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Rajnish Bharadwaj, M.B.B.S., Ph.D.

Rajnish Bharadwaj, M.B.B.S., Ph.D.

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Contact

Office (585) 275-3202
Fax (585) 273-1027

About Me

Dr. Bharadwaj is a physician-scientist with clinical expertise in neuropathology. He received his MBBS from All India Institute of Medical Sciences, New Delhi and Ph.D. from University of Texas Southwestern Medical Center, Dallas. After finishing his graduate studies, he joined Johns Hopkins Unive...
Dr. Bharadwaj is a physician-scientist with clinical expertise in neuropathology. He received his MBBS from All India Institute of Medical Sciences, New Delhi and Ph.D. from University of Texas Southwestern Medical Center, Dallas. After finishing his graduate studies, he joined Johns Hopkins University School of Medicine as a postdoctoral fellow and worked on various problems pertaining to muscular and neuronal biology. Subsequently, he completed his residency in anatomic pathology and fellowship in neuropathology from University of Washington Medical Center, Seattle.

Languages

English, Hindi

Certified Specialties

Neuropathology - American Board of Pathology

Pathology - Anatomic - American Board of Pathology

Faculty Appointments

Assistant Professor - Department of Pathology and Laboratory Medicine (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Neuropathology, University of Washington School of Medicine. 2016 - 2018

Residency, Pathology - Anatomic, University of Washington School of Medicine. 2015 - 2016

Internship, Pathology - Anatomic, University of Washington School of Medicine. 2014 - 2015

Fellowship, Research, Johns Hopkins Bloomberg School of Public Health. 2004 - 2012

Education

PhD | UT Southwestern Medical Center (Allied Health). Clinical Genetics and Genomics (MD). 2004

MBBS | All India Institute of Medical Sciences (India). 1998

Awards

Weil Award. 2017

Environmental Pathology/Toxicology (EP/T) Training Grant T32. 2016 - 2017

Research

Dr. Bharadwaj's primary research interests are in molecular mechanisms of neurodegenerative diseases.
His ongoing research revolves around understanding the role of mitochondrial and lysosomal dysfunction in neurodegeneration, particularly in the context of Parkinsonism, for which these processes...
Dr. Bharadwaj's primary research interests are in molecular mechanisms of neurodegenerative diseases.
His ongoing research revolves around understanding the role of mitochondrial and lysosomal dysfunction in neurodegeneration, particularly in the context of Parkinsonism, for which these processes are especially important. He is currently focusing on a few genes, implicated in Parkinson's disease and a related movement disorder- Neurodegeneration with Brain Iron Accumulation (NBIA). Using the model organism Drosophila melanogaster as well as in vitro cell culture systems, and employing a combination of genetic, biochemical and cell biological approaches, he is trying to elucidate the roles of these genes in health and disease. To assess the broader relevance of the insights gleaned from basic research, Dr. Bharadwaj also plans to pursue translational research using postmortem brain tissue obtained from human patients.

Publications

Journal Articles

Nazo, the Drosophila homolog of the NBIA-mutated protein-c19orf12, is required for triglyceride homeostasis.

Sreejith P, Lolo S, Patten KR, Gunasinghe M, More N, Pallanck LJ, Bharadwaj R

PLoS genetics.. 2024 February 20 (2):e1011137. Epub 02/09/2024.

Error codes at autopsy to study potential biases in diagnostic error.

Goldman BI, Bharadraj R, Fuller M, Love T, Metlay L, Dignan C

Diagnosis.. 2023 November 110 (4):375-382. Epub 10/05/2023.

Granulomatous Amoebic Encephalitis Mimicking Neuromyelitis Optica Spectrum Disorder.

Douglas CE, Haynie ML, Weinberg GA, Johnson MD, Bharadwaj R, Williams ZR

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.. 2022 June 142 (2):e473-e475. Epub 07/01/2021.

In the Eye of the Beholder: A Conjunctival Lesion in a Woman With Acute Myelogenous Leukemia.

McGuffin SA, Bharadwaj R, Gonzalez-Cuyar LF, Schiffer JT, Stacey AW, Walter RB, Duke ER

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2019 January 1868 (3):525-529. Epub 1900 01 01.

Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice.

Bharadwaj R, Cimino PJ, Flanagan ME, Latimer CS, Gonzalez-Cuyar LF, Juric-Sekhar G, Montine TJ, Marshall DA, Keene CD

Histopathology.. 2018 February 72 (3):433-440. Epub 11/22/2017.

FIG4 regulates lysosome membrane homeostasis independent of phosphatase function.

Bharadwaj R, Cunningham KM, Zhang K, Lloyd TE

Human molecular genetics.. 2016 February 1525 (4):681-92. Epub 12/11/2015.

WIDE AWAKE mediates the circadian timing of sleep onset.

Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN

Neuron.. 2014 April 282 (1):151-66. Epub 03/13/2014.

Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila.

Bharadwaj R, Roy M, Ohyama T, Sivan-Loukianova E, Delannoy M, Lloyd TE, Zlatic M, Eberl DF, Kolodkin AL

Development.. 2013 February 1140 (3):627-38. Epub 1900 01 01.

Semaphorin regulation of cellular morphology.

Tran TS, Kolodkin AL, Bharadwaj R

Annual review of cell and developmental biology.. 2007 23 :263-92. Epub 1900 01 01.

Descrambling Dscam diversity.

Bharadwaj R, Kolodkin AL

Cell.. 2006 May 5125 (3):421-4. Epub 1900 01 01.

Identification of two novel components of the human NDC80 kinetochore complex.

Bharadwaj R, Qi W, Yu H

The Journal of biological chemistry.. 2004 March 26279 (13):13076-85. Epub 12/29/2003.

The spindle checkpoint, aneuploidy, and cancer.

Bharadwaj R, Yu H

Oncogene.. 2004 March 1523 (11):2016-27. Epub 1900 01 01.

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.

Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H

Molecular biology of the cell.. 2001 December 12 (12):3839-51. Epub 1900 01 01.

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

Tang Z, Bharadwaj R, Li B, Yu H

Developmental cell.. 2001 August 1 (2):227-37. Epub 1900 01 01.

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