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Charlotte K. Ryan, M.D.

Charlotte K. Ryan, M.D.

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UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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Contact

Office (585) 275-3191
Fax (585) 273-3637

About Me

Dr. Ryan participates in gastrointestinal, liver transplant and hepatobiliary working conferences for clinicians. Strong Memorial Hospital is a United Network for Organ Sharing (UNOS) transplant center for adult and pediatric transplant surgery and the only hospital in New York serving the upstate a...
Dr. Ryan participates in gastrointestinal, liver transplant and hepatobiliary working conferences for clinicians. Strong Memorial Hospital is a United Network for Organ Sharing (UNOS) transplant center for adult and pediatric transplant surgery and the only hospital in New York serving the upstate and western regions. Dr. Ryan is responsible for diagnosing the great majority of liver transplant biopsies and has received additional training at the University of Pittsburgh in the interpretation of both liver and small bowel transplant biopsies. She has also studied heart transplant pathology at the Mt. Sinai Medical Center in New York City and has helped cover that service for the last 9 years.

Certified Specialties

Pathology - Anatomic - American Board of Pathology

Faculty Appointments

Professor Emeritus - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Fellowship, Pathology, Anatomic Pathology & Clinical Pathology, University of Rochester Medical Center. 1990 - 1990

Residency, Pathology, Anatomic Pathology & Clinical Pathology, University of Rochester Medical Center. 1982 - 1982

Fellowship, Pathology, University of Rochester Medical Center. 1977 - 1981

Internship, Pathology, Anatomic Pathology & Clinical Pathology, University of Rochester Medical Center. 1975 - 1976

Education

MD | Johns Hopkins University School of Medicine (USA). 1975

Research

Dr. Ryan's research endeavors with the liver transplant program include the study of post transplant biopsies in hepatitis C patients more particularly regarding response to antiviral therapy and the treatment of acute cellular rejection. Additional projects have included liver grafts from donors wi...
Dr. Ryan's research endeavors with the liver transplant program include the study of post transplant biopsies in hepatitis C patients more particularly regarding response to antiviral therapy and the treatment of acute cellular rejection. Additional projects have included liver grafts from donors with CNS tumors and analysis of outcomes in patients with primary sclerosing cholangitis. Collaboration with Oncology is ongoing and involves the association of tissue factor (TF) with VEGF expression in colorectal, pancreatic and gastric carcinomas, suggesting a link between hemostatic activation and angiogenesis. Past studies included EGFR and VEGF expression and mutated K12-ras as indicators of survival in colon cancer. Another field of investigation concerns the development and evaluation of microtubule-targeting agents as therapeutic candidates in hepatic and colorectal cancers.

Publications

Journal Articles

Micro RNA expression profiles as adjunctive data to assess the risk of hepatocellular carcinoma recurrence after liver transplantation.

Barry CT, D'Souza M, McCall M, Safadjou S, Ryan C, Kashyap R, Marroquin C, Orloff M, Almudevar A, Godfrey TE

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2012 February 12 (2):428-37. Epub 10/18/2011.

Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.

Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C

Science translational medicine.. 2010 May 192 (32):32ra35. Epub 1900 01 01.

Safety and efficacy of fluoroscopic versus ultrasound guided core liver biopsies for potential living related liver transplant donors.

Saad, WEA; Ryan, CK; Davies, MG; Fultz, PJ; Rubens, DJ; Patel, NC; Sahler, LG; Lee, DE; Kitanosono, T; Sasson, T; Waldman, DL.

J. Vasc Interv Radiol. 2006; 17(11).

Incidence of arterial injuries detected by angiography following percutaneous right-lobe ultrasound-guided core liver biopsies in human subjects.

Saad, WEA; Davies, MG; Ryan, CK; Rubens, DJ; Lee, DE; Sahler, LG; Patel, NC; Waldman, DL.

Am J Gastro. 2006; 101: 1-5.

Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis.

Baichi MM, Arifuddin RM, Mantry PS, Bozorgzadeh A, Ryan C

Transplantation.. 2005 December 1580 (11):1630-2. Epub 1900 01 01.

Does valganciclovir hydrochloride (valcyte) provide effective prophylaxis against cytomegalovirus infection in liver transplant recipients?

Jain A, Orloff M, Kashyap R, Lansing K, Betts R, Mohanka R, Menegus M, Ryan C, Bozorgzadeh A

Transplantation proceedings.. 2005 September 37 (7):3182-6. Epub 1900 01 01.

Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer.

Khorana AA, Hu YC, Ryan CK, Komorowski RA, Hostetter G, Ahrendt SA

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2005 9 (7):903-11. Epub 1900 01 01.

The influence of host response on colorectal cancer prognosis.

Shunyakov L, Ryan CK, Sahasrabudhe DM, Khorana AA

Clinical colorectal cancer.. 2004 May 4 (1):38-45. Epub 1900 01 01.

Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living-donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus.

Bozorgzadeh A, Jain A, Ryan C, Ornt D, Zand M, Mantry P, Lansing K, Orloff M

Transplantation.. 2004 April 1577 (7):1066-70. Epub 1900 01 01.

Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA

Archives of dermatology.. 2004 April 140 (4):466-72. Epub 1900 01 01.

Adult onset appendicitis: Colonoscopy should be part of routine evaluation.

Sinha, A.; De Cross, A. ; Nazareth, M. ; Ryan, C.K ; Sundaram, U.;.

Practical Gastroenterology. 2004; 28(3): 74-78.

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.

Na X, Duan HO, Messing EM, Schoen SR, Ryan CK, di Sant'Agnese PA, Golemis EA, Wu G

The EMBO journal.. 2003 August 1522 (16):4249-59. Epub 1900 01 01.

Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.

Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM

The Journal of urology.. 2003 August 170 (2 Pt 1):588-92. Epub 1900 01 01.

Growth hormone and epidermal growth factor together enhance amino acid transport systems B(0,+) and A in remnant small intestine after massive enterectomy.

Ray EC, Avissar NE, Vukcevic D, Toia L, Ryan CK, Berlanga-Acosta J, Sax HC

The Journal of surgical research.. 2003 August 113 (2):257-63. Epub 1900 01 01.

Epithelioid hemangioendothelioma and the elusive vacuole.

Elias KR, Ryan CK

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.. 2003 March 9 (3):310-2. Epub 1900 01 01.

Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis.

Khorana AA, Ryan CK, Cox C, Eberly S, Sahasrabudhe DM

Cancer.. 2003 February 1597 (4):960-8. Epub 1900 01 01.

Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture.

Daikh BE, Ryan CK, Schwartz RH

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2003 January 90 (1):23-7. Epub 1900 01 01.

One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantation.

Ryan CK, Johnson LA, Germin BI, Marcos A

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.. 2002 December 8 (12):1114-22. Epub 1900 01 01.

Liver transplantation in mushroom poisoning.

Burton JR, Ryan C, Shaw-Stiffel TA

Journal of clinical gastroenterology.. 2002 September 35 (3):276-80. Epub 1900 01 01.

Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein.

Avissar NE, Ryan CK, Ganapathy V, Sax HC

American journal of physiology. Cell physiology.. 2001 September 281 (3):C963-71. Epub 1900 01 01.

Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.

Belly RT, Rosenblatt JD, Steinmann M, Toner J, Sun J, Shehadi J, Peacock JL, Raubertas RF, Jani N, Ryan CK

Clinical colorectal cancer.. 2001 August 1 (2):110-6. Epub 1900 01 01.

Development of Cystic Renal Disease in Interleukin-3 Transgenic Mice.

Bergeron, D.R. ; Barth, R.K. ; Ryan, C.K.;.

Transgenics. 2001; 3(2-4): 215-226.

Infliximab for Refactory Ulcerative Colitis.

Chey, W.Y.; Hussain, A.; Ryan, C.K. ; Potter, G. ; Shah, A.;.

Am J of Gastro. 2001; 96(8): 2373-2381.

CD-20 expression in post-transplant lymphoproliferative disorders: treatment with rituximab.

Ifthikharuddin JJ, Mieles LA, Rosenblatt JD, Ryan CK, Sahasrabudhe DM

American journal of hematology.. 2000 October 65 (2):171-3. Epub 1900 01 01.

Multiple esophageal rings: an association with eosinophilic esophagitis: case report and review of the literature.

Siafakas CG, Ryan CK, Brown MR, Miller TL

The American journal of gastroenterology.. 2000 June 95 (6):1572-5. Epub 1900 01 01.

Effects of 5-fluorouracil on flexor tendon repair.

Moran SL, Ryan CK, Orlando GS, Pratt CE, Michalko KB

The Journal of hand surgery.. 2000 March 25 (2):242-51. Epub 1900 01 01.

Brainstem progesterone receptor RNA upregulation in a rat model of hepatic cirrhosis.

Abt, P.L. ; Hisatake, G.M. ; Lustik, S.J. ; Ryan, C.K. ; Tessi, K. ; Orloff, M. ; Bronsther, O.L.;.

Applied Cardiopulmonary Pathophysiology. 2000; 8: 1-7.

Chronic expresion of interleukin-3 in the livers of transgenic mice results in injury to the liver and spleen.

Bergeron-Ramirez, D. ; Ryan, C.K. ; Barth, R.K.;.

Transgenics. 2000; 3(1): 71-80.

Seven cases of complete and incomplete forms of Churg-Strauss syndrome not related to leukotriene receptor antagonists.

Bili A, Condemi JJ, Bottone SM, Ryan CK

The Journal of allergy and clinical immunology.. 1999 November 104 (5):1060-5. Epub 1900 01 01.

Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis.

Hofgärtner WT, Thorp M, Ramus MW, Delorefice G, Chey WY, Ryan CK, Takahashi GW, Lobitz JR

The American journal of gastroenterology.. 1999 August 94 (8):2275-81. Epub 1900 01 01.

Tolerance induction permits the development of graft-versus-host disease: donor-mediated attack following small bowel transplantation in mixed chimeras.

Morrissey NJ, Blom D, Ryan CK, Fisher T, Bronsther O, Orloff MS

Transplant immunology.. 1999 March 7 (1):19-25. Epub 1900 01 01.

Enterocyte nutrient transport is preserved in a rabbit model of acute intestinal ischemia.

Iannoli P, Miller JH, Ryan CK, Sax HC

JPEN. Journal of parenteral and enteral nutrition.. 1998 22 (6):387-92. Epub 1900 01 01.

Glucocorticoids upregulate intestinal nutrient transport in a time-dependent and substrate-specific fashion.

Iannoli P, Miller JH, Ryan CK, Sax HC

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 1998 2 (5):449-57. Epub 1900 01 01.

Epidermal growth factor and human growth hormone accelerate adaptation after massive enterectomy in an additive, nutrient-dependent, and site-specific fashion.

Iannoli P, Miller JH, Ryan CK, Gu LH, Ziegler TR, Sax HC

Surgery.. 1997 October 122 (4):721-8; discussion 728-9. Epub 1900 01 01.

Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli.

Zwick A, Munir M, Ryan CK, Gian J, Burt RW, Leppert M, Spirio L, Chey WY

Gastroenterology.. 1997 August 113 (2):659-63. Epub 1900 01 01.

Resolution of anorectal incontinence in herpes proctitis confirmed by anorectal manometry.

Joseph D, Jin H, Ryan C, Chey WY

Gastrointestinal endoscopy.. 1997 May 45 (5):429-32. Epub 1900 01 01.

Graft versus host disease in rats made tolerant for organ allografts.

Morrissey NJ, Blom D, Ryan C, Fisher T, Bronsther O, Orloff M

The Journal of surgical research.. 1997 May 69 (2):307-15. Epub 1900 01 01.

Human growth hormone induces system B transport in short bowel syndrome.

Iannoli P, Miller JH, Ryan CK, Gu LH, Ziegler TR, Sax HC

The Journal of surgical research.. 1997 April 69 (1):150-8. Epub 1900 01 01.

Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy.

Ryan CK, Miller JH, Seydel AS, de Mesy Jensen K, Sax HC

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 1997 1 (5):467-73. Epub 1900 01 01.

Sequential alterations in gut mucosal amino acid and glucose transport after 70% small bowel resection.

Sarac TP, Seydel AS, Ryan CK, Bessey PQ, Miller JH, Souba WW, Sax HC

Surgery.. 1996 September 120 (3):503-8. Epub 1900 01 01.

Octreotide diminishes luminal nutrient transport activity, which is reversed by epidermal growth factor.

Seydel AS, Miller JH, Sarac TP, Ryan CK, Chey WY, Sax HC

American journal of surgery.. 1996 September 172 (3):267-71. Epub 1900 01 01.

Low-dose enteral feeding is beneficial during total parenteral nutrition.

Sax HC, Illig KA, Ryan CK, Hardy DJ

American journal of surgery.. 1996 June 171 (6):587-90. Epub 1900 01 01.

Evaluation of a carboxymethylcellulose sponge for prevention of postoperative adhesions.

Ryan CK, Sax HC

American journal of surgery.. 1995 January 169 (1):154-9; discussion 159-60. Epub 1900 01 01.

Disinfectant Colitis-Rinse As Well As You Wash.

Ryan, C.K. ; Potter, G.D. ;.

J Clinical Gastroenterol. 1995; 21(1): 6-9.

Starvation induces differential small bowel luminal amino acid transport.

Sarac TP, Souba WW, Miller JH, Ryan CK, Koch M, Bessey PQ, Sax HC

Surgery.. 1994 October 116 (4):679-85; discussion 685-6. Epub 1900 01 01.

Collective review: xanthogranulomatous cholecystitis.

Reed, A. ; Ryan, C. K.; Schwartz, S.I.;.

J Amer College of Surgeons. 1994; 179(2): 249-252.

Massive enterectomy alters brush border amino acid and glucose transport.

Sarac, T.P. ; Souba, W.W. ; Seydel, A. ; Ryan, C.K. ; Miller, J.H. ; Bessey, P.Q. ; Sax, H.C.;.

Surgical Forum. 1994; 45: 184 -187.

Pathologic quiz case 2. Chondrosarcoma of the maxilla.

Panosian MS, Hengerer AS, Ryan CK

Archives of otolaryngology--head & neck surgery.. 1993 February 119 (2):246-7, 249-50. Epub 1900 01 01.

Total parenteral nutrition-induced changes in gut mucosal function: atrophy alone is not the issue.

Illig KA, Ryan CK, Hardy DJ, Rhodes J, Locke W, Sax HC

Surgery.. 1992 October 112 (4):631-7. Epub 1900 01 01.

Histiomonocytic malignancy. A spectrum of disease in an 11-month-old infant.

Di Sant'Agnese PA, Ettinger LJ, Ryan CK, Jensen KL, Anderson VM, Biro FM, Emmens RW

Cancer.. 1983 October 1552 (8):1417-22. Epub 1900 01 01.

Malignant adenolymphoma.

Moosavi, H; Ryan, C; Schwartz, S; Donnelly, JA.

Human Pathology. 1982; 11: 80-83.

Ovarian lipoid cell tumor. Steroid hormones and ultrastructure.

Muechler EK, Gillette MB, Cary D, Ryan CK, di Sant' Agnese PA, Markham RE, Jacobs LS

Diagnostic gynecology and obstetrics.. 1982 4 (4):309-15. Epub 1900 01 01.

Oral mucosal neuromas leading to the diagnosis of MEN Type 2B in a child with intestinal pseudoobstruction.

Qualia, CM; Brown, MR; Ryan, CK; Rossi, TM.

Gastroenterology and Hepatology (in press).

Rectal and cutaneous malakoplakia in an orthotopic cardiac transplant recipient.

Teeters, J; Betts, R; Ryan, C; Huether, J; Elias, K; Hartmann, D; Massey, H; Chen, L.

J of Heart and Lung Transplantation (in press).

Tissue factor expression, angiogenesis and thrombosis in pancreatic cancer.

Khorana, A; Ahrendt, S; Ryan, C; Francis, C; Hruban, R; Hu, Y; Taubman, M.

Clinical Cancer Research (in press). .

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