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Radiation Oncology

URMC / Radiation Oncology / Research / Dr. Marples

Dr. Marples

Brian Marples, Ph.D.

My CV: Brian Marples, Ph.D.

Grants

  • 1RO1CA227493-01 NIH/NCI "Targeting SMPDL3b to Prevent Radiation-Induced Nephrotoxicity.” The project investigates the molecular and cellular pathways of radiation nephropathy, and focuses on an enzyme sphingomyelin-phosphodiesterase acid-like-3b (SMPDL3b) in cell culture and animal models. (PIs Marples and Fornoni)
  • 5U19AI067773-17: G16051 "Mitigating Viral Impact on Lung Radiosensitivity.” NIH Centers for Medical Countermeasures Against Radiation Consortium (CMCRC).  The project investigates the molecular regulation of radiation-induced damage in the lung, and how these events affect the susceptibility and severity to pulmonary viral infections. (PI Marples)
  • DOD GR531829 "A Novel Targeted Therapy for Metastases from TNBC.” To test a novel engineered macrophage that directly targets triple negative breast cancer to prevent and treat their metastasis in lung, bone, and brain. (PI-Yao, Co-I-Marples)
  • 1S10OD021548-01 "SARRP 200 Platform for Image Guided Micro Irradiation.” (PI Marples)
  • Wilmot Cancer Institute's Research Development Funding Program "Elucidating the Role of the Renin-Angiotensin Pathway in Development of Hemorrhagic Radiation Cystitis." (PIs Kerns and Marples)

Research

Radiobiology of Normal Tissues

  • Collaborative project with Dr. Alessia Fornoni at the University of Miami
  • Defining mechanisms of renal injury in cancer patients treated with radiotherapy.
  • Assessing the role of sphingomyelinase in mediating radiation injury.

Radiation-Induced Bladder Injury

  • Defining the molecular response of bladder injury.
  • Characterizing of biomarkers of bladder injury and tissue recovery.
  • Evaluation of medications targeting the angiotensin pathway as radioprotectors.

Radiation-Induced Lung Injury

  • Defining gene expression changes in response to irradiation and role in acute and late toxicity.
  • Investigating the role of macrophages in tissue remodeling after pulmonary irradiation.
  • Functional studies to identify the risks of combined viral and radiation injury to the lungs.

Collaborative Studies

  • Targeting triple negative breast cancer to prevent and treat their metastasis in lung, bone, brain
  • Neural damage and neuroinflammation, microglial and preservation of cognitive function.

Staff & Student Researchers

Collaborators at URMC