URMC / Labs / Nedergaard Lab / Publications

Recent Publications

1. Kritsilis M
2. Vanherle L
3. Rosenholm M
4. In 't Zandt R
5. Yao Y
6. Swanberg KM
7. Weikop P
8. Gottschalk M
9. Shanbhag NC
10. Luo J
11. Boster K
12. Nedergaard M
13. Meissner A
14. Lundgaard I
Loss of glymphatic homeostasis in heart failure.; Brain : a journal of neurology. 2024 Dec 18.
1. Untiet V
2. Rose CR
3. Nedergaard M
4. Verkhratsky A
Ionic signalling (beyond calcium) in the nervous system: Physiology and pathophysiology.; Cell calcium; Vol 125, pp. 102984. 2024 Dec 07.
1. Toscano JD
2. Wu C
3. Ladrón-de-Guevara A
4. Du T
5. Nedergaard M
6. Kelley DH
7. Karniadakis GE
8. Boster KAS
Inferring in vivo murine cerebrospinal fluid flow using artificial intelligence velocimetry with moving boundaries and uncertainty quantification.; Interface focus; Vol 14(6), pp. 20240030. 2024 Dec 06.
1. Bork PAR
2. Gianetto M
3. Newbold E
4. Hablitz L
5. Bohr T
6. Nedergaard M
Blood osmolytes such as sugar can drive brain fluid flows in a poroelastic model.; Scientific reports; Vol 14(1), pp. 29017. 2024 Nov 22.
1. Cankar N
2. Beschorner N
3. Tsopanidou A
4. Qvist FL
5. Colaço AR
6. Andersen M
7. Kjaerby C
8. Delle C
9. Lambert M
10. Mundt F
11. Weikop P
12. Jucker M
13. Mann M
14. Skotte NH
15. Nedergaard M
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model.; Cell reports; Vol 43(11), pp. 114977. 2024 Nov 13.
1. Sun Q
2. Peng S
3. Xu Q
4. Weikop P
5. Hussain R
6. Song W
7. Nedergaard M
8. Ding F
Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.; Nature communications; Vol 15(1), pp. 9600. 2024 Nov 06.
1. Wostyn P
2. Mader TH
3. Gibson CR
4. Nedergaard M
New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?; Eye (London, England). 2024 Nov 04.
1. Li B
2. Sun Q
3. Ding F
4. Xu Q
5. Kang N
6. Xue Y
7. Ladron-de-Guevara A
8. Hirase H
9. Weikop P
10. Gong S
11. Nathan S
12. Nedergaard M
Anti-seizure effects of norepinephrine-induced free fatty acid release.; Cell metabolism. 2024 Oct 29.
1. Iden CR
2. Mustafa SM
3. Øgaard N
4. Henriksen T
5. Jensen SØ
6. Ahlborn LB
7. Egebjerg K
8. Baeksgaard L
9. Garbyal RS
10. Nedergaard MK
11. Achiam MP
12. Andersen CL
13. Mau-Sørensen M
Circulating tumor DNA predicts recurrence and survival in patients with resectable gastric and gastroesophageal junction cancer.; Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024 Oct 05.
1. Asiminas A
2. Gomolka RS
3. Gregoriades S
4. Hirase H
5. Nedergaard M
6. Beinlich FRM
Protocol to study oxygen dynamics in the in vivo mouse brain using bioluminescence microscopy.; STAR protocols; Vol 5(4), pp. 103334. 2024 Sep 25.
1. Cao Q
2. Yang S
3. Wang X
4. Sun H
5. Chen W
6. Wang Y
7. Gao J
8. Wu Y
9. Yang Q
10. Chen X
11. Yuan S
12. Xiao M
13. Nedergaard M
14. Huo Y
15. Liu Q
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease.; The Journal of experimental medicine; Vol 221(11). 2024 Sep 24.
1. Kroesbergen E
2. Riesselmann LV
3. Gomolka RS
4. Plá V
5. Esmail T
6. Stenmo VH
7. Kovács ER
8. Nielsen ES
9. Goldman SA
10. Nedergaard M
11. Weikop P
12. Mori Y
Glymphatic clearance is enhanced during sleep.; bioRxiv : the preprint server for biology. 2024 Sep 15.
1. Plá V
2. Bitsika S
3. Giannetto MJ
4. Ladrón-de-Guevara A
5. Gahn-Martinez D
6. Mori Y
7. Nedergaard M
8. Møllgård K
Response to Commentary on "Structural characterization of SLYM - a 4th meningeal membrane" by Julie Siegenthaler and Christer Betsholtz.; Fluids and barriers of the CNS; Vol 21(1), pp. 70. 2024 Sep 09.
1. Xu C
2. Nedergaard M
3. Fowell DJ
4. Friedl P
5. Ji N
Multiphoton fluorescence microscopy for in vivo imaging.; Cell; Vol 187(17), pp. 4458-4487. 2024 Aug 22.
1. Du T
2. Raghunandan A
3. Mestre H
4. Plá V
5. Liu G
6. Ladrón-de-Guevara A
7. Newbold E
8. Tobin P
9. Gahn-Martinez D
10. Pattanayak S
11. Huang Q
12. Peng W
13. Nedergaard M
14. Kelley DH
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.; Nature aging. 2024 Aug 15.
1. Smyth LCD
2. Beschorner N
3. Nedergaard M
4. Kipnis J
Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain.; Cold Spring Harbor perspectives in biology. 2024 Aug 12.
1. Wostyn P
2. Nedergaard M
The potential influence of sleep on translaminar pressure dynamics and ocular glymphatic outflow in microgravity: implications for optic disc edema in astronauts.; Eye (London, England). 2024 Jul 30.
1. Kaag Rasmussen M
2. Møllgård K
3. Bork PAR
4. Weikop P
5. Esmail T
6. Drici L
7. Wewer Albrechtsen NJ
8. Carlsen JF
9. Huynh NPT
10. Ghitani N
11. Mann M
12. Goldman SA
13. Mori Y
14. Chesler AT
15. Nedergaard M
Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.; Science (New York, N.Y.); Vol 385(6704), pp. 80-86. 2024 Jul 04.
1. Plá V
2. Bitsika S
3. Giannetto MJ
4. Ladron-de-Guevara A
5. Gahn-Martinez D
6. Mori Y
7. Nedergaard M
8. Møllgård K
In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.".; Fluids and barriers of the CNS; Vol 21(1), pp. 49. 2024 Jun 03.
1. Ge GR
2. Song W
3. Giannetto MJ
4. Rolland JP
5. Nedergaard M
6. Parker KJ
Mouse Brain Elastography Changes with Sleep/Wake Cycles, Aging, and Alzheimer's Disease.; NeuroImage. 2024 May 30.
1. Delle C
2. Wang X
3. Nedergaard M
The Ocular Glymphatic System-Current Understanding and Future Perspectives.; International journal of molecular sciences; Vol 25(11). 2024 May 24.
1. Persson NDÅ
2. Lohela TJ
3. Mortensen KN
4. Rosenholm M
5. Li Q
6. Weikop P
7. Nedergaard M
8. Lilius TO
Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.; Anesthesiology. 2024 May 24.
1. Zhou XA
2. Man W
3. Liu X
4. Choi S
5. Jiang Y
6. Hike D
7. Cid LG
8. Lin C
9. Nedergaard M
10. Yu X
Mapping glymphatic solute transportation through the perivascular space of hippocampal arterioles with 14 Tesla MRI.; bioRxiv : the preprint server for biology. 2024 May 20.
1. Mader TH
2. Gibson CR
3. Wostyn P
4. Nedergaard M
Enlargement of Perivascular Spaces as a Downstream Consequence of Spaceflight Analog-Induced Alterations in Cerebral Venous Hemodynamics.; AJNR. American journal of neuroradiology; Vol 45(5), pp. E6. 2024 May 09.
1. Wostyn P
2. Nedergaard M
A new look at ocular glymphatic transport in space.; Journal of applied physiology (Bethesda, Md. : 1985); Vol 136(5), pp. 1129-1130. 2024 May 01.
1. Deng S
2. Hu Y
3. Chen S
4. Xue Y
5. Yao D
6. Sun Q
7. Nedergaard M
8. Wang W
9. Ding F
Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2024 Apr 19.
1. van Osch MJP
2. Wåhlin A
3. Scheyhing P
4. Mossige I
5. Hirschler L
6. Eklund A
7. Mogensen K
8. Gomolka R
9. Radbruch A
10. Qvarlander S
11. Decker A
12. Nedergaard M
13. Mori Y
14. Eide PK
15. Deike K
16. Ringstad G
Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood.; NMR in biomedicine. 2024 Apr 18.
1. Bork PAR
2. Hauglund NL
3. Mori Y
4. Møllgård K
5. Hjorth PG
6. Nedergaard M
Modeling of brain efflux: Constraints of brain surfaces.; Proceedings of the National Academy of Sciences of the United States of America; Vol 121(16), pp. e2318444121. 2024 Apr 10.
1. Beinlich FRM
2. Asiminas A
3. Untiet V
4. Bojarowska Z
5. Plá V
6. Sigurdsson B
7. Timmel V
8. Gehrig L
9. Graber MH
10. Hirase H
11. Nedergaard M
Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.; Science (New York, N.Y.); Vol 383(6690), pp. 1471-1478. 2024 Mar 28.
1. Delle C
2. Wang X
3. Giannetto M
4. Newbold E
5. Peng W
6. Gomolka RS
7. Ladrón-de-Guevara A
8. Cankar N
9. Schiøler Nielsen E
10. Kjaerby C
11. Weikop P
12. Mori Y
13. Nedergaard M
Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.; Fluids and barriers of the CNS; Vol 21(1), pp. 26. 2024 Mar 12.
1. Ding F
2. Sun Q
3. Long C
4. Rasmussen RN
5. Peng S
6. Xu Q
7. Kang N
8. Song W
9. Weikop P
10. Goldman SA
11. Nedergaard M
Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.; Brain : a journal of neurology. 2024 Mar 11.
1. Hablitz L
2. Nedergaard M
Synchronized neuronal activity drives waste fluid flow.; Nature. 2024 Feb 28.
1. Giannetto MJ
2. Gomolka RS
3. Gahn-Martinez D
4. Newbold EJ
5. Bork PAR
6. Chang E
7. Gresser M
8. Thompson T
9. Mori Y
10. Nedergaard M
Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.; Glia. 2024 Feb 16.
1. Beschorner N
2. Nedergaard M
Glymphatic system dysfunction in neurodegenerative diseases.; Current opinion in neurology. 2024 Feb 13.
1. Eisen A
2. Nedergaard M
3. Gray E
4. Kiernan MC
THE GLYMPHATIC SYSTEM AND AMYOTROPHIC LATERAL SCLEROSIS.; Progress in neurobiology. 2024 Jan 22.
1. Hussain R
2. Nedergaard M
Managing noradrenaline after traumatic brain injury.; Clinical and translational medicine; Vol 14(1), pp. e1562. 2024 Jan.
1. Untiet V
2. Nedergaard M
3. Verkhratsky A
Astrocyte chloride, excitatory-inhibitory balance and epilepsy.; Neural regeneration research; Vol 19(9), pp. 1887. 2023 Dec 15.
1. Kim D
2. Gan Y
3. Nedergaard M
4. Kelley DH
5. Tithof J
Image analysis techniques for in vivo quantification of cerebrospinal fluid flow.; Experiments in fluids; Vol 64(11). 2023 Oct 30.
1. Dietz AG
2. Weikop P
3. Hauglund N
4. Andersen M
5. Petersen NC
6. Rose L
7. Hirase H
8. Nedergaard M
Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(40), pp. e2305071120. 2023 Sep 29.
1. Hussain R
2. Graham U
3. Elder A
4. Nedergaard M
Air pollution, glymphatic impairment, and Alzheimer's disease.; Trends in neurosciences. 2023 Sep 28.
1. Gan Y
2. Holstein-Rønsbo S
3. Nedergaard M
4. Boster KAS
5. Thomas JH
6. Kelley DH
Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.; Journal of the Royal Society, Interface; Vol 20(206), pp. 20230288. 2023 Sep 20.
1. Holstein-Rønsbo S
2. Gan Y
3. Giannetto MJ
4. Rasmussen MK
5. Sigurdsson B
6. Beinlich FRM
7. Rose L
8. Untiet V
9. Hablitz LM
10. Kelley DH
11. Nedergaard M
Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Sep 04.
1. Ozawa K
2. Nagao M
3. Konno A
4. Iwai Y
5. Vittani M
6. Kusk P
7. Mishima T
8. Hirai H
9. Nedergaard M
10. Hirase H
Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.; International journal of molecular sciences; Vol 24(17). 2023 Sep 02.
1. Staudt M
2. Shalgunov V
3. Nedergaard M
4. Herth MM
Development of 11 C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species.; Journal of labelled compounds & radiopharmaceuticals. 2023 Aug 31.
1. Andersen M
2. Tsopanidou A
3. Radovanovic T
4. Compere VN
5. Hauglund N
6. Nedergaard M
7. Kjaerby C
Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.; Bio-protocol; Vol 13(15), pp. e4734. 2023 Aug 05.
1. Kim D
2. Gan Y
3. Nedergaard M
4. Kelley DH
5. Tithof J
Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.; bioRxiv : the preprint server for biology. 2023 Jul 24.
1. Miyakoshi LM
2. Stæger FF
3. Li Q
4. Pan C
5. Xie L
6. Kang H
7. Pavan C
8. Dang J
9. Sun Q
10. Ertürk A
11. Nedergaard M
The state of brain activity modulates cerebrospinal fluid transport.; Progress in neurobiology. 2023 Jul 21.
1. Raicevic N
2. Forer JM
3. Ladrón-de-Guevara A
4. Du T
5. Nedergaard M
6. Kelley DH
7. Boster K
Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
1. Bork PAR
2. Ladrón-de-Guevara A
3. Christensen AH
4. Jensen KH
5. Nedergaard M
6. Bohr T
Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.; Journal of the Royal Society, Interface; Vol 20(204), pp. 20230050. 2023 Jul 12.
1. Vittani M
2. Knak PAG
3. Fukuda M
4. Nagao M
5. Wang X
6. Kjaerby C
7. Konno A
8. Hirai H
9. Nedergaard M
10. Hirase H
Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.; bioRxiv : the preprint server for biology. 2023 Jul 10.