Dr. Benesch completed his Neurology Residency and Fellowship Training in Experimental Therapeutics in Cerebrovascular Disease at the University of Rochester School of Medicine and Dentistry. He is board-certified in Neurology and Vascular Neurology and has been the Director of the URMC Stroke Center since its inception in 1996. He is also the Director of the Vascular Neurology Fellowship Program. His research interests include acute stroke treatment, secondary stroke prevention, development of community-wide approaches to stroke care, and cost-effectiveness of stroke treatment.

Certified Specialties

Neurology - American Board of Psychiatry & Neurology

Vascular Neurology - American Board of Psychiatry & Neurology

Faculty Appointments

Professor - Department of Neurology, Stroke Division (SMD)

Professor - Department of Neurosurgery (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Neurology, University of Rochester Medical Center. 1992 - 1994

Residency, Neurology, University of Rochester Medical Center. 1989 - 1992

Internship, Internal Medicine, University of Rochester Medical Center. 1988 - 1989

Education

MPH | University of Rochester School of Medicine/Dentistry (USA). 2000

MD | University of Nebraska College of Medicine (USA). 1988

Awards

Neurology Faculty Teaching Award. 2007

Volunteer of the Year Award. 2006

Bob Tietje Award, Volunteer Service. 2001

New York State Affiliate Service Award. 2000

Neurology Faculty Teaching Award. 1996

Alpha Omega Alpha. 1988

Phi Kappi Phi. 1984

Research

Major research interests are: Clinical trials of acute stroke treatment, Secondary prevention of stroke, and Cost-effectiveness of diagnostic testing, evaluation, and care of patients with stroke.

Clinical Trials

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA),Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)

Lead Researcher: Curtis George Benesch MD

The purpose of this research study is to see whether ticagrelor and aspirin or rivaroxaban and aspirin compared to clopidogrel and aspirin may have the most success in preventing another stroke, bleed in the brain, or death in participants who have a...

Publications

Journal Articles

Was COVID-19 Associated With Worsening Inequities in Stroke Treatment and Outcomes?

Glance LG, Benesch CG, Joynt Maddox KE, Bender MT, Shang J, Stone PW, Lustik SJ, Nadler JW, Galton C, Dick AW

Journal of the American Heart Association.. 2023 October 312 (19):e031221. Epub 09/26/2023.

Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology: Case Report.

Johnson MD, Rogers EJ, Khan MW, McMullen PD, Akkipeddi SMK, Mattingly T, Benesch CG, Bender MT

Neurology. Clinical practice.. 2023 February 13 (1):e200129. Epub 01/19/2023.

Association of Time Elapsed Since Ischemic Stroke With Risk of Recurrent Stroke in Older Patients Undergoing Elective Nonneurologic, Noncardiac Surgery.

Glance LG, Benesch CG, Holloway RG, Thirukumaran CP, Nadler JW, Eaton MP, Fleming FJ, Dick AW

JAMA surgery.. 2022 August 1157 (8):e222236. Epub 08/10/2022.

Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy.

Bender MT, Mattingly TK, Rahmani R, Proper D, Burnett WA, Burgett JL, LEsperance J, Cushman JT, Pilcher WH, Benesch CG, Kelly AG, Bhalla T

Stroke and vascular neurology.. 2022 June 7 (3):209-214. Epub 12/24/2021.

Functional status at 30 and 90 days after mild ischaemic stroke.

Gardener H, Romano LA, Smith EE, Campo-Bustillo I, Khan Y, Tai S, Riley N, Sacco RL, Khatri P, Alger HM, Mac Grory B, Gulati D, Sangha NS, Olds KE, Benesch CG, Kelly AG, Brehaut SS, Kansara AC, Schwamm LH, Romano JG

Stroke and vascular neurology.. 2022 April 267 (5):375-80. Epub 04/26/2022.

Frequency and Prognostic Significance of Clinical Fluctuations Before Hospital Arrival in Stroke.

Romano JG, Gardener H, Smith EE, Campo-Bustillo I, Khan Y, Tai S, Riley N, Sacco RL, Khatri P, Alger HM, Mac Grory B, Gulati D, Sangha NS, Olds KE, Benesch CG, Kelly AG, Brehaut SS, Kansara AC, Schwamm LH,

Stroke.. 2022 February 53 (2):482-487. Epub 10/14/2021.

Mobile Stroke Unit Operational Metrics: Institutional Experience, Systematic Review and Meta-Analysis.

Ellens NR, Schartz D, Rahmani R, Akkipeddi SMK, Kelly AG, Benesch CG, Parker SA, Burgett JL, Proper D, Pilcher WH, Mattingly TK, Grotta JC, Bhalla T, Bender MT

Frontiers in neurology. 2022 13 :868051. Epub 05/09/2022.

Predictors of Outcomes in Patients With Mild Ischemic Stroke Symptoms: MaRISS.

Romano JG, Gardener H, Campo-Bustillo I, Khan Y, Tai S, Riley N, Smith EE, Sacco RL, Khatri P, Alger HM, Mac Grory B, Gulati D, Sangha NS, Craig JM, Olds KE, Benesch CG, Kelly AG, Brehaut SS, Kansara AC, Schwamm LH,

Stroke.. 2021 June 52 (6):1995-2004. Epub 05/05/2021.

Folate deficiency drives mitotic missegregation of the human locus.

Bjerregaard VA, Garribba L, McMurray CT, Hickson ID, Liu Y

Proceedings of the National Academy of Sciences of the United States of America.. 2018 December 18115 (51):13003-13008. Epub 12/03/2018.

Immediate and Sustained Decrease in Smoking Urges After Acute Insular Cortex Damage.

Abdolahi A, Williams GC, Benesch CG, Wang HZ, Spitzer EM, Scott BE, Block RC, van Wijngaarden E

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.. 2017 June 119 (6):756-762. Epub 1900 01 01.

Factors associated with recurrent stroke and recanalization in patients presenting with isolated symptomatic carotid occlusion.

Damania D, Kung NT, Jain M, Jain AR, Liew JA, Mangla R, Koch GE, Sahin B, Miranpuri AS, Holmquist TM, Replogle RE, Benesch CG, Kelly AG, Jahromi BS

European journal of neurology.. 2016 January 23 (1):127-32. Epub 09/01/2015.

Smoking cessation behaviors three months following acute insular damage from stroke.

Abdolahi A, Williams GC, Benesch CG, Wang HZ, Spitzer EM, Scott BE, Block RC, van Wijngaarden E

Addictive behaviors.. 2015 December 51 :24-30. Epub 07/06/2015.

Damage to the insula leads to decreased nicotine withdrawal during abstinence.

Abdolahi A, Williams GC, Benesch CG, Wang HZ, Spitzer EM, Scott BE, Block RC, van Wijngaarden E

Addiction.. 2015 December 110 (12):1994-2003. Epub 09/08/2015.

The cost-utility of CT angiography and conventional angiography for people presenting with intracerebral hemorrhage.

Aviv RI, Kelly AG, Jahromi BS, Benesch CG, Young KC

PloS one.. 2014 9 (5):e96496. Epub 05/13/2014.

Transesophageal echocardiography screening in subjects with a first cerebrovascular ischemic event.

Young KC, Benesch CG

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2011 November 20 (6):503-9. Epub 09/02/2010.

Evidence-based treatment of carotid artery stenosis.

Young KC, Jain A, Jain M, Replogle RE, Benesch CG, Jahromi BS

Neurosurgical focus.. 2011 June 30 (6):E2. Epub 1900 01 01.

Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease.

Costa A, Gao L, Carrillo F, Cáceres-Redondo MT, Carballo M, Díaz-Martín J, Gómez-Garre P, Sobrino F, Lucas M, López-Barneo J, Mir P, Pintado E

Parkinsonism & related disorders.. 2011 May 17 (4):281-4. Epub 01/22/2011.

Cost-effectiveness of multimodal CT for evaluating acute stroke.

Young KC, Benesch CG, Jahromi BS

Neurology.. 2010 November 975 (19):1678-85. Epub 10/06/2010.

Hospital resource use following carotid endarterectomy in 2006: analysis of the nationwide inpatient sample.

Young KC, Jahromi BS, Singh MJ, Illig KA, Benesch CG

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2010 19 (6):458-64. Epub 06/09/2010.

A cost-effectiveness analysis of carotid artery stenting compared with endarterectomy.

Young KC, Holloway RG, Burgin WS, Benesch CG

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2010 19 (5):404-9. Epub 1900 01 01.

Cost-effectiveness of treating resistant hypertension with an implantable carotid body stimulator.

Young KC, Teeters JC, Benesch CG, Bisognano JD, Illig KA

The journal of clinical hypertension.. 2009 October 11 (10):555-63. Epub 1900 01 01.

Public reporting of quality data for stroke: is it measuring quality?

Kelly A, Thompson JP, Tuttle D, Benesch C, Holloway RG

Stroke.. 2008 December 39 (12):3367-71. Epub 09/04/2008.

Human chromosome fragility.

Lukusa T, Fryns JP

Biochimica et biophysica acta.. 2008 January 1779 (1):3-16. Epub 12/03/2007.

Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID.

Kasner SE, Lynn MJ, Chimowitz MI, Frankel MR, Howlett-Smith H, Hertzberg VS, Chaturvedi S, Levine SR, Stern BJ, Benesch CG, Jovin TG, Sila CA, Romano JG,

Neurology.. 2006 October 1067 (7):1275-8. Epub 1900 01 01.

Lowering cholesterol in patients with stroke: raising the standard.

Elkind MS, Benesch CG

Neurology.. 2006 April 2566 (8):1140-1. Epub 1900 01 01.

Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis.

Kasner SE, Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Benesch CG, Sila CA, Jovin TG, Romano JG, Cloft HJ,

Circulation.. 2006 January 31113 (4):555-63. Epub 01/23/2006.

Prognosis and decision making in severe stroke.

Holloway RG, Benesch CG, Burgin WS, Zentner JB

JAMA.. 2005 August 10294 (6):725-33. Epub 1900 01 01.

Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.

Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Kasner SE, Benesch CG, Sila CA, Jovin TG, Romano JG,

The New England journal of medicine.. 2005 March 31352 (13):1305-16. Epub 1900 01 01.

Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study.

Cramer SC, Rordorf G, Maki JH, Kramer LA, Grotta JC, Burgin WS, Hinchey JA, Benesch C, Furie KL, Lutsep HL, Kelly E, Longstreth WT

Stroke.. 2004 January 35 (1):46-50. Epub 12/04/2003.

Antithrombotic and thrombolytic therapy for ischemic stroke.

Benesch C

Current atherosclerosis reports.. 2003 July 5 (4):267-75. Epub 1900 01 01.

Is the rationale for carotid angioplasty and stenting in patients excluded from NASCET/ACAS or eligible for ARCHeR justified?

Illig KA, Zhang R, Tanski W, Benesch C, Sternbach Y, Green RM

Journal of vascular surgery.. 2003 March 37 (3):575-81. Epub 1900 01 01.

Design, progress and challenges of a double-blind trial of warfarin versus aspirin for symptomatic intracranial arterial stenosis.

Neuroepidemiology.. 2003 22 (2):106-17. Epub 1900 01 01.

Instability of the fragile X syndrome repeat in mice: the effect of age, diet and mutations in genes that affect DNA replication, recombination and repair proficiency.

Fleming K, Riser DK, Kumari D, Usdin K

Cytogenetic and genome research.. 2003 100 (1-4):140-6. Epub 1900 01 01.

Development of performance measures for acute ischemic stroke.

Holloway RG, Vickrey BG, Benesch C, Hinchey JA, Bieber J,

Stroke.. 2001 September 32 (9):2058-74. Epub 1900 01 01.

Thrombolytic therapy in patients with acute ischemic stroke.

Hinchey JA, Benesch C

Archives of neurology.. 2000 October 57 (10):1430-6. Epub 1900 01 01.

Stroke prevention: narrowing the evidence-practice gap.

Holloway RG, Benesch C, Rush SR

Neurology.. 2000 May 2354 (10):1899-906. Epub 1900 01 01.

Perioperative stroke associated with postoperative epidural analgesia.

Wu CL, Francisco DR, Benesch CG

Journal of clinical anesthesia.. 2000 February 12 (1):61-3. Epub 1900 01 01.

Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter survey. The t-PA Stroke Survey Group.

Tanne D, Bates VE, Verro P, Kasner SE, Binder JR, Patel SC, Mansbach HH, Daley S, Schultz LR, Karanjia PN, Scott P, Dayno JM, Vereczkey-Porter K, Benesch C, Book D, Coplin WM, Dulli D, Levine SR

Neurology.. 1999 July 2253 (2):424-7. Epub 1900 01 01.

A systematic review of cost-effectiveness research of stroke evaluation and treatment.

Holloway RG, Benesch CG, Rahilly CR, Courtright CE

Stroke.. 1999 July 30 (7):1340-9. Epub 1900 01 01.

Economic impact of stroke and implications for interventions.

Benesch CG; Holloway RG.

CNS Drugs. 1998; Suppl. 1: 29-39.

Inaccuracy of the International Classification of Diseases (ICD-9-CM) in identifying the diagnosis of ischemic cerebrovascular disease.

Benesch C, Witter DM, Wilder AL, Duncan PW, Samsa GP, Matchar DB

Neurology.. 1997 September 49 (3):660-4. Epub 1900 01 01.

Screening for fragile X syndrome: information needs for health planners.

Murray J, Cuckle H, Taylor G, Hewison J

Journal of medical screening.. 1997 4 (2):60-94. Epub 1900 01 01.

[Chromosomal fragile sites].

Hori T, Yamauchi M, Tsuji S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 1996 November 41 (15 Suppl):2315-24. Epub 1900 01 01.

Folic acid in neurodevelopment and child psychiatry.

Greenblatt JM, Huffman LC, Reiss AL

Progress in neuro-psychopharmacology & biological psychiatry.. 1994 July 18 (4):647-60. Epub 1900 01 01.

Fragile X syndrome.

Wiebe E, Wiebe A

Canadian family physician Me?decin de famille canadien.. 1994 February 40 :290-5. Epub 1900 01 01.

Picture of the month. Fragile X syndrome.

Leung AK, McLeod DR, Robson WL, Fagan JE

Archives of pediatrics & adolescent medicine.. 1994 January 148 (1):63-4. Epub 1900 01 01.

Fragile X syndrome.

Laxova R

Advances in pediatrics.. 1994 41 :305-42. Epub 1900 01 01.

End-stage Alzheimer's disease. Glasgow Coma Scale and the neurologic examination.

Benesch CG, McDaniel KD, Cox C, Hamill RW

Archives of neurology.. 1993 December 50 (12):1309-15. Epub 1900 01 01.

Wasp sting-associated cerebral infarction: a role for cerebrovascular sympathetic innervation.

Riggs JE, Ketonen LM, Bodensteiner JB, Benesch CG

Clinical neuropharmacology.. 1993 August 16 (4):362-5. Epub 1900 01 01.

Identification of the FRAXE fragile site in two families ascertained for X linked mental retardation.

Flynn GA, Hirst MC, Knight SJ, Macpherson JN, Barber JC, Flannery AV, Davies KE, Buckle VJ

Journal of medical genetics.. 1993 February 30 (2):97-100. Epub 1900 01 01.

The usefulness of the neurologic examination and the Glasgow Coma Scale in endstage Alzheimer's disease.

Benesch CG; McDaniel K; Hamill RW.

Arch Neurology. 1993; 50: 1309-15.

Cytogenetic guidelines for fragile X studies tested in routine practice.

Dewald GW, Buckley DD, Spurbeck JL, Jalal SM

American journal of medical genetics.. 1992 December 144 (6):816-21. Epub 1900 01 01.

Double-blind, placebo-controlled crossover study of folinic acid (Leucovorin for the treatment of fragile X syndrome.

Strom CM, Brusca RM, Pizzi WJ

American journal of medical genetics.. 1992 November 1544 (5):676-82. Epub 1900 01 01.

Experience with direct molecular diagnosis of fragile X.

Mulley JC, Yu S, Gedeon AK, Donnelly A, Turner G, Loesch D, Chapman CJ, Gardner RJ, Richards RI, Sutherland GR

Journal of medical genetics.. 1992 June 29 (6):368-74. Epub 1900 01 01.

Dialyzed fetal bovine serum increases cytogenetic fragile X expression.

Jenkins EC, Duncan CJ, Gu H, Genovese M, Krawczun MS

American journal of medical genetics.. 1992 43 (1-2):155-60. Epub 1900 01 01.

Imipramine treatment of ADHD in a fragile X child.

Hilton DK, Martin CA, Heffron WM, Hall BD, Johnson GL

Journal of the American Academy of Child and Adolescent Psychiatry.. 1991 September 30 (5):831-4. Epub 1900 01 01.

Fragile X-linked mental retardation and the difficulties of reverse genetics.

Jordan BR

BioEssays : news and reviews in molecular, cellular and developmental biology.. 1991 May 13 (5):243-51. Epub 1900 01 01.

Distribution of diploidy, polyploidy, and endoreduplication in fra(X) positive and negative lymphocytes, amniocytes, and chorionic villi.

Jenkins EC, Sanz MM, Ray JH, Stark-Houck SL, Brown WT

American journal of medical genetics.. 1991 38 (2-3):434-6. Epub 1900 01 01.

Fragile X expression: use of a double induction system.

Howard-Peebles PN

American journal of medical genetics.. 1991 38 (2-3):445-6. Epub 1900 01 01.

Guidelines for the preparation and analysis of the fragile X chromosome in lymphocytes.

Jacky PB, Ahuja YR, Anyane-Yeboa K, Breg WR, Carpenter NJ, Froster-Iskenius UG, Fryns JP, Glover TW, Gustavson KH, Hoegerman SF

American journal of medical genetics.. 1991 38 (2-3):400-3. Epub 1900 01 01.

Autosomal folate sensitive fragile sites in normal and mentally retarded individuals in Greece.

Mavrou A, Syrrou M, Tsenghi C, Metaxotou C

American journal of medical genetics.. 1991 38 (2-3):437-9. Epub 1900 01 01.

Telomeric associations involving Yq12 in a lymphoblastoid cell line.

Abruzzo MA, Miller JA, Singer VL

Cytogenetics and cell genetics.. 1991 56 (3-4):149-51. Epub 1900 01 01.

Folate treatment of a boy with fragile-X syndrome.

Webb T, Crawley P, Bundey S

Journal of mental deficiency research.. 1990 February 34 ( Pt 1) :67-73. Epub 1900 01 01.

[Questions about fragile X syndrome and mental retardation. Clinical and therapeutic aspects].

Suerinck-Neoussikhin E, Noël B, Quack B, Bonnaure C, Nougier B, Moulin B, Bénézech M

Annales médico-psychologiques. 1989 December 147 (10):1071-7; discussion 1077-8. Epub 1900 01 01.

Fragile-X syndrome.

Simensen RJ, Rogers RC

American family physician.. 1989 May 39 (5):185-93. Epub 1900 01 01.

The fragile-X syndrome.

Ho HZ, Glahn TJ, Ho JC

Developmental medicine and child neurology.. 1988 April 30 (2):257-61. Epub 1900 01 01.

Chromosome breakage in control and fragile X subjects using folate-deficient culture conditions.

Butler MG, Joseph GM, Rames LJ, Cacheiro N, Lozzio CB

Human genetics.. 1988 April 78 (4):383. Epub 1900 01 01.

Folic acid treatment of fragile X males: a further study.

Fisch GS, Cohen IL, Gross AC, Jenkins V, Jenkins EC, Brown WT

American journal of medical genetics.. 1988 30 (1-2):393-9. Epub 1900 01 01.

The behaviour of fragile X and other aberrations during recovery from low folate conditions.

Savage JR, Fitchett M

Chromosoma. 1988 96 (5):391-6. Epub 1900 01 01.

Fragile-X syndrome: variability of phenotypic expression.

Bregman JD, Dykens E, Watson M, Ort SI, Leckman JF

Journal of the American Academy of Child and Adolescent Psychiatry.. 1987 July 26 (4):463-71. Epub 1900 01 01.

Fragile X syndrome: a common etiology of mental retardation.

Rogers RC, Simensen RJ

American journal of mental deficiency.. 1987 March 91 (5):445-9. Epub 1900 01 01.

Fragile X syndrome in Japanese patients with infantile autism.

Matsuishi T, Shiotsuki Y, Niikawa N, Katafuchi Y, Otaki E, Ando H, Yamashita Y, Horikawa M, Urabe F, Kuriya N

Pediatric neurology.. 1987 3 (5):284-7. Epub 1900 01 01.

Folic acid as an adjunct in the treatment of children with the autism fragile-X syndrome (AFRAX).

Gillberg C, Wahlström J, Johansson R, Törnblom M, Albertsson-Wikland K

Developmental medicine and child neurology.. 1986 October 28 (5):624-7. Epub 1900 01 01.

A controlled study of folic acid treatment in three fragile X syndrome males.

Madison LS, Wells TE, Fristo TE, Benesch CG

Journal of developmental and behavioral pediatrics : JDBP.. 1986 August 7 (4):253-6. Epub 1900 01 01.

[Chromosomal characteristics of X-linked recessive mental retardation. I. The X chromosome].

Baranovskaia LI, Bedel'baeva KhA, Zakharov AF

Genetika.. 1986 May 22 (5):877-84. Epub 1900 01 01.

Enhanced sensitivity of lymphoblastoid cells from individuals carrying the mutation for the fragile X syndrome to the clastogenic effects of FUdR.

Duncan AM

Mutation research.. 1986 March 173 (3):201-5. Epub 1900 01 01.

Fragile-X syndrome: diagnosis and research.

Madison LS, Mosher GA, George CH

Journal of pediatric psychology.. 1986 March 11 (1):91-102. Epub 1900 01 01.

Frequency of tri- or multiradial configurations in fragile X identification.

Jenkins EC, Duncan CJ, Krawczun MS, Berns LM, Sanz MM, Brown WT

American journal of medical genetics.. 1986 23 (1-2):531-5. Epub 1900 01 01.

Expression of the autosomal folate-sensitive fragile sites in ten kindreds with Martin-Bell syndrome.

Ventruto V, Stabile M, Gentile G, de Tollis G, Colantuoni M, Sirone P, Perone L, Lonardo F, Della Monica M, Fiore M

Annales de génétique. 1986 29 (1):59-61. Epub 1900 01 01.

Oral folic acid versus placebo in the treatment of males with the fragile X syndrome.

Hagerman RJ, Jackson AW, Levitas A, Braden M, McBogg P, Kemper M, McGavran L, Berry R, Matus I, Hagerman PJ

American journal of medical genetics.. 1986 23 (1-2):241-62. Epub 1900 01 01.

High dose folic acid treatment of fragile (X) males.

Brown WT, Cohen IL, Fisch GS, Wolf-Schein EG, Jenkins VA, Malik MN, Jenkins EC

American journal of medical genetics.. 1986 23 (1-2):263-71. Epub 1900 01 01.

Folic acid treatment in males and females with fragile-(X)-syndrome.

Froster-Iskenius U, Bödeker K, Oepen T, Matthes R, Piper U, Schwinger E

American journal of medical genetics.. 1986 23 (1-2):273-89. Epub 1900 01 01.

The fragile X syndrome.

Brown WT, Jenkins EC, Krawczun MS, Wisniewski K, Rudelli R, Cohen IL, Fisch G, Wolf-Schein E, Miezejeski C, Dobkin C

Annals of the New York Academy of Sciences.. 1986 477 :129-50. Epub 1900 01 01.

Assessment of behavior change in a fragile-X syndrome male treated with folic acid.

Wells TE, Madison LS

American journal of medical genetics.. 1986 23 (1-2):291-6. Epub 1900 01 01.

Effects of nucleotides on expression of the folate sensitive fragile sites.

Sutherland GR, Baker E

American journal of medical genetics.. 1986 23 (1-2):409-17. Epub 1900 01 01.

Differential expression of fragile site Xq27 in cultured fibroblasts from hemizygotes and heterozygotes and its implications for prenatal diagnosis.

Schmidt A, Passarge E

American journal of medical genetics.. 1986 23 (1-2):515-25. Epub 1900 01 01.

[Encephalopathies tied to a fragility of the X chromosome].

Fabre JM

Soins. Psychiatrie.. 1985 October (60):17-20. Epub 1900 01 01.

Excess thymidine induces folate sensitive fragile sites.

Sutherland GR, Baker E, Fratini A

American journal of medical genetics.. 1985 October 22 (2):433-43. Epub 1900 01 01.

Fragile X syndrome.

de la Cruz FF

American journal of mental deficiency.. 1985 September 90 (2):119-23. Epub 1900 01 01.

Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome.

Wang JC, Beardsley GP, Erbe RW

American journal of medical genetics.. 1985 August 21 (4):691-6. Epub 1900 01 01.

Thymidylate metabolism in fragile X syndrome cells.

Wang JC, Erbe RW

Somatic cell and molecular genetics.. 1985 July 11 (4):353-7. Epub 1900 01 01.

Chromosome abnormalities in infantile autism and other childhood psychoses: a population study of 66 cases.

Gillberg C, Wahlström J

Developmental medicine and child neurology.. 1985 June 27 (3):293-304. Epub 1900 01 01.

Folic acid blinded trial in identical twins with fragile X syndrome.

Rosenblatt DS, Duschenes EA, Hellstrom FV, Golick MS, Vekemans MJ, Zeesman SF, Andermann E

American journal of human genetics.. 1985 May 37 (3):543-52. Epub 1900 01 01.

Effect of folic acid treatment in the fragile X syndrome.

Gustavson KH, Dahlbom K, Flood A, Holmgren G, Blomquist HK, Sanner G

Clinical genetics.. 1985 May 27 (5):463-7. Epub 1900 01 01.

A "new" chromosome marker common to the Rett syndrome and infantile autism? The frequency of fragile sites at X p22 in 81 children with infantile autism, childhood psychosis and the Rett syndrome.

Gillberg C, Wahlström J, Hagberg B

Brain & development.. 1985 7 (3):365-7. Epub 1900 01 01.

Human chromosome hot points. IV. Uridine-induced hot-point breaks at 3p14 and 16q23-24 and increased expression of fragile site Xq27 in folate-free medium.

Li N, Zhou XT

Human genetics.. 1985 71 (4):363-5. Epub 1900 01 01.

Folate metabolism and chromosomal stability in the fragile X syndrome.

Branda RF, Arthur DC, Woods WG, Danzl TJ, King RA

The American journal of medicine.. 1984 October 77 (4):602-11. Epub 1900 01 01.

[Mental retardation linked to fragility of chromosome X: current knowledge].

Mattei JF, Mattei MG, Auger M, Giraud F

Journal de génétique humaine. 1984 July 32 (3):167-92. Epub 1900 01 01.

[Mental retardation and fragile X chromosome. Clinical and cytogenetic study of 3 families].

Gilgenkrantz S, Boué J, Grégoire MJ, Tejada I

Journal de génétique humaine. 1984 July 32 (3):199-207. Epub 1900 01 01.

[Preliminary evaluation of the treatment with folic acid in 2 patients with sex-linked mental retardation and macroorchidism].

Lacassie Y, Curotto B, Alliende MA, De Andraca I, Zavala A

Revista me?dica de Chile.. 1984 May 112 (5):469-73. Epub 1900 01 01.

Folate metabolism in cells from fragile X syndrome patients and carriers.

Wang JC, Erbe RW

American journal of medical genetics.. 1984 January 17 (1):303-10. Epub 1900 01 01.

Folic acid therapy in the fragile X syndrome.

Brown WT, Jenkins EC, Friedman E, Brooks J, Cohen IL, Duncan C, Hill AL, Malik MN, Morris V, Wolf E

American journal of medical genetics.. 1984 January 17 (1):289-97. Epub 1900 01 01.

Folic acid therapy in the fragile X syndrome.

Erbe RW

American journal of medical genetics.. 1984 January 17 (1):299-301. Epub 1900 01 01.

[Trial of folic acid treatment in fragile X syndrome].

Lejeune J, Rethoré MO, de Blois MC, Ravel A

Annales de génétique. 1984 27 (4):230-2. Epub 1900 01 01.

[Fragile X and autistic mental retardation].

Yvonneau M, Grasset M, Ben Hamida M, Germe G

L'Encéphale.. 1984 10 (2):93-7. Epub 1900 01 01.

Chromosomal breakage in normal and fragile X subjects using low folate culture conditions.

Vekemans M, Popovich B, Rosenblatt D, Monroe P

Journal of medical genetics.. 1983 December 20 (6):404-7. Epub 1900 01 01.

Thymidylate synthetase inhibitors and fragile site expression in lymphocytes.

Jacky PB, Sutherland GR

American journal of human genetics.. 1983 November 35 (6):1276-83. Epub 1900 01 01.

Fragile X demonstrated retrospectively in amniotic cells cultured in low folate medium.

Nielsen LB, Nielsen KB, Tommerup N

Prenatal diagnosis.. 1983 October 3 (4):367-9. Epub 1900 01 01.

Intracellular folate distribution in cultured fibroblasts from patients with the fragile X syndrome.

Popovich BW, Rosenblatt DS, Cooper BA, Vekemans M

American journal of human genetics.. 1983 September 35 (5):869-78. Epub 1900 01 01.

[Mental retardation with X fragility: Armenfrax. Review and personal studies].

Engel E

Revue médicale de la Suisse romande.. 1983 April 103 (4):333-44. Epub 1900 01 01.

Fragile (X) X-linked mental retardation I: relationship between age and intelligence and the frequency of expression of fragil (X)(q28).

Chudley AE, Knoll J, Gerrard JW, Shepel L, McGahey E, Anderson J

American journal of medical genetics.. 1983 April 14 (4):699-712. Epub 1900 01 01.

Antibiotics containing trimethoprim and the fragile X chromosome.

Hecht F, Glover TW

The New England journal of medicine.. 1983 February 3308 (5):285-6. Epub 1900 01 01.

The combined effects of FUdR addition and methionine depletion on the X-chromosome fragile site.

Glover TW, Howard-Peebles PN

American journal of human genetics.. 1983 January 35 (1):117-22. Epub 1900 01 01.

The fragile X chromosome.

Sutherland GR

International review of cytology.. 1983 81 :107-43. Epub 1900 01 01.

Fragile X-linked mental retardation of macro-orchidism.

Moore BC, Glover TW, Kaiser-McCaw B, Hecht F

The Western journal of medicine.. 1982 October 137 (4):278-81. Epub 1900 01 01.

[Metabolism of monocarbons and the fragile X syndrome].

Lejeune J

Bulletin de l'Académie nationale de médecine.. 1981 December 165 (9):1197-1206. Epub 1900 01 01.

Inpatient complications and discharge to hospice for acute ischemic stroke patients based on treatment.

Young KC; Hosley C; Leonhardt AM, Jahromi BS, Benesch CG.

Clinical Neurosurgery. .

Books

Approach to Coma, in The Intensive Care Manual (2001)

Authors: Benesch, C

Publisher: McGraw-Hill, New York 2001

Current Therapy, in Clinical Neurology (2001)

Authors: Counihan TJ, Plotkin K, Deiparine JA, King A, Cleland J, Barbano RL, Rempe D, Benesch C.

Publisher: Lippincott-Raven, Philadelphia 2001

Current Therapy, in Clinical Neurology (1996)

Authors: Goodman A, Benesch C, Berg M, Braun T, Calabresi PA, Holloway R, Joynt RJ, Samuels O, Williams LS, Wymer J.

Publisher: Lippincott-Raven, Philadelphia 1996

Current Therapy, in Clinical Neurology (1995)

Authors: Jozefowicz RF, Benesch C, Berg M, Calabresi PA, Dimitsopulos T, Goodman A, Holloway R, Joynt RJ, Williams L, Wojcieszek J.

Publisher: Lippincott-Raven, Philadelphia 1995

Current Therapy, in Clinical Neurology (1994)

Authors: Jozefowicz RF, Benesch C, Berg M, Dimitsopulos T, Gilmore J, Goodman A, Joynt RJ, Kieburtz K.

Publisher: Lippincott-Raven, Philadelphia 1994

Ratings & Comments

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Ratings

During this visit, did this provider spend enough time with you?

5.0

During this visit, did this provider show respect for what you had to say?

5.0

During this visit did this provider give you easy to understand information about these health questions or concerns?

4.9

During this visit, did this provider listen carefully to you?

5.0

During this visit, did this provider explain things in a way that was easy to understand?

5.0

Patient Comments

One of the best Doctor visits I've ever had. He took the time to explain possible causes and how tests would work to narrow cause down. OUTSTANDING communication skills!!

Aug 10, 2024

5.0

I feel so lucky to have Dr. Benesch as my doctor. I truly believe he saved my life.

Jun 05, 2024

5.0

My experience with my provider was good

Apr 15, 2024

5.0

Dr. B. listened and explained to all our concerns and questions.

Mar 14, 2024

5.0

The doctor is a stroke specialist, I have seen a good number of physicians, he's fine. I have to travel about 200 miles to see him it is worth it. He knows his practice very well.

Feb 14, 2024

5.0

Dr. Benesch made me feel comfortable. We developed the plan together. Felt he took me seriously and my symptoms. Felt I was in good hands.

Jan 29, 2024

5.0

They really care for and know their patients well

Oct 17, 2023

5.0

Dr. Benesch is the best, most caring provider I have ever had.

Jul 26, 2023

5.0

Yearly visit generally doesn't generate further therapy. Just repeat of prior year. Looking for new innovations.

Apr 27, 2023

5.0

Excellent.

Apr 04, 2023

5.0

He was the best!

Apr 04, 2023

5.0

Rare quality MD - very appreciated

Mar 03, 2023

5.0

Dr Benesch is a wonderful physician. My husband has aphasia from his stroke and he always takes the time it takes for my husband to express himself.

Dec 21, 2022

5.0

I was very pleased with my visit with Dr. Benesch. He was very thorough and spent very much time with me during the visit - much more than is typical these days in a medical office. I am very grateful to Dr. Benesch for his dedication and concern for his patients.

Oct 17, 2022

5.0

Have been a pt. of Dr. Benesch since 2010. Am very satisfied with his care through this illness.

Sep 08, 2022