URMC / Labs / Chia-Lung Wu Lab / Publications

Recent Publications

1. Ackerman JE
2. Best KT
3. Muscat SN
4. Pritchett EM
5. Nichols AEC
6. Wu CL
7. Loiselle AE
Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.; Cell reports; Vol 41(8), pp. 111706. 2022 Nov 22.
1. Kenney HM
2. Wu CL
3. Loiselle AE
4. Xing L
5. Ritchlin CT
6. Schwarz EM
Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model.; Arthritis research & therapy; Vol 24(1). 2022 Mar 07.
1. Wu CL
2. Dicks A
3. Steward N
4. Tang R
5. Katz DB
6. Choi YR
7. Guilak F
Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis.; Nature communications; Vol 12(1). 2021 Jan 13.
1. Oestreich AK
2. Collins KH
3. Harasymowicz NS
4. Wu CL
5. Guilak F
Is Obesity a Disease of Stem Cells?; Cell stem cell; Vol 27(1). 2020 Jul 02.
1. Wu CL
2. Harasymowicz NS
3. Klimak MA
4. Collins KH
5. Guilak F
The role of macrophages in osteoarthritis and cartilage repair.; Osteoarthritis and cartilage; Vol 28(5). 2020 May.
1. Bailey KN
2. Furman BD
3. Zeitlin J
4. Kimmerling KA
5. Wu CL
6. Guilak F
7. Olson SA
Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee.; Osteoarthritis and cartilage; Vol 28(5). 2020 May.
1. Tang R
2. Harasymowicz NS
3. Wu CL
4. Collins KH
5. Choi YR
6. Oswald SJ
7. Guilak F
Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity.; Science advances; Vol 6(19). 2020 May.
1. Kimmerling KA
2. Oswald SJ
3. Huebner JL
4. Little D
5. Kraus VB
6. Kang JX
7. Wu CL
8. Guilak F
Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.; Arthritis research & therapy; Vol 22(1). 2020 Apr 15.
1. Harasymowicz NS
2. Choi YR
3. Wu CL
4. Iannucci L
5. Tang R
6. Guilak F
Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 72(4). 2020 Apr.
1. Dicks A
2. Wu CL
3. Steward N
4. Adkar SS
5. Gersbach CA
6. Guilak F
Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.; Stem cell research & therapy; Vol 11(1). 2020 Feb 18.
1. Choi YR
2. Collins KH
3. Springer LE
4. Pferdehirt L
5. Ross AK
6. Wu CL
7. Moutos FT
8. Harasymowicz NS
9. Brunger JM
10. Pham CT
Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery.; bioRxiv; Vol 535609. 2019 Jan 01.
1. Votava L
2. Schwartz AG
3. Harasymowicz NS
4. Wu CL
5. Guilak F
Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 37(3). 2019 Mar.
1. Harasymowicz NS
2. Dicks A
3. Wu CL
4. Guilak F
Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.; Annals of the New York Academy of Sciences; Vol 1440(1). 2019 Mar.
1. Adkar SS
2. Wu CL
3. Willard VP
4. Dicks A
5. Ettyreddy A
6. Steward N
7. Bhutani N
8. Gersbach CA
9. Guilak F
Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.; Stem cells (Dayton, Ohio); Vol 37(1). 2019 Jan.
1. Tang R
2. Jing L
3. Willard VP
4. Wu CL
5. Guilak F
6. Chen J
7. Setton LA
Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.; Stem cell research & therapy; Vol 9(1). 2018 Mar 09.
1. Guilak F
2. Nims RJ
3. Dicks A
4. Wu CL
5. Meulenbelt I
Osteoarthritis as a disease of the cartilage pericellular matrix.; Matrix biology : journal of the International Society for Matrix Biology; Vol 71-72. 2018 Jan.
1. Wu CL
2. McNeill J
3. Goon K
4. Little D
5. Kimmerling K
6. Huebner J
7. Kraus V
8. Guilak F
Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 69(9). 2017 Sep.
1. Wu CL
2. Kimmerling KA
3. Little D
4. Guilak F
Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair.; Scientific reports; Vol 7. 2017 Mar 20.
1. Adkar SS
2. Brunger JM
3. Willard VP
4. Wu CL
5. Gersbach CA
6. Guilak F
Genome Engineering for Personalized Arthritis Therapeutics.; Trends in molecular medicine; Vol 23(10). 2017 Jan.
1. O'Conor CJ
2. Ramalingam S
3. Zelenski NA
4. Benefield HC
5. Rigo I
6. Little D
7. Wu CL
8. Chen D
9. Liedtke W
10. McNulty AL
11. Guilak F
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.; Scientific reports; Vol 6. 2016 Jul 08.
1. Wu CL
2. Jain D
3. McNeill JN
4. Little D
5. Anderson JA
6. Huebner JL
7. Kraus VB
8. Rodriguiz RM
9. Wetsel WC
10. Guilak F
Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.; Annals of the rheumatic diseases; Vol 74(11). 2015 Nov.
1. McNeill JN
2. Wu CL
3. Rabey KN
4. Schmitt D
5. Guilak F
Life-long caloric restriction does not alter the severity of age-related osteoarthritis.; Age (Dordrecht, Netherlands); Vol 36(4). 2014.
1. Wu CL
2. Diekman BO
3. Jain D
4. Guilak F
Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids.; International journal of obesity (2005); Vol 37(8). 2013 Aug.
1. Diekman BO
2. Wu CL
3. Louer CR
4. Furman BD
5. Huebner JL
6. Kraus VB
7. Olson SA
8. Guilak F
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.; Cell transplantation; Vol 22(8). 2013.