URMC / Labs / Sarkar Lab / Publications

Publications

1. Sarkar S
Microglial ion channels: Key players in non-cell autonomous neurodegeneration.; Neurobiology of disease; Vol 174, pp. 105861. 2022 Sep 14.
1. Langley MR
2. Rangaraju S
3. Dey A
4. Sarkar S
Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration.; Frontiers in cellular neuroscience; Vol 16, pp. 935190. 2022 Jun 21.
1. Hallacli E
2. Kayatekin C
3. Nazeen S
4. Wang XH
5. Sheinkopf Z
6. Sathyakumar S
7. Sarkar S
8. Jiang X
9. Dong X
10. Di Maio R
11. Wang W
12. Keeney MT
13. Felsky D
14. Sandoe J
15. Vahdatshoar A
16. Udeshi ND
17. Mani DR
18. Carr SA
19. Lindquist S
20. De Jager PL
21. Bartel DP
22. Myers CL
23. Greenamyre JT
24. Feany MB
25. Sunyaev SR
26. Chung CY
27. Khurana V
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.; Cell; Vol 185(12), pp. 2035-2056.e33. 2022 Jun 09.
1. Palanisamy BN
2. Sarkar S
3. Malovic E
4. Samidurai M
5. Charli A
6. Zenitsky G
7. Jin H
8. Anantharam V
9. Kanthasamy A
10. Kanthasamy AG
Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis.; The international journal of biochemistry & cell biology; Vol 147, pp. 106225. 2022 May 12.
1. Ghaisas S
2. Harischandra DS
3. Palanisamy B
4. Proctor A
5. Jin H
6. Dutta S
7. Sarkar S
8. Langley M
9. Zenitsky G
10. Anantharam V
11. Kanthasamy A
12. Phillips GJ
13. Kanthasamy A
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study.; Environmental health perspectives; Vol 129(8), pp. 87005. 2021 Aug 19.
1. Sarkar S
2. Feany MB
Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 182(2), pp. 159-167. 2021 Aug 03.
1. Sarkar S
Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson's Diseases.; Current environmental health reports; Vol 8(3), pp. 203-211. 2021 May 27.
1. Sarkar S
2. Bardai F
3. Olsen AL
4. Lohr KM
5. Zhang YY
6. Feany MB
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.; Molecular neurodegeneration; Vol 16(1), pp. 33. 2021 May 24.
1. Sarkar S
2. Olsen AL
3. Sygnecka K
4. Lohr KM
5. Feany MB
α-synuclein impairs autophagosome maturation through abnormal actin stabilization.; PLoS genetics; Vol 17(2), pp. e1009359. 2021 Feb 08.
1. Sarkar S
2. Nguyen HM
3. Malovic E
4. Luo J
5. Langley M
6. Palanisamy BN
7. Singh N
8. Manne S
9. Neal M
10. Gabrielle M
11. Abdalla A
12. Anantharam P
13. Rokad D
14. Panicker N
15. Singh V
16. Ay M
17. Charli A
18. Harischandra D
19. Jin LW
20. Jin H
21. Rangaraju S
22. Anantharam V
23. Wulff H
24. Kanthasamy AG
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.; The Journal of clinical investigation; Vol 130(8), pp. 4195-4212. 2020 Aug 03.
1. Sarkar S
2. Dammer EB
3. Malovic E
4. Olsen AL
5. Raza SA
6. Gao T
7. Xiao H
8. Oliver DL
9. Duong D
10. Joers V
11. Seyfried N
12. Huang M
13. Kukar T
14. Tansey MG
15. Kanthasamy AG
16. Rangaraju S
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.; Frontiers in immunology; Vol 11, pp. 33. 2020 Jan 31.
1. Sarkar S
2. Murphy MA
3. Dammer EB
4. Olsen AL
5. Rangaraju S
6. Fraenkel E
7. Feany MB
Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.; NPJ Parkinson's disease; Vol 6(1), pp. 40. 2020 Jan 11.
1. Ghaisas S
2. Langley MR
3. Palanisamy BN
4. Dutta S
5. Narayanaswamy K
6. Plummer PJ
7. Sarkar S
8. Ay M
9. Jin H
10. Anantharam V
11. Kanthasamy A
12. Kanthasamy AG
MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.; Neurotoxicology; Vol 75, pp. 186-199. 2019 Sep 07.
1. Panicker N
2. Sarkar S
3. Harischandra DS
4. Neal M
5. Kam TI
6. Jin H
7. Saminathan H
8. Langley M
9. Charli A
10. Samidurai M
11. Rokad D
12. Ghaisas S
13. Pletnikova O
14. Dawson VL
15. Dawson TM
16. Anantharam V
17. Kanthasamy AG
18. Kanthasamy A
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.; The Journal of experimental medicine; Vol 216(6), pp. 1411-1430. 2019 Apr 29.
1. Harischandra DS
2. Rokad D
3. Neal ML
4. Ghaisas S
5. Manne S
6. Sarkar S
7. Panicker N
8. Zenitsky G
9. Jin H
10. Lewis M
11. Huang X
12. Anantharam V
13. Kanthasamy A
14. Kanthasamy AG
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.; Science signaling; Vol 12(572). 2019 Mar 12.
1. Sarkar S
2. Rokad D
3. Malovic E
4. Luo J
5. Harischandra DS
6. Jin H
7. Anantharam V
8. Huang X
9. Lewis M
10. Kanthasamy A
11. Kanthasamy AG
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.; Science signaling; Vol 12(563). 2019 Jan 08.
1. Neal M
2. Luo J
3. Harischandra DS
4. Gordon R
5. Sarkar S
6. Jin H
7. Anantharam V
8. Désaubry L
9. Kanthasamy A
10. Kanthasamy A
Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.; Glia; Vol 66(10), pp. 2137-2157. 2018 Sep 12.
1. Singh N
2. Lawana V
3. Luo J
4. Phong P
5. Abdalla A
6. Palanisamy B
7. Rokad D
8. Sarkar S
9. Jin H
10. Anantharam V
11. Kanthasamy AG
12. Kanthasamy A
Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.; Neurobiology of disease; Vol 117, pp. 82-113. 2018 May 31.
1. Sarkar S
2. Malovic E
3. Sarda D
4. Lawana V
5. Rokad D
6. Jin H
7. Anantharam V
8. Kanthasamy A
9. Kanthasamy AG
Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.; Neurotoxicology; Vol 67, pp. 129-140. 2018 May 30.
1. Anantharam P
2. Whitley EM
3. Mahama B
4. Kim DS
5. Sarkar S
6. Santana C
7. Chan A
8. Kanthasamy AG
9. Kanthasamy A
10. Boss GR
11. Rumbeiha WK
Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.; Annals of the New York Academy of Sciences; Vol 1408(1), pp. 61-78. 2017 Nov.
1. Sarkar S
2. Malovic E
3. Harischandra DS
4. Ngwa HA
5. Ghosh A
6. Hogan C
7. Rokad D
8. Zenitsky G
9. Jin H
10. Anantharam V
11. Kanthasamy AG
12. Kanthasamy A
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.; Neurotoxicology; Vol 64, pp. 204-218. 2017 May 21.
1. Lawana V
2. Singh N
3. Sarkar S
4. Charli A
5. Jin H
6. Anantharam V
7. Kanthasamy AG
8. Kanthasamy A
Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 12(4), pp. 624-660. 2017 May 02.
1. Sarkar S
2. Malovic E
3. Plante B
4. Zenitsky G
5. Jin H
6. Anantharam V
7. Kanthasamy A
8. Kanthasamy AG
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.; Journal of visualized experiments : JoVE. 2017 Apr 13.
1. Langley M
2. Ghosh A
3. Charli A
4. Sarkar S
5. Ay M
6. Luo J
7. Zielonka J
8. Brenza T
9. Bennett B
10. Jin H
11. Ghaisas S
12. Schlichtmann B
13. Kim D
14. Anantharam V
15. Kanthasamy A
16. Narasimhan B
17. Kalyanaraman B
18. Kanthasamy AG
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.; Antioxidants & redox signaling; Vol 27(14), pp. 1048-1066. 2017 Apr 04.
1. Sharma S
2. Carlson S
3. Puttachary S
4. Sarkar S
5. Showman L
6. Putra M
7. Kanthasamy AG
8. Thippeswamy T
Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.; Neurobiology of disease; Vol 110, pp. 102-121. 2017 Jan 29.
1. Sarkar S
2. Malovic E
3. Harishchandra DS
4. Ghaisas S
5. Panicker N
6. Charli A
7. Palanisamy BN
8. Rokad D
9. Jin H
10. Anantharam V
11. Kanthasamy A
12. Kanthasamy AG
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.; NPJ Parkinson's disease; Vol 3, pp. 30. 2017 Jan 17.
1. Gordon R
2. Singh N
3. Lawana V
4. Ghosh A
5. Harischandra DS
6. Jin H
7. Hogan C
8. Sarkar S
9. Rokad D
10. Panicker N
11. Anantharam V
12. Kanthasamy AG
13. Kanthasamy A
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.; Neurobiology of disease; Vol 93, pp. 96-114. 2016 May 02.
1. Panicker N
2. Saminathan H
3. Jin H
4. Neal M
5. Harischandra DS
6. Gordon R
7. Kanthasamy K
8. Lawana V
9. Sarkar S
10. Luo J
11. Anantharam V
12. Kanthasamy AG
13. Kanthasamy A
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(27), pp. 10058-77. 2015 Jul 08.