Associate Professor
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Department of Microbiology and Immunology (SMD)
Credentials
Post-doctoral Training & Residency
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 1990 - 1995
Education
PhD | Japan-Hokkaido University - Sapporo.Microbiology.1994
DVM | Japan-Hokkaido University - Sapporo.Veterinary Medicine.1989
MS | Japan-Hokkaido University - Sapporo.Microbiology.1988
BS | Japan-Hokkaido University - Sapporo.Veterinary Medicine.1986
Research
RESEARCH ACTIVITIES
Research project in progress The major areas of research in my laboratory are as follows: Molecular mechanism of paramyxovirus assembly: Efficient assembly and release of progeny virions from infected cells are major determinants of viral pathogenicity. Molecular mec...
RESEARCH ACTIVITIES
Research project in progress The major areas of research in my laboratory are as follows: Molecular mechanism of paramyxovirus assembly: Efficient assembly and release of progeny virions from infected cells are major determinants of viral pathogenicity. Molecular mechanism of paramyxovirus assembly is not well understood. We are characterizing the trafficking of viral nucleocapsid to the site of assembly at the plasma membrane to understand the cellular machinery viruses utilize for assembly of progeny virions. URSMD Collaborators = Brian Ward, Minsoo Kim.
Assembly of Influenza A viruses: Influenza viruses replicate and form nucleocapsid core in nuclei of infected cells. The progeny nucleocapsid cores are then transported to the plasma membrane budding sites. This study analyzes cellular and viral protein interactions required for the nuclear export of nucleocapsid and budding of progeny virions. URSMD Collaborators = Brian Ward
Role of Influenza Virus Polymerase in Host Adaptation: We participate in the virology research team of the New York Influenza Center of Excellence (NYICE), which is part of the NIH Centers of Excellence for Influenza Research and Surveillance (CEIRS) network. Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo. URSMD Collaborators = David Topham, John Treanor, Steve Dewhurst, Baek Kim.
Scaggs Huang F, Bernstein DI, Slobod KS, Portner A, Takimoto T, Russell CJ, Meagher M, Jones BG, Sealy RE, Coleclough C, Branum K, Dickey M, Buschle K, McNeal M, Makowski M, Nakamura A, Hurwitz JL
Human vaccines & immunotherapeutics.. 2021 February 117 (2):554-559. Epub 08/04/2020.
Noronha JM, Liu M, Squires RB, Pickett BE, Hale BG, Air GM, Galloway SE, Takimoto T, Schmolke M, Hunt V, Klem E, García-Sastre A, McGee M, Scheuermann RH
Journal of virology.. 2012 May 86 (10):5857-66. Epub 03/07/2012.
