Recent Publications

• 1. Cankar N
  2. Beschorner N
  3. Tsopanidou A
  4. Qvist FL
  5. Colaço AR
  6. Andersen M
  7. Kjaerby C
  8. Delle C
  9. Lambert M
  10. Mundt F
  11. Weikop P
  12. Jucker M
  13. Mann M
  14. Skotte NH
  15. Nedergaard M
  Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model.; Cell reports; Vol 43(11), pp. 114977. 2024 Nov 13.
• 1. Sun Q
  2. Peng S
  3. Xu Q
  4. Weikop P
  5. Hussain R
  6. Song W
  7. Nedergaard M
  8. Ding F
  Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.; Nature communications; Vol 15(1), pp. 9600. 2024 Nov 06.
• 1. Wostyn P
  2. Mader TH
  3. Gibson CR
  4. Nedergaard M
  New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?; Eye (London, England). 2024 Nov 04.
• 1. Li B
  2. Sun Q
  3. Ding F
  4. Xu Q
  5. Kang N
  6. Xue Y
  7. Ladron-de-Guevara A
  8. Hirase H
  9. Weikop P
  10. Gong S
  11. Nathan S
  12. Nedergaard M
  Anti-seizure effects of norepinephrine-induced free fatty acid release.; Cell metabolism. 2024 Oct 29.
• 1. Iden CR
  2. Mustafa SM
  3. Øgaard N
  4. Henriksen T
  5. Jensen SØ
  6. Ahlborn LB
  7. Egebjerg K
  8. Baeksgaard L
  9. Garbyal RS
  10. Nedergaard MK
  11. Achiam MP
  12. Andersen CL
  13. Mau-Sørensen M
  Circulating tumor DNA predicts recurrence and survival in patients with resectable gastric and gastroesophageal junction cancer.; Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024 Oct 05.
• 1. Asiminas A
  2. Gomolka RS
  3. Gregoriades S
  4. Hirase H
  5. Nedergaard M
  6. Beinlich FRM
  Protocol to study oxygen dynamics in the in vivo mouse brain using bioluminescence microscopy.; STAR protocols; Vol 5(4), pp. 103334. 2024 Sep 25.
• 1. Cao Q
  2. Yang S
  3. Wang X
  4. Sun H
  5. Chen W
  6. Wang Y
  7. Gao J
  8. Wu Y
  9. Yang Q
  10. Chen X
  11. Yuan S
  12. Xiao M
  13. Nedergaard M
  14. Huo Y
  15. Liu Q
  Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease.; The Journal of experimental medicine; Vol 221(11). 2024 Sep 24.
• 1. Kroesbergen E
  2. Riesselmann LV
  3. Gomolka RS
  4. Plá V
  5. Esmail T
  6. Stenmo VH
  7. Kovács ER
  8. Nielsen ES
  9. Goldman SA
  10. Nedergaard M
  11. Weikop P
  12. Mori Y
  Glymphatic clearance is enhanced during sleep.; bioRxiv : the preprint server for biology. 2024 Sep 15.
• 1. Plá V
  2. Bitsika S
  3. Giannetto MJ
  4. Ladrón-de-Guevara A
  5. Gahn-Martinez D
  6. Mori Y
  7. Nedergaard M
  8. Møllgård K
  Response to Commentary on "Structural characterization of SLYM - a 4th meningeal membrane" by Julie Siegenthaler and Christer Betsholtz.; Fluids and barriers of the CNS; Vol 21(1), pp. 70. 2024 Sep 09.
• 1. Xu C
  2. Nedergaard M
  3. Fowell DJ
  4. Friedl P
  5. Ji N
  Multiphoton fluorescence microscopy for in vivo imaging.; Cell; Vol 187(17), pp. 4458-4487. 2024 Aug 22.
• 1. Du T
  2. Raghunandan A
  3. Mestre H
  4. Plá V
  5. Liu G
  6. Ladrón-de-Guevara A
  7. Newbold E
  8. Tobin P
  9. Gahn-Martinez D
  10. Pattanayak S
  11. Huang Q
  12. Peng W
  13. Nedergaard M
  14. Kelley DH
  Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.; Nature aging. 2024 Aug 15.
• 1. Smyth LCD
  2. Beschorner N
  3. Nedergaard M
  4. Kipnis J
  Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain.; Cold Spring Harbor perspectives in biology. 2024 Aug 12.
• 1. Wostyn P
  2. Nedergaard M
  The potential influence of sleep on translaminar pressure dynamics and ocular glymphatic outflow in microgravity: implications for optic disc edema in astronauts.; Eye (London, England). 2024 Jul 30.
• 1. Kaag Rasmussen M
  2. Møllgård K
  3. Bork PAR
  4. Weikop P
  5. Esmail T
  6. Drici L
  7. Wewer Albrechtsen NJ
  8. Carlsen JF
  9. Huynh NPT
  10. Ghitani N
  11. Mann M
  12. Goldman SA
  13. Mori Y
  14. Chesler AT
  15. Nedergaard M
  Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.; Science (New York, N.Y.); Vol 385(6704), pp. 80-86. 2024 Jul 04.
• 1. Plá V
  2. Bitsika S
  3. Giannetto MJ
  4. Ladron-de-Guevara A
  5. Gahn-Martinez D
  6. Mori Y
  7. Nedergaard M
  8. Møllgård K
  In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.".; Fluids and barriers of the CNS; Vol 21(1), pp. 49. 2024 Jun 03.
• 1. Ge GR
  2. Song W
  3. Giannetto MJ
  4. Rolland JP
  5. Nedergaard M
  6. Parker KJ
  Mouse Brain Elastography Changes with Sleep/Wake Cycles, Aging, and Alzheimer's Disease.; NeuroImage. 2024 May 30.
• 1. Delle C
  2. Wang X
  3. Nedergaard M
  The Ocular Glymphatic System-Current Understanding and Future Perspectives.; International journal of molecular sciences; Vol 25(11). 2024 May 24.
• 1. Persson NDÅ
  2. Lohela TJ
  3. Mortensen KN
  4. Rosenholm M
  5. Li Q
  6. Weikop P
  7. Nedergaard M
  8. Lilius TO
  Anesthesia blunts carbon dioxide effects on glymphatic cerebrospinal fluid dynamics in mechanically ventilated rats.; Anesthesiology. 2024 May 24.
• 1. Zhou XA
  2. Man W
  3. Liu X
  4. Choi S
  5. Jiang Y
  6. Hike D
  7. Cid LG
  8. Lin C
  9. Nedergaard M
  10. Yu X
  Mapping glymphatic solute transportation through the perivascular space of hippocampal arterioles with 14 Tesla MRI.; bioRxiv : the preprint server for biology. 2024 May 20.
• 1. Mader TH
  2. Gibson CR
  3. Wostyn P
  4. Nedergaard M
  Enlargement of Perivascular Spaces as a Downstream Consequence of Spaceflight Analog-Induced Alterations in Cerebral Venous Hemodynamics.; AJNR. American journal of neuroradiology; Vol 45(5), pp. E6. 2024 May 09.
• 1. Wostyn P
  2. Nedergaard M
  A new look at ocular glymphatic transport in space.; Journal of applied physiology (Bethesda, Md. : 1985); Vol 136(5), pp. 1129-1130. 2024 May 01.
• 1. Deng S
  2. Hu Y
  3. Chen S
  4. Xue Y
  5. Yao D
  6. Sun Q
  7. Nedergaard M
  8. Wang W
  9. Ding F
  Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2024 Apr 19.
• 1. van Osch MJP
  2. Wåhlin A
  3. Scheyhing P
  4. Mossige I
  5. Hirschler L
  6. Eklund A
  7. Mogensen K
  8. Gomolka R
  9. Radbruch A
  10. Qvarlander S
  11. Decker A
  12. Nedergaard M
  13. Mori Y
  14. Eide PK
  15. Deike K
  16. Ringstad G
  Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood.; NMR in biomedicine. 2024 Apr 18.
• 1. Bork PAR
  2. Hauglund NL
  3. Mori Y
  4. Møllgård K
  5. Hjorth PG
  6. Nedergaard M
  Modeling of brain efflux: Constraints of brain surfaces.; Proceedings of the National Academy of Sciences of the United States of America; Vol 121(16), pp. e2318444121. 2024 Apr 10.
• 1. Beinlich FRM
  2. Asiminas A
  3. Untiet V
  4. Bojarowska Z
  5. Plá V
  6. Sigurdsson B
  7. Timmel V
  8. Gehrig L
  9. Graber MH
  10. Hirase H
  11. Nedergaard M
  Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.; Science (New York, N.Y.); Vol 383(6690), pp. 1471-1478. 2024 Mar 28.
• 1. Delle C
  2. Wang X
  3. Giannetto M
  4. Newbold E
  5. Peng W
  6. Gomolka RS
  7. Ladrón-de-Guevara A
  8. Cankar N
  9. Schiøler Nielsen E
  10. Kjaerby C
  11. Weikop P
  12. Mori Y
  13. Nedergaard M
  Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.; Fluids and barriers of the CNS; Vol 21(1), pp. 26. 2024 Mar 12.
• 1. Ding F
  2. Sun Q
  3. Long C
  4. Rasmussen RN
  5. Peng S
  6. Xu Q
  7. Kang N
  8. Song W
  9. Weikop P
  10. Goldman SA
  11. Nedergaard M
  Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.; Brain : a journal of neurology. 2024 Mar 11.
• 1. Hablitz L
  2. Nedergaard M
  Synchronized neuronal activity drives waste fluid flow.; Nature. 2024 Feb 28.
• 1. Giannetto MJ
  2. Gomolka RS
  3. Gahn-Martinez D
  4. Newbold EJ
  5. Bork PAR
  6. Chang E
  7. Gresser M
  8. Thompson T
  9. Mori Y
  10. Nedergaard M
  Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.; Glia. 2024 Feb 16.
• 1. Beschorner N
  2. Nedergaard M
  Glymphatic system dysfunction in neurodegenerative diseases.; Current opinion in neurology. 2024 Feb 13.
• 1. Eisen A
  2. Nedergaard M
  3. Gray E
  4. Kiernan MC
  THE GLYMPHATIC SYSTEM AND AMYOTROPHIC LATERAL SCLEROSIS.; Progress in neurobiology. 2024 Jan 22.
• 1. Hussain R
  2. Nedergaard M
  Managing noradrenaline after traumatic brain injury.; Clinical and translational medicine; Vol 14(1), pp. e1562. 2024 Jan.
• 1. Untiet V
  2. Nedergaard M
  3. Verkhratsky A
  Astrocyte chloride, excitatory-inhibitory balance and epilepsy.; Neural regeneration research; Vol 19(9), pp. 1887. 2023 Dec 15.
• 1. Dietz AG
  2. Weikop P
  3. Hauglund N
  4. Andersen M
  5. Petersen NC
  6. Rose L
  7. Hirase H
  8. Nedergaard M
  Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(40), pp. e2305071120. 2023 Sep 29.
• 1. Hussain R
  2. Graham U
  3. Elder A
  4. Nedergaard M
  Air pollution, glymphatic impairment, and Alzheimer's disease.; Trends in neurosciences. 2023 Sep 28.
• 1. Gan Y
  2. Holstein-Rønsbo S
  3. Nedergaard M
  4. Boster KAS
  5. Thomas JH
  6. Kelley DH
  Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.; Journal of the Royal Society, Interface; Vol 20(206), pp. 20230288. 2023 Sep 20.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Sep 04.
• 1. Ozawa K
  2. Nagao M
  3. Konno A
  4. Iwai Y
  5. Vittani M
  6. Kusk P
  7. Mishima T
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.; International journal of molecular sciences; Vol 24(17). 2023 Sep 02.
• 1. Staudt M
  2. Shalgunov V
  3. Nedergaard M
  4. Herth MM
  Development of 11 C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species.; Journal of labelled compounds & radiopharmaceuticals. 2023 Aug 31.
• 1. Andersen M
  2. Tsopanidou A
  3. Radovanovic T
  4. Compere VN
  5. Hauglund N
  6. Nedergaard M
  7. Kjaerby C
  Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep.; Bio-protocol; Vol 13(15), pp. e4734. 2023 Aug 05.
• 1. Kim D
  2. Gan Y
  3. Nedergaard M
  4. Kelley DH
  5. Tithof J
  Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.; bioRxiv : the preprint server for biology. 2023 Jul 24.
• 1. Miyakoshi LM
  2. Stæger FF
  3. Li Q
  4. Pan C
  5. Xie L
  6. Kang H
  7. Pavan C
  8. Dang J
  9. Sun Q
  10. Ertürk A
  11. Nedergaard M
  The state of brain activity modulates cerebrospinal fluid transport.; Progress in neurobiology. 2023 Jul 21.
• 1. Raicevic N
  2. Forer JM
  3. Ladrón-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster K
  Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
• 1. Bork PAR
  2. Ladrón-de-Guevara A
  3. Christensen AH
  4. Jensen KH
  5. Nedergaard M
  6. Bohr T
  Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.; Journal of the Royal Society, Interface; Vol 20(204), pp. 20230050. 2023 Jul 12.
• 1. Vittani M
  2. Knak PAG
  3. Fukuda M
  4. Nagao M
  5. Wang X
  6. Kjaerby C
  7. Konno A
  8. Hirai H
  9. Nedergaard M
  10. Hirase H
  Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice.; bioRxiv : the preprint server for biology. 2023 Jul 10.
• 1. Mathiesen BK
  2. Miyakoshi LM
  3. Cederroth CR
  4. Tserga E
  5. Versteegh C
  6. Bork PAR
  7. Hauglund NL
  8. Gomolka RS
  9. Mori Y
  10. Edvall NK
  11. Rouse S
  12. Møllgård K
  13. Holt JR
  14. Nedergaard M
  15. Canlon B
  Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.; Science translational medicine; Vol 15(702), pp. eabq3916. 2023 Jun 28.
• 1. Hirase H
  2. Nedergaard M
  Locomotion Induces Fundamentally Different Patterns of Ca2+ Signaling in Astrocytes and Neurons.; Function (Oxford, England); Vol 4(4), pp. zqad028. 2023 Jun 05.
• 1. Holstein-Rønsbo S
  2. Gan Y
  3. Giannetto MJ
  4. Rasmussen MK
  5. Sigurdsson B
  6. Beinlich FRM
  7. Rose L
  8. Untiet V
  9. Hablitz LM
  10. Kelley DH
  11. Nedergaard M
  Glymphatic influx and clearance are accelerated by neurovascular coupling.; Nature neuroscience. 2023 Jun 01.
• 1. Raizen DM
  2. Mullington J
  3. Anaclet C
  4. Clarke G
  5. Critchley H
  6. Dantzer R
  7. Davis R
  8. Drew KL
  9. Fessel J
  10. Fuller PM
  11. Gibson EM
  12. Harrington M
  13. Lipkin WI
  14. Klerman EB
  15. Klimas N
  16. Komaroff AL
  17. Koroshetz W
  18. Krupp L
  19. Kuppuswamy A
  20. Lasselin J
  21. Lewis LD
  22. Magistretti PJ
  23. Matos HY
  24. Miaskowski C
  25. Miller AH
  26. Nath A
  27. Nedergaard M
  28. Opp MR
  29. Ritchie MD
  30. Rogulja D
  31. Rolls A
  32. Salamone JD
  33. Saper C
  34. Whittemore V
  35. Wylie G
  36. Younger J
  37. Zee PC
  38. Heller HC
  Beyond the Symptom: The Biology of Fatigue.; Sleep. 2023 May 24.
• 1. Agarwal N
  2. Lewis LD
  3. Hirschler L
  4. Rivera LR
  5. Naganawa S
  6. Levendovszky SR
  7. Ringstad G
  8. Klarica M
  9. Wardlaw J
  10. Iadecola C
  11. Hawkes C
  12. Carare RO
  13. Wells J
  14. Bakker ENTP
  15. Kurtcuoglu V
  16. Bilston L
  17. Nedergaard M
  18. Mori Y
  19. Stoodley M
  20. Alperin N
  21. de Leon M
  22. van Osch MJP
  Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.; Journal of magnetic resonance imaging : JMRI. 2023 May 04.