Lab Members

Molecular mechanisms of Neurodegeneration

The molecular mechanisms of tau clearance by autophagy and endocytosis using mammalian model sytems (primary neurons and mice)

Using pharmaco-genetics, fluorescent biosensor imaging, and proximity labeling to unravel the molecular mechanism through which pTau impairs mitophagy

The molecular mechanisms of pathological tau-induced mitochondrial dysfunction

The effects of pathological tau uptake by astrocytes on mitochondrial function and the impact on their ability to support neuron health

Tau Post-Translational Modifications mediate cellular dysfunctions in Alzheimer’s Disease

 Investigating the Role of Presenilin Proteins and BAG3 in Vacuolar Function and Tau Dynamics

The role of transglutaminase 2 in mediating the response of astrocytes to injury and their ability to support neuron survival and neurite outgrowth

The effect of mitochondrial dysfunction and oxidative stress on tau pathology.

The relationship between tau pathology and mitochondrial dysfunction as regulated by BAG3