O'Banion-Olschowka Labs
CNS Neuroinflammation Research
There is increasing recognition that inflammatory processes underlie many acute and chronic diseases, including those of the central nervous system (CNS). In particular, the glial and vascular components of the brain play significant and unique roles in inflammatory processes, both as sources of inflammatory mediators and as targets for local innate and acquired immune responses. Moreover, there is increasing recognition of the importance for glia in all aspects of brain function, ranging from normal homeostasis to repair and repopulation following injury. Our laboratories utilize mouse models to focus on the role of neuroinflammation in neurodegeneration and CNS injury.
M. Kerry O'Banion, M.D., Ph.D.
Principal Investigator
John A. Olschowka, Ph.D.
Principal Investigator
Projects
View All ProjectsPublications
- Partial microglial depletion and repopulation exert subtle but differential effects on amyloid pathology at different disease stages.; Scientific reports; Vol 14(1), pp. 30912. 2024 Dec 28.
- Neuroinflammation in Alzheimer disease.; Nature reviews. Immunology. 2024 Dec 09.
- Basic Science and Pathogenesis.; Alzheimer's & dementia : the journal of the Alzheimer's Association; Vol 20 Suppl 1, pp. e090717. 2024 Dec.
- Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice.; Brain, behavior, & immunity - health; Vol 43, pp. 100911. 2024 Nov 25.
- DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity.; Free radical biology & medicine. 2024 Sep 22.
Affiliations
- Neuroscience
- Del Monte Institute for Neuroscience
- Environmental Health Sciences Center
- James P. Wilmot Cancer Center
- NIH T32 Training Grant in Immunology
- Medical Scientist Training Program (M.D., Ph.D.)
- Neurobiology & Anatomy Ph.D. Program
- Neuroscience Ph.D. Program
- Toxicology Ph.D. Program
- Translational Biomedical Science Ph.D. Program
News
October 16, 2024
Comparing gene sequences across species to understand aging and dementia
January 18, 2023
Kerry O'Banion speaks with Medical News Today
November 3, 2022
Kerry O’Banion recognized for national contributions to MD-PhD training
November 5, 2021
Multiple sclerosis drug improves memory in mice modeling Alzheimer’s disease
Contact Us
Kerry O'Banion
KMRB G-9602
601 Elmwood Ave,
Rochester, NY 14642
John Olschowka
KMRB G-9619
601 Elmwood Ave,
Rochester, NY 14642