Manoj J. Mammen, M.D.
he/him/his
Pulmonary & Critical Care Medicine , Internal Medicine
Contact
Manoj J. Mammen, M.D.
View Contact & SchedulingLocations
Red Creek (Calkins Corporate Park)
400 Red Creek Drive, Suite 110
Rochester, NY 14623
About Me
In my clinical practice, primarily at Strong Memorial Hospital, I provide comprehensive care to patients with various pulmonary conditions, including ARDS, asthma, COPD, interstitial lung disease, pleural disease, pulmonary hypertension, and lung cancer. Additionally, I am actively involved in the Mary Parkes Asthma Center, evaluating patients in the outpatient setting who present with pulmonary disorders. Collaborating with a dedicated team of healthcare professionals, I strive to deliver exceptional care across multiple practice locations.
Beyond my clinical, research, and educational activities, I am dedicated to leadership and service in the field. As an executive board member of the New York State Thoracic Society (NYSTS), I have held positions such as program chair of the annual conference, secretary, treasurer, vice president and currently serve as the president-elect. Additionally, I am a chapter council representative to the ATS and have served as the president of the ATS's Council of Chapters Committee and ATS board of directors. These roles allow me to contribute to the advancement of the field, impact global health, and transform patient care.
In summary, my passion lies in advancing the field of pulmonary and critical care medicine through clinical practice, research, education, leadership, and service. My focus on computational approaches, multi-omic data analysis, and guideline development allows me to make significant contributions to understanding COPD pathogenesis, identifying therapeutic targets, and improving patient outcomes. I strive to empower the next generation of healthcare professionals to provide exceptional care through my dedication to education and professional development.
Certified Specialties
Internal Medicine - American Board of Internal Medicine
Internal Medicine-Critical Care Medicine - American Board of Internal Medicine
Pulmonary Disease - American Board of Internal Medicine
Faculty Appointments
Associate Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)
Credentials
Residency & Fellowship
Fellowship, National Cancer Institute/National Institute of Health. 2016 - 2018
Fellowship, Buffalo General Hospital-Kaleida Health. 2014 - 2016
Fellowship, Pulmonary and Critical Care Medicine, Baylor College of Medicine-Pulmonary/Critical Care Fellowship. 2007 - 2010
Residency, Internal Medicine, Baylor College of Medicine. 2005 - 2007
Internship, Internal Medicine, Baylor College of Medicine. 2004 - 2005
Education
MS | SUNY at Buffalo-School of Medicine & Biomedical Sciences (USA). Medical Genetics, Clinical Genetics (M.D.). 2016
MD | Rutgers New Jersey Medical School. 2004
Research
One of the main focuses of my research has been chronic obstructive pulmonary disease (COPD), a complex respiratory condition associated with significant morbidity and mortality. Collaborating with renowned experts, I have explored the intricate mechanisms driving COPD pathogenesis, particularly the network biology of pathogen-host interactions during disease exacerbations. As a co-investigator, I have played a crucial role in analyzing transcriptome and microbiome data obtained from clinical samples. This research, funded by esteemed organizations, aims to uncover novel insights into COPD exacerbations and identify potential therapeutic targets.
Additionally, I have actively contributed to the study of COVID-19, a global pandemic that has posed significant challenges to healthcare systems worldwide. As a site principal investigator, I have made substantial contributions to two prominent clinical trials investigating potential treatments for COVID-19. These trials, funded by the NIH and NCATS/NIH, are evaluating the efficacy and safety of immune-based interventions for COVID-19. My responsibilities have included overseeing trial selection, site activation, and study execution, with a focus on maximizing enrollment and data quality. The outcomes of these trials have the potential to shape treatment strategies and improve patient outcomes.
Furthermore, I have explored the connection between the airway microbiome and lung cancer in a COPD cohort, offering valuable insights into the complex relationships between these conditions.
In my research, I have also focused on investigating the role of galectin-3 in asthma. Galectin-3 is a protein involved in inflammation and tissue remodeling. By studying its implications in asthma, I aim to gain insights into the underlying mechanisms of the disease and potentially identify novel therapeutic targets. This research contributes to our understanding of asthma pathogenesis and may lead to the development of more effective treatment strategies for individuals with this chronic respiratory condition.
In addition to translational and clinical research, I actively engage in developing and implementing clinical practice guidelines, utilizing the GRADE methodology, and advancing evidence-based medicine. As a member of the American Thoracic Society (ATS), I have played a critical role in creating guidelines for the treatment of COPD and interstitial lung disease. I additionally co-authored surviving sepsis guidelines for COVID-19 management during the COVID-19 pandemic. These guidelines, based on rigorous evaluation of the available evidence, optimize patient care and ensure standardized approaches to management.
In summary, my research journey is dedicated to unraveling the complexities of respiratory diseases, identifying therapeutic targets, and making meaningful contributions to patient care. Through collaborations, funding support, and guideline development, I aim to transform patient care, improve outcomes, and shape the future of pulmonary medicine.
Publications
Journal Articles
Farhat Z, Scheving T, Aga DS, Hershberger PA, Freudenheim JL, Hageman Blair R, Mammen MJ, Mu L
Nutrients.. 2023 September 2215 (19)Epub 09/22/2023.
Amberson T, Heagele T, Wyte-Lake T, Couig MP, Bell SA, Mammen MJ, Wells V, Castner J
Frontiers in public health.. 2023 11 :1257714. Epub 02/23/2024.
Mattle AG, McGrath P, Sanu A, Kunadharaju R, Kersten B, Zammit K, Mammen MJ
Drug and alcohol dependence.. 2022 December 1241 :109671. Epub 10/21/2022.
Self WH, Wheeler AP, Stewart TG, Schrager H, Mallada J, Thomas CB, Cataldo VD, O'Neal HR, Shapiro NI, Higgins C, Ginde AA, Chauhan L, Johnson NJ, Henning DJ, Jaiswal SJ, Mammen MJ, Harris ES, Pannu SR, Laguio-Vila M, El Atrouni W, de Wit M, Hoda D, Cohn CS, McWilliams C, Shanholtz C, Jones AE, Raval JS, Mucha S, Ipe TS, Qiao X, Schrantz SJ, Shenoy A, Fremont RD, Brady EJ, Carnahan RH, Chappell JD, Crowe JE, Denison MR, Gilchuk P, Stevens LJ, Sutton RE, Thomsen I, Yoder SM, Bistran-Hall AJ, Casey JD, Lindsell CJ, Wang L, Pulley JM, Rhoads JP, Bernard GR, Rice TW,
Chest.. 2022 November 162 (5):982-994. Epub 07/01/2022.
Kheir F, Uribe Becerra JP, Bissell BD, Ghazipura M, Herman DD, Hon SM, Hossain T, Khor YH, Knight SL, Kreuter M, Macrea M, Mammen MJ, Martinez FJ, Poletti V, Troy L, Raghu G, Wilson KC
Annals of the American Thoracic Society.. 2022 July 19 (7):1193-1202. Epub 1900 01 01.
Thomas P, Alexander PE, Ahmed U, Elderhorst E, El-Khechen H, Mammen MJ, Debono VB, Aponte Torres Z, Aryal K, Brocard E, Sagastuy B, Alhazzani W
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.. 2022 June 35 (12):2387-2394. Epub 07/01/2020.
Ghazipura M, Mammen MJ, Bissell BD, Macrea M, Herman DD, Hon SM, Kheir F, Khor YH, Knight SL, Raghu G, Wilson KC, Hossain T
Annals of the American Thoracic Society.. 2022 June 19 (6):1030-1039. Epub 1900 01 01.
Ghazipura M, Mammen MJ, Herman DD, Hon SM, Bissell BD, Macrea M, Kheir F, Khor YH, Knight SL, Raghu G, Wilson KC, Hossain T
Annals of the American Thoracic Society.. 2022 June 19 (6):1040-1049. Epub 1900 01 01.
Duhailib ZA, Oczkowski S, Polok K, Fronczek J, Szczeklik W, Piticaru J, Mammen MJ, Alshamsi F, Eikelboom J, Belley-Cote E, Alhazzani W
Journal of infection and public health.. 2022 June 15 (6):689-702. Epub 05/14/2022.
Raghu G, Remy-Jardin M, Richeldi L, Thomson CC, Inoue Y, Johkoh T, Kreuter M, Lynch DA, Maher TM, Martinez FJ, Molina-Molina M, Myers JL, Nicholson AG, Ryerson CJ, Strek ME, Troy LK, Wijsenbeek M, Mammen MJ, Hossain T, Bissell BD, Herman DD, Hon SM, Kheir F, Khor YH, Macrea M, Antoniou KM, Bouros D, Buendia-Roldan I, Caro F, Crestani B, Ho L, Morisset J, Olson AL, Podolanczuk A, Poletti V, Selman M, Ewing T, Jones S, Knight SL, Ghazipura M, Wilson KC
American journal of respiratory and critical care medicine.. 2022 May 1205 (9):e18-e47. Epub 1900 01 01.
Mammen MJ, Tu C, Morris MC, Richman S, Mangione W, Falls Z, Qu J, Broderick G, Sethi S, Samudrala R
Pharmaceuticals.. 2022 May 115 (5)Epub 05/01/2022.
Kheir F, Uribe Becerra JP, Bissell B, Ghazipura M, Herman D, Hon SM, Hossain T, Khor YH, Knight SL, Kreuter M, Macrea M, Mammen MJ, Martinez FJ, Poletti V, Troy L, Raghu G, Wilson KC
Annals of the American Thoracic Society.. 2022 May 19 (5):827-832. Epub 1900 01 01.
Khor YH, Bissell B, Ghazipura M, Herman D, Hon SM, Hossain T, Kheir F, Knight SL, Kreuter M, Macrea M, J Mammen M, Molina-Molina M, Selman M, Wijsenbeek M, Raghu G, Wilson KC
Annals of the American Thoracic Society.. 2022 May 19 (5):833-844. Epub 1900 01 01.
Elkin PL, Resendez S, Mullin S, Troen BR, Mammen MJ, Chang S, Franklin G, McCray W, Brown SH
Journal of clinical and translational science.. 2022 6 (1):e74. Epub 05/16/2022.
Farhat Z, Hershberger PA, Freudenheim JL, Mammen MJ, Hageman Blair R, Aga DS, Mu L
European journal of nutrition.. 2021 October 60 (7):3585-3609. Epub 02/04/2021.
Chaudhuri D, Sasaki K, Karkar A, Sharif S, Lewis K, Mammen MJ, Alexander P, Ye Z, Lozano LEC, Munch MW, Perner A, Du B, Mbuagbaw L, Alhazzani W, Pastores SM, Marshall J, Lamontagne F, Annane D, Meduri GU, Rochwerg B
Intensive care medicine.. 2021 May 47 (5):521-537. Epub 04/19/2021.
Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW,
Trials.. 2021 March 2022 (1):221. Epub 03/20/2021.
Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW
Research square.. 2021 March 2 Epub 03/02/2021.
Alhazzani W, Evans L, Alshamsi F, Møller MH, Ostermann M, Prescott HC, Arabi YM, Loeb M, Ng Gong M, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Machado F, Wunsch H, Crowther M, Cecconi M, Koh Y, Burry L, Chertow DS, Szczeklik W, Belley-Cote E, Greco M, Bala M, Zarychanski R, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Nainan Myatra S, Arrington A, Kleinpell R, Citerio G, Lewis K, Bridges E, Memish ZA, Hammond N, Hayden FG, Alshahrani M, Al Duhailib Z, Martin GS, Kaplan LJ, Coopersmith CM, Antonelli M, Rhodes A
Critical care medicine.. 2021 March 149 (3):e219-e234. Epub 1900 01 01.
Mammen MJ, Charbek E, Alexander PE, Nici L, Aaron SD
American journal of respiratory and critical care medicine.. 2021 January 15203 (2):267-269. Epub 1900 01 01.
Gartman EJ, Mulpuru SS, Mammen MJ, Alexander PE, Nici L, Aaron SD, Ruminjo JK, Thomson CC
Annals of the American Thoracic Society.. 2021 January 18 (1):11-16. Epub 1900 01 01.
Akl EA, Morgan RL, Rooney AA, Beverly B, Katikireddi SV, Agarwal A, Alper BS, Alva-Diaz C, Amato L, Ansari MT, Brozek J, Chu DK, Dahm P, Darzi AJ, Falavigna M, Gartlehner G, Pardo-Hernandez H, King V, Klugarová J, Langendam MWM, Lockwood C, Mammen M, Mathioudakis AG, McCaul M, Meerpohl JJ, Minozzi S, Mustafa RA, Nonino F, Piggott T, Qaseem A, Riva J, Rodin R, Sekercioglu N, Skoetz N, Traversy G, Thayer K, Schünemann H
Journal of clinical epidemiology.. 2021 January 129 :1-11. Epub 09/30/2020.
Mammen MJ, Ali J, Aurora A, Sharma UC, Aalinkeel R, Mahajan SD, Sands M, Schwartz SA
International journal of cell biology.. 2021 2021 :9997625. Epub 06/09/2021.
Mammen MJ, Lloyd DR, Kumar S, Ahmed AS, Pai V, Kunadharaju R, Gupta S, Nici L, Aaron SD, Alexander PE
Annals of the American Thoracic Society.. 2020 October 17 (10):1308-1318. Epub 1900 01 01.
Mammen MJ, Pai V, Aaron SD, Nici L, Alhazzani W, Alexander PE
Annals of the American Thoracic Society.. 2020 September 17 (9):1133-1143. Epub 1900 01 01.
Alexander PE, Debono VB, Mammen MJ, Iorio A, Aryal K, Deng D, Brocard E, Alhazzani W
Journal of clinical epidemiology.. 2020 July 123 :120-126. Epub 04/21/2020.
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A
Critical care medicine.. 2020 June 48 (6):e440-e469. Epub 1900 01 01.
Mammen MJ, Scannapieco FA, Sethi S
Periodontology 2000.. 2020 June 83 (1):234-241. Epub 1900 01 01.
Nici L, Mammen MJ, Charbek E, Alexander PE, Au DH, Boyd CM, Criner GJ, Donaldson GC, Dreher M, Fan VS, Gershon AS, Han MK, Krishnan JA, Martinez FJ, Meek PM, Morgan M, Polkey MI, Puhan MA, Sadatsafavi M, Sin DD, Washko GR, Wedzicha JA, Aaron SD
American journal of respiratory and critical care medicine.. 2020 May 1201 (9):e56-e69. Epub 1900 01 01.
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A
Intensive care medicine.. 2020 May 46 (5):854-887. Epub 03/28/2020.
Mammen MJ, Aryal K, Alhazzani W, Alexander PE
Polish archives of internal medicine.. 2020 April 30130 (4):276-286. Epub 03/18/2020.
Mammen MJ, Aryal K, Alhazzani W, Deng DY, Alexander PE
Polish archives of internal medicine.. 2020 April 30130 (4):287-296. Epub 04/03/2020.
Castner J, Jungquist CR, Mammen MJ, Pender JJ, Licata O, Sethi S
Heart & lung : the journal of critical care.. 2020 49 (5):548-555. Epub 02/20/2020.
Castner J, Mammen MJ, Jungquist CR, Licata O, Pender JJ, Wilding GE, Sethi S
The Journal of asthma : official journal of the Association for the Care of Asthma.. 2019 July 56 (7):719-730. Epub 08/24/2018.
Mammen MJ, Sands MF, Abou-Jaoude E, Aalinkeel R, Reynolds JL, Parikh NU, Sharma U, Schwartz SA, Mahajan SD
Immunology.. 2018 March 153 (3):387-396. Epub 11/07/2017.
Aalinkeel R, Mangum CS, Abou-Jaoude E, Reynolds JL, Liu M, Sundquist K, Parikh NU, Chaves LD, Mammen MJ, Schwartz SA, Mahajan SD
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2017 March 12 (1):133-151. Epub 12/27/2016.
Mammen MJ, Sethi S
Respirology : official journal of the Asian Pacific Society of Respirology.. 2016 May 21 (4):590-9. Epub 01/27/2016.
Parikh NU, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Mammen MJ, Schwartz SA, Mahajan SD
Brain research.. 2015 October 221624 :175-187. Epub 07/30/2015.
Ignatowski TA, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Gleason CP, Law WC, Mammen MJ, Prasad PN, Schwartz SA, Mahajan SD
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2015 March 10 (1):136-52. Epub 01/22/2015.
Berenson CS, Kruzel RL, Wrona CT, Mammen MJ, Sethi S
PloS one.. 2015 10 (9):e0134209. Epub 09/11/2015.
Tu C, Mammen MJ, Li J, Shen X, Jiang X, Hu Q, Wang J, Sethi S, Qu J
Journal of proteome research.. 2014 February 713 (2):627-639. Epub 12/02/2013.
Reynolds JL, Law WC, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Mammen MJ, Yong KT, Hui R, Prasad PN, Schwartz SA
The Journal of immunology : official journal of the American Association of Immunologists.. 2012 April 15188 (8):3757-65. Epub 03/19/2012.
Mammen MJ, Sethi S
Polskie Archiwum Medycyny Wewn?trznej.. 2012 122 (1-2):54-9. Epub 1900 01 01.
Hesselbacher SE, Ross R, Schabath MB, Smith EO, Perusich S, Barrow N, Smithwick P, Mammen MJ, Coxson H, Krowchuk N, Corry DB, Kheradmand F
International journal of environmental research and public health.. 2011 May 8 (5):1324-40. Epub 04/29/2011.
Ratings & Comments
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Ratings
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Patient Comments
Dr Mammen is amazing!
Jan 05, 2024
Mr. Mammen is an outstanding doctor. In one visit he addresses a number of issues and is extremely efficient. I am so lucky to have help from this provider!!!
Nov 17, 2023
Dr. Mammen has been fantastic with everything. He explains things very well and always checks to see if I have any questions.
Jun 16, 2023
This provider is a specialist and if someone ask me who did I see for my pulmonary problem I will recommend.
Jun 02, 2023
Dr. Mammen is the best provider I have had at URMC. He is a very kind person.
Apr 06, 2023
He is very polite & shows true concern, also, very knowledgeable.
Feb 23, 2023
Excellent listening skills thorough explanations of conditions.
Feb 16, 2023
Dr. Mammen is very good at explaining this condition and the treatment plan very well to me.
Feb 13, 2023
He was awesome. He spent time and actually listened to me.
Dec 30, 2022