Project 3 - Dissecting the Neural and Neuromodulatory Control Mechanisms of Arterial Dynamics During Sleep

Sleep is accompanied by large changes in neural activity, modulatory state, and hemodynamics.  The Large arterial dilaions and contractions during sleep could drive perivascular pumping of CSF, which would help clear fluid and solutes from the brain. The goal of our project is to understand how neural and modulatory drivers that control arterial diameter changes during sleep.  This will reveal the local and global controllers of the periarterial pumping of cerebrospinal fluid.

Research Aims

Aim 1: Determine the role of cell-type specific neurovascular coupling in vasodilation during NREM sleep

Aim 2: Determine the role of neuromodulation (ACh/NE) on vascular dynamics during sleep

Aim 3: Undrstanding the spatiotemporal dynamics of arterial dilations during wake/NREM sleep and their effect on CSF movement. 

Publications

Understanding the Influence of Cholinergic and Noradrenergic Modulation on Hemodynamics during Sleep, M. Hossain, K.L. Turner, Q. Zhang, P.J. Drew; SFN2023, Sleep Regulation and Function, Gordon Research Conference 2024

The dynamics of Tac1-expressing neuron activity during sleep and wake states, F. Salehi,  M. Hossain, P.J. Drew;   SFN2023, Sleep Regulation and Function, Gordon Research Conference 2024

Type-I nNOS neurons orchestrate cortical neural activity and vasomotion, K.L. Turner, D.F. Brockway, M. Hossain, K.R. Griffith, D.I. Greenawalt, Q. Zhang, K.W. Gheres,  N.A. Crowley, P.J. Drew -Submitted