Affiliated Faculty
Optics
Research Interest: Biomedical optics, specifically spectroscopic diagnostic techniques
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Research Interest: Diffuse optics for in vivo cancer detection, diagnosis and therapy monitoring
Biochemistry & Biophysics
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Biochemistry & Biophysics
Research Interest:
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Molecular mechanisms of prion propagation and pathogenesis
Research Interest:
Investigating membranes and membrane proteins via computer simulation
William A. Bernhard Memorial Lab
Biochemistry & BiophysicsResearch Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: G protein coupled receptor signaling and modulation of ion channels in neurons
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Research Interest:
Biomimetic nanoparticles, super-resolution microscopy, and bio-inspired photocatalysis
Research Interest:
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest:
In vitro models of human lung and vascular barriers during inflammation
Biomedical Engineering
Dermatology
Research Interest:
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Microbiology & Immunology
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Research Interest:
Organic Electronics, Plasmon-enhanced Spectroscopy and Biomolecular Sensing
Research Interest: Computational biology of RNA; RNA comparative sequence analysis; RNA structure prediction; analysis of HIV RNA genomes.
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyResearch Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest:
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Pharmacology & Physiology
Research Interest:
Cell Adhesion, Mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Research Interest:
My group uses experiments, molecular simulations, and machine-learning to design new materials. Experiments answer the essential question of if and how well a material works for a particular application. Molecular simulation provides the molecular insight into why a material works.
Imaging Sciences
Biomedical Engineering
Research Interest: Intelligent image acquisition and analysis systems in biomedicine
Pharmacology & Physiology
Research Interest: Mechanisms Underlying Ca2+ Signaling Events in Exocrine Cells