Recent Research Publications
Academic Year 2023-2024
Fukushima CT, Dancil IS, Shah ND, Nadtochiy SM, Brookes PS. "Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions." Redox Biology. Apr 2024;70103047. doi:10.1016/j.redox.2024.103047
Fukushima CT, Dancil IS, Shah ND, Brookes PS, Nadtochiy SM. "Relative Importance Of Reactive Oxygen Species From Reverse Electron Transfer At Mitochondrial Complex I In Reperfusion Injury." Circulation Research. Aug 2023;133doi:10.1161/res.133.suppl_1.P2121
Mia S, Sonkar R, Williams L, Brookes PS et al. Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology. Jacc-Basic to Translational Science. Sep 2023;8(9):1141-1156. doi:10.1016/j.jacbts.2023.03.016
Beutner G, Burris JR, Collins MP, Nadtochiy SM, Brookes PS, et al. Coordinated metabolic responses to cyclophilin D deletion in the developing heart. Iscience. Mar 2024;27(3)109157. doi:10.1016/j.isci.2024.109157
Aguilar GR, Chandrasekar E, Swetschinski LR, Weaver ND, et al. The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis. Article. Lancet Regional Health-Americas. Sep 2023;25:16. 100561. doi:10.1016/j.lana.2023.100561
Kim MS, Hwang J, Chandrasekar E, Yon DK, et al. Global burden of peripheral artery disease and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Article. Lancet Glob Health. Oct 2023;11(10):E1553-E1565. doi:10.1016/s2214-109x(23)00355-8
Cohen SP, Carcini A, Kapural L, Kohan L, et al. Cooled radiofrequency ablation versus standard medical management for chronic sacroiliac joint pain: a multicenter, randomized comparative effectiveness study. Article. Region Anesth Pain Med. Mar 2024;49(3):184-191. doi:10.1136/rapm-2023-104568
Eaton MP, Nadtochiy SM, Angona RE. Dabigatran in Rabbit Cardiopulmonary Bypass: Reply. Letter. Anesthesiology. Dec 2023;139(6):4. doi:10.1097/aln.0000000000004701
Eaton MP, Nadtochiy SM, Stefanos T, Anderson BJ. Dabigatran pharmacokinetic-pharmacodynamic in sheep: Informing dose for anticoagulation during cardiopulmonary bypass. Article; Early Access. Perfusion-UK. 2024 Jan 2024:9. doi:10.1177/02676591231226291
Nadtochiy SM, Stefanos T, Eaton, MP, Wissler R, et al. Effect of bivalirudin on coagulation in neonatal (cord) and adult human blood in vitro. Article. Pediatr Anesth. May 2024;34(5):415-421. doi:10.1111/pan.14814
Dworkin RH, McDermott MP, Nayak SM, Strain EC. "Psychedelics and Psychotherapy: Is the Whole Greater than the Sum of its Parts?" Clinical Pharmacology & Therapeutics. Dec 2023;114(6):1166-1169. doi:10.1002/cpt.3050
Dworkin RH, McDermott MP, Nayak SM, Strain EC. "Reply to 'Capturing Synergy Holistically in Psychedelic Clinical Trials'." Clinical Pharmacology & Therapeutics. Mar 2024;115(3):401-402. doi:10.1002/cpt.3130
Bergeria CL, Park B, Satyavolu PU, Dunn KE, Dworkin RH, Strain EC. Virtual focus groups among individuals with use disorders: assessing feasibility and acceptability in an underserved clinical population. Frontiers in Psychiatry. Mar 2024;151352300. doi:10.3389/fpsyt.2024.1352300
Haroutounian S, Holzer KJ, Kerns RD, Dworkin RH et al. Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations. Pain. May 2024;165(5):1013-1028. doi:10.1097/j.pain.0000000000003121
Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Dworkin RH et al. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain. Jul 2023;164(7):1457-1472. doi:10.1097/j.pain.0000000000002888
Jackson SS, Lee JJ, Jackson WM, Dworkin RH et al. Sedation Research in Critically Ill Pediatric Patients: Proposals for Future Study Design From the Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research IV Workshop. Pediatric Critical Care Medicine. Apr 2024;25(4):e193-e204. doi:10.1097/pcc.0000000000003426
Langford DJ, Baron R, Edwards RR, Dworkin RH et al. What should be the entry pain intensity criteria for chronic pain clinical trials? An IMMPACT update. Pain. Sep 2023;164(9):1927-1930. doi:10.1097/j.pain.0000000000002930
Linguiti S, Vogel JW, Sydnor VJ, Dworkin RH et al. Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results. Neuroscience and Biobehavioral Reviews. Nov 2023;154105421. doi:10.1016/j.neubiorev.2023.105421
Michelson D, Chin WW, Dworkin RH, et al. A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy. Pain Reports. Dec 2023;8(6)e1114. doi:10.1097/pr9.0000000000001114
Nishtar M, Mark R, Langford DJ, Dworkin RH et al. Evaluating the balance of benefits and harms in chronic pain clinical trials: prioritizing individual participants over individual outcomes. Region Anesth Pain Med. May 2024;49(5):363-367. doi:10.1136/rapm-2023-104809
Ren JM, Bushmakin AG, Cislo PR, Dworkin RH et al. Meaningful within-patient change for clinical outcome assessments: model-based approach versus cumulative distribution functions. Journal of Biopharmaceutical Statistics. 2023 Nov 2023;doi:10.1080/10543406.2023.2281575
Zia FZ, Baumann MH, Belouin SJ, Dworkin RH et al. Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs. Neuropharmacology. Aug 2023;233109528. doi:10.1016/j.neuropharm.2023.109528
Langford DJ, Sharma S, McDermott MP, Dworkin RH et al. Covariate Adjustment in Chronic Pain Trials: An Oft-Missed Opportunity. Journal of Pain. Sep 2023;24(9):1555-1569. doi:10.1016/j.jpain.2023.06.007
Glance LG, Benesch CG, Maddox KEJ, et al. "Was COVID-19 Associated With Worsening Inequities in Stroke Treatment and Outcomes?" J Am Heart Assoc. Oct 2023;12(19):12. e031221. doi:10.1161/jaha.123.031221
Glance LG, Maddox KEJ, Shang JJ, et al. "The COVID-19 Pandemic and Associated Inequities in Acute Myocardial Infarction Treatment and Outcomes." JAMA Netw Open. Aug 2023;6(8):15. e2330327. doi:10.1001/jamanetworkopen.2023.30327
Glance LG, Smith DI, Maddox KEJ. "Do Anesthesiologists Have a Role in Promoting Equitable Health Care?"Anesthesiology. Sep 2023;139(3):244-248. doi:10.1097/aln.0000000000004672
Laserna A, VanWijngaarden E, Nates J, Li Y, Sun E, Glance L. "Racial and Ethnic Disparities in Failure-to-Rescue After Sepsis in Noncardiac Surgery." Crit Care Med. Jan 2024;52:1.
Panda K, Glance LG, Mazzeffi M, et al. Perioperative Extracorporeal Cardiopulmonary Resuscitation in Adult Patients: A Review for the Perioperative Physician. Review. Anesthesiology. May 2024;140(5):1026-1042. doi:10.1097/aln.0000000000004916
Stone PW, Zhao SN, Glance LG, Chastain AM, et al. State- and Territory-Level Nursing Home and Home Health Care COVID-19 Policies and Disease Burden. Article. JAMA Netw Open. Apr 2024;7(4):4. e247683. doi:10.1001/jamanetworkopen.2024.7683
Estrada LV, Barcelona V, Dhingra L, Luchsinger JA, Dick AW, Glance LG, Stone PW Potentially Avoidable Hospitalizations Among Historically Marginalized Nursing Home Residents. JAMA Netw Open. 2024 May 1;7(5):e249312. doi: 10.1001/jamanetworkopen.2024.9312.PMID: 38696169
Sekeres G, Miller TR, Mariano ER, Glance LG, Sun EC. Association between Anesthesia Group Size and Merit-Based Incentive Payment System Scores. Anesthesiology 2024 Apr 1;140(4):853-855. doi: 10.1097/ALN.0000000000004887.PMID: 38470114
Kang JA, Stone PW, Glance LG, Dick AW. The association of nursing home infection preventionists' training and credentialing with resident COVID 19 deaths. J Am Geriatr Soc. 2024 Apr;72(4):1070-1078. doi: 10.1111/jgs.18760. Epub 2024 Jan 19.PMID: 38241196
Mazzeffi M, Curley J, Gallo P, Stombaugh DK, Roach J, Lundardi N, Yount K, Thiele R, Glance LG, Naik B. Variations in Hospitalizations, Costs, Charges, And Lengths of Stay for Coronavirus Disease 2019 Patients Treated with Venovenous Extracorporeal Membrane Oxygenation in the United States: A Cohort Study. J Cardiothoracic Vascular Anesthesiology. 2023 Aug; 37(8): 1449-1455.
Acquisto NM, Galton C, Mosier JM, Bittner EA, et al. Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient: Executive Summary. Article. Crit Care Med. Oct 2023;51(10):1407-1410. doi:10.1097/ccm.0000000000005999
Glance LG, Galton C, Benesch CG, Maddox KEJ, et al. Was COVID-19 Associated With Worsening Inequities in Stroke Treatment and Outcomes? Article. J Am Heart Assoc. Oct 2023;12(19):12. e031221. doi:10.1161/jaha.123.031221
Juviler P, Meyers JM, Gloff M, Levatino E, et al. Reducing Unplanned Intubations in the Neonatal Intensive Care Unit After Children's Surgery: A Quality Improvement Project. Article. J Pediatr Surg. Jan 2024;59(1):45-52. doi:10.1016/j.jpedsurg.2023.09.029
Pai SL, Gloff M, Blitz J. Preoperative Considerations for Ambulatory Surgery: What Is New, What Is Controversial. Article. Curr Anesthesiol Rep. Jun 2024;14(2):263-273. doi:10.1007/s40140-024-00616-1
Gewandter J. Treatment and assessment of neuropathic pain: Insights into clinical trial development. Journal of the Neurological Sciences. Dec 2023;455doi:10.1016/j.jns.2023.120990
Haroutounian S, Holzer KJ, Kerns RD, Gewandter J. et al. Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations. Pain. May 2024;165(5):1013-1028. doi:10.1097/j.pain.0000000000003121
Langford DJ, Baron R, Edwards RR, Gewandter J. et al. What should be the entry pain intensity criteria for chronic pain clinical trials? An IMMPACT update. Pain. Sep 2023;164(9):1927-1930. doi:10.1097/j.pain.0000000000002930
Langford DJ, Sharma S, McDermott MP, et al. Gewandter J. Covariate Adjustment in Chronic Pain Trials: An Oft-Missed Opportunity. Journal of Pain. Sep 2023;24(9):1555-1569. doi:10.1016/j.jpain.2023.06.007
Nishtar M, Mark R, Langford DJ, et al. Gewandter J. Evaluating the balance of benefits and harms in chronic pain clinical trials: prioritizing individual participants over individual outcomes. Region Anesth Pain Med. May 2024;49(5):363-367. doi:10.1136/rapm-2023-104809
Gewandter JS, Culakova E, Davis JN, et al. Gewandter J. "Wireless Transcutaneous Electric Nerve Stimulation (TENS) for Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Proof-of-Concept Randomized Clinical Trial." Journal of Pain. May 2024;25(5)104431. doi:10.1016/j.jpain.2023.11.014
Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Gewandter J. et al. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain. Jul 2023;164(7):1457-1472. doi:10.1097/j.pain.0000000000002888
Gu Y, Bjelic M, Panda K, Usman AA, Magnuson R, Gosev I. "Cannula-Associated Deep Vein Thrombosis After Venovenous Extracorporeal Membrane Oxygenation in Patients with and Without Systemic Anticoagulation." J Cardiothorac Vasc Anesth. Jan 2024;38(1):230-236. doi:10.1053/j.jvca.2023.09.009
Nadtochiy SM, Gu Y,, Wissler R, et al. Effect of bivalirudin on coagulation in neonatal (cord) and adult human blood in vitro. Article. Pediatr Anesth. May 2024;34(5):415-421. doi:10.1111/pan.14814
Panda K, Gu Y, Mazzeffi M, et al. Perioperative Extracorporeal Cardiopulmonary Resuscitation in Adult Patients: A Review for the Perioperative Physician. Review. Anesthesiology. May 2024;140(5):1026-1042. doi:10.1097/aln.0000000000004916
Isei MO, Girardi PA, Rodwell-Bullock J, Nehrke K, Johnson GVW. "Site-specific phosphorylation of tau impacts mitochondrial function and response to stressors." Journal of Neurochemistry. Jun 2024;168(6):1019-1029. doi:10.1111/jnc.15975
Lin H, Sandkuhler S, Dunlea C, Rodwell-Bullock J, King DH, Johnson GVW. "BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1." Autophagy. Mar 2024;20(3):577-589. doi:10.1080/15548627.2023.2276622
Pérez MJ, Ibarra-García-Padilla R, Tang MP, Porter GA Jr., Johnson GVW, Quintanilla RA. "Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore."Biochimica Et Biophysica Acta-Molecular Basis of Disease. Jan 2024;1870(1)166898. doi:10.1016/j.bbadis.2023.166898
Olesen MA, Pradenas E, Villavicencio-Tejo F, Porter GA, Johnson GVW, Quintanilla RA. "Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging." Free Radical Biology and Medicine. May 2024;217:141-156. doi:10.1016/j.freeradbiomed.2024.03.017
Koren SA, Selim NA, De la Rosa L, Johnson GVW et al. All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ (vol 14, 6036, 2023). Nature Communications. Dec 2023;14(1)8230. doi:10.1038/s41467-023-44146-6
Florentino SA, Karan SB, Ramirez G, Baumhauer JF. "Evaluating medical students' knowledge of patient-reported outcomes and the impact of curriculum intervention in consecutive cohorts." J Patient Rep Outcomes. Dec 13 2023;7(1):131. doi:10.1186/s41687-023-00670-z
Hutchison CE, Reminick JI, Love ER, Karan SB, Gundle KR. Does "Hoarding" Impact Interview Distribution Among Orthopaedic Surgery Residency Applicants? A Modeling Study Based on a Large Database. Clin Orthop Relat Res. Oct 1 2023;481(10):1870-1877. doi:10.1097/corr.0000000000002795
Glance LG, Maddox KEJ, Lander H, Mazzeffi M, et al. Insurance-based Disparities in Outcomes and Extracorporeal Membrane Oxygenation Utilization for Hospitalized COVID-19 Patients. Article. Anesthesiology. Jul 2024;141(1):116-130. doi:10.1097/aln.0000000000004985
Glance LG, Benesch CG, Lustik S, Maddox KEJ, et al. Was COVID-19 Associated With Worsening Inequities in Stroke Treatment and Outcomes? Article. J Am Heart Assoc. Oct 2023;12(19):12. e031221. doi:10.1161/jaha.123.031221
Glance LG, Lustik S, Maddox KEJ, Mazzeffi M, et al. Insurance-based Disparities in Outcomes and Extracorporeal Membrane Oxygenation Utilization for Hospitalized COVID-19 Patients. Article. Anesthesiology. Jul 2024;141(1):116-130. doi:10.1097/aln.0000000000004985
Glance LG, Lustik S, Maddox KEJ, Shang JJ, et al. "The COVID-19 Pandemic and Associated Inequities in Acute Myocardial Infarction Treatment and Outcomes." JAMA Netw Open. Aug 2023;6(8):15. e2330327. doi:10.1001/jamanetworkopen.2023.30327
Koltenyuk V, Mrad I, Choe I, Ayoub MI, Kumaraswami S, Xu JL. Multimodal Acute Pain Management in the Parturient with Opioid Use Disorder: A Review. Journal of Pain Research. 2024;17:797-813. doi:10.2147/jpr.S434010
Glance LG, Nadler J, Benesch CG, Maddox KEJ, et al. Was COVID-19 Associated With Worsening Inequities in Stroke Treatment and Outcomes? Article. J Am Heart Assoc. Oct 2023;12(19):12. e031221. doi:10.1161/jaha.123.031221
Jennifer E Dominguez, Sarah Cantrell, Ashraf S Habib, Bilgay Izci-Balserak, Ellen Lockhart , Judette M Louis , Alice Miskovic , Jacob W Nadler, et al. Society of Anesthesia and Sleep Medicine and the Society for Obstetric Anesthesia and Perinatology Consensus Guideline on the Screening, Diagnosis, and Treatment of Obstructive Sleep Apnea in Pregnancy. Practice Guideline, Obstet Gynecol 2023 Aug 1;142(2):403-423. Epub 2023 Jul 5.
Abhijit V Lele , Ananya Abate Shiferaw , Marie Angele Theard, Monica S Vavilala , Cristiane Tavares , Ruquan Han, Denekew Assefa, Mihret Dagne Alemu , Charu Mahajan, Monica S Tandon, Neeta V Karmarkar, Vasudha Singhal , Ritesh Lamsal, Umeshkumar Athiraman; Global-SAH project collaborators: Jacob W Nadler. A Global Review of the Perioperative Care of Patients With Aneurysmal Subarachnoid Hemorrhage Undergoing Microsurgical Repair of Ruptured Intracerebral Aneurysm. J Neurosurg Anesthesiol. 2024 Apr 1;36(2):164-171.
Eaton MP, Nadtochiy SM, Angona RE. "Dabigatran in Rabbit Cardiopulmonary Bypass: Reply."Anesthesiology. Dec 2023;139(6):4. doi:10.1097/aln.0000000000004701
Eaton MP, Nadtochiy SM, Stefanos T, Anderson BJ. "Dabigatran pharmacokinetic-pharmacodynamic in sheep: Informing dose for anticoagulation during cardiopulmonary bypass." Perfusion-UK. Jan 2024;9. doi:10.1177/02676591231226291
Fukushima CT, Dancil IS, Clary H, Shah ND, Nadtochiy SM, Brookes PS. "Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions."Redox Biology. Apr 2024;70103047. doi:10.1016/j.redox.2024.103047
Nadtochiy SM, Stefanos T, Wissler R, et al. "Effect of bivalirudin on coagulation in neonatal (cord) and adult human blood in vitro." Pediatric Anesthesia. May 2024;34(5):415-421. doi:10.1111/pan.14814
Beutner G, Burris JR, Collins MP, Nadtochiy SM et al. Coordinated metabolic responses to cyclophilin D deletion in the developing heart. Iscience. Mar 2024;27(3)109157. doi:10.1016/j.isci.2024.109157
Gu Y, Bjelic M, Panda K, Usman AA, Magnuson R, Gosev I. "Cannula-Associated Deep Vein Thrombosis After Venovenous Extracorporeal Membrane Oxygenation in Patients with and Without Systemic Anticoagulation." J Cardiothorac Vasc Anesth. Jan 2024;38(1):230-236. doi:10.1053/j.jvca.2023.09.009
Panda K, Glance LG, Mazzeffi M, et al. "Perioperative Extracorporeal Cardiopulmonary Resuscitation in Adult Patients: A Review for the Perioperative Physician." Anesthesiology. May 2024;140(5):1026-1042. doi:10.1097/aln.0000000000004916
Glance LG, Smith DI, Maddox KEJ. Do Anesthesiologists Have a Role in Promoting Equitable Health Care? Anesthesiology. Sep 2023;139(3):244-248. doi:10.1097/aln.0000000000004672
Glance LG, Wyroberk J, Maddox KEJ, Mazzeffi M, et al. Insurance-based Disparities in Outcomes and Extracorporeal Membrane Oxygenation Utilization for Hospitalized COVID-19 Patients. Article. Anesthesiology. Jul 2024;141(1):116-130. doi:10.1097/aln.0000000000004985
Hack M, Wyroberk J Wood KL, Bjelic M, et al. Less Invasive Left Ventricular Assist Device Implantation Is Safe and Feasible in Patients With Smaller Body Surface Area. Innovations-Technology and Techniques in Cardiothoracic and Vascular Surgery. Sep 2023;18(5):445-451. doi:10.1177/15569845231198088
Akiyama K, Wu IY, Hori K, et al. ST Segment Elevation Immediately After Cardiopulmonary Bypass During Modified Blalock-Taussig Shunt and Pulmonary Artery Banding. J Cardiothorac Vasc Anesth. Sep 2023;37(9):1833-1834. doi:10.1053/j.jvca.2023.05.034
Glance LG, Wu IY, Mazzeffi M, et al. Insurance-based Disparities in Outcomes and Extracorporeal Membrane Oxygenation Utilization for Hospitalized COVID-19 Patients. Article. Anesthesiology. Jul 2024;141(1):116-130. doi:10.1097/aln.0000000000004985
Panda K, Wu IY, Glance LG, Mazzeffi M, et al. Perioperative Extracorporeal Cardiopulmonary Resuscitation in Adult Patients: A Review for the Perioperative Physician. Review. Anesthesiology. May 2024;140(5):1026-1042. doi:10.1097/aln.0000000000004916
Webber AM, Brennan MP. "The high-risk pediatric patient for ambulatory surgery." Current Opinion in Anesthesiology. Dec 2023;36(6):630-635. doi:10.1097/aco.0000000000001321
Webber AM, Brennan MP, Bradley J. "Pediatric Ambulatory Surgery: What's New, What's Controversial."Curr Anesthesiol Rep. June 2024;14(2):255-262. doi:10.1007/s40140-024-00624-1
Bischer AP, Baran TM, Wojtovich AP. "Reactive oxygen species drive foraging decisions in Caenorhabditis elegans." Redox Biology. Nov 2023;67102934. doi:10.1016/j.redox.2023.102934
Okoye CN, Koren SA, Wojtovich AP. "Mitochondrial complex I ROS production and redox signaling in hypoxia." Redox Biology. Nov 2023;67102926. doi:10.1016/j.redox.2023.102926
Tiwary V, Galow AM, Wojtovich AP, Peleg S. "Using light to drive energy transduction in metazoan aging."Trends in Biochemical Sciences. Nov 2023;48(11):920-922. doi:10.1016/j.tibs.2023.08.010
Koren SA, Selim NA, De la Rosa L, Wojtovich AP et al. All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ (vol 14, 6036, 2023). Nature Communications. Dec 2023;14(1)8230. doi:10.1038/s41467-023-44146-6
Tavarez ZQ, Croft DP, Li DM,Wojtovich AP et al. Fruit flavors in electronic cigarettes (ECIGs) are associated with nocturnal dry cough: A population longitudinal analysis. Plos One. Jun 2024;19(6)e0306467. doi:10.1371/journal.pone.0306467
Vodickova A, Müller-Eigner A, Okoye CN, Wojtovich AP et al. Mitochondrial energy state controls AMPK-mediated foraging behavior in <i>C. elegans</i>. Science Advances. Apr 2024;10(16)eadm8815. doi:10.1126/sciadv.adm8815
Cheng QE, Yung A, Schriefer J, Sosa T, et al. GJ Express: an improvement initiative to decrease sedation and anesthesia for gastrojejunostomy tube exchanges. Pediatric Research. 2024 Feb 2024;doi:10.1038/s41390-024-03070-1