Leon L. Miller, M.D., Ph.D.

Introduction

Leon L. Miller, M.D., Ph.D. was a physician and biochemist known for his development of a technique for rat liver perfusion (RLP), and for his studies of the liver in the biosynthesis of plasma proteins. Miller joined the faculty of the University of Rochester School of Medicine & Dentistry in 1938 and became professor emeritus in 1978. He continued to teach and do research into the 21st century. Dr. Miller’s papers were transferred from his office and laboratory to the Miner Library several months after his death. Contained in forty-one boxes and occupying thirty-three linear feet, the collection largely reflects Dr. Miller’s research activity (i.e., grant applications, laboratory notebooks, publications), and to a lesser extent his teaching. Processing of the Miller collection was completed in October 2015.

Biography

Leon Lee Miller was born in Rochester, New York on December 7, 1912, one of four children born to Abraham Calmen Miller, a Russian-Jewish immigrant and wrought-iron worker, and Hinda Rosenblum Miller. He attended East High School in the city of Rochester. Miller subsequently entered Cornell University from which he received his undergraduate degree (chemistry) in 1934 and his Ph.D. (organic chemistry) in 1937. Miller remained at Cornell as a research fellow through September 1937. In October of that year he began work in the pharmaceutical division of Calco Chemical Co. in New Jersey, but was laid-off early in 1938. Miller was not long unemployed when he was approached by George Hoyt Whipple, M.D., founding dean of the University of Rochester School of Medicine & dentistry and chairman of the department of pathology, to accept a position in Rochester. Whipple was in need of a chemist in the pathology department to assist in his metabolic studies. Miller joined the department in 1938 as a Lilly Fellow in Pathology and Pharmacology with the title instructor in pathology, biochemistry and pharmacology. He was responsible for the biochemical end of Whipple’s studies of hemoglobin and plasma protein production.

Although he had never considered medicine as an undergraduate or graduate student, Miller approached Whipple after two years in Rochester about pursuing a medical degree. As early as 1939 he began to take classes within the School of Medicine while continuing his research responsibilities in the pathology department (see class notes in Box 2, Folder 6). Miller received his medical degree (with honor) in 1945 with a thesis entitled “Proteins and protein factors in liver injury” (Box 2, Folder 7). He was appointed assistant professor of biochemistry in June 1945, but left Rochester to accept a position at Jefferson Medical College in 1946 as assistant professor of biochemistry. About this time, his older brother, Mitchill William “Mitch” Miller (1911-2010), a 1932 Eastman School of Music graduate, was beginning a career in New York as a jazz musician and recording industry executive.

Early in 1948 Miller was persuaded to return to Rochester by William Freer Bale, Ph.D., who headed the biophysics division of the Department of Radiation Biology in the School of Medicine. Miller was appointed associate professor of biochemistry and head of the Section on Tracer Chemistry for the Atomic Energy Project (see Bale correspondence, Box 4, Folder 3). In 1958 he was made professor of radiation biology, and in 1978 professor emeritus of biochemistry and biophysics.

Miller summarized his research activities between 1948 and 1990 in a document appended to one of his later curricula vitae (Box 1, Folder 1). In the 1940s he “participated in studies using 15N- and 14C-lysine not only to characterize the metabolism of plasma proteins, and labeled hemoglobin, and to characterize the life cycle of the red cell, but also to work out in detail, the intermediary metabolic steps in the overall metabolism of lysine.” Miller regarded as his most important contribution the “development of the isolated liver perfusion technique which fulfilled the need for a method allowing the protracted (up to 24 hours) direct study of the liver, uncomplicated by the contribution from other organs. We demonstrated that the isolated perfused rat liver simulated the physiological behavior of the liver in the intact rat with respect to metabolism of glucose, amino acids, and the synthesis and secretion of plasma proteins and bile production.” The use of the isolated perfused rat liver led to multiple discoveries described in this same document. In addition to his research, Miller was highly regarded an an educator of medical students, graduate students and post-doctoral fellows.

Miller was the author of more than 150 journal articles and book chapters. He was a member of the American Chemical Society, the American Association for the Advancement of Science, the American Society of Biological Chemists, the Society of Experimental Biology and Medicine, the American Society for Cancer Research, the American Society for Radiation Research, and the the New York Academy of Sciences.

In 1935 Miller married Pearl Sternberg, with whom he had three children. They were divorced in 1956. In 1958 Miller married Elizabeth Plumb, with whom he also had three children. Leon L. Miller died in Rochester on September 3, 2010. A very interesting forty-five minute oral history with Dr. Miller was recorded in 1990. It is accessible from this link.

Organization of the Miller Papers

Institutions & Societies (Boxes 1-3)

This series provides a limited sample of material documenting Dr. Miller’s involvement in national and international scientific societies, attendance at conferences, participation in organizational and institutional committees, etc. Two of the three boxes in this series pertain to his activity within the University of Rochester School of Medicine & Dentistry. The third box, containing his work on the Admissions Committee, is closed to the public indefinitely.

Correspondence (Boxes 4-7)

This comparatively small series contains some very interesting correspondence with Dr. Miller’s colleagues and former students. The bulk of this correspondence spans the years 1960-1980. This series is arranged alphabetically by correspondents’ last names. Individuals with whom Dr. Miller maintained a larger volume of correspondence have individual folders integrated into the alphabetical series.

Teaching (Boxes 8-9)

In addition to his research, Dr. Miller maintained an active teaching schedule within the Dept. of Radiation Biology & Biophysics. This series contains syllabi, class schedules, lecture notes, exams and related material pertaining to Dr. Miller’s instruction of medical and graduate students. These materials are arranged chronologically.

Theses (Boxes 10-11)

This collection of doctoral and masters theses supervised by Dr. Miller is arranged alphabetically by authors’ names. It is uncertain whether this collection contains the theses of all those who trained under Dr. Miller.

Publications (Boxes 12-13)

Dr. Miller was the author of 151 journal articles and book chapters. The publications contained in this series are nearly complete and are arranged chronologically by date of publication. A complete bibliography of Dr. Miller’s publishing history is included in his 1996 curriculum vitae (Box 1, Folder 1).

Grant Applications (Boxes 14-15)

These two boxes of grant applications, acceptances and renewals provide an overview of Dr, Miller’s research activity from the early 1950s through the mid-1980s. The bulk of this series dates from the early 1950s through the mid-1970s, and includes his work on plasma and tissue protein metabolism in normal and experimental disease states (1951-77); plasma and tissue protein studies with isotopically labeled substances (1953-64); net synthesis of plasma proteins by perfused liver (1966-75); and other grant-funded research.

Laboratory Notebooks, 3-Ring (Boxes 16-29)

The twenty-three boxes of laboratory notebooks in this collection represent the single largest category of material among Dr. Miller’s papers. These notebooks record work done in Dr. Miller’s laboratory by himself, by technicians under his supervision, and by graduate students. Dr. Miller’s laboratory notebooks were maintained in two formats: material inserted into three-ring binders, and material recorded in student composition books. The laboratory notebooks in the Miller collection are divided according to format.

When transferred to the Miner Library, virtually all the three-ring binders were found to be in varying states of disintegation that threatened the integrity of their contents. These materials were therefore removed from the binders and transferred to acid-free folders, which in turn have been boxed. The labelling of each folder copies the label on the original three-ring binder.

The content of the fourteen boxes of three-ring laboratory notebooks in the Miller collection are arranged chronologically. The earliest three-ring notebook was dated 1943, but the bulk of this collection spans the years 1950-1986. The three-ring series seems to contain more bulk data, summaries and graphs than the composition series. For an understanding of research activity in Dr. Miller’s laboratory, the content of the three-ring series of laboratory notebooks should be compared with notebooks for the same years in the composition book series.

Laboratory Notebooks, Composition Books (Boxes 30-39)

The laboratory notebooks in the composition book series appears to represent daily laboratory activity than the compiled data found in the three-ring series. The ten cartons of notebooks in this series span the years 1934-2000. Use of these notebooks should be coordinated with materials of the same period contained in the three-ring series and with the grant applications in Boxes 14 and 15.

Bound Collections of Computer-Generated Data (not boxed)

An apparently incomplete series of computer-generated summary data on rat liver perfusion studies conducted in Miller’s laboratory between 1975 and 1980. The data collected in these volumes obviously overlaps with the data recorded in the 3-ring and composition book laboratory notebooks.

Container List

BOX ONE – INSTITUTIONS & SOCIETIES

• Folder 1: Curricula vitae & biographical information
• Folder 2: Altman (Kurt L.) memorial service
• Folder 3: American Chemical Society
• Folder 4: American Diabetes Association
• Folder 5: American Journal of Physiology
• Folder 6: Atomic Energy Commission
• Folder 7: Atomic Energy Project program (196?)
• Folder 8: Brookhaven National Laboratory
• Folder 9: Ciba Foundation
• Folder 10: Colloquium on Protides of the Biological Fluids (23rd : Brugge : May 1975)
• Folder 11: European Meeting on the Technique of Perfusion of the Isolated Liver and its Application (1st : Milan : Jul 1971)
• Folder 12: International Congress on Biochemistry (5th : Moscow : Aug 1961)
• Folder 13: International Study Group on Plasma Protein Metabolism annual meeting (6th : Turin : May 1974)
• Folder 14: International Symposium on Intracellular Protein Catabolism (5th : Airlie, Va. : Jun 1984)
• Folder 15: Journal of Biological Chemistry
• Folder 16: Journal of Clinical Investigation
• Folder 17: Journal of Laboratory and Clinical Medicine
• Folder 18: Lilly Research Laboratories
  Folder 19: New England Nuclear Corp.
• Folder 20: Oak Ridge Institute of Nuclear Studies. Radioisotope Training Program (1948)

BOX TWO – INSTITUTIONS & SOCIETIES

• Folder 1: Society of Sigma Xi. Rochester Chapter
• Folder 2: University of Rochester School of Medicine & Dentistry. Personnel A-C
• Folder 3: University of Rochester School of Medicine & Dentistry. Personnel D-K
• Folder 4: University of Rochester School of Medicine & Dentistry. Personnel L-Y
• Folder 5: University of Rochester School of Medicine & Dentistry. Alumni Association
• Folder 6: University of Rochester School of Medicine & Dentistry. LLM’s student lecture notes for pharmacology courses (1939, 1942)
• Folder 7: University of Rochester School of Medicine & Dentistry. Proteins and protein factors in liver injury (LLM’s 1945 M.D. thesis)
• Folder 8: University of Rochester School of Medicine & Dentistry. Tutorial program (1963-64)
• Folder 9: University of Rochester School of Medicine & Dentistry. Tutorial program (1965-68)
• Folder 10: University of Rochester School of Medicine & Dentistry. First & second year electives (1967)
• Folder 11: University of Rochester School of Medicine & Dentistry. Visiting committee on biochemistry (Oct 1968)
• Folder 12: University of Rochester School of Medicine & Dentistry. Radiation Biology & Biophysics. Distinguished lecturer series (1969-74)
• Folder 13: University of Rochester School of Medicine & Dentistry. Medical Library Committee
• Folder 14: University of Rochester School of Medicine & Dentistry. Committee on Animal Resources (1986-87)
• Folder 15: University of Rochester School of Medicine & Dentistry. Radiation Biology & Biophysics. Departmental Mission Committee (1991)
• Folder 16: Utica Mutual Insurance Co.

BOX THREE – INSTITUTIONS & SOCIETIES

(This box is closed to the public)

• Folder 1: University of Rochester School of Medicine & Dentistry. Admissions Committee (1966-70)
• Folder 2: University of Rochester School of Medicine & Dentistry. Admissions Committee (1974)
• Folder 3: University of Rochester School of Medicine & Dentistry. Admissions Committee (1975)
• Folder 4: University of Rochester School of Medicine & Dentistry. Admissions Committee (1976)
• Folder 5: University of Rochester School of Medicine & Dentistry. Admissions Committee (1977)
• Folder 6: University of Rochester School of Medicine & Dentistry. Admissions Committee (1978-79)

BOX FOUR – CORRESPONDENCE

• Folder 1: Correspondence: A
• Folder 2: Correspondence: BA-BON
• Folder 3: Correspondence: Bale, William F.
• Folder 4: Correspondence: BOO-BU
• Folder 5: Correspondence: Burke, William T.
• Folder 6: Correspondence: CA-CIA
• Folder 7: Correspondence: CIBA-CU
• Folder 8: Correspondence: Clark, Leland C.
• Folder 9: Correspondence: Cohen, A. M.
• Folder 10: Correspondence: Croall, Dorothy E.
• Folder 11: Correspondence: DA-DEP
• Folder 12: Correspondence: Decker, Karl
• Folder 13: Correspondence: DeMartino, George N.
• Folder 14: Correspondence: Di Ferrante, Nicola
• Folder 15: Correspondence: DO-DU
• Folder 16: Correspondence: E
• Folder 17: Correspondence: F
• Folder 18: Correspondence: Fansah, Naji
• Folder 19: Correspondence: Fritz, Irving B.
• Folder 20: Correspondence: G

BOX FIVE – CORRESPONDENCE

• Folder 1: Correspondence: Griffin, Edmond E.
• Folder 2: Correspondence: HA-HON
• Folder 3: Correspondence: Haft, David E.
• Folder 4: Correspondence: Harper, Alfred E.
• Folder 5: Correspondence: Harris, Linda
• Folder 6: Correspondence: Hawley, Estelle E.
• Folder 7: Correspondence: HOR-HU
• Folder 8: Correspondence: I
• Folder 9: Correspondence: Irwin, John Foster
• Folder 10: Correspondence: J
• Folder 11: Correspondence: John, David W.
• Folder 12: Correspondence: KA-KI
• Folder 13: Correspondence: Katz, Joseph
• Folder 14: Correspondence: Kim, Je Hyun
• Folder 15: Correspondence: KN-KU
• Folder 16: Correspondence: Koszalka, Thomas R.
• Folder 17: Correspondence: L
• Folder 18: Correspondence: Litwack, Gerald
• Folder 19: Correspondence: Loeb, Robert
• Folder 20: Correspondence: Lueck, James D.

BOX SIX – CORRESPONDENCE

• Folder 1: Correspondence: MAC-ME
• Folder 2: Correspondence: MI-MY
• Folder 3: Correspondence: Minthorn, Martin L.
• Folder 4: Correspondence: Mutschler Naismith, Letitia E.
• Folder 5: Correspondence: N
• Folder 6: Correspondence: Nadkarni, Ganeshunder
• Folder 7: Correspondence: Nassett, E. S.
• Folder 8: Correspondence: Nesbit, Robert R.
• Folder 9: Correspondence: Neuhaus, Otto W.
• Folder 10: Correspondence: O
• Folder 11: Correspondence: Olson, John P.
• Folder 12: Correspondence: P
• Folder 13: Correspondence: Poffenbarger, Phillip L.
• Folder 14: Correspondence: R
• Folder 15: Correspondence: Rowe, W. Bruce
• Folder 16: Correspondence: SA-SH
• Folder 17: Correspondence: Schalch, Don S.
• Folder 18: Correspondence: Schmid, Karl
• Folder 19: Correspondence: Schreiber, Gerhard
• Folder 20: Correspondence: Segal, Harry L.
• Folder 21: Correspondence: Seijffers, Max J.
• Folder 22: Correspondence: SI-ST
• Folder 23: Correspondence: Squibb, Robert L.
• Folder 24: Correspondence: Staib, Wolfgang

BOX SEVEN – CORRESPONDENCE

• Folder 1: Correspondence: Szegedy, Alexander S.
• Folder 2: Correspondence: T
• Folder 3: Correspondence: Turner, Michael D.
• Folder 4: Correspondence: U-V
• Folder 5: Correspondence: W
• Folder 6: Correspondence: Woodside, Kenneth
• Folder 7: Correspondence: Z

BOX EIGHT – TEACHING

• Folder 1: Biochem 200 (1953)
• Folder 2: RB 251, Tracer chemistry (1953-55)
• Folder 3: RB 251, Tracer chemistry (1958)
• Folder 4: RB 251, Tracer chemistry (1958)
• Folder 5: RB 251, Tracer chemistry (1960)
• Folder 6: RB 551, Tracer chemistry (1960-69)
• Folder 7: RB 551, Tracer chemistry lecture notes (1964)
• Folder 8: Radiation Biology & Biophysics. Graduate studies bulletin summary (1965)
• Folder 9: RB 501, Biophysics (1966-69)
• Folder 10: RB 518, Tracer chemistry (1967-71)
• Folder 11: RB 567, Seminars for protein structure
• Folder 12: Biochem 502 (1969?)
• Folder 13: Biochemistry schedule (1970-71)

BOX NINE – TEACHING

• Folder 1: RB 542, Tracer chemistry (1973-75)
• Folder 2: RB 542: Tracer chemistry. Student experiment results
• Folder 3: Nutrition 1974)
• Folder 4: Biochem 500 (1978)
• Folder 5: Biochem 500 (1978)
• Folder 6: Biochemistry & endocrinology (1979)
• Folder 7: Biochem 500 (1980)
• Folder 8: Biochem 524 (1984)
• Folder 9: RB 451, Isolated rat liver perfusion (undated)
• Folder 10: Miscellaneous lecture notes

BOX TEN – THESES

• Bly, Chauncey G.  Some studies in the biosynthesis of plasma and tissue proteins (1952)
• Burday, Michele Sandra.  Net C3 complement synthesis in the isolated perfused rat liver system (1977)
• Cloutier, Paul Frederick.  Some effects of glucocorticoids and glucagon on enzymes of protein catabolism in the rat (1965)
• DeMartino, George Nicholas.  Isolation, characterization, and purification if the pepstatin-insensitive proteolytic enzymes of rat liver (1976)
• Deshpande, Madhuri V.  Studies on protein catabolism of HeLa cells in tissue culture (1964)
• Engert, Richard F.  Studies on the measurement of bile acids with 3 α-hydroxysteroid dehydrogenase (1974)
• Ganis, Frank M. Gangarosa. Some observations on the in vitro metabolism of hormones (1956)
• Goldstein, Madeline.  The relation of salicylate treatment to the metabolism of hydrocortisone in the perfused isolated rat liver (1957)
• Haft, David E.  Metabolic studies on the isolated perfused rat liver (1957)
• Harris, Linda Jean.  Quantitation of mRNAs for α1-acid glycoprotein and for serum albumin in livers of normal, stressed, fasted and refed rats (1978)
• Irwin, John Foster.  The effects of X-irradiation upon the metabolism of fibrinogen and other plasma proteins in rats (1969)
• Koszalka, Thomas R.  The proteolytic activity of rat skeletal muscle (1958)
• Lebda, Nancy Jean Abbott.  The effect of varying doses of cortisol on the incorporation of ³H-thymidine into rat liver DNA and on the synthesis of five plasma proteins in the isolated perfused regenerating rat liver (1972)
• Lueck, James Dodds.  Studies on glutamine metabolism in the isolated perfused rat liver (1969)
• Murkofsky, Nelia Adams.  Relationships between liver cell polysome fractions and synthesis of serum albumin (1968)
• Rowe, William B.  Studies on the deoxribonucleases in the rat (1959)

BOX ELEVEN – THESES

• Schumacher, Randal Peter.  Effects of cadmium in the isolated perfused rat liver (1977)
• Toribara, Neil W.  Rat liver regeneration … (1981)
• Turner, Michael D.  Some aspects of amine metabolism in relation to liver disease (1964)
• Woodside, Kenneth Hall.  Effects of glucagon and cyclic 3’, 5-AMP on glycogenolysis and protein catabolism in rat liver (1968)

BOX TWELVE – PUBLICATIONS

• Folder 1: Reprints, 1940-1943
• Folder 2: Reprints, 1944-1946
• Folder 3: Reprints, 1947
• Folder 4: Reprints, 1948
• Folder 5: Reprints, 1949-1950
• Folder 6: Reprints, 1951
• Folder 7: Reprints, 1952-1953
• Folder 8: Reprints, 1954
• Folder 9: Reprints, 1955-1956
• Folder 10: Reprints, 1957-1958
• Folder 11: Reprints, 1959
• Folder 12: Reprints, 1960-1961
• Folder 13: Reprints, 1962-1963
• Folder 14: Reprints, 1964
• Folder 15: Reprints, 1965-1966

BOX THIRTEEN – PUBLICATIONS

• Folder 1: Reprints, 1967-1969
• Folder 2: Reprints, 1970-1972
• Folder 3: Reprints, 1974-1976
• Folder 4: Reprints, 1977
• Folder 5: Reprints, 1978
• Folder 6: Reprints, 1978 or later
• Folder 7: Reprints, 1979-1983
• Folder 8: Reprints, 1995

BOX FOURTEEN – GRANT APPLICATIONS

• Folder 1: Jane Coffin Childs Fund (1951-59)
• Folder 2: Plasma and tissue protein metabolism in normal and experimental disease states and in irradiated animals (1951-62)
• Folder 3: Plasma and tissue protein metabolism in normal and experimental disease states and in irradiated animals (1963-66)
• Folder 4: Plasma and tissue protein metabolism in normal and experimental disease states and in irradiated animals (1967-77)
• Folder 5: Plasma and tissue protein studies with isotopically labeled substances (1953-56)
• Folder 6: Plasma and tissue protein studies with isotopically labeled substances (1957-64)
• Folder 7: Radioisotope Research Support Program (1954-61)
• Folder 8: An outline of the major research activities in the tracer chemistry section of the department of Radiation Biology (ca. 1960-65)
• Folder 9: Sulfate mucoprotein metabolism in perfused rat livers (1963)
• Folder 10: Net synthesis of plasma proteins by perfused liver (1966)
• Folder 11: Net synthesis of plasma proteins by perfused liver (1967)
• Folder 12: Net synthesis of plasma proteins by perfused liver (1969-72)
• Folder 13: Net synthesis of plasma proteins by perfused liver (1973-75, 1978)

BOX FIFTEEN – GRANT APPLICATIONS

• Folder 1: Atomic Energy Project. Quarterly review submissions. Tracer chemistry (Jan/Mar 1955-Jan/Mar 1964)
• Folder 2: Jane Coffin Childs Fund (1970-71)
• Folder 3: Diabetes mellitus and plasma glycoprotein synthesis (1977-83)
• Folder 4: Diabetes mellitus and plasma glycoprotein biosynthesis (1984-87)

BOX SIXTEEN – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Dog experiments. Chlornaphthalenes (1943)
• Folder 2: Liver perfusion data #1-#90 (1950-52)
• Folder 3: Liver perfusion data #120-#200 (1954)
• Folder 4: Whole rats, EVR, TR, WR (1950-54?)
• Folder 5: EVR Vol. I (1956-62)
• Folder 6: EVR Vol. II (1955-60)
• Folder 7: EVR Vol. III (1959-60)

BOX SEVENTEEN – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Dr. Miller (1957)
• Folder 2: Fibrinogen (1960)
• Folder 3: C14 data RLP 900-1050 (1961-63)
• Folder 4: RLP chemistries B51-B184 (1963-66)
• Folder 5: RLP P34-P87 (1963)
• Folder 6: RLP P36-P87, data & graphs (1963)

BOX EIGHTEEN – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Rat liver perfusion methods
• Folder 2: Amino acid data sheets #261-#400 (1963-64)
• Folder 3: Amino acid data sheets #401-#499 (1964-65)
• Folder 4: Amino acid data sheets #500-#544 (1965)
• Folder 5: Amino acid records #381-#396
• Folder 6: Amino acid records #397-#420
• Folder 7: Regenerating livers P118-P185 (1964)

BOX NINETEEN – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: RLP methods. D.M. Eddy (ca. 1967)
• Folder 2: RLP methods. D.M. Eddy (ca. 1967)
• Folder 3: Nutrition studies summary data. Raw vol. I (late 1960s?)
• Folder 4: Nutrition studies summary data. Raw vol. II (undated)
• Folder 5: Nutrition old graphs
• Folder 6: Nutrition. IPRL enzyme adaptation (late 1960s)
• Folder 7: Glutamine metabolism on normal and cirrotic rats. J.H. Kim (1969)

BOX TWENTY – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Projects 1970-73. Immunoelectrophoresis, albumin prep., AGP prep.
• Folder 2: Amino acids graphs vol. I.1 (1970-73)
• Folder 3: Amino acids graphs vol. I.2 (1970-73)
• Folder 4: Amino acids graphs vol. II.1 (1973-75)
• Folder 5: Amino acids graphs vol. II.2 (1973-75)
• Folder 6: Amino acids graphs vol. III.1 (1975-76)

BOX TWENTY-ONE  – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Amino acids graphs vol. III.2 (1975-76)
• Folder 2: Glucoses graphs vol. I.1 (1970-73)
• Folder 3: Glucoses graphs vol. I.2 (1970-73)
• Folder 4: Glucoses graphs vol. II.1 (1973-75)
• Folder 5: Glucoses graphs vol. II.2 (1973-75)

BOX TWENTY-TWO – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Glucoses graphs vol. III.1 (1975-76)
• Folder 2: Glucoses graphs vol. III.2 (1975-76)
• Folder 3: Glucoses graphs vol. IV.1 (1977-78)
• Folder 4: Glucoses graphs vol. IV.2 (1977-78)
• Folder 5: Ureas graphs vol. I.1 (1970-73)

BOX TWENTY-THREE – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Urea graphs vol. I.2 (1970-73)
• Folder 2: Urea graphs vol. II.1 (1973-75)
• Folder 3: Urea graphs vol. II.2 (1973-75)
• Folder 4: Urea graphs vol. III.1 (1975-76)
• Folder 5: Urea graphs vol. III.2 (1975-76)

BOX TWENTY-FOUR – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: “New” urea method (1972)
• Folder 2: Autoanalyzer log vol. I.1 (1971-74)
• Folder 3: Autoanalyzer log vol. I.2 (1971-74)
• Folder 4: Autoanalyzer (1972)
• Folder 5: RLP P639-P699 (1971)
• Folder 6: RLP P700-P799 (1971-72)
• Folder 7: RLP P800-P899 (1973)
• Folder 8: RLP P900-P999 (1974-75)

BOX TWENTY-FIVE – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: RLP P1000-P1077 (1975-76)
• Folder 2: RLP P1078-P1199 (1976-77)
• Folder 3: RLP P1200-P1316 (1977-80)
• Folder 4: Chemistries “B” perfusions (1971-75)
• Folder 5: Chemistries “B” perfusions (1975-79)
• Folder 6: Chemistries RLP 667-1011 (1971-75)

BOX TWENTY-SIX – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Chemistries “P” perfusions (1977-78)
• Folder 2: NPN, NH & glutamine studies (1972-72)
• Folder 3: Affinity chromatography (1972-73)
• Folder 4: Affinity chromatography (1972-73)
• Folder 5: 5-Bromotubercidin, ACD, duromycin, cordelypin ½ life study (1972-73)
• Folder 6: Pevikon blocks (1975)
• Folder 7: Perfusion groups and electrode data (ca. 1975)

BOX TWENTY-SEVEN – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: RLP B669-B799 (1974-76)
• Folder 2: RLP B800-B899 (1976-77)
• Folder 3: RLP B900-B1018 (1977-80)
• Folder 4: Acidosis study: Ig6 purification. D. Eddy (1979)
• Folder 5: Agarose isoelectric focusing: 2 dimension CON A study (1979-80)
• Folder 6: Electrofocusing (1980)
• Folder 7: Diabetic rats (1982)
• Folder 8: Rat IgA clearance studies (1985)

BOX TWENTY-EIGHT – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Male rats, female rats (1985-86)
• Folder 2: D. Eddy data summaries, A-B
• Folder 3: D. Eddy data summaries, C
• Folder 4: D. Eddy data summaries, D-L
• Folder 5: D. Eddy data summaries, P-S

BOX TWENTY-NINE – LABORATORY NOTEBOOKS, 3-RING

• Folder 1: Photographs: Ella M. Russ
• Folder 2: Photographs: Harold P. Rush, University of Wisconsin (1962)
• Folder 3: Photographs: prints and graphs

BOX 30 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Baker Laboratory. 1 vol., 1934-37
• Dept. of Pathology. Notes, Research Data, Research Notes, 5 vols., 1938-42
• C14 Counter. 1 vol., 1947
• Unlabeled single vol., 1948-50
• R-III, R-VI. 2 vols., 1948-49
• Research I, 3-50, 10-51. 1st vol. of 3, 1949-51
• Research II, 10-51, 2-53. 2nd vol. of 3, 1951-53
• Research III, 2-63? 3rd vol. of 3, 1953-54
• Spine label missing. Table of contents on p. 1. 1 vol., 1951
• Liver Perfusions, Progress Notes, RLP 21-223. 1 vol., 1950-54
• RPAc Control Data, C.L. Mackay … Spring 1954. 1 vol.
• Glucose & Fructose. Books I?, III, IV. 3 vols., 1953-55

BOX 31 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Glucose, Fructose, Amino Acids. Books II-VI, X. 7 vols., 1953-60
• Glucoses, Halligan. 2 vols., 1955-57
• Dorothy Walton. Books I-IX. 9 vols., 1959-61
• Electrophoresis experiments 1960. 1 vol.
• Tissue culture. Ilse N. Lurie. 1960. 1 vol.
• Haptoglobin. K. Temple. 1 vol., 1961

BOX 32 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• RLP 220-RLP 1000 (1954-61), RLP B1-B668 (1962-74). 12 vols.

BOX 33 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• David W. John. 7 vols., 1961-69
• Free amino acid experiments. 1 vol., 1961-62
• Hela cells. 3 vols., 1962-63
• RLP P1-RLP P638. 10 vols., 1962-70

BOX 34 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Rat liver perfusion coagulation studies. John Olson. 1 vol., 1963
• Liver perfusions P35-P86. L.E. Mutscher. 3 vols., 1963
• Daily notes & data records. Notebooks 1-10. Cathy Schwalb. 10 vols., 1964-69
• Louise Rogers. Books I-III, V-VI. 6 vols., 1966-68

BOX 35 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Serological plates. Fibrinogen & albumin. Books 1-11, 15-21. 18 vols., 1965-76
• Rat. Sex dependent protein. Isolation & serological quantitation. Notebook 1. 1 vol., 1967-68
• Procedures. Chemistries. Ruth A. Butler. 1 vol., undated
• Chemistry data: glucoses, amino acids. Nadia Taylor. Books XVII, XVIII, XX. 3 vols., 1968-70
• Chemistries. B437-B668. 4 vols., 1969-197?

BOX 36 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Serological quantitation. Acid glycoprotein; acute phase protein. P & B series. Books 1-19, 22, 23 1967-76. 22 vols.
• Immunoelectrophoresis assays. March 1969. 1 vol.
• Urea book XII. 1 vol., 1969-71

BOX 37 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Haptoglobin. Serological quantitation; serological plates; radial diffusion plates. Books 1-6, 8-10. 8 vols., 1969-76
• Serological plates, Summary books. B series. 4 vols., undated.
• R. Nesbit. Sep ’70-Jun ’72. 1 vol.
• Adrenalectomized rats and ETOH rats. 1 vol., 1970-74
• Protein preps. L.L. Miller. 1 vol., 1972-79
• Procedures. 1 vol., 1972-74?
• Development of Kjeldahl-NPN autoanalyzer method. Vol. III. 1 vol., 1973
• RNA & DNA. 1 vol., 1973
• Total & partial Hepx rats after enterectomy. 1 vol., 1973-77
• Lowrys P1224- ; B924- . 1 vol., 1978
• Streptozotocin diabetes-I. L.L. Miller. 1 vol., 1978-84

BOX 38 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• D.M. Eddy Laboratory notebook. 1 vol., 1983?
• Bile IgA studies. Leon L. Miller. 1 vol., 1984-87
• IgA. 3 vols., 1984-88
• Pepsin-Pepsinogen. L.L. Miller. 1 vol., 1984
• Protein purification. L.L. Miller. 2 vols., 1986-93
• Dr. Miller’s lab. Books 7-8 (1982-82), 12-18 (1983-85), 20-24 (1985-86), 26 (1987), 31-32 (1991-92). 17 vols.

BOX 39 – LABORATORY NOTEBOOKS, COMPOSITION BOOKS

• Dr. Miller’s lab. Books 33-45  (1992-2000)

BOUND VOLUMES OF COMPUTER-GENERATED RLP DATA

• P612 to P711 (1970-1971)
• P801 to P900 (1972-1973)
• P901 to P999 (1973-1974)
• P1000 to P1100 (1975-1977)
• P1101 to P1200 (1976-1977)
• P1201 to P1317 (1977-1980
• B700 to B799 (1975)
• B800 to B899 (1976-1977)
• B900 to B1018 (1977-1979)

BOX 40 – DIPLOMAS

BOX 41 – MISCELLANEA