URMC / Labs / Wojtovich Lab / Publications

Recent Publications

1. Müller-Eigner A
2. Wojtovich AP
Mitochondrial metabolism and redox signaling.; Redox biology. 2024 Nov 29.
1. Peng W
2. Chung KB
3. Lawrence BP
4. O'Banion MK
5. Dirksen RT
6. Wojtovich AP
7. Onukwufor JO
DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity.; Free radical biology & medicine. 2024 Sep 22.
1. Quinones Tavarez Z
2. Croft DP
3. Li D
4. Gill SR
5. Wojtovich AP
6. Rahman I
7. Ossip DJ
Fruit flavors in electronic cigarettes (ECIGs) are associated with nocturnal dry cough: A population longitudinal analysis.; PloS one; Vol 19(6), pp. e0306467. 2024 Jun 28.
1. Vodičková A
2. Müller-Eigner A
3. Okoye CN
4. Bischer AP
5. Horn J
6. Koren SA
7. Selim NA
8. Wojtovich AP
Mitochondrial energy state controls AMPK-mediated foraging behavior in C. elegans.; Science advances; Vol 10(16), pp. eadm8815. 2024 Apr 17.
1. Cooper JF
2. Nguyen K
3. Gates D
4. Wolfrum E
5. Capan C
6. Lee H
7. Williams D
8. Okoye C
9. Wojtovich AP
10. Burton NO
Oocyte mitochondria link maternal environment to offspring phenotype.; Research square. 2024 Mar 29.
1. Koren SA
2. Ahmed Selim N
3. De la Rosa L
4. Horn J
5. Farooqi MA
6. Wei AY
7. Müller-Eigner A
8. Emerson J
9. Johnson GVW
10. Wojtovich AP
All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ.; Nature communications; Vol 14(1), pp. 6036. 2023 Sep 27.
1. Tiwary V
2. Galow AM
3. Wojtovich AP
4. Peleg S
Using light to drive energy transduction in metazoan aging.; Trends in biochemical sciences. 2023 Sep 11.
1. Chaubey AH
2. Sojka SE
3. Onukwufor JO
4. Ezak MJ
5. Vandermeulen MD
6. Bowitch A
7. Vodičková A
8. Wojtovich AP
9. Ferkey DM
The C. elegans Innexin INX-20 Regulates Nociceptive Behavioral Sensitivity.; Genetics. 2023 Feb 08.
1. Okoye CN
2. Koren SA
3. Wojtovich AP
Mitochondrial complex I ROS production and redox signaling in hypoxia.; Redox biology; Vol 67, pp. 102926. 2023 Jan 16.
1. Bischer AP
2. Baran TM
3. Wojtovich AP
Reactive oxygen species drive foraging decisions in Caenorhabditis elegans.; Redox biology; Vol 67, pp. 102934. 2023 Jan 13.
1. Onukwufor JO
2. Farooqi MA
3. Vodičková A
4. Koren SA
5. Baldzizhar A
6. Berry BJ
7. Beutner G
8. Porter GA
9. Belousov V
10. Grossfield A
11. Wojtovich AP
A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans.; Nature communications; Vol 13(1). 2022 May 03.
1. Kleckner AS
2. Kleckner IR
3. Culakova E
4. Wojtovich AP
5. Klinedinst NJ
6. Kerns SL
7. Hardy SJ
8. Inglis JE
9. Padula GDA
10. Mustian KM
11. Janelsins MC
12. Dorsey SG
13. Saligan LN
14. Peppone LJ
Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors.; Nursing research. 2022 Apr 13.
1. Onukwufor JO
2. Dirksen RT
3. Wojtovich AP
Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer's Disease.; Antioxidants (Basel, Switzerland); Vol 11(4). 2022 Mar 31.
1. Vodičková A
2. Koren SA
3. Wojtovich AP
Site-specific mitochondrial dysfunction in neurodegeneration.; Mitochondrion. 2022 Feb 16.
1. Berry BJ
2. Vodičková A
3. Müller-Eigner A
4. Meng C
5. Ludwig C
6. Kaeberlein M
7. Peleg S
8. Wojtovich AP
Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan.; Nature aging; Vol 3(2), pp. 157-161. 2022 Jan 30.
1. Berry BJ
2. Nieves TO
3. Wojtovich AP
Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response.; microPublication biology; Vol 2021. 2021.
1. Amitrano AM
2. Berry BJ
3. Lim K
4. Kim KD
5. Waugh RE
6. Wojtovich AP
7. Kim M
Optical Control of CD8+ T Cell Metabolism and Effector Functions.; Frontiers in immunology; Vol 12. 2021.
1. Berry BJ
2. Baldzizhar A
3. Nieves TO
4. Wojtovich AP
Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 Oct 15.
1. Berry BJ
2. Wojtovich AP
Mitochondrial Light Switches: Optogenetic Approaches to Control Metabolism.; The FEBS journal. 2020 May 27.
1. Berry BJ
2. Trewin AJ
3. Milliken AS
4. Baldzizhar A
5. Amitrano AM
6. Lim Y
7. Kim M
8. Wojtovich AP
Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.; EMBO reports. 2020 Feb 11.
1. Onukwufor JO
2. Trewin AJ
3. Baran TM
4. Almast A
5. Foster TH
6. Wojtovich AP
Quantification of reactive oxygen species production by the red fluorescent proteins KillerRed, SuperNova and mCherry.; Free radical biology & medicine; Vol 147. 2019 Dec 10.
1. Onukwufor JO
2. Berry BJ
3. Wojtovich AP
Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport.; Antioxidants (Basel, Switzerland); Vol 8(8). 2019 Aug 06.
1. Philip NS
2. Escobedo F
3. Bahr LL
4. Berry BJ
5. Wojtovich AP
Mos1 Element-Mediated CRISPR Integration of Transgenes in Caenorhabditis elegans.; G3 (Bethesda, Md.). 2019 Jun 11.
1. Wojtovich AP
2. Berry BJ
3. Galkin A
Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease.; Antioxidants & redox signaling. 2019 May 14.
1. Trewin AJ
2. Bahr LL
3. Almast A
4. Berry BJ
5. Wei AY
6. Foster TH
7. Wojtovich AP
Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain have distinct effects on redox signaling and stress sensitivity in <i>C. elegans</i>.; Antioxidants & redox signaling. 2019 Mar 19.
1. Berry BJ
2. Trewin AJ
3. Amitrano AM
4. Kim M
5. Wojtovich AP
Use the protonmotive force: Mitochondrial uncoupling and reactive oxygen species.; Journal of molecular biology. 2018 Apr 04.
1. Trewin AJ
2. Berry BJ
3. Wei AY
4. Bahr LL
5. Foster TH
6. Wojtovich AP
Light-induced oxidant production by fluorescent proteins.; Free radical biology & medicine. 2018 Feb 06.
1. Barnett ME
2. Baran TM
3. Foster TH
4. Wojtovich AP
Quantification of light-induced miniSOG superoxide production using the selective marker, 2-hydroxyethidium.; Free radical biology & medicine; Vol 116. 2018 Jan 17.
1. Trewin AJ
2. Berry BJ
3. Wojtovich AP
Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK.; Antioxidants (Basel, Switzerland); Vol 7(1). 2018 Jan 06.
1. Wojtovich AP
2. Wei AY
3. Sherman TA
4. Foster TH
5. Nehrke K
Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans.; Scientific reports; Vol 6. 2016 Jul 21.
1. Stoveken HM
2. Bahr LL
3. Anders MW
4. Wojtovich AP
5. Smrcka AV
6. Tall GG
Dihydromunduletone is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.; Molecular pharmacology. 2016 Jun 23.
1. Wojtovich AP
2. Smith CO
3. Urciuoli WR
4. Wang YT
5. Xia XM
6. Brookes PS
7. Nehrke K
Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.; Anesthesiology; Vol 124(5). 2016 May.
1. Raphemot R
2. Swale DR
3. Dadi PK
4. Jacobson DA
5. Cooper P
6. Wojtovich AP
7. Banerjee S
8. Nichols CG
9. Denton JS
Direct activation of β-cell KATP channels with a novel xanthine derivative.; Molecular pharmacology; Vol 85(6). 2014 Jun.
1. Wojtovich AP
2. Foster TH
Optogenetic control of ROS production.; Redox biology; Vol 2. 2014.
1. Wojtovich AP
2. Urciuoli WR
3. Chatterjee S
4. Fisher AB
5. Nehrke K
6. Brookes PS
Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.; American journal of physiology. Heart and circulatory physiology; Vol 304(11). 2013 Jun 01.
1. Wojtovich AP
2. Smith CO
3. Haynes CM
4. Nehrke KW
5. Brookes PS
Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.; Biochimica et biophysica acta; Vol 1827(5). 2013 May.
1. Wojtovich AP
2. Nadtochiy SM
3. Urciuoli WR
4. Smith CO
5. Grunnet M
6. Nehrke K
7. Brookes PS
A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.; PeerJ; Vol 1. 2013.
1. Guo S
2. Olm-Shipman A
3. Walters A
4. Urciuoli WR
5. Devito S
6. Nadtochiy SM
7. Wojtovich AP
8. Brookes PS
A cell-based phenotypic assay to identify cardioprotective agents.; Circulation research; Vol 110(7). 2012 Mar 30.
1. Wojtovich AP
2. DiStefano P
3. Sherman T
4. Brookes PS
5. Nehrke K
Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.; FEBS letters; Vol 586(4). 2012 Feb 17.
1. Wojtovich AP
2. Nadtochiy SM
3. Brookes PS
4. Nehrke K
Ischemic preconditioning: the role of mitochondria and aging.; Experimental gerontology; Vol 47(1). 2012 Jan.
1. Queliconi BB
2. Wojtovich AP
3. Nadtochiy SM
4. Kowaltowski AJ
5. Brookes PS
Redox regulation of the mitochondrial K(ATP) channel in cardioprotection.; Biochimica et biophysica acta; Vol 1813(7). 2011 Jul.
1. Wojtovich AP
2. Sherman TA
3. Nadtochiy SM
4. Urciuoli WR
5. Brookes PS
6. Nehrke K
SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.; PloS one; Vol 6(12). 2011.
1. Gunter TE
2. Gerstner B
3. Lester T
4. Wojtovich AP
5. Malecki J
6. Swarts SG
7. Brookes PS
8. Gavin CE
9. Gunter KK
An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays.; Toxicology and applied pharmacology; Vol 249(1). 2010 Nov 15.
1. Wojtovich AP
2. Williams DM
3. Karcz MK
4. Lopes CM
5. Gray DA
6. Nehrke KW
7. Brookes PS
A novel mitochondrial K(ATP) channel assay.; Circulation research; Vol 106(7). 2010 Apr 16.
1. Gohil VM
2. Sheth SA
3. Nilsson R
4. Wojtovich AP
5. Lee JH
6. Perocchi F
7. Chen W
8. Clish CB
9. Ayata C
10. Brookes PS
11. Mootha VK
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.; Nature biotechnology; Vol 28(3). 2010 Mar.
1. Roser KS
2. Brookes PS
3. Wojtovich AP
4. Olson LP
5. Shojaie J
6. Parton RL
7. Anders MW
Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria.; Bioorganic & medicinal chemistry; Vol 18(4). 2010 Feb 15.
1. Wojtovich AP
2. Nehrke KW
3. Brookes PS
The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.; Acta biochimica Polonica; Vol 57(4). 2010.
1. Miller CL
2. Oikawa M
3. Cai Y
4. Wojtovich AP
5. Nagel DJ
6. Xu X
7. Xu H
8. Florio V
9. Rybalkin SD
10. Beavo JA
11. Chen YF
12. Li JD
13. Blaxall BC
14. Abe J
15. Yan C
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.; Circulation research; Vol 105(10). 2009 Nov 06.
1. Wojtovich AP
2. Brookes PS
The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.; Basic research in cardiology; Vol 104(2). 2009 Mar.
1. Wojtovich AP
2. Burwell LS
3. Sherman TA
4. Nehrke KW
5. Brookes PS
The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning.; Biochemical and biophysical research communications; Vol 376(3). 2008 Nov 21.
1. Wojtovich AP
2. Brookes PS
The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning.; Biochimica et biophysica acta; Vol 1777(7-8). 2008 Jul.
1. di Bernardo D
2. Thompson MJ
3. Gardner TS
4. Chobot SE
5. Eastwood EL
6. Wojtovich AP
7. Elliott SJ
8. Schaus SE
9. Collins JJ
Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks.; Nature biotechnology; Vol 23(3). 2005 Mar.