Recent Publications

• 1. Heffer A
  2. Lee C
  3. Holt JC
  4. Kiernan AE
  Notch1 is required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs.; bioRxiv : the preprint server for biology. 2024 Jun 21.
• 1. Na D
  2. Zhang J
  3. Beaulac HJ
  4. Piekna-Przybylska D
  5. Nicklas PR
  6. Kiernan AE
  7. White PM
  Corrigendum: Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.; Frontiers in neuroscience; Vol 17, pp. 1250244. 2023 Jul 18.
• 1. Na D
  2. Zhang J
  3. Beaulac HJ
  4. Piekna-Przybylska D
  5. Nicklas PR
  6. Kiernan AE
  7. White PM
  Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.; Frontiers in neuroscience; Vol 17, pp. 1106570. 2023 May 26.
• 1. Heffer A
  2. Gilels FA
  3. Kiernan AE
  Deletion of Notch1 during cochlear maturation leads to rapid supporting cell death and profound deafness.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Jan 23.
• 1. Gilels FA
  2. Wang J
  3. Bullen A
  4. White PM
  5. Kiernan AE
  Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss.; Cell death & disease; Vol 13(11), pp. 971. 2022 Jan 18.
• 1. Brown RM
  2. Nelson JC
  3. Zhang H
  4. Kiernan AE
  5. Groves AK
  Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.; Developmental biology; Vol 462(1). 2020 Jun 01.
• 1. Steevens AR
  2. Glatzer JC
  3. Kellogg CC
  4. Low WC
  5. Santi PA
  6. Kiernan AE
  SOX2 is required for inner ear growth and cochlear nonsensory formation prior to sensory development.; Development (Cambridge, England). 2019 May 31.
• 1. Johnson KR
  2. Gagnon LH
  3. Tian C
  4. Longo-Guess CM
  5. Low BE
  6. Wiles MV
  7. Kiernan AE
  Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.; Genetics; Vol 208(3). 2018 Mar.
• 1. Rausch RL
  2. Libby RT
  3. Kiernan AE
  Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.; Experimental eye research. 2018 Feb 13.
• 1. Rausch RL
  2. Libby RT
  3. Kiernan AE
  Ciliary margin-derived BMP4 does not have a major role in ocular development.; PloS one; Vol 13(5). 2018.
• 1. Steevens AR
  2. Sookiasian DL
  3. Glatzer JC
  4. Kiernan AE
  SOX2 is required for inner ear neurogenesis.; Scientific reports; Vol 7(1). 2017 Jun 22.
• 1. Fernandes KA
  2. Harder JM
  3. Williams PA
  4. Rausch RL
  5. Kiernan AE
  6. Nair KS
  7. Anderson MG
  8. John SW
  9. Howell GR
  10. Libby RT
  Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.; Experimental eye research; Vol 141. 2015 Dec.
• 1. Deng M
  2. Luo XJ
  3. Pan L
  4. Yang H
  5. Xie X
  6. Liang G
  7. Huang L
  8. Hu F
  9. Kiernan AE
  10. Gan L
  LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 34(30). 2014 Jul 23.
• 1. Savoy-Burke G
  2. Gilels FA
  3. Pan W
  4. Pratt D
  5. Que J
  6. Gan L
  7. White PM
  8. Kiernan AE
  Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.; PloS one; Vol 9(9). 2014.
• 1. Pan W
  2. Jin Y
  3. Chen J
  4. Rottier RJ
  5. Steel KP
  6. Kiernan AE
  Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(41). 2013 Oct 9.
• 1. Zhou Y
  2. Tanzie C
  3. Yan Z
  4. Chen S
  5. Duncan M
  6. Gaudenz K
  7. Li H
  8. Seidel C
  9. Lewis B
  10. Moran A
  11. Libby RT
  12. Kiernan AE
  13. Xie T
  Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(22). 2013 May 28.
• 1. Kiernan AE
  Notch signaling during cell fate determination in the inner ear.; Seminars in cell & developmental biology; Vol 24(5). 2013 May.
• 1. Steffes G
  2. Lorente-Cánovas B
  3. Pearson S
  4. Brooker RH
  5. Spiden S
  6. Kiernan AE
  7. Guénet JL
  8. Steel KP
  Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects.; PloS one; Vol 7(11). 2012.
• 1. Pan W
  2. Jin Y
  3. Stanger B
  4. Kiernan AE
  Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(36). 2010 Sep 7.
• 1. Kiernan AE
  2. Li R
  3. Hawes NL
  4. Churchill GA
  5. Gridley T
  Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice.; Genetics; Vol 177(1). 2007 Sep.
• 1. Kiernan AE
  The paintfill method as a tool for analyzing the three-dimensional structure of the inner ear.; Brain research; Vol 1091(1). 2006 May 26.
• 1. Kiernan AE
  2. Xu J
  3. Gridley T
  The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.; PLoS genetics; Vol 2(1). 2006 Jan.
• 1. Kiernan AE
  2. Cordes R
  3. Kopan R
  4. Gossler A
  5. Gridley T
  The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.; Development (Cambridge, England); Vol 132(19). 2005 Oct.
• 1. Kiernan AE
  2. Pelling AL
  3. Leung KK
  4. Tang AS
  5. Bell DM
  6. Tease C
  7. Lovell-Badge R
  8. Steel KP
  9. Cheah KS
  Sox2 is required for sensory organ development in the mammalian inner ear.; Nature; Vol 434(7036). 2005 Apr 21.
• 1. Hulander M
  2. Kiernan AE
  3. Blomqvist SR
  4. Carlsson P
  5. Samuelsson EJ
  6. Johansson BR
  7. Steel KP
  8. Enerbäck S
  Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.; Development (Cambridge, England); Vol 130(9). 2003 May.
• 1. Kiernan AE
  2. Erven A
  3. Voegeling S
  4. Peters J
  5. Nolan P
  6. Hunter J
  7. Bacon Y
  8. Steel KP
  9. Brown SD
  10. Guénet JL
  ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis.; Mammalian genome : official journal of the International Mammalian Genome Society; Vol 13(3). 2002 Mar.
• 1. Alavizadeh A
  2. Kiernan AE
  3. Nolan P
  4. Lo C
  5. Steel KP
  6. Bucan M
  The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.; Developmental biology; Vol 234(1). 2001 Jun 01.
• 1. Kiernan AE
  2. Ahituv N
  3. Fuchs H
  4. Balling R
  5. Avraham KB
  6. Steel KP
  7. Hrabé de Angelis M
  The Notch ligand Jagged1 is required for inner ear sensory development.; Proceedings of the National Academy of Sciences of the United States of America; Vol 98(7). 2001 Mar 27.
• 1. Tsai H
  2. Hardisty RE
  3. Rhodes C
  4. Kiernan AE
  5. Roby P
  6. Tymowska-Lalanne Z
  7. Mburu P
  8. Rastan S
  9. Hunter AJ
  10. Brown SD
  11. Steel KP
  The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.; Human molecular genetics; Vol 10(5). 2001 Mar 01.
• 1. Brigande JV
  2. Kiernan AE
  3. Gao X
  4. Iten LE
  5. Fekete DM
  Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?; Proceedings of the National Academy of Sciences of the United States of America; Vol 97(22). 2000 Oct 24.
• 1. Kiernan AE
  2. Steel KP
  Mouse homologues for human deafness.; Advances in oto-rhino-laryngology; Vol 56. 2000.
• 1. Kiernan AE
  2. Zalzman M
  3. Fuchs H
  4. Hrabe de Angelis M
  5. Balling R
  6. Steel KP
  7. Avraham KB
  Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.; Journal of neurocytology; Vol 28(10-11). 1999 Oct.
• 1. Kiernan AE
  2. Nunes F
  3. Wu DK
  4. Fekete DM
  The expression domain of two related homeobox genes defines a compartment in the chicken inner ear that may be involved in semicircular canal formation.; Developmental biology; Vol 191(2). 1997 Nov 15.
• 1. Kiernan AE
  2. Fekete DM
  In vivo gene transfer into the embryonic inner ear using retroviral vectors.; Audiology & neuro-otology; Vol 2(1-2). 1997 Jan.