMA network open.. 2021 June 14 (6):e2116420. Epub 06/01/2021.

Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.

LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG,

JAMA neurology.. 2021 May 178 (5):536-547. Epub 1900 01 01.

Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.

Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC,

Critical care medicine.. 2021 April 149 (4):e369-e380. Epub 1900 01 01.

Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.

Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC,

Critical care medicine.. 2021 March 149 (3):e235-e246. Epub 1900 01 01.

Intraoperative Cortical Asynchrony Predicts Abnormal Postoperative Electroencephalogram.

Swartz MF, Seltzer LE, Cholette JM, Yoshitake S, Darrow N, Algahim MF, Alfieris GM

The Annals of thoracic surgery.. 2021 February 111 (2):645-654. Epub 06/06/2020.

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.

Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai SP, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG

The New England journal of medicine.. 2020 July 23383 (4):334-346. Epub 06/29/2020.

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF,

JAMA.. 2019 December 10322 (22):2179-2190. Epub 1900 01 01.

Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity.

Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O,

Critical care medicine.. 2019 December 47 (12):1766-1772. Epub 1900 01 01.

Transfusion medicine: A research agenda for the coming years.

Blumberg N, Cholette JM, Cahill C, Pietropaoli AP, Winters S, Phipps R, Noronha SA, Heal JM, Kirkley SA, Fountaine TJ, Henrichs K, Masel D, Refaai MA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2019 October 58 (5):698-700. Epub 08/06/2019.

Met-Hemoglobin Is a Biomarker for Poor Oxygen Delivery in Infants Following Surgical Palliation.

Swartz MF, Makhija P, Rubenstein J, Henrichs KF, Powers KS, Wang HY, Simon BV, Alfieris GM, Blumberg N, Cholette JM

World journal for pediatric & congenital heart surgery.. 2019 July 10 (4):485-491. Epub 05/29/2019.

Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.

Pietropaoli AP, Henrichs KF, Cholette JM, Spinelli SL, Phipps RP, Refaai MA, Blumberg N

Transfusion.. 2019 June 59 (6):2007-2015. Epub 02/27/2019.

Patient Blood Management in Pediatric Cardiac Surgery: A Review.

Cholette JM, Faraoni D, Goobie SM, Ferraris V, Hassan N

Anesthesia and analgesia.. 2018 October 127 (4):1002-1016. Epub 1900 01 01.

The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology.

Bembea MM, Valentine SL, Bateman ST, Wilson LM, Anton B, Harger N, Robinson KA, ,

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2018 September 19 (9S Suppl 1):S93-S97. Epub 1900 01 01.

Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Doctor A, Cholette JM, Remy KE, Argent A, Carson JL, Valentine SL, Bateman ST, Lacroix J,

Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Demaret P, Emeriaud G, Hassan NE, Kneyber MCJ, Valentine SL, Bateman ST, Tucci M, ,

Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, ,

Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, Spinella PC, ,

Recommendations on RBC Transfusion in Critically Ill Children With Acute Brain Injury From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Tasker RC, Turgeon AF, Spinella PC, ,

Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Cholette JM, Willems A, Valentine SL, Bateman ST, Schwartz SM, ,

Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Steiner ME, Zantek ND, Stanworth SJ, Parker RI, Valentine SL, Lehmann LE, Josephson CD, Bateman ST, Luban NLC, ,

Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Bembea MM, Cheifetz IM, Fortenberry JD, Bunchman TE, Valentine SL, Bateman ST, Steiner ME, ,

Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Zantek ND, Parker RI, van de Watering LM, Josephson CD, Bateman ST, Valentine SL, Delaney M, ,

Implementation of the Recommendations for RBC Transfusions for Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Steffen KM, Bateman ST, Valentine SL, Small S, Spinella PC, Doctor A, ,

Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST,

Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride.

Refaai MA, Conley GW, Henrichs KF, McRae H, Schmidt AE, Phipps RP, Spinelli SL, Masel D, Cholette JM, Pietropaoli A, Eaton MP, Blumberg N

American journal of clinical pathology.. 2018 July 3150 (2):146-153. Epub 1900 01 01.

Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Gensini F, Rubenstein JS, Sweeney D, Phipps R, Spinelli SL, Refaai MA, Eaton MP, Blumberg N

Transfusion.. 2018 July 58 (7):1631-1639. Epub 03/30/2018.

Indications for red cell transfusions in pediatric patients.

Cholette JM, Noronha SA, Seghatchian J, Blumberg N

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2018 June 57 (3):342-346. Epub 05/10/2018.

Left Main Coronary Artery Atresia in an Infant With Inclusion-Cell Disease.

Bounds RL, Kuebler J, Cholette JM, Alfieris GM, Emani SM, Wittlieb-Weber CA

World journal for pediatric & congenital heart surgery.. 2018 March 9 (2):246-250. Epub 09/12/2016.

Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery.

Schmidt AE, Gore E, Henrichs KF, Conley G, Dorsey C, Bjugstad KB, Refaai MA, Blumberg N, Cholette JM

Pediatric cardiology.. 2018 February 39 (2):299-306. Epub 10/31/2017.

0.9% NaCl (Normal Saline) - Perhaps not so normal after all?

Blumberg N, Cholette JM, Pietropaoli AP, Phipps R, Spinelli SL, Eaton MP, Noronha SA, Seghatchian J, Heal JM, Refaai MA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2018 February 57 (1):127-131. Epub 02/21/2018.

Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease.

Stolla M, Henrichs K, Cholette JM, Pietropaoli AP, Phipps RP, Spinelli SL, Blumberg N

Vox sanguinis.. 2018 January 113 (1):72-75. Epub 10/16/2017.

Modified Repair of Type I and II Truncus Arteriosus Limits Early Right Ventricular Outflow Tract Reoperation.

Louis C, Swartz MF, Simon BV, Cholette JM, Atallah-Yunes N, Wang H, Gensini F, Alfieris GM

Seminars in thoracic and cardiovascular surgery.. 2018 30 (2):199-204. Epub 02/08/2018.

Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ

Transfusion medicine reviews.. 2017 October 31 (4):252-257. Epub 05/04/2017.

Transfer of Neonates with Critical Congenital Heart Disease Within a Regionalized Network.

Swartz MF, Cholette JM, Orie JM, Jacobs ML, Jacobs JP, Alfieris GM

Pediatric cardiology.. 2017 October 38 (7):1350-1358. Epub 07/15/2017.

International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study.

Fink EL, Kochanek PM, Tasker RC, Beca J, Bell MJ, Clark RS, Hutchison J, Vavilala MS, Fabio A, Angus DC, Watson RS,

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2017 April 18 (4):330-342. Epub 1900 01 01.

Use of a Dacron Annular Sparing Versus Limited Transannular Patch With Nominal Pulmonary Annular Expansion in Infants With Tetralogy of Fallot.

Simon BV, Swartz MF, Egan M, Cholette JM, Gensini F, Alfieris GM

The Annals of thoracic surgery.. 2017 January 103 (1):186-192. Epub 07/29/2016.

Outcomes Using a Conservative Versus Liberal Red Blood Cell Transfusion Strategy in Infants Requiring Cardiac Operation.

Cholette JM, Swartz MF, Rubenstein J, Henrichs KF, Wang H, Powers KS, Daugherty LE, Alfieris GM, Gensini F, Blumberg N

The Annals of thoracic surgery.. 2017 January 103 (1):206-214. Epub 08/03/2016.

Muszynski JA, Spinella PC, Cholette JM, Acker JP, Hall MW, Juffermans NP, Kelly DP, Blumberg N, Nicol K, Liedel J, Doctor A, Remy KE, Tucci M, Lacroix J, Norris PJ,

Transfusion.. 2017 January 57 (1):195-206. Epub 10/02/2016.

Continuous Cardiopulmonary Bypass During the Repair of Total Anomalous Pulmonary Venous Return.

Parzen JS, Swartz MF, Cholette JM, Smith F, Gensini F, Alfieris GM

World journal for pediatric & congenital heart surgery.. 2016 November 7 (6):750-752. Epub 1900 01 01.

Cuffed endotracheal tubes in neonates and infants undergoing cardiac surgery are not associated with airway complications.

DeMichele JC, Vajaria N, Wang H, Sweeney DM, Powers KS, Cholette JM

Journal of clinical anesthesia.. 2016 September 33 :422-7. Epub 06/04/2016.

Neurodevelopmental outcomes after neonatal cardiac surgery: Role of cortical isoelectric activity.

Seltzer L, Swartz MF, Kwon J, Burchfiel J, Cholette JM, Wang H, Sweeney D, Adams HR, Meagher C, Angona R, Guillet R, Alfieris GM

The Journal of thoracic and cardiovascular surgery.. 2016 April 151 (4):1137-42. Epub 10/27/2015.

Left Main Coronary Artery Atresia in an Infant with Inclusion-Cell Disease

Bounds RL; Kuebler J; Cholette JM; Emani S; Alfieris GM; Wittlieb-Weber CA.

World Journal for Pediatric and Congenital Heart Surgery. 2016; .

Distal Transverse Arch to Left Carotid Artery Ratio Helps to Identify Infants With Aortic Arch Hypoplasia.

Swartz MF, Simon B, Atallah-Yunes N, Cholette JM, Orie J, Gensini F, Alfieris GM

The Annals of thoracic surgery.. 2015 September 100 (3):1004-11; discussion 1011-2. Epub 07/23/2015.

Pharmacokinetics of ?-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass.

Eaton MP, Alfieris GM, Sweeney DM, Angona RE, Cholette JM, Venuto C, Anderson B

Anesthesiology.. 2015 May 122 (5):1002-9. Epub 1900 01 01.

Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spineli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Blumberg N

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2015 March 16 (3):227-35. Epub 1900 01 01.

The authors reply.

Cholette J, Rubenstein JS

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2015 January 16 (1):95-6. Epub 1900 01 01.

Regression of left ventricular hypertrophy in children following the Ross procedure.

Lehoux J, Swartz MF, Atallah-Yunes N, Cholette JM, Alfieris GM

Interactive cardiovascular and thoracic surgery.. 2014 May 18 (5):607-10. Epub 1900 01 01.

Risk factors for a positive neoaortic arch gradient after stage I palliation for hypoplastic left heart syndrome.

Walters AM, Swartz MF, Patel S, Cholette JM, Atallah-Yunes N, Alfieris GM

The Annals of thoracic surgery.. 2013 August 96 (2):645-50. Epub 06/16/2013.

Hypertensive changes within the aortic arch of infants and children with isolated coarctation.

Swartz MF, Morrow D, Atallah-Yunes N, Cholette JM, Gensini F, Kavey RE, Alfieris GM

The Annals of thoracic surgery.. 2013 July 96 (1):190-5. Epub 05/31/2013.

Transfusion of cell saver salvaged blood in neonates and infants undergoing open heart surgery significantly reduces RBC and coagulant product transfusions and donor exposures: results of a prospective, randomized, clinical trial.

Cholette JM, Powers KS, Alfieris GM, Angona R, Henrichs KF, Masel D, Swartz MF, Daugherty LE, Belmont K, Blumberg N

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2013 February 14 (2):137-47. Epub 1900 01 01.

The effect of repeat sternotomy during right ventricular outflow tract reconstruction.

Swartz MF, Schiralli MP, Cholette JM, Angona R, Alfieris GM.

Congenital Heart Disease. 2013; 8(2): 142-8.

on behalf of the PROphylaxis against ThRombosis prACTice (PROTRACT) Study Investigators of the PALISI BloodNet. A Multinational Study of Thromboprophylaxis Practice in Critically Ill Children.

Faustino EV, Hanson S, Spinella PC, Tucci M, O'Brien SH, Nunez AR, Yung M, Truemper E, Qin L, Li S, Marohn K, Randolph AG.

Critical Care Medicine. 2013; .

The effect of repeat sternotomy during right ventricular outflow tract reconstruction.

Swartz MF, Schiralli MP, Angona R, Cholette JM, Gensini F, Alfieris GM

Congenital heart disease.. 2013 8 (2):142-8. Epub 06/14/2012.

Decreased incidence of supravalvar pulmonary stenosis after arterial switch operation.

Swartz MF, Sena A, Atallah-Yunes N, Meagher C, Cholette JM, Gensini F, Alfieris GM

Circulation.. 2012 September 11126 (11 Suppl 1):S118-22. Epub 1900 01 01.

Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial.

Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2012 May 13 (3):290-9. Epub 1900 01 01.

Prolonged Red Cell Storage is Associated with Dramatic Increases in Post-Operative Infections in Pediatric Cardiac Surgery – A prospective, minimally confounded cohort study.

Cholette JM, Henrichs KF, Powers KS, Alfieris GM, Phipps RP, Spinelli SL, Gensini FJ, Blumberg N.

Transfusion. 2012; : 52S:51.

Carpentier edwards porcine valved conduit for right ventricular outflow tract reconstruction.

Schiralli MP, Cholette JM, Swartz MF, Vermilion R, Meagher C, Alfieris GM

Journal of cardiac surgery.. 2011 November 26 (6):643-9. Epub 09/26/2011.

Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy.

Cholette JM, Rubenstein JS, Alfieris GM, Powers KS, Eaton M, Lerner NB

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2011 January 12 (1):39-45. Epub 1900 01 01.

Children with single ventricle physiology do not benefit from higher hemoglobin levels following cavopulmonary connection: Results of a prospective, randomized controlled trial of a restrictive v. liberal red cell transfusion strategy.

Cholette, JM; Rubenstein, JS; Alfieris, GM; Powers, KS; Eaton, MP.

Pediatr Crit Care Med. 2011; 12(1): 39-45.

Washing Blood Transfused in Pediatric Open Heart Surgery Reduces Post-Operative Inflammation and Immunomodulation: Results of a Prospective Randomized Controlled Trial.

Cholette, JM; Henrichs, KF; Powers, KS; Alfieris, GM; Phipps, R; Spinelli, S; Daugherty, LE; Nazarian, E; Rubenstein, J; Swartz, M; Gensini, F; Eaton, M; Sweeney, D; Lerner, NB; Blumberg, N.

Pediatr Crit Care Med. 2011; .

Washed Red Cells Reduce the Inflammatory Response to Transfusion in Pediatric Cardiac Surgery: Results of a Randomized Clinical Trial.

Cholette, JM; Henrichs, KF; Phipps, R; Spinelli, S; Gensini, F; Blumberg, N.

Abstract, Transfusion. 2011; Supplement.

Carpentier Edwards Porcine Valved Conduit for Right Ventricular Outflow Tract Reconstruction.

Schiralli, MP; Cholette, JM; Swartz, MF; Vermilion, R; Meagher, C; Alfieris, GM; Carpentier, Edwards.

Journal of Cardiac Surgery. 2011; 26(6): 643-9.

Surgical strategy for Aortic Coarctation Repair resulting in physiologic arm and leg blood pressures.

Swartz, MF; Kavey, RE; Cholette, JM; Meagher, C; Gensini, F; Alfieris, GM.

Congenital Heart Disease. 2011; 6(6): 583-91.

Decreased Incidence of Supravalvar pulmonary stenosis following modified technique of arterial switch operation.

Swartz, MF; Sena, A; Atallah-Yunes, N; Meagher, C; Cholette, J; Gensini, F; Alfieris, GM.

Circulation. 2011; A124: 15017.

Cell Saver for volume replacement in children following cardiopulmonary bypass reduces the number of RBC and blood product transfusions and donor exposures.

Cholette, JM; Powers, KS; Alfieris, GM; Angona, R; Henrichs, K; Blumberg, N.

Critical Care Medicine;. 2011; 39(12S).

Cell saver salvaged blood can safely be transfused for up to 24 hours post-collection.

Cholette, JM; Powers, KS; Angona, R; Alfieris; Henrichs, K; Masel, D; Blumberg, N.

Critical Care Medicine;. 2011; 39(12S).

Use of continuous calcium drips for calcium replacement is associated with increased thrombotic risk in infants following open-heart surgery.

Tomek, S; Alfieris, G; Macri, D; Cholette, JM.

Critical Care Medicine. 2011; 39(12S).

Aspirin resistance following pediatric cardiac surgery.

Cholette JM, Mamikonian L, Alfieris GM, Blumberg N, Lerner NB

Thrombosis research.. 2010 September 126 (3):200-6. Epub 06/13/2010.

Modified repair of truncus arteriosus to maintain pulmonary artery architecture.

Alfieris GM, Gangemi JJ, Schiralli MP, Swartz MF, Cholette JM

The Annals of thoracic surgery.. 2010 September 90 (3):1038-9. Epub 1900 01 01.

Cyanotic children undergoing open heart surgery do not appear to benefit from higher hemoglobin levels: Results of a restrictive v. liberal RBC transfusion strategy.

Cholette J; Rubenstein J; Powers K; Alfieris G; Lerner N.

Crit Care Med. 2010; 37(12S): A434.

Modified repair of Truncus Arteriosus to Maintain Pulmonary Artery Architecture.

Alfieris, GM; Gangemi, JJ; Schiralli, M; Swartz, M; Cholette JM.

Thorac Surg. 2010; 90(3): 1038-9.

Aspirin resistance following pediatric cardiac surgery.

Cholette, JM; Mamikonian, L; Alfieris, GM; , Blumberg N ; Lerner, NB.

Thromb Res. 2010; 126(3): 200-6.

Developmental changes in soluble CD40 ligand.

Cholette JM, Blumberg N, Phipps RP, McDermott MP, Gettings KF, Lerner NB

The Journal of pediatrics.. 2008 January 152 (1):50-4, 54.e1. Epub 10/24/2007.

Truncus Arteriosus Repair: Mid-Term Results Using a Modified Technique.

Gangemi JJ; Cholette JM; Alfieris GM.

Cardiol Young. 2008; 18: 195-196.

Elevated risk of thrombosis in neonates undergoing initial palliative cardiac surgery.

Cholette JM, Rubenstein JS, Alfieris GM, McDermott MP, Harmon WG, Vermilion R, Eaton MP, Gangemi JJ, Lerner NB

The Annals of thoracic surgery.. 2007 October 84 (4):1320-5. Epub 1900 01 01.

Outcome of pulmonary function in Lemierre's disease-associated acute respiratory distress syndrome.

Cholette JM, Caserta M, Hardy D, Connolly HV

Pediatric pulmonology.. 2007 April 42 (4):389-92. Epub 1900 01 01.

Outcome of Pulmonary Function in Lemierre's Disease-Associated Acute Repiratory Distress Syndrome

Cholette J, Caserta M, Hardy D, Connolly H.

Pediatric Pulmonary. 2007; 42: 389-392.

Thrombosis in Infants with Single Ventricle Physiology Undergoing Stage 1 Surgical Palliation.

Cholette JM; Rubenstein J; Alfieris GM; Harmon WG; Vermilion R; Lerner NB.

E-PAS. 2007; .

Suicide and Schizophrenia: Identifying Risk Factors and Preventive Strategies.

Conwell Y, Cholette J, Duberstein PR.

Medscape Mental Health. 1998; 3((3)).

Books

Pediatric Critical Care Study Guide (2012)

Chapter: Use of blood products

Authors: Cholette, JM; Lerner, NB

Publisher: Springer-Verlag, London 2012

Textbook of Pediatric Care (2008)

Chapter: Esophageal Caustic Injury

Authors: J Cholette; G Drugas.

Publisher: American Academy of Pediatrics, Elk Grove Village, IL 2008

Pediatric Clinical Advisor- Instant Diagnosis & Treatment (2007)

Chapter: Neuroleptic Malignant Syndrome

Authors: J Cholette

Publisher: Mosby Elsevier, St. Louis, MO 2007

Pediatric Critical Care Medicine: Basic Science & Clinical Evidence (2007)

Chapter: Toxic Exposures: Diagnosis and Management

Authors: J Cholette; KS Powers; P. Abboud

Publisher: Springer-Verlag 2007

The Merck Manual (2006)

Chapter: Perinatal Hematologic Disorders

Authors: J Cholette, NB Lerner

Publisher: Merck & Co., West Point, PA 2006

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